메뉴 건너뛰기




Volumn 5, Issue 4, 2000, Pages 145-156

Chemical ligands, genomics and drug discovery

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND;

EID: 0034177001     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(00)01468-9     Document Type: Review
Times cited : (110)

References (45)
  • 1
    • 0013664370 scopus 로고    scopus 로고
    • Genomics, target selection, validation, and assay considerations in the development of antibacterial screens
    • Guild B.C. Genomics, target selection, validation, and assay considerations in the development of antibacterial screens. Annu. Rep. Med. Chem. 34:1999;227-236.
    • (1999) Annu. Rep. Med. Chem. , vol.34 , pp. 227-236
    • Guild, B.C.1
  • 2
    • 84984934477 scopus 로고    scopus 로고
    • Expression profiling using cDNA arrays
    • Duggan D.J.et al. Expression profiling using cDNA arrays. Nat. Genet. 21(Suppl. 1):1998;10-14.
    • (1998) Nat. Genet. , vol.21 , Issue.SUPPL. 1 , pp. 10-14
    • Duggan, D.J.1
  • 3
    • 0033520298 scopus 로고    scopus 로고
    • Proteome analysis: A pathway to the functional analysis of proteins
    • Lottspeich F. Proteome analysis: A pathway to the functional analysis of proteins. Angew. Chem., Int. Ed. Engl. 38:1999;2476-2492.
    • (1999) Angew. Chem., Int. Ed. Engl. , vol.38 , pp. 2476-2492
    • Lottspeich, F.1
  • 4
    • 0032555218 scopus 로고    scopus 로고
    • Systematic identification of essential genes by in vitro mariner mutagenesis
    • Ackerly B.J.et al. Systematic identification of essential genes by in vitro mariner mutagenesis. Proc. Natl. Acad. Sci. U. S. A. 95:1998;8927-8932.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 8927-8932
    • Ackerly, B.J.1
  • 5
    • 0030801002 scopus 로고    scopus 로고
    • Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
    • Altschul S.F.et al. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res. 25:1997;3389-3402.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 3389-3402
    • Altschul, S.F.1
  • 6
    • 0032983055 scopus 로고    scopus 로고
    • Functional insights from structural predictions: Analysis of the Escherichia coli genome
    • Rychlewski L.et al. Functional insights from structural predictions: Analysis of the Escherichia coli genome. Protein Sci. 8:1999;614-624.
    • (1999) Protein Sci. , vol.8 , pp. 614-624
    • Rychlewski, L.1
  • 7
    • 0344417226 scopus 로고    scopus 로고
    • The Helicobacter pylori genome: From sequence analysis to structural and functional predictions
    • Pawlowski K.et al. The Helicobacter pylori genome: From sequence analysis to structural and functional predictions. Proteins. 36:1999;20-30.
    • (1999) Proteins , vol.36 , pp. 20-30
    • Pawlowski, K.1
  • 8
    • 0031787022 scopus 로고    scopus 로고
    • Arise, go forth, and solve structures
    • Šali A. Arise, go forth, and solve structures. Nat. Struct. Biol. 5:1998;1029-1032.
    • (1998) Nat. Struct. Biol. , vol.5 , pp. 1029-1032
    • Šali, A.1
  • 9
    • 0033602488 scopus 로고    scopus 로고
    • Structure prediction: The state of the art
    • Shortle D. Structure prediction: The state of the art. Curr. Biol. 9:1999;R205-R209.
    • (1999) Curr. Biol. , vol.9 , pp. 205-R209
    • Shortle, D.1
  • 10
    • 0033150685 scopus 로고    scopus 로고
    • Progress in protein structure prediction: Assessment of CASP3
    • Sternberg M.J.E.et al. Progress in protein structure prediction: Assessment of CASP3. Curr. Opin. Struct. Biol. 9:1999;368-373.
    • (1999) Curr. Opin. Struct. Biol. , vol.9 , pp. 368-373
    • Sternberg, M.J.E.1
  • 11
    • 0032932490 scopus 로고    scopus 로고
    • From fold predictions to function predictions: Automation of functional site conservation analysis for functional genome predictions
    • Zhang B.et al. From fold predictions to function predictions: Automation of functional site conservation analysis for functional genome predictions. Protein Sci. 8:1999;1104-1115.
