A new view of mRNA export: Separating the wheat from the chaff

Nature Cell Biology

Volumn 3, Issue 9, 2001, Pages

  Reed, Robin ^a   Magni, Keith ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; MESSENGER RNA; NUCLEAR RNA; RNA BINDING PROTEIN;

ARTICLE; CELL NUCLEUS; EUKARYOTE; GENETIC CONSERVATION; INTRON; NONHUMAN; PRIORITY JOURNAL; RNA SPLICING; RNA TRANSPORT; SPLICEOSOME; YEAST;

ANIMALS; CELL NUCLEUS; EXONS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; INTRONS; MODELS, BIOLOGICAL; RIBONUCLEOPROTEINS; RNA PRECURSORS; RNA SPLICING; RNA, MESSENGER; RNA-BINDING PROTEINS;

EID: 0034848163     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb0901-e201     Document Type: Article

References (54)

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2. Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins
3. Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences
4. Differential binding of heterogeneous nuclear ribonucleo-proteins to mRNA precursors prior to spliceosome assembly in vitro
5. An ATP-independent complex commits pre-mRNA to the mammalian spliceosome assembly pathway
6. hnRNP A1 binds promiscuously to oligoribonucleotides: Utilization of random and homo-oligonucleotides to discriminate sequence from base-specific binding
7. Splicing is required for rapid and efficient mRNA export in metazoans
8. SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex
9. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm
10. The hnRNP C proteins contain a nuclear retention sequence that can override nuclear export signals
11. The structure and function of proteins involved in mammalian pre-mRNA splicing
12. A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm
13. Sorting out the complexity of SR protein functions
14. The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3′ splice site
15. Macromolecular domains within the cell nucleus
16. Association of nuclear matrix antigens with exon-containing splicing complexes
17. Pre-mRNA splicing alters mRNP composition: Evidence for stable association of proteins at exon-exon junctions
18. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
19. A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export
20. Analysis of the RNA-recognition motif and RS and RGG domains: Conservation in metazoan pre-mRNA splicing factors
21. Nucleocytoplasmic transport: The soluble phase
22. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates
23. A Ran-independent pathway for export of spliced mRNA
24. Nuclear RNA export pathways
25. + RNA and nuclear pores
26. Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores
27. The product of the Saccharomyces cerevisiae RSS1 gene, identified as a highcopy suppressor of the rat7-1 temperature-sensitive allele of the RAT7/NUP159 nucleoporin, is required for efficient mRNA export
28. An RNA-export mediator with an essential nuclear export signal
29. GLE2, a Saccharomyces cerevisiae homologue of the Schizosaccharomyces pombe export factor RAE1, is required for nuclear pore complex structure and function
30. Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export
31. + RNA export
32. Yralp, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export
33. mRNA export: The long and winding road
34. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human
35. RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains
36. mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm
37. + RNA export
38. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p
39. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export
40. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
41. REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus
42. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus
43. The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences
44. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm
45. The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes
46. Exon recognition in vertebrate splicing
47. Initial splice-site recognition and pairing during pre-mRNA splicing
48. Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription
49. A multicomponent complex is involved in the splicing of messenger RNA precursors
50. Early commitment of yeast pre-mRNA to the spliceosome pathway
51. Regulation by HIV Rev depends upon recognition of splice sites
52. Transport of proteins and RNAs in and out of the nucleus
53. A pre-mRNA-binding protein accompanies the RNA from the gene through the nuclear pores and into polysomes
54. Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA