TRA-1 regulates the cellular distribution of the tra-2 mRNA in C. elegans

Nature

Volumn 399, Issue 6738, 1999, Pages 802-805

  Graves, L E ^a   Segal, S ^a   Goodwin, E B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MESSENGER RNA; PROTEIN; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

ARTICLE; CAENORHABDITIS ELEGANS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE EXPRESSION; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; TRANSGENE;

3' UNTRANSLATED REGIONS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; GENES, HELMINTH; HELMINTH PROTEINS; MEMBRANE PROTEINS; RIBONUCLEOPROTEINS; RNA, HELMINTH; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

CAENORHABDITIS ELEGANS; CUBITUS; INVERTEBRATA; VERTEBRATA;

EID: 0033600265     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/21682     Document Type: Article

References (22)

1. Weed, M., Mundlos, S. & Olsen, B. R. The role of sonic hedgehog in vertebrate development. Matrix Biol. 16, 53-58 (1997).
2. Hodgkin, J. Sex determination in the nematode C. elegans: analysis of tra-3 suppressors and characterization of fem genes. Genetics 114, 15-52 (1986).
3. Hodgkin, I. A genetic analysis of the sex-determining gene, tra-1, in the nematode Caenorhabditis elegans. Genes Der. 1, 731-745 (1987).
4. Kinzler, K. W., Ruppert, J. M., Bigner, S. H. & Vogelstein, B. The GLI gene is a member of the Kruppel family of zinc-finger proteins. Nature 332, 371-374 (1988).
5. Alexandre, C., Jacinto, A. & Ingham, P. W. Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev. 10, 2003-2013 (1996).
6. Zarkower, D. & Hodgkin, J. Molecular analysis of the C. elegans sex-determining gene tra-1: a gene encoding two zinc finger proteins. Cell 70, 237-249 (1992).
7. Kuwabara, P. E., Okkema, P. G. & Kimble, J. tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway. Mol. Biol. Cell 3, 461-473 (1992).
8. Hodgkin, J. A. & Brenner, S. Mutations causing transformation of sexual phenotype in the nematode Caenorhabditis elegans. Genetics 86, 275-287 (1977).
9. Okkema, P. G. & Kimble, J. Molecular analysis of tra-2, a sex determining gene in C. elegans. EMBO J. 10, 171-176 (1991).
10. Spieth, J., Brooke, G., Kuersten, S., Lea, K. & Blumenthal, T. Operons in C. elegans. polycistronic mRNA precursors are processed by trans-splicing of SL2 to downstream coding regions. Cell 73, 521-532 (1993).
11. Goodwin, E. B., Okkema, P. G., Evans, T. C. & Kimble, J. Translational regulation of tra-2 by its 3′ untranslated region controls sexual identity in C. elegans. Cell 75, 329-339 (1993).
12. Zarkower, D. & Hodgkin, J. Zinc fingers in sex determination: only one of the two C. elegans Tra-1 proteins binds DNA in vitro. Nucleic Acids Res. 21, 3691-3698 (1993).
13. Stutz, F. & Rosbash, M. Nuclear RNA export. Genes Dev. 12, 3303-3319 (1998).
14. Brenner, S. The genetics of Caenarhabditis elegans. Genetics 77, 71-94 (1974).
15. Seydoux, G. & Fire, A. Semi-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans. Development 120, 2823-2834 (1994).
16. Kuwabara, P. E. & Kirshle, J. Molecular genetic of sex determination in C. elegans.Trends Genet. 8, 164-168 (1992).
17. Kuwabara, P. E., Okkama P. G. & Kimble, J. Germ-line regulation of the Caenorhabditis elegans sex-determining gene tra-2. Dev. Biol. 204, 2S1-262 (1998).
18. Jan, E., Yoon, J. W., Walterhouse, D., Iannaccone, P. & Goodwin, E. B. Conservation of the C. elegans tra-2 3′UTR translational control. EMBO J. 16, 6301-6313 (1997).
19. Goodwin, E. B., Hofstra, K., Hurney, C. A., Mango, S. & Kimble, J. A genetic pathway for regulation of tran-2 translation. Development 124, 749-758 (1997).
20. Mello, C. & Fire, A. DNA transformation. Methods Cell Biol. 48, 451-482 (1995).
21. Fire, A. Histochemical techniques for locating Escherichia coli beta-galactosidase activity in transgenic organisms. Genet. Anal. Tech. Appl. 9, 151-158 (1992).
22. Hodgkin, J. Molecular cloning and duplication of the nematode sex-determining gene tra-1. Genetics 133, 543-560 (1993).