High-throughput mass spectrometric analysis of xenobiotics in biological fluids

Journal of Liquid Chromatography and Related Technologies

Volumn 25, Issue 4, 2002, Pages 507-540

  Bakhtiar, Ray ^a   Ramos, Luis ^a   Tse, Francis L S ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PHARMACOKINETICS;

XENOBIOTICS;

DRUG DOSAGE;

XENOBIOTIC AGENT;

ANALYTIC METHOD; ARTICLE; BODY FLUID; DRUG DETERMINATION; DRUG DEVELOPMENT; DRUG FORMULATION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG SCREENING; EXTRACTION; HUMAN; IONIZATION; LABORATORY TEST; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEDICAL TECHNOLOGY; NONHUMAN; PHARMACOKINETICS; QUANTITATIVE ANALYSIS; RELIABILITY; SAMPLING; TECHNIQUE; TOXICOKINETICS;

ANIMALIA;

EID: 0036121738     PISSN: 10826076     EISSN: None     Source Type: Journal    
DOI: 10.1081/JLC-120008809     Document Type: Article

References (144)

1. Drug discovery: A historical perspective
2. High-throughput and ultra-high-throughput screening: Solution- and cell-based approaches
3. High-throughput screening: New technology for the 21st century
4. Drug discovery in the next millennium
5. The impact of genomics on drug discovery
6. Chemical ligands, genomics and drug discovery
7. Using bioinformatics in gene and drug discovery
8. High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery
9. The impact of genomics-based technologies on drug safety evaluation
10. Mass spectrometric analysis in combinatorial chemistry
11. Combinatorial chemistry and mass spectrometry in the 21st century drug discovery laboratory
12. Applications of mass spectrometry in combinatorial chemistry
13. High-performance liquid chromatography-electrospray ionization mass spectrometric analyses for the integration of natural products with model high-throughput screening
14. Systematic LC/MS metabolite identification in drug discovery
15. Mass spectrometry in the clinical laboratory
16. LC/MS applications in drug development
17. Mass spectrometry innovations in drug discovery and development
18. High-throughput quantitative bioanalysis by LC/MS/MS
19. Liquid-chromatography-mass spectrometry in forensic and clinical toxicology
20. Applications of protein mass spectrometry in cell biology
21. Proteomics to study genes and genomes
22. Perspectives for mass spectrometry and functional proteomics
23. Mass spectrometry in proteomics
24. Analysis of proteins and proteomes by mass spectrometry
25. Electrospray and tandem mass spectrometry in biochemistry
26. Proteome analysis: A pathway to the functional analysis of proteins
27. Separations combined with mass spectrometry
28. The coupling of gas and liquid chromatography with mass spectrometry
29. State-of-the-art liquid chromatography-mass spectrometry
30. Effect of solvent on dynamic range and sensitivity in pneumatically-assisted electrospray (ion spray) mass spectrometry
31. Comparison of conventional, narrow-bore and capillary liquid chromatography/mass spectrometry for electrospray ionization mass spectrometry: Practical considerations
32. Mechanistic aspects of electrospray ionization
33. High-throughput analysis of everolimus (RAD001) and Cyclosporin A (CsA) in whole blood by liquid chromatography/mass spectrometry using a semi-automated 96-well solid-phase extraction system
34. Automated 96-well SPE and LC-MS-MS for determination of protease inhibitors in plasma and cartilage tissues
35. High-throughput simultaneous determination of the HIV protease inhibitors indinavir and L-756423 in human plasma using semi-automated 96-well solid phase extraction and LC-MS/MS
36. Semi-automated 96-well solid-phase extraction and gas-chromatography-negative chemical ionization tandem mass spectrometry for the trace analysis of fluprostenol in rat plasma
37. Quantitative and qualitative determination of estrogen sulfates in human urine by liquid chromatography/tandem mass spectrometry using 96-well technology
38. High-throughput sample preparation and analysis using 96-well membrane solid-phase extraction and liquid-chromatography-tandem mass spectrometry for the determination of steroids in human urine
39. Liquid-chromatographic-tandem mass spectrometric method for the analysis of a neurokinin-1 antagonist and its metabolite using automated solid-phase sample preparation and automated data handling and reporting
40. High-throughput liquid chromatography/mass spectrometry bioanalysis using 96-well disk solid phase extraction plate for the sample preparation
41. High-throughput method development approaches for bioanalytical mass spectrometry
42. A highly automated 96-well solid phase extraction and liquid chromatography/tandem mass spectrometry method for the determination of fentanyl in human plasma
