High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy: III. Validation of a direct injection/on-line guard cartridge extraction - Tandem mass spectrometry method for CYP2C19 inhibition evaluation

Journal of Pharmaceutical and Biomedical Analysis

Volumn 25, Issue 3-4, 2001, Pages 437-442

  Bu, Hai Zhi ^a   Knuth, Kim ^a   Magis, Lisa ^a   Teitelbaum, Philip ^a  

^a Late Stage Developmental Services Covance Inc   (United States)

Author keywords

Cytochrome P450; Direct injection; High throughput; Inhibition; Mass spectrometry; On line extraction

Indexed keywords

4 HYDROXYMEPHENYTOIN; CHLORZOXAZONE; CYTOCHROME P450 2C19; PHENYTOIN DERIVATIVE; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; DEVICE; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; LIVER MICROSOME; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; TECHNIQUE; VALIDATION PROCESS;

ARYL HYDROCARBON HYDROXYLASES; CALIBRATION; CYTOCHROME P-450 ENZYME SYSTEM; MASS SPECTROMETRY; MIXED FUNCTION OXYGENASES;

EID: 0035013940     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(00)00518-5     Document Type: Article

References (10)