    • (1999) Protein Sci. , vol.8 , pp. 1104-1115
    • Zhang, B.1
  • 12
    • 1842830270 scopus 로고    scopus 로고
    • Are predicted structures good enough to preserve functional sites
    • Wei L.et al. Are predicted structures good enough to preserve functional sites. Structure. 7:1999;643-650.
    • (1999) Structure , vol.7 , pp. 643-650
    • Wei, L.1
  • 13
    • 0032509105 scopus 로고    scopus 로고
    • Sequence comparisons using multiple sequences detect three times as many remote homologs as pairwise methods
    • Park J.et al. Sequence comparisons using multiple sequences detect three times as many remote homologs as pairwise methods. J. Mol. Biol. 284:1998;1201-1210.
    • (1998) J. Mol. Biol. , vol.284 , pp. 1201-1210
    • Park, J.1
  • 14
    • 0032568596 scopus 로고    scopus 로고
    • Assessing sequence comparison methods with reliable structurally identified distant evolutionary relationships
    • Brenner S.E.et al. Assessing sequence comparison methods with reliable structurally identified distant evolutionary relationships. Proc. Natl. Acad. Sci. U. S. A. 95:1998;6073-6078.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 6073-6078
    • Brenner, S.E.1
  • 15
    • 0033580887 scopus 로고    scopus 로고
    • Protein interaction methods - Towards an end game
    • Mendelsohn A.R., Brent R. Protein interaction methods - towards an end game. Science. 284:1999;1948-1950.
    • (1999) Science , vol.284 , pp. 1948-1950
    • Mendelsohn, A.R.1    Brent, R.2
  • 16
    • 0033618555 scopus 로고    scopus 로고
    • Detecting protein function and protein-protein interactions from genome sequences
    • Marcotte E.M.et al. Detecting protein function and protein-protein interactions from genome sequences. Science. 285:1999;751-753.
    • (1999) Science , vol.285 , pp. 751-753
    • Marcotte, E.M.1
  • 17
    • 9444236174 scopus 로고    scopus 로고
    • Small peptides as potent mimetics of the protein hormone erythropoietin
    • Wrighton N.C.et al. Small peptides as potent mimetics of the protein hormone erythropoietin. Science. 273:1996;458-463.
    • (1996) Science , vol.273 , pp. 458-463
    • Wrighton, N.C.1
  • 18
    • 0032533467 scopus 로고    scopus 로고
    • A peptidomimetic antagonist of TNF-alpha-mediated cytotoxicity identified from a phage-displayed random peptide library
    • Chirinos-Rojas C.L.et al. A peptidomimetic antagonist of TNF-alpha-mediated cytotoxicity identified from a phage-displayed random peptide library. J. Immunol. 161:1998;5621-5626.
    • (1998) J. Immunol. , vol.161 , pp. 5621-5626
    • Chirinos-Rojas, C.L.1
  • 19
    • 0027997580 scopus 로고
    • Construction and screening of biological peptide libraries
    • Schatz P.J. Construction and screening of biological peptide libraries. Curr. Opin. Biotechnol. 5:1994;487-494.
    • (1994) Curr. Opin. Biotechnol. , vol.5 , pp. 487-494
    • Schatz, P.J.1
  • 20
    • 0033597939 scopus 로고    scopus 로고
    • Genetic selection of peptide inhibitors of biological pathways
    • Norman T.C.et al. Genetic selection of peptide inhibitors of biological pathways. Science. 285:1999;591-595.
    • (1999) Science , vol.285 , pp. 591-595
    • Norman, T.C.1
  • 21
    • 0000532176 scopus 로고    scopus 로고
    • Emerging approaches to target-assisted screening of combinatorial mixtures
    • Eliseev A.V. Emerging approaches to target-assisted screening of combinatorial mixtures. Curr. Opin. Drug Dis. Dev. 1:1998;106-115.
    • (1998) Curr. Opin. Drug Dis. Dev. , vol.1 , pp. 106-115
    • Eliseev, A.V.1
  • 22
    • 0032879750 scopus 로고    scopus 로고
    • Synthesis and preliminary evaluation of a library of polycyclic small molecules for use in chemical genetic assays
    • Tan D.S.et al. Synthesis and preliminary evaluation of a library of polycyclic small molecules for use in chemical genetic assays. J. Amer. Chem. Soc. 121:1999;9073-9087.