43. Rapid determination of the anti-cancer drug Chlorambucil (Leukeran™) and its phenyl acetic acid mustard metabolite in human serum and plasma by automated solid-phase extraction and liquid chromatography-tandem mass spectrometry
44. Liquid chromatography/electrospray tandem mass spectrometry method for the quantitation of fosinoprilat in human serum using automated 96-well solid-phase extraction for sample preparation
45. Higher-throughput bioanalysis by automation of a protein precipitation assay using a 96-well format with detection by LC-MS/MS
46. Integrated sample collection and handling for drug discovery bioanalysis
47. A clinical trial on a plate? The potential of a 384-well format solid phase extraction for high-throughput bioanalysis using liquid-chromatography/tandem mass spectrometry
48. A 384-well solid-phase extraction for LC/MS/MS determination of methotrexate and its 7-hydroxy metabolite in human urine and plasma
49. Matrix effect in quantitative LC/MS/MS analyses of biological fluids: A method for determination of finasteride in human plasma at picogram per milliliter concentrations
50. Quantitation of SR 27417 in human plasma using electrospray liquid chromatography-tandem mass spectrometry: A study of ion suppression
51. Mechanistic investigation of ionization suppression in electrospray ionization
52. Effect of the sample matrix on the determination of indinavir in human urine by HPLC with turbo ion spray tandem mass spectrometric detection
53. The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds
54. Quantitative liquid chromatographic-tandem mass spectrometric determination of reserpine in FVB/N mouse plasma using a "chelating" agent (disodium EDTA) for releasing protein-bound analytes during 96-well liquid-liquid extraction
55. Bioanalytical high-throughput selected reaction monitoring-LC/MS determination of selected estrogen receptor modulators in human plasma: 2000 Samples/day
56. Comparison of plasma sample purification by manual liquid-liquid extraction, automated 96-well liquid-liquid extraction and automated 96-well solid-phase extraction for analysis by high-performance liquid chromatography with tandem mass spectrometry
57. Increasing bioanalytical throughput using pcSFC-MS/MS: 10 Minutes per 96-well plate
58. Quantification and rapid metabolite identification in drug discovery using API time-of-flight LC/MS
59. Fully automated 96-well liquid-liquid extraction for analysis of biological samples by liquid chromatography with tandem mass spectrometry
60. Automated high-throughput liquid-liquid extraction for initial purification of combinatorial libraries
61. Semi-automated 96-well liquid-liquid extraction for quantitation of drugs in biological fluids
62. Liquid-liquid extraction in the 96-well plate format with SRM LC/MS quantitative determination of methotrexate and its major metabolite in human plasma
63. High-throughput semi-automated 96-well liquid-liquid extraction and liquid chromatography/mass spectrometric analysis of everolimus (RAD 001) and cyclo-sporin A (CsA) in whole blood
64. Selected reaction monitoring LC-MS determination of idoxifene and its pyrrolidinone metabolite in human plasma using robotic high-throughput, sequential sample injection
65. Liquid-liquid extraction using 96-well plate format in conjunction with liquid chromatography/tandem mass spectrometry for quantitative determination of methylphenidate (Ritalin®) in human plasma
66. Cassette-accelerated rapid rat screen: A systematic procedure for the dosing and liquid-chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of a new chemical entities as part of new drug discovery
67. Quantitative determination of L-775,606, a selective 5-hydroxytryptamine 1D agonist, in rat plasma using automated sample preparation and detection by liquid chromatography-tandem mass spectrometry
68. High-throughput approaches to the quantitative analysis of ketoconazole, a potent inhibitor of cytochrome P450 3A4, in human plasma
69. Automated protein precipitation by filtration in the 96-well format
70. Comparison of manual protein precipitation (PPT) versus a new small volume PPT 96-well filter plate to decrease sample preparation time
71. Determination of a cyclic hexapeptide, a novel antifungal agent, in human plasma by high-performance liquid chromatography with ion spray and turbo ion spray tandem mass spectrometic detection
72. High-speed liquid chromatography/tandem mass spectrometry using a monolithic column for high-throughput bioanalysis
73. Use of monolithic silica columns to increase analytical throughput for metabolite identification by liquid chromatographic/tandem mass spectrometry
74. Comparison between liquid chromatography-time-of-flight mass spectrometry and selected reaction monitoring liquid chromatography-mass spectrometry for quantitative determination of idoxifene in human plasma
