Pre-mrna splicing and mRNA export linked by direct interactions between UAP56 and aly

Nature

Volumn 413, Issue 6856, 2001, Pages 644-647

  Luo, Ming Juan ^a   Zhou, Zhaolan ^a   Magni, Keith ^a   Christoforides, Claudine ^a   Rappsilber, Juri ^b   Mann, Matthias ^b   Reed, Robin ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENZYME INHIBITION; PROTEINS; RNA;

SPLICING FACTORS;

NATURAL SCIENCES;

HELICASE; MESSENGER RNA; RIBONUCLEOPROTEIN;

BIOCHEMISTRY; RNA;

ARTICLE; CONTROLLED STUDY; GENE TARGETING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN RNA BINDING; RNA SPLICING; SPLICEOSOME; XENOPUS LAEVIS;

ADENOSINE TRIPHOSPHATASES; ANIMALS; BIOLOGICAL TRANSPORT; CELL NUCLEUS; CYTOPLASM; HELA CELLS; HUMANS; NUCLEAR PROTEINS; RIBONUCLEOPROTEIN, U2 SMALL NUCLEAR; RNA PRECURSORS; RNA SPLICING; RNA, MESSENGER; RNA-BINDING PROTEINS; SPLICEOSOMES; TRANSCRIPTION FACTORS; XENOPUS;

EID: 0035846138     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35098106     Document Type: Article

References (23)

1. Splicing is required for rapid and efficient mRNA export in metazoans
2. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
3. Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA
4. REP proteins mediate the export of spiked and unspliced mRNAs from the nucleus
5. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
6. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm
7. U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction
8. Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase
9. Multiple roles for the yeast SUB2/γUAP56 gene in splicing
10. Identification and characterization of γUAP/Sub2p, a yeast homolog of the essential human pre-mRNA splicing factor hUAP56
11. Mechanical devices of the spliceosome: Motors, clocks, springs, and things
12. Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export
13. The Y14 protein communicates to the cytoplasm the position of exon-exon junctions
14. Nucleocytoplasmic transport enters the atomic age
15. A human nuclear-localized chaperone that regulates dimerization, DNA binding, and transcriptional activity of bZIP proteins
16. ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRα enhancer function
17. Silent information regulator protein complexes in Saccharomyces cerevisiae: A SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3
18. The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus
19. Monomethylated cap structures facilitate RNA export from the nucleus
20. Functional association of U2 snRNP with the ATP-independent spliceosomal complex E
21. Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus
22. Improved resolution and very high sensitivity in MALD1 TDf of matrix surfaces made by fast evaporation
23. Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p