Liquid-liquid extraction in the 96-well plate format with SRM LC/MS quantitative determination of methotrexate and its major metabolite in human plasma

Analytical Chemistry

Volumn 71, Issue 13, 1999, Pages 2340-2345

  Steinborner, Simon ^a   Henion, Jack ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYMETHOTREXATE; DEUTERIUM; METHOTREXATE;

ARTICLE; DEVICE; DRUG STRUCTURE; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; PLASMA; QUANTITATIVE ASSAY; REACTION ANALYSIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FOLIC ACID ANTAGONISTS; HUMANS; INDICATORS AND REAGENTS; MASS SPECTROMETRY; METHOTREXATE;

EID: 0033168125     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac981294y     Document Type: Article

References (2)

1. Simpson, H.; Berthemy, A.; Buhrman, D.; Burton, R.; Newton, J.; Kealy, M.; Wells, D.; Wu, D. Rapid Commun. Mass Spectrom. 1998, 12, 75-82.
2. Janiszewski, J.; Schneider, R. P.; Hoffmaster, K.; Swyden, M.; Wells, D.; Fonda, H. Rapid. Commun. Mass Spectrom. 1997, 11, 1033-1037.