75. A preliminary study using fast gradient liquid chromatography coupled to a quadrupole orthogonal time-of-flight mass spectrometer
76. Ultrafast liquid chromatography/ultraviolet and liquid chromatography/tandem mass spectrometric analysis
77. Ultra-short columns and ballistic gradients: Considerations for ultra-fast chromatographic liquid chromatographic-tandem mass spectrometric analysis
78. Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry
79. A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry
80. Validation of higher-throughput high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry assays to conduct cytochrome P450s CYP2D6 and CYP3A4 enzyme inhibition studies in human liver microsomes
81. The application of fast gradient capillary liquid chromatography/mass spectrometry to the analysis of pharmaceuticals in biofluids
82. Ultrafast reversed-phase high-performance liquid chromatographic separations: An overview
83. High-throughput chiral liquid chromatography/tandem mass spectrometry
84. The need for adequate chromatographic separation in the quantitative determination of drugs in biological samples by high performance liquid chromatography with tandem mass spectrometry
85. The use of turbulent flow chromatography/mass spectrometry for the rapid, direct analysis of a novel pharmaceutical compound in plasma
86. Comparison of turbulent-flow chromatography with automated solid-phase extraction in 96-well plates and liquid-liquid extraction used as plasma sample preparation techniques for liquid chromatography-tandem mass spectrometry
87. Direct plasma sample injection in multiple-component LC-MS-MS assays for high-throughput pharmacokinetic screening
88. Direct analysis of crude plasma samples by turbulent flow chromatography/tandem mass spectrometry
89. Quantitative analysis of terbinafine (lamisil®) in human and minipig plasma by liquid chromatography tandem mass spectrometry
90. High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy: III. Validation of a direct injection/on-line guard cartridge extraction-tandem mass spectrometry method for CYP2C19 inhibition evaluation
91. High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and their metabolites
92. High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1
93. Capillary solid-phase extraction-tandem mass spectrometry for fast quantification of free concentrations of tolterodine and two metabolites in ultrafiltered plasma samples
94. Quantitation of entacapone glucuronide in rat plasma by on-line coupled restricted access media column and liquid chromatography-tandem mass spectrometry
95. Fully automated determination of eserine N-oxide in human plasma using online solid-phase extraction with liquid chromatography coupled with electrospray ionization tandem mass spectrometry
96. Determination of pranlukast and its metabolites in human plasma by LC/MS/MS with PROSPEKT™ on-line solid-phase extraction
97. In vivo pharmacokinetic screening in cassette dosing experiments: The use of on-line Prospekt® liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry technology in drug discovery
98. High-throughput on-line solid-phase extraction tandem mass spectrometric determination of paclitaxel in human serum
99. Direct-injection LC-MS-MS method for high-throughput simultaneous quantitation of simvastatin and simvastatin acid in human plasma
100. Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: Immunosuppressants
101. High-throughput caco-2 cell permeability screening by cassette dosing and sample pooling approaches using direct injection/on-line guard cartridge extraction/tandem mass spectrometry
102. Direct determination of ecgonine methyl ester and cocaine in rat plasma, utilizing online sample extraction coupled with rapid chromatography/quadrupole orthogonal acceleration time-of-flight detection
103. Determination of tetracyclines in bovine kidney by liquid chromatography/tandem mass spectrometry with on-line extraction and clean-up
104. Determination of retigabine and its acetyl metabolite in biological matrices by on-line solid-phase extraction (column switching) liquid chromatography with tandem mass spectrometry
105. A new approach to the effective preparation of plasma samples for rapid drug quantitation using on-line solid phase extraction mass spectrometry
106. Rapid bioanalytical determination of dextromethorphan in canine plasma by dilute-and-shoot preparation combined with one minute per sample LC-MS/MS analysis to optimize formulations for drug delivery
107. Direct analysis of plasma samples for drug discovery compounds using mixed-function column liquid chromatography tandem mass spectrometry
