Direct-injection LC-MS-MS method for high-throughput simultaneous quantitation of simvastatin and simvastatin acid in human plasma

Journal of Pharmaceutical and Biomedical Analysis

Volumn 23, Issue 2-3, 2000, Pages 323-340

  Jemal, Mohammed ^a   Ouyang, Zheng ^a   Powell, Mark L ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

Human plasma; Liquid chromatography mass spectrometry mass spectrometry method; Simvastatin; Simvastatin acid

Indexed keywords

DRUG METABOLITE; MEVINOLIN; SIMVASTATIN; SIMVASTATIN ACID; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BLOOD PH; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; QUALITY CONTROL; TECHNIQUE;

ANTICHOLESTEREMIC AGENTS; CHROMATOGRAPHY, LIQUID; HUMANS; HYDROGEN-ION CONCENTRATION; MASS SPECTROMETRY; REFERENCE STANDARDS; SIMVASTATIN;

EID: 0034663877     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(00)00309-5     Document Type: Article

References (15)

1. Vickers S., Duncan C.A., Chen I.-W., Rosegay A., Duggan D.E. Drug Metab. Dispos. 18:1990;138.
2. Vickers S., Duncan C.A., Vyas K.P., Kari P.H., Arison B., Prakash S.R., Ramjit H.G., Pitzenberger S.M., Stokker G., Duggan D.E. Drug Metab. Dispos. 18:1990;476.
3. Desager J.-P., Horsmans Y. Clin. Pharmacokinet. 31:1996;348.
4. Kantola T., Kivisto K.T., Neuvonen P.J. Clin. Pharmacol. Ther. 64:1999;177.
5. Carlucci G., Mazzeo P., Biordi L., Bologna M. J. Pharm. Biomed. Anal. 10:1992;693.
6. Bologna M., Carlucci G., Biordi L., Mazzeo P., Iannarelli R. Int. J. Immunopathol. Pharmacol. 7:1994;79.
7. Ochiai H., Uchiyama N., Imagaki K., Hata S., Kamei T. J. Chromatogr. B. 694:1997;211.
8. Takano T., Abe S., Hata S. Biomed. Environ. Mass Spectrom. 19:1990;577.
9. Morris M.J., Gilbert J.D., Hsieh J.Y.-K., Matuszewski B.K., Ramjit H.G., Bayne W.F. Biol. Mass Spectrom. 22:1993;1.
10. Gilbert J.D., Olah T.V., Morris M.J., Schwartz M.S., McLoughlin D.A. Methodol. Surv. Bioanal. Drugs. 23:1994;157.
11. Jemal M., Xia Y.-Q. Rapid Commun. Mass Spectrom. 13:1999;97.
12. Jemal M., Xia Y.-Q., Whigan D.B. Rapid Commun. Mass Spectrom. 12:1998;1389.
13. Jemal M., Ouyang Z., Xia Y.-Q., Powell M.L. Rapid Commun. Mass Spectrom. 13:1999;1462.
14. Jemal M., Ouyang Z., Chen B.-C., Teitz D. Rapid Commun. Mass Spectrom. 13:1999;1003.
15. Jemal M., Rao S., Salahudeen I., Chen B.-C., Kates R. J. Chromatogr. B. 736:1999;19.