Validation of higher-throughput high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry assays to conduct cytochrome P450s CYP2D6 and CYP3A4 enzyme inhibition studies in human liver microsomes

Rapid Communications in Mass Spectrometry

Volumn 14, Issue 4, 2000, Pages 207-214

  Chu, Inhou ^a   Favreau, Leonard ^a   Soares, Tony ^a   Lin, Chin chung ^a   Nomeir, Amin A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION OF GASES; MASS SPECTROMETRY; THROUGHPUT;

ATMOSPHERIC PRESSURE CHEMICAL IONIZATION; CYTOCHROMES P450; DRUG DISCOVERY; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH-THROUGHPUT; HUMAN LIVER MICROSOMES; ISOFORMS; LC-MS-MS; TANDEM MASS SPECTROMETRY; TANDEM-MASS SPECTROMETRY;

ENZYME INHIBITION;

EID: 0033976657     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-0231(20000229)14:4<207::aid-rcm863>3.0.co;2-%23     Document Type: Article

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