    • (1999) J. Amer. Chem. Soc. , vol.121 , pp. 9073-9087
    • Tan, D.S.1
  • 23
    • 0032569205 scopus 로고    scopus 로고
    • Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniaturized cell-based assays
    • Tan D.S.et al. Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniaturized cell-based assays. J. Amer. Chem. Soc. 120:1998;8565-8566.
    • (1998) J. Amer. Chem. Soc. , vol.120 , pp. 8565-8566
    • Tan, D.S.1
  • 25
    • 33751157590 scopus 로고
    • A general method for molecular tagging of encoded combinatorial libraries
    • Nestler H.P.et al. A general method for molecular tagging of encoded combinatorial libraries. J. Org. Chem. 59:1994;4723-4724.
    • (1994) J. Org. Chem. , vol.59 , pp. 4723-4724
    • Nestler, H.P.1
  • 26
    • 0031444011 scopus 로고    scopus 로고
    • Small-molecule dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale
    • Borchardt A.et al. Small-molecule dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale. Chem. Biol. 4:1997;961-968.
    • (1997) Chem. Biol. , vol.4 , pp. 961-968
    • Borchardt, A.1
  • 27
    • 0031472576 scopus 로고    scopus 로고
    • A miniaturized arrayed assay format for detecting small molecule-protein interactions in cells
    • You A.J.et al. A miniaturized arrayed assay format for detecting small molecule-protein interactions in cells. Chem. Biol. 4:1997;969-975.
    • (1997) Chem. Biol. , vol.4 , pp. 969-975
    • You, A.J.1
  • 28
    • 0033199751 scopus 로고    scopus 로고
    • Printing small molecules as microarrays and detecting protein-ligand interactions en masse
    • MacBeath G.et al. Printing small molecules as microarrays and detecting protein-ligand interactions en masse. J. Amer. Chem. Soc. 121:1999;7967-7968.
    • (1999) J. Amer. Chem. Soc. , vol.121 , pp. 7967-7968
    • MacBeath, G.1
  • 30
    • 0031876832 scopus 로고    scopus 로고
    • From peptides to drugs via phage display
    • Kay B.K.et al. From peptides to drugs via phage display. Drug Discovery Today. 3:1998;370-378.
    • (1998) Drug Discovery Today , vol.3 , pp. 370-378
    • Kay, B.K.1
  • 32
    • 53249119425 scopus 로고    scopus 로고
    • Affinity selection and mass spectrometry-based strategies to identify lead compounds in combinatorial libraries
    • Kaur S.et al. Affinity selection and mass spectrometry-based strategies to identify lead compounds in combinatorial libraries. J. Protein. Chem. 16:1997;505-511.
    • (1997) J. Protein. Chem. , vol.16 , pp. 505-511
    • Kaur, S.1
  • 33
    • 33748235487 scopus 로고
    • A novel procedure for the synthesis of libraries containing small organic molecules
    • Carell T.et al. A novel procedure for the synthesis of libraries containing small organic molecules. Angew. Chem., Int. Ed. Engl. 33:1994;2059-2061.
    • (1994) Angew. Chem., Int. Ed. Engl. , vol.33 , pp. 2059-2061
    • Carell, T.1
  • 34
    • 0029994357 scopus 로고    scopus 로고
    • Application of capillary electrophoresis-electrospray ionization mass spectrometry in the determination of molecular diversity
    • Dunayevskiy Y.M.et al. Application of capillary electrophoresis-electrospray ionization mass spectrometry in the determination of molecular diversity. Proc. Natl. Acad. Sci. U. S. A. 93:1996;6152-6157.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 6152-6157
    • Dunayevskiy, Y.M.1
  • 35
    • 0032789224 scopus 로고    scopus 로고
    • High resolution NMR for screening ligand/protein binding
    • Shapiro M.J., Wareing J.R. High resolution NMR for screening ligand/protein binding. Curr. Opin. Drug Dis. Dev. 2:1999;396-400.
