Quality control of mRNA 3′-end processing is linked to the nuclear exosome

Nature

Volumn 413, Issue 6855, 2001, Pages 538-542

  Hilleren, Patricia ^a   McCarthy, Terri ^b   Rosbash, Michael ^b   Parker, Roy ^a   Jensen, Torben Heick ^b,c  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b BRANDEIS UNIVERSITY   (United States)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; METABOLISM; MUTAGENESIS; RNA;

NUCLEAR EXOSOMES;

NATURAL SCIENCES;

CELL PROTEIN; MESSENGER RNA; NUCLEAR PROTEIN; POLYADENYLIC ACID; PROTEIN RRP6P; UNCLASSIFIED DRUG;

RNA;

ARTICLE; CONTROLLED STUDY; EXOSOME; NONHUMAN; POLYADENYLATION; PRIORITY JOURNAL; QUALITY CONTROL; RNA PROCESSING; RNA TRANSCRIPTION; RNA TRANSLATION; RNA TRANSPORT; SACCHAROMYCES CEREVISIAE;

CELL NUCLEUS; FUNGAL PROTEINS; GENES, FUNGAL; HEAT-SHOCK PROTEINS; MULTIENZYME COMPLEXES; POLY A; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, FUNGAL; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 0035807308     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35097110     Document Type: Article

References (18)

1. Quality control of mRNA function
2. Mature mRNA 3′ end formation stimulates RNA export from the nucleus
3. Role of polyadenylation in nucleocytoplasmic transport of mRNA
4. Defects in mRNA export factors Rat7p, Glelp, Mex67p and Rat8p cause hyperadenylation during 3′ end formation of nascent transcripts
5. A block to mRNA nuclear export in Saccharomyces cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription
6. Rrp6p, the yeast homologue of the human PM-Scl 100-kDa autoantigen, is essential for efficient 5.8 S rRNA 3′ end formation
7. The exosome: A conserved eukaryotic RNA processing complex containing multiple 3′ → 5′ exoribonucleases
8. Conditional defect in mRNA 3′ end processing caused by a mutation in the gene for poly(A) polymerase
9. A nuclear 3′-5′ exonuclease involved in mRNA degradation interacts with poly(A) polymerase and the nnRNA protein Npl3p
10. A turnover pathway for both stable and unstable mRNAs in yeast: Evidence for a requirement for deadenylation
11. Functions of the exosome in rRNA, snoRNA and snRNA synthesis
12. Yeast exesome mutants accumulate 3′ extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs
13. Identification of a regulated pathway for nuclear pre-mRNA turnover
14. A conditional allele of the novel repeat-containing yeast nudeoporin RAT7/NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes
15. A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export
16. Nuclear export of heat shock and non-heat-shock mRNA occurs via similar pathways
17. Effects of mutations in the Saccharomyces cerevisiae RNA14, RNA15, and PAPI genes on polyadenylation in vivo
18. Mutations in STS1 suppress the defect in 3′ mRNA processing caused by the ma15-2 mutation in Saccharomyces cerevisiae