Yeast heat shock mRNAs are exported through a distinct pathway defined by Rip1p

Genes and Development

Volumn 11, Issue 21, 1997, Pages 2845-2856

  Saavedra, Claudio A ^a,b   Hammell, Christopher M ^a   Heath, Catherine V ^a   Cole, Charles N ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Heat shock; hnRNP; Rev; RIP1; RNA export; RSS1 GLE1

Indexed keywords

FUNGAL PROTEIN; GUANOSINE TRIPHOSPHATASE; HEAT SHOCK PROTEIN 70; MESSENGER RNA; NUCLEOPORIN; POLYADENYLATED RNA; RIP 1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL GROWTH; CONTROLLED STUDY; HEAT SHOCK; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; RNA TRANSPORT; SACCHAROMYCES CEREVISIAE; YEAST CELL;

EID: 9844219734     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.21.2845     Document Type: Article

References (64)

1. Adam, S.A., R.S. Marr, and L. Gerace 1990. Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J. Cell Biol. 111: 807-816.
2. Aitchison, J.D., G. Blobel, and M.P. Rout. 1995. Nup120p: A yeast nucleoporin required for NPC distribution and mRNA transport. J. Cell Biol. 131: 1659-1675.
3. Amberg, D.A., A.L. Goldstein, and C.N. Cole. 1992. Isolation and characterization of RAT1, an essential gene of Saccharomyccs cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA. Genes & Dev. 6: 1173-1189.
4. Amberg, D.C., M. Fleischmann, I. Stagljar, C.N. Cole, and M. Aebi. 1993. Nuclear PRP20 protein is required for mRNA export. EMBO J. 12: 233-241.
5. Baudin, A., O. Ozier-Kalogeropoulos, A. Denouel, F. Lacroute, and C. Cullin. 1993. A simple and efficient method for direct gene deletion in Saccharomyccs cerevisiae. Nucleic Acids Res. 21: 3329-3330.
6. Bogerd, H.P., R.A. Fridell, S. Madore, and B.R. Cullen. 1995. Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins. Cell 82: 485-494.
7. Bram, R.J. and R.D. Kornberg. 1985. Specific protein binding to far upstream activating sequences in polymerase II promoters. Proc. Natl. Acad. Sci. 82: 43-47.
8. Cadwell, R.C. and G.F. Joyce. 1992. Randomization of genes by PCR mutagenesis. PCR Methods & Applic. 2: 28-33.
9. Corbett, A.H. and P.A. Silver. 1997. Nucleocytoplasmic transport of macromolecules. Microbiol. Mol. Biol. Rev. 61: 193-211.
10. Davis, L.I. 1995. The nuclear pore complex. Annu. Rev. Biochem. 64: 865-896.
11. DeHoratius, C. and P. A. Silver. 1996. Nuclear transport defects and nuclear envelope alterations are associated with mutation of the Saccharomyces cerevisiae NPL4 gene. Mol. Biol. Cell 7: 1835-1855.
12. Del Priore, V., C.A. Snay, A. Bahr, and C.N. Cole. 1996. Identification of RSS1, a high-copy extragenic suppressor of the rat7-1 temperature-sensitive allele of the Saccharomyces cerevisiae RAT7/NUP159 nucleoporin. Mol. Biol. Cell 7: 1601-1621.
13. Dockendorff, T.C., C.V. Heath, A.L. Goldstein, C.A. Snay, and C.N. Cole. 1997. C-terminal truncations of the yeast nucleoporin Nup145p produce conditional mRNA export defects and alterations to nuclear structure. [Published erratum in Mol. Cell. Biol. 17: 2347-2350] Mol. Cell. Biol. 17: 906-920.
14. + RNA transport and nuclear pore distribution. EMBO J. 13: 6062-6075.
15. Fabre, E., W.C. Boelens, C. Wimmer, I.W. Mattaj, and E.C. Hurt. 1994. Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif. Cell 78: 275-289.
16. Fay, F.S., K.L. Taneja, S. Shenoy, L. Lifshitz, and R.H. Singer. 1997. Quantitative digital analysis of diffuse and concen-trated nuclear distributions of nascent transcripts, SC35 and poly(A). Exp. Cell Res. 231: 27-37.
