Direct plasma sample injection in multiple-component LC-MS-MS assays for high-throughput pharmacokinetic screening

Analytical Chemistry

Volumn 72, Issue 1, 2000, Pages 61-67

  Wu, Jing Tao ^a   Zeng, Hang ^a   Qian, Mingxin ^a   Brogdon, Bernice L ^a   Unger, Steve E ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPRAZOLAM; BROMAZEPAM; CARBAMAZEPINE; ESTAZOLAM; FENFLURAMINE