Pre-mRNA processing factors are required for nuclear export

RNA

Volumn 6, Issue 12, 2000, Pages 1737-1749

  Brodsky, A S ^a   Silver, P A ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

3' processing; ASH1 3' UTR; mRNA export; Polyadenylation

Indexed keywords

GREEN FLUORESCENT PROTEIN; MESSENGER RNA; NUCLEOPORIN; RIBONUCLEOPROTEIN; RNA BINDING PROTEIN;

3' UNTRANSLATED REGION; ARTICLE; CHEMICAL MUTAGENESIS; GENETIC ENGINEERING; INTRON; NONHUMAN; NUCLEOLUS; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN PROCESSING; RNA PROCESSING; RNA TRANSPORT; YEAST CELL;

3' UNTRANSLATED REGIONS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL NUCLEOLUS; CELL NUCLEUS; FUNGAL PROTEINS; GREEN FLUORESCENT PROTEINS; INTRONS; LUMINESCENT PROTEINS; MEMBRANE PROTEINS; NUCLEAR PROTEINS; NUCLEIC ACID CONFORMATION; POLY A; RECOMBINANT FUSION PROTEINS; RIBONUCLEOPROTEIN, U1 SMALL NUCLEAR; RIBONUCLEOPROTEINS; RNA PRECURSORS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA SPLICING; RNA, FUNGAL; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE;

EID: 0034544815     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838200001059     Document Type: Article

References (55)

1. A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation
2. Nuclear PRP20 protein is required for mRNA export
3. Isolation and characterization of RAT1: An essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA
4. Localization and anchoring of mRNA in budding yeast
5. Localization of ASH1 mRNA particles in living yeast
6. Coupling termination of transcription to messenger RNA maturation in yeast
7. Polyadenylation of telomerase RNA in budding yeast
8. Terminal exon definition occurs cotranscriptionally and promotes termination of RNA polymerase II
9. Mature mRNA 3' end formation stimulates RNA export from the nucleus
10. CRM1 is an export receptor for leucine-rich nuclear export signals
11. Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: Possible coupling of mRNA processing and chromatin structure
12. HuR binding to cytoplasmic mRNA is perturbed by heat shock
13. The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay
14. Transport between the cell nucleus and the cytoplasm
15. A conditional allele of the novel repeat-containing yeast nucleoporin RAT7/NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes
16. TAP, the human hemolog of Mex67p, mediates CTE-dependent RNA expert from the nucleus
17. Nuclear pore complex clustering and nuclear accumulation of poly(A)+ RNA associated with mutation of the Saccharomyces cerevisiae RAT2/NUP120 gene
18. Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells
19. The yeast RNA1 gene product necessary for RNA processing is located in the cytosel and apparently excluded from the nucleus
20. Role of polyadenylation in nucleocytoplasmic transport of mRNA
21. Mex67p mediates nuclear export of a variety of RNA polymerase II transcripts
22. Isolation and characterization of Saccharomyces cerevisiae mRNA transport-defective (mtr) mutants
23. Mutations in nucleolar proteins lead to nucleolar accumulation of polyA + RNA in Saccharomyces cerevisiae
24. A conditional yeast mutant deficient in mRNA transport from nucleus to cytoplasm
25. The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences
26. Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3'-end formation in yeast
27. Uncoupling of the hnRNP Np3p from mRNAs during the stress-induced block in mRNA export
28. The cis-acting sequences responsible for the differential decay of the unstable MFA2 and stable PGK1 transcripts in yeast include the context of the translational start codon
29. Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm
30. Spatial consequences of defective processing of specific yeast mRNAs revealed by fluorescent in situ hybridization
31. Splicing is required for rapid and efficient mRNA export in metazoans
32. Effects of mutations in the Saccharomyces cerevisiae RNA14, RNA15, and PAP1 genes on polyadenylation in vivo
33. Mutations in the yeast RNA14 and RNA15 genes result in an abnormal mRNA decay rate; sequence analysis reveals an RNA-binding domain in the RNA15 protein
34. The NES-Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiae
35. The nucleolus and the four ribonucleoproteins of translation
36. The heat shock and ethanol stress responses of yeast exhibit extensive similarity and functional overlap
37. Efficient translation of poly(A)-deficient mRNAs in Saccharomyces cerevisiae
38. Regulation of mRNA export in response to stress in Saccharomyces cerevisiae
39. Yeast heat shock mRNAs are exported through a distinct pathway defined by Rip1p
40. tRNA nuclear export in Saccharomyces cerevisiae: In situ hybridization analysis
41. mRNA transport in yeast: Time to reinvestigate the functions of the nucleolus
42. PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome
43. Inter-actions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase
44. Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores
45. Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export
46. Exportin 1 (Crm1p) is an essential nuclear export factor
47. Characterization of yeast U1 snRNP A protein: Identification of the N-terminal RNA binding domain (RBD) binding site and evidence that the C-terminal RBD functions in splicing
48. Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export
49. Nuclear export of heat shock and non-heat-shock mRNA occurs via similar pathways
50. Yeast exosome mutants accumulate 3'-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs
51. Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae
52. A new family of yeast nuclear pore complex proteins
53. Construction of a Set of convenient Saccharomyces cerevisiae strains that are isogenic to S288C
54. Contribution of the C-terminal tail of U1A RBD1 to RNA recognition and protein stability
55. Formation of mRNA 3' ends in eukaryotes: Mechanism, regulation, and interrelationships with other steps in mRNA synthesis