17. Fischer, U., S. Meyer, M. Teufel, C. Heckel, R. Lührmann, and G. Rautmann. 1994. Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA. EMBO J. 13: 4105-4112.
18. Fischer, U., J. Huber, W.C. Boelens, I.W. Mattaj, and R. Lührmann. 1995. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82: 475-483.
19. Forrester, W., F. Stutz, M. Rosbash, and M. Wickens. 1992. Defects in mRNA 3′-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: Possible coupling of mRNA processing and chromatin structure. Genes & Dev. 6: 1914-1926.
20. Fridell, R.A., H.P. Bogerd, and B.R. Cullen. 1996. Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway. Proc. Natl. Acad. Sci. 93: 4421-4424.
21. Fritz, C.C. and MR. Green. 1996. HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs. Curr. Biol. 6: 848-854.
22. Fritz, C.C., M.L. Zapp, and M.R. Green. 1995. A human nucleoporin-like protein that specifically interacts with HIV Rev. Nature 376: 530-533.
23. Goldstein, A.L., C.A. Snay, C.V. Heath, and C.N. Cole. 1996. Pleiotropic nuclear detects associated with a conditional allele of the novel nucleoporin Rat9p/Nup85p. Mol. Biol. Cell 7: 917-934.
24. Görlich, D. and I.W. Mattaj. 1996. Protein kinesis - Nucleocytoplasmic transport. Science 271: 1512-1518.
25. Gorsch, L.C., T.C. Dockendorff, and C.N. Cole. 1995. A conditional allele of the novel repeat-containing yeast nucleoporin RAT7/NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes. J. Cell Biol. 129: 9399-9355.
26. + RNA associated with mutations of the Saccharomyces cerevisiae RAT2/ NUP120gene. J. Cell Biol. 131: 1677-1697.
27. Hicks, G.R. and N.V. Raikhel. 1996. Protein import into the nucleus: An integrated view. Annu. Rev. Cell Biol. 11: 155-188.
28. + RNA export. J. Cell Biol. 130: 1275-1281.
29. Jarmolowski, A., W.C. Boelens, E. Izaurralde, and I.W. Mattaj. 1994. Nuclear export of different classes of RNA is mediated by specific factors. J. Cell Biol. 124: 627-635.
30. Jost, H.J. and S. Lindquist. 1988. Translation of unspliced transcripts after heat shock. Science 242: 1544-1548.
31. Kadowaki, T., Y. Zhao, and A.M. Tartakoff. 1992. A conditional yeast mutant deficient in mRNA transport from nucleus to cytoplasm. Proc. Natl. Acad. Sci. 89: 2312-2316.
32. Kraemer, D.M., C. Strambio-de-Castillia, G. Blobel, and M.P. Rout. 1995. The essential yeast nucleoporin NUP159 is located on the cytoplasmic side of the nuclear pore complex and serves in karyopherin-mediated binding of transport substrate. J. Biol. Chem. 270: 19017-19021.
33. Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
34. Lee, M., M. Henry, and P.A. Silver. 1996. A protein that shuttles between nucleus and cytoplasm, is an important mediator of mRNA export. Genes & Dev. 10: 1233-1246.
35. + RNA and constitutive clustering of nuclear pore complexes. Mol. Biol. Cell 6: 401-417.
36. Lindquist, S. 1986. The heat-shock response. Annu. Rev. Biochem. 55: 1151-1191.
37. Lindquist, S. and R. Petersen. 1990. Selective translation and degradation of heat-shock messenger RNAs in Drosophila. Enzyme 44: 147-166.
38. + RNA export. EMBO J. 15: 6750-6757.
39. Malim, M.H., D.F. McCarn, L.S. Tiley, and B.R. Cullen. 1991. Mutational definition of the human immunodeficiency vi-rus type 1 Rev activation domain. J. Virol. 65: 4248-4254.
40. Meyer, B.W. and M.H. Malim. 1994. The HIV-1 Rev trans-activator shuttles between the nucleus and cytoplasm. Genes & Dev. 8: 1538-1547.
41. Michael, W.M., M. Choi, and G. Dreyfuss. 1995. A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway. Cell 83: 415-422.
42. Moore, M.S. and G. Blobel. 1992. The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors. Cell 69: 939-950.
