NXF1/p15 heterodimers are essential for mRNA nuclear export in Drosophila

RNA

Volumn 7, Issue 12, 2001, Pages 1768-1780

  Herold, A ^a   Klymenko, T ^a   Izaurralde, E ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

mRNA export; Nuclear export; NXF; NXT; p15; Small bristles; TAP

Indexed keywords

DIMER; GENE PRODUCT; HEAT SHOCK PROTEIN; MESSENGER RNA; NUCLEAR PROTEIN; PROTEIN MEX67P; PROTEIN NXF1; PROTEIN P15; UNCLASSIFIED DRUG;

ARTICLE; CELL SPECIFICITY; CONTROLLED STUDY; DIMERIZATION; DROSOPHILA; ESSENTIAL GENE; FLUORESCENCE IN SITU HYBRIDIZATION; GROWTH INHIBITION; INTRACELLULAR TRANSPORT; INTRON; METAZOON; NONHUMAN; NUCLEOTIDE SEQUENCE; NXF GENE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE PROTEINS; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P15; DIMERIZATION; DROSOPHILA; DROSOPHILA PROTEINS; HEAT-SHOCK PROTEINS; HEAT-SHOCK RESPONSE; HSP70 HEAT-SHOCK PROTEINS; INSECT PROTEINS; NUCLEAR PROTEINS; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; RNA-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EUKARYOTA; METAZOA;

EID: 0035671563     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Micro-injection of anti-coilin antibodies affects the structure of coiled bodies
2. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates
3. Identification of novel import and export signals of human TAP, the protein that binds to the CTE element of the type D retrovirus mRNAs
4. NXT1 is necessary for the terminal step of Crm1-mediated nuclear export
5. Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export
6. Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export
7. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways
8. Nucleocytoplasmic transport enters the atomic age
9. Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor
10. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus
11. NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells
12. TAP/NXF1 belongs to a multigene family of putative RNA export factors with a conserved modular architecture
13. Defects in the mRNA export factors Rat7p, Gle1p, Mex67p, and Rat8p cause hyperadenylation during 3′-end formation of nascent transcripts
14. Mex67p mediates nuclear export of a variety of RNA polymerase II transcripts
15. A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription
16. NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation
17. Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant
18. Analysis of cellular factors that mediate nuclear export of RNAs bearing the Mason-Pfizer monkey virus constitutive transport element
19. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human
20. Small bristles, DmNXF1, is required for the morphogenesis of multiple tissues during Drosophila development
21. The structure of the mRNA nuclear export factor TAP reveals a cis arrangement of a non-canonical RNP domain and a leucine-rich-repeat domain
22. Nucleocytoplasmic transport: The soluble phase
23. Transport of proteins and RNAs in and out of the nucleus
24. RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro
25. The constitutive transport element (CTE) of Mason-Pfizer Monkey Virus (MPMV) accesses an RNA export pathway utilized by cellular messenger RNAs
26. REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus
27. The simian retrovirus-1 constitutive transport element CTE, unlike HIV-1 RRE, utilizes factors required for cellular RNA export
28. Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores
29. Mex67p, a novel factor for nuclear mRNA export binds to both poly(A)+ RNA and nuclear pores
30. Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export
31. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export
32. Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins
33. The mRNA export in C. elegans is mediated by Ce NXF1, an orthologue of human TAP/NXF1 and S. cerevisiae Mex67p
34. Nuclear export of heat shock and non-heat-shock mRNA occurs via similar pathways
35. Small bristles, the Drosophila ortholog of human TAP/NXF1 and yeast Mex67p, is essential for mRNA nuclear export in all tissues throughout development
36. Two closely related human nuclear export factors utilize entirely distinct export pathways
37. Tap: A novel cellular protein that interacts with tip of herpes virus saimiri and induces lymphocyte aggregation
38. RNA splicing is interrupted by heat shock and is rescued by heat shock protein synthesis