108. High throughput liquid chromatography/mass spectrometric analyses using a novel multiplexed electrospray interface
109. Evaluation of a four-channel multiplexed electrospray triple quadrupole mass spectrometer for the simultaneous validation of LC/MS/MS methods in four different preclinical matrixes
110. Applications of new liquid chromatography-tandem mass spectrometry technologies for drug development support
111. Faster compound analysis by mass spectrometry-The TOF revolution
112. Multiple-sprayer tandem mass spectrometry with parallel high flow extraction and parallel separation for high-throughput quantitation in biological fluids
113. A high-capacity LC/MS system for the bioanalysis of samples generated from plate-based metabolic screening
114. Increased throughput in quantitative bioanalysis using parallel-column liquid chromatography with mass spectrometric detection
115. High-throughput bioanalytical LC/MS/MS determination of benzodiazepines in human urine: 1000 Samples per 12 hours
116. A four-column parallel chromatography system for isocratic or gradient LC/MS analyses
117. Demonstration of the capabilities of a parallel high performance liquid chromatography tandem mass spectrometry system for use in the analysis of drug discovery plasma samples
118. Ternary column system for high-throughput direct-injection bioanalysis by liquid chromatography/tandem mass spectrometry
119. The development of a staggered parallel separation liquid chromatography/tandem mass spectrometry system with on-line extraction for high-throughput screening of drug candidates in biological fluids
120. Rapid bioanalysis of vancomycin in serum and urine by high-performance liquid chromatography tandem mass spectrometry using on-line sample extraction and parallel analytical columns
121. A preliminary study on the feasibility of an automated blood-sampling system in conjunction with liquid chromatography/mass spectrometry
122. Simultaneous pharmacokinetic screening of a mixture of compounds in the dog using API LC/MS/MS analysis for increased throughput
123. The simultaneous determination of mixtures of drug candidates by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry as an in vivo drug screening procedure
124. Use of "N-in-one" dosing to create an in vivo pharmacokinetics database for use in developing structure-pharmacokinetic relationships
125. Sample pooling to expedite bioanalysis and pharmacokinetic research
126. Novel in vivo procedure for rapid pharmacokinetic screening of discovery compounds in rats
127. Pharmacokinetics and its role in small molecule drug discovery research
128. Optimization of metabolic stability as a goal of modem drug design
129. Role of drug metabolism in drug discovery and development
130. Automated identification of isotopically labeled pesticides and metabolites by intelligent 'real time' liquid chromatography tandem mass spectrometry using a bench-top ion trap mass spectrometer
131. n analyses to the characterization of novel glyburide metabolites formed in vitro
132. Broad spectrum drug identification directly from urine, using liquid chromatography-tandem mass spectrometry
133. Identification of in vitro metabolites of indinavir by 'intelligent automated LC-MS/MS' (INTAMS) utilizing triple quadrupole tandem mass spectrometry
134. Identification of drug metabolites in biological matrices by intelligent automated liquid chromatography/tandem mass spectrometry
135. Rapid liquid chromatography with tandem mass spectrometry-based screening procedures for studies on the biotransformation of drug candidates
136. Accurate mass liquid chromatography/mass spectrometry on orthogonal acceleration time-of-flight mass analyzers using switching between separate sample and reference sprays. 1. Proof of concept
137. Accurate mass liquid chromatography/mass spectrometry on quadrupole orthogonal acceleration time-of-flight mass analyzers using switching between separate sample and reference sprays. 2. Applications using the dual-electrospray ion source
138. An introduction to quadrupole-time-of-flight mass spectrometry
139. Metabolic screening using on-line ultrafiltration mass spectrometry
140. Chip-based quantitative capillary electrophoresis/mass spectrometry determination of drugs in human plasma
141. Chip-based capillary electrophoresis/mass spectrometry determination of carnitines in human urine
142. Development of multichannel devices with an array of electrospray tips for high-throughput mass spectrometry
143. A rapid and efficient approach to metabolite identification using nuclear magnetic resonance spectroscopy, liquid chromatography/mass spectrometry, and liquid chromatography/nuclear magnetic resonance spectroscopy/sequential mass spectrometry
144. Directly coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development