    • (1999) Curr. Opin. Drug Dis. Dev. , vol.2 , pp. 396-400
    • Shapiro, M.J.1    Wareing, J.R.2
  • 36
    • 0033168872 scopus 로고    scopus 로고
    • High-throughput nuclear magnetic resonance-based screening
    • Hajduk P.J.et al. High-throughput nuclear magnetic resonance-based screening. J. Med. Chem. 42:1999;2315-2317.
    • (1999) J. Med. Chem. , vol.42 , pp. 2315-2317
    • Hajduk, P.J.1
  • 37
    • 0032779273 scopus 로고    scopus 로고
    • RNA as a small-molecule drug target: Doubling the value of genomics
    • Ecker D.J., Griffey R.H. RNA as a small-molecule drug target: Doubling the value of genomics. Drug Discovery Today. 4:1999;420-429.
    • (1999) Drug Discovery Today , vol.4 , pp. 420-429
    • Ecker, D.J.1    Griffey, R.H.2
  • 38
    • 0033621114 scopus 로고    scopus 로고
    • Determinants of aminoglycoside-binding specificity for rRNA by using mass spectrometry
    • Griffey R.H.et al. Determinants of aminoglycoside-binding specificity for rRNA by using mass spectrometry. Proc. Natl. Acad. Sci. U. S. A. 96:1999;10129-10133.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 10129-10133
    • Griffey, R.H.1
  • 39
    • 0033585581 scopus 로고    scopus 로고
    • Targeted site-specific gas-phase cleavage of oligoribonucleotides. Application in mass spectrometry-based identification of ligand binding sites
    • Griffey R.H.et al. Targeted site-specific gas-phase cleavage of oligoribonucleotides. Application in mass spectrometry-based identification of ligand binding sites. J. Amer. Chem. Soc. 121:1999;474-475.
    • (1999) J. Amer. Chem. Soc. , vol.121 , pp. 474-475
    • Griffey, R.H.1
  • 40
    • 0033566617 scopus 로고    scopus 로고
    • Multiplexed screening of neutral mass-tagged RNA targets against ligand libraries with electrospray ionization FTICR MS: A paradigm for high-throughput affinity screening
    • Hofstadler S.A.et al. Multiplexed screening of neutral mass-tagged RNA targets against ligand libraries with electrospray ionization FTICR MS: A paradigm for high-throughput affinity screening. Anal. Chem. 71:1999;3436-3440.
    • (1999) Anal. Chem. , vol.71 , pp. 3436-3440
    • Hofstadler, S.A.1
  • 41
    • 0034093179 scopus 로고    scopus 로고
    • Quantized surface complementarity diversity: A model based on small molecule-target complementarity
    • (in press)
    • Wintner, E.A. and Moallemi, C.C. Quantized surface complementarity diversity: A model based on small molecule-target complementarity. J. Med. Chem. (in press).
    • J. Med. Chem.
    • Wintner, E.A.1    Moallemi, C.C.2
  • 42
    • 0030759661 scopus 로고    scopus 로고
    • Strategic choices facing the pharmaceutical industry: A case for innovation
    • Drews J. Strategic choices facing the pharmaceutical industry: A case for innovation. Drug Discovery Today. 2:1997;72-78.
    • (1997) Drug Discovery Today , vol.2 , pp. 72-78
    • Drews, J.1
  • 43
    • 0030274647 scopus 로고    scopus 로고
    • Genomic sciences and the medicine of tomorrow
    • Drews J. Genomic sciences and the medicine of tomorrow. Nat. Biotechnol. 14:1996;1516-1518.
    • (1996) Nat. Biotechnol. , vol.14 , pp. 1516-1518
    • Drews, J.1
  • 44
    • 0032504007 scopus 로고    scopus 로고
    • A small, nonpeptidyl mimic of granulocyte-colony-stimulating factor
    • Tian S.S.et al. A small, nonpeptidyl mimic of granulocyte-colony-stimulating factor. Science. 281:1998;257-259.
    • (1998) Science , vol.281 , pp. 257-259
    • Tian, S.S.1
  • 45
    • 0033532347 scopus 로고    scopus 로고
    • Discovery of a small molecule insulin mimetic with antidiabetic activity in mice
    • Zhang B.et al. Discovery of a small molecule insulin mimetic with antidiabetic activity in mice. Science. 284:1999;974-977.
    • (1999) Science , vol.284 , pp. 974-977
    • Zhang, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.