43. Morimoto, R.I. 1993. Cells m stress: Transcriptional activation of heat shock genes. Science 259: 1409-1410.
44. Morimoto, R., A. Tissières, and C. Georgopoulos. 1994. The biology of heat shock proteins and molecular chaperones Cold Spring Harbor Press, Cold Spring Harbor, NY.
45. Murphy, R. and S.R. Wente. 1996. An RNA-export mediator with an essential nuclear export signal. Nature 383: 357-360.
46. Murphy, R., J.L. Watkins, and S.R. Wente. 1996. GLE2. a Saccharomyces cerevisiae homologue of the Schizonaccharomyces pombe export factor RAE1. is required for nuclear pore complex structure and function. Mol. Biol. Cell 7: 1921-1937.
47. Neville, M., L. Lee, F. Stutz, L.I. Davis, and M. Rosbash. 1997. Evidence that the importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export in S. cerevisiae. Curr. Biol. (in press).
48. Nigg, E.A. 1997. Nucleocytoplasmic transport: Signals, mechanisms and regulation. Nature 386: 779-787.
49. Panniers, R. 1994. Translational control during heat shock. Biochimie 76: 737-747.
50. Panté, N. and U. Aebi. 1996. Molecular dissection of the nuclear pore complex. Crit. Rev. Biochem. Molec. Biol. 31: 153-199.
51. Pikielny, C.W. and M. Rosbash. 1985. mRNA splicing efficiency in yeast and the contribution of non-conserved sequences. Cell 41: 119-126.
52. Rose, M.D., F. Winston, and P. Hieter. 1989. Methods in yeast genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
53. Saavedra, C., K.-S. Tung, D.C. Amberg, A.K. Hopper, and C.N. Cole. 1996. Regulation of mRNA export in response to stress in Saccharomyces cerevisiae. Genes & Dev. 10: 1608-1620.
54. Schlenstedt, G., E. Hurt, V. Doye, and P.A. Silver. 1993. Reconstitution of nuclear protein transport with semi-intact yeast cells. J. Cell Biol. 123: 785-798.
55. Shiokawa, K. and K.O. Pogo. 1974. The role of cytoplasmic membranes in controlling the transport of nuclear messenger RNA and initiation of protein synthesis. Proc. Natl. Acad. Sci. 71: 2658-2662.
56. Sierra, J.M. and J.M. Zapata. 1994. Translational regulation of the heat shock response. Mol. Biol. Rep. 19: 211-220.
57. Siniossoglou, S., C. Wimmer, M. Rieger, V. Doye, H. Tekotte, C. Weise, S. Emig, A. Segref, and E. C. Hurt. 1996. A novel complex of nucleoporins which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores. Cell 84: 265-275.
58. Stutz, F. and M. Rosbash. 1994. A functional interaction between Rev and yeast pre-mRNA is related to splicing complex formation. EMBO J. 17: 4096-4104.
59. Stutz, F., M. Neville, and M. Rosbash. 1995. Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast. Cell 82: 495-506.
60. Stutz, S., E. Izaurralde, I. Mattaj, and M. Rosbash. 1996. A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus. Mol. Cell. Biol. 16: 7144-7150.
61. Stutz, F., J. Kantor, D. Zhang, T. McCarthy, M. Neville, and M. Rosbash. 1997. The yeast nucleoporin Rip1p contributes to multiple export pathways with no essential role for its FG-repeat region.Genes & Dev. (this issue).
62. Wente, S.R. and G. Blobel. 1994. NUP145 encodes a novel yeast glycine-leucine-phenylalanine-glycine (GLFG) nucleoporin required for nuclear envelope structure. J. Cell Biol. 125: 955-969.
63. Winston, F., C. Dollard, and S.L. Ricupero-Hovasse. 1995. Construction of a set of convenient Saccharomyces cerevisiae strains that are isogenic to S288C. Yeast 11: 53-55.
64. Wong, D.H., A.H. Corbett, H.K. Kent, M. Stewart, and P.A. Silver. 1997. Interaction between the small GTPase Ran/ Gsp1p and Ntf2p is required for nuclear transport. Mol. Cell. Biol. 17: 3755-3767.