-
1
-
-
0000074870
-
Strategy and tactics in combinatorial organic synthesis: Application to drug discovery
-
Gordon EM, Gallop MA and Patel DV (1996) Strategy and tactics in combinatorial organic synthesis: application to drug discovery. Acc Chem Res 29:144-154.
-
(1996)
Acc Chem Res
, vol.29
, pp. 144-154
-
-
Gordon, E.M.1
Gallop, M.A.2
Patel, D.V.3
-
2
-
-
2842561522
-
Synthesis and applications of small molecule libraries
-
Thompson LA and Ellman JA (1996) Synthesis and applications of small molecule libraries. Chem Rev 29:132-143.
-
(1996)
Chem Rev
, vol.29
, pp. 132-143
-
-
Thompson, L.A.1
Ellman, J.A.2
-
3
-
-
0002974025
-
Mass spectrometry in the combinatorial chemistry revolution
-
Loo JA (1997) Mass spectrometry in the combinatorial chemistry revolution. Eur Mass Spectrom 3:93-104.
-
(1997)
Eur Mass Spectrom
, vol.3
, pp. 93-104
-
-
Loo, J.A.1
-
4
-
-
0030927388
-
Pulsed Ultrafiltration mass spectrometry: A new method for screening combinatorial libraries
-
van Breemen RB, Huang C-R, Nikolic D, Woodbury CP and Venton DL (1997) Pulsed Ultrafiltration mass spectrometry: A new method for screening combinatorial libraries. Anal Chem 69:2159-2164.
-
(1997)
Anal Chem
, vol.69
, pp. 2159-2164
-
-
Van Breemen, R.B.1
Huang, C.-R.2
Nikolic, D.3
Woodbury, C.P.4
Venton, D.L.5
-
5
-
-
0031468941
-
Screening solution-phase combinatorial libraries using pulsed ultrafiltration/electrospray mass spectrometry
-
Zhao Y-Z, van Breemen RB, Nikolic D, Huang C-R, Woodbury CP, Schilling A and Venton DL (1997) Screening solution-phase combinatorial libraries using pulsed ultrafiltration/electrospray mass spectrometry. J Med Chem, 40:4006-4012.
-
(1997)
J Med Chem
, vol.40
, pp. 4006-4012
-
-
Zhao, Y.-Z.1
Van Breemen, R.B.2
Nikolic, D.3
Huang, C.-R.4
Woodbury, C.P.5
Schilling, A.6
Venton, D.L.7
-
6
-
-
0030022629
-
An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials
-
Parkinson A (1996) An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials. Toxicol Pathol 24:45-57.
-
(1996)
Toxicol Pathol
, vol.24
, pp. 45-57
-
-
Parkinson, A.1
-
7
-
-
0030588645
-
The use of adult human hepatocytes in primary culture and other in vitro systems to investigate drug metabolism in man
-
Maurel P (1996) The use of adult human hepatocytes in primary culture and other in vitro systems to investigate drug metabolism in man. Adv Drug Delivery Rev 22:105-132.
-
(1996)
Adv Drug Delivery Rev
, vol.22
, pp. 105-132
-
-
Maurel, P.1
-
8
-
-
0345540297
-
Norepinephrine and the andrenergic receptors
-
Oxford University Press, New York
-
Nogrady T (1988) Norepinephrine and the andrenergic receptors. In Medicinal Chemistry: A Biochemical Approach, 2nd edition, p. 177, Oxford University Press, New York.
-
(1988)
Medicinal Chemistry: A Biochemical Approach, 2nd Edition
, pp. 177
-
-
Nogrady, T.1
-
9
-
-
0016157033
-
Metabolism of tricyclic antidepressants
-
Gram LF (1974) Metabolism of tricyclic antidepressants. Dan Med Bull 21:218-231.
-
(1974)
Dan Med Bull
, vol.21
, pp. 218-231
-
-
Gram, L.F.1
-
10
-
-
0027230584
-
Major pathway of imipramine metabolism is catalyzed by cytochromes P450 1A2 and P450 3A4 in human liver
-
Lemoine A, Gautier JC, Azoulay D, Kiffel L, Belloc C, Guengerich FP, Maurel P, Beaune P and Leroux JP (1993) Major pathway of imipramine metabolism is catalyzed by cytochromes P450 1A2 and P450 3A4 in human liver. Mol Pharmacol 43:827-832.
-
(1993)
Mol Pharmacol
, vol.43
, pp. 827-832
-
-
Lemoine, A.1
Gautier, J.C.2
Azoulay, D.3
Kiffel, L.4
Belloc, C.5
Guengerich, F.P.6
Maurel, P.7
Beaune, P.8
Leroux, J.P.9
-
11
-
-
0025733250
-
Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine
-
Brosen K, Zeugin T and Meyer UA (1991) Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine. Clin Pharmacol Ther 49:609-617.
-
(1991)
Clin Pharmacol Ther
, vol.49
, pp. 609-617
-
-
Brosen, K.1
Zeugin, T.2
Meyer, U.A.3
-
12
-
-
0024260137
-
Parallel pathway interactions in imipramine metabolism in rats
-
Chiba M, Fujita S and Suzuki T (1988) Parallel pathway interactions in imipramine metabolism in rats. J Pharm Sci 77:944-947.
-
(1988)
J Pharm Sci
, vol.77
, pp. 944-947
-
-
Chiba, M.1
Fujita, S.2
Suzuki, T.3
-
13
-
-
0028955961
-
Brief comparison of the pharmacokinetics and pharmacodynamics of the traditional and newer antipsychotic drugs
-
DeVane CL (1995) Brief comparison of the pharmacokinetics and pharmacodynamics of the traditional and newer antipsychotic drugs. Am J Health Syst Pharm 52:S15-S18.
-
(1995)
Am J Health Syst Pharm
, vol.52
-
-
DeVane, C.L.1
-
14
-
-
0022357068
-
Ethoxy-, pentoxy-, and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P450
-
Burke MD, Thompson S, Elcombe CR, Halpert J, Haaparanta T and Mayer RT (1985) Ethoxy-, pentoxy-, and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P450. Biochem Pharmacol 34:3337-3347.
-
(1985)
Biochem Pharmacol
, vol.34
, pp. 3337-3347
-
-
Burke, M.D.1
Thompson, S.2
Elcombe, C.R.3
Halpert, J.4
Haaparanta, T.5
Mayer, R.T.6
-
15
-
-
0023585268
-
Oxidative metabolism of butylated hydroxytoluene by hepatic and pulmonary microsomes from rats and mice
-
Thompson JA, Malkinson AM, Wand MD, Mastovich SL, Mead EW, Schullek KM and Laudenschlager WG (1987) Oxidative metabolism of butylated hydroxytoluene by hepatic and pulmonary microsomes from rats and mice. Drug Metab Dispos 15:833-840.
-
(1987)
Drug Metab Dispos
, vol.15
, pp. 833-840
-
-
Thompson, J.A.1
Malkinson, A.M.2
Wand, M.D.3
Mastovich, S.L.4
Mead, E.W.5
Schullek, K.M.6
Laudenschlager, W.G.7
-
16
-
-
0025685663
-
In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids
-
Guengerich FP and Kim DH (1990) In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids. Carcinogenesis 11:2275-2279.
-
(1990)
Carcinogenesis
, vol.11
, pp. 2275-2279
-
-
Guengerich, F.P.1
Kim, D.H.2
-
17
-
-
0028828379
-
High-performance liquid Chromatographic method for the analysis of imipramine metabolism in vitro by liver and brain microsomes
-
Sequeira DJ and HW Strobel (1995) High-performance liquid Chromatographic method for the analysis of imipramine metabolism in vitro by liver and brain microsomes. J Chromatogr B 673:251-258.
-
(1995)
J Chromatogr B
, vol.673
, pp. 251-258
-
-
Sequeira, D.J.1
Strobel, H.W.2
-
18
-
-
0029926747
-
Quinidine inhibits 7-hydroxylation of chlorpromazine in extensive metabolisers of debrisoquine
-
/accom
-
Muralidharan G, Cooper JK, Hawes EM, Korchincki ED and Midha KK (1996) Quinidine inhibits 7-hydroxylation of chlorpromazine in extensive metabolisers of debrisoquine. Eur J Clin Pharmacol 50:121-128. [/accom]
-
(1996)
Eur J Clin Pharmacol
, vol.50
, pp. 121-128
-
-
Muralidharan, G.1
Cooper, J.K.2
Hawes, E.M.3
Korchincki, E.D.4
Midha, K.K.5
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