Applications of mass spectrometry in combinatorial chemistry

Biotechnology and Bioengineering

Volumn 61, Issue 2, 1998, Pages 127-134

  Siuzdak, Gary ^a   Kathleen Lewis, J ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Mass Consortium Corporation   (United States)

Author keywords

Cyclosporin A; Electrospray ionization mass spectrometry; Matrix assisted laser desorption ionization

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; CARBOHYDRATES; CATALYST ACTIVITY; DRUG PRODUCTS; ENZYMES; EXTRACTION; IONIZATION; LASER APPLICATIONS; SOLVENTS;

COMBINATORIAL CHEMISTRY; CYCLOSPORIN A; DRUG DISCOVERY; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; GLYCOSYLATION; IMMUNOSUPPRESSANT DRUG; MATRIX ASSISTED LASER DESORPTION IONIZATION; PEPTIDE;

MASS SPECTROMETRY;

CARBOHYDRATE; CYCLOSPORIN A; ENZYME INHIBITOR; HEXANE; METHYL CHLORIDE; PEPTIDE; POLYMER; RESIN; SOLVENT;

ARTICLE; AUTOMATION; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG SCREENING; ENZYME GLYCOSYLATION; MASS SPECTROMETRY; PHOTOLYSIS; ULTRAVIOLET RADIATION;

CYCLOSPORINE; GALACTOSIDASES; HUMANS; INHIBITORY CONCENTRATION 50; MASS SPECTROMETRY; TECHNOLOGY, PHARMACEUTICAL;

EID: 0345020358     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(199821)61:2<127::AID-BIT7>3.0.CO;2-O     Document Type: Article

References (34)

1. Cheng, X.; Chen, R.; Bruce, J. E.; Schwartz, B. L.; Anderson, G. A.; Hofstadler, S. A.; Gale, D. C.; Smith, R. D. J. Am. Chem. Soc. 1995, 117, 8859-8860.
2. Youngquist, R. S.; Fuentes, G. R.; Lacey, M. P.; Keough, T. J. Am. Chem. Soc. 1995, 117, 3900-3906.
3. Boutin, J. A.; Hennig, P.; Lambert, P. H.; Bertin, S.; Petit, L.; Mahieu, J.-P.; Serkiz, B.; Volland, J.-P.; J.-L., F. Anal. Biochem. 1996, 234, 126-141.
4. Gao, J.; Cheng, X.; Chen, R.; Sigal, G. B.; Bruce, J. E.; Schwartz, B. L.; Hofstadler, S. A.; Anderson, G. A.; Smith, R. D.; Whitesides, G. M. J. Med. Chem. 1996, 39, 1949-1955.
5. Boyce, R.; Li, G.; Nestler, H. P.; Suenaga, T.; Still, W. C. J. Am. Chem. Soc. 1994, 116, 7955-7956.
6. Liang, R.; Yan, L.; Loebach, J.; Ge, M.; Uozumi, Y.; Sekanina, K.; Horan, N.; Gildersleeve, J.; Thompaon, C.; Smith, A.; Biswas, K.; Still, W. C., Kahne, D. Science 1996, 274, 1996.
7. Georgiou, G.; Stathopoulos, C.; Daugherty, P. S.; Nayak, A. R., Iverson, B. L.; Curtiss III, R. Nature Biotech. 1997, 15, 29-34.
8. Wu, J.; Takayama, S.; Wong, C.-H.; Siuzdak, G. Chem. Biol.. 1997, 4, 653-657.
9. Lee, E. D.; Muck, W.; Henion, J. D.; Covey, T. R. J. Am. Chem. Soc. 1989, 111, 4600-4604.
10. Henion, J. D.; Nlordehai, A. V.; Cai, J. Y. Anal. Chem. 1994, 66, 2103-2109.
11. Hegy, G.; Gorlach, E.; Richmond, R.; Bitsch, F. Rapid Commun. Mass Spectrom. 1996, 10, 1894-1900.
12. Siuzdak, G. Mass Spectrometry for Biotechnology; Academic: San Diego, 1996.
13. Varki, A. Glycobiol. 1993, 3, 97-130.
14. Takayama, S.; Martin, R.; Wu, J.; Laslo, K.; Qiao, L.; Siuzdak, G.; Wong, C.-H. J. Am. Chem. Soc. 1997, 119, 8146-8151.
15. Ichikawa, Y.; Lin, Y.-C.; Dumas, D. P.; Shen, G.-J.; Garcia-Junceda, E.; Williams, M. A.; Bayer, R.; Ketcham, C.; Walker, L. E.; Paulson, J. C.; Wong, C.-H. J. Am. Chem. Soc. 1992, 114, 9283-9298.
16. Murray, B. W.; Wittmann, V.; Burkart, M. D.; Hung, S.-C.; Wong, C.-H. Biochem. 1997, 36, 823-831.
17. Rideout, D.; Bustamante, A.; Siuzdak, G. Proc. Nat. Acad. Sciences USA. 1993, 90, 10226-10229.
18. Rustum, A. M. J. of Chromatogr. Sci. 1990, 28, 594-598.
19. Muddiman, D. C.; Gusev, A. I.; Proctor, A.; Hercules, D. M.; Venkataramanan, R.; Diven, W. Anal. Chem. 1994, 66, 2362-2368.
20. Rosano, T. G.; Freed, B. M.; Cerilli, J.; Lempert, N. Transplantation. 1986, 42, 262-267.
21. Freed, B. M.; Rosano, T. G.; Lempert, N. Transplantation. 1987, 43, 123-127.
22. Muddiman, D. C.; Gusev, A. I.; Langner, K. S.; Proctor, A.; Hercues, D. M.; Tata, P.; Venkataramanan, R.; Diven, W. J. Mass Spec. 1995, 30, 1469-1479.
23. Wu, J.; Chatman, K.; Harris, K.; Siuzdak, G. Anal. Chem. 1997, 69, 3767-3771.
24. Garraffo, R.; Lapalus, P. J. Chromatogr. 1985, 337, 416-422.
25. Brummel, C. L.; Lee, I. N.; Zhou, Y.; Benkovic, S. J.; Winograd, N. Science 1994, 264, 399.
26. Egner, B. J.; Cardno, M.; Bradley, M. J. Chem. Soc.-Chem. Comm. 1995, 21, 2163.
27. Egner, B. J.; Langley, G. J.; Bradley, M. J. Org. Chem. 1995, 60, 2652.
28. Haskins, N. J.; Hunter, D. J.; Organ, A. J.; Rahman, S.; Thom, C. Rapid Comm. Mass Spectrom. 1995, 9, 1437.
29. Brummel, C. L.; Vickerman, J. C.; Carr, S. A.; Hemling, M. E.; Roberts, G. D.; Johnson, W.; Weinstock, J.; Gaitonopoulos, D.; Benkovic, S. J.; Winograd, N. Anal. Chem. 1996, 68, 237.
30. Fitzgerald, M. C.; Harris, K.; Shevlin, C. G.; Siuzdak, G. Biorg. Med. Chem. Lett. 1996, 6, 979-982.
31. Schnölzer, M.; Alewood, P. A. J.; Alewood, D.; Kent, S. B. Int. J. Pep. Prot. Res. 1992, 40, 180.
32. Sheehan, J. C.; Umezawa, K. J. Org. Chem. 1973, 38, 3771.
33. Wang, S. S. J. Org. Chem. 1976, 41, 3258.
34. Cerpa-Poljak, A.; Jenkins, A.; Duncan, M. W. Rapid Commun. Mass Spectrom. 1995, 9, 233-239.