Defects in the mRNA export factors Rat7p, Gle1p, Mex67p, and Rat8p cause hyperadenylation during 3′-end formation of nascent transcripts

RNA

Volumn 7, Issue 5, 2001, Pages 753-764

  Hilleren, P ^a   Parker, R ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

3 end formation; mRNA export; mRNP remodeling; Polyadenylation

Indexed keywords

CARRIER PROTEIN; GENE PRODUCT; MESSENGER RNA; POLYADENYLIC ACID; PROTEIN GLE1P; PROTEIN MEX67P; PROTEIN RAT7P; PROTEIN RAT8P; RIBONUCLEOPROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CYTOPLASM; MESSENGER RNA SYNTHESIS; POLYADENYLATION; PRIORITY JOURNAL; RNA DEGRADATION; RNA TRANSLATION; RNA TRANSPORT;

ACTIVE TRANSPORT, CELL NUCLEUS; CARRIER PROTEINS; CELL NUCLEUS; CYTOPLASM; GENE EXPRESSION; MEMBRANE PROTEINS; NUCLEAR PORE COMPLEX PROTEINS; NUCLEAR PROTEINS; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; PHENOTYPE; POLY A; PROTEIN BIOSYNTHESIS; RNA, FUNGAL; RNA, MESSENGER; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EUKARYOTA;

EID: 0035047844     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838201010147     Document Type: Article

References (43)

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19. Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells
20. Yeast cells lacking 5′ → 3′ exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5′ cap structure
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27. Premature translational termination triggers mRNA decapping
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34. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p
35. Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores
36. A yeast protein that bidirectionally affects nucleocytoplasmic transport
37. Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export
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39. Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export
40. The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p
41. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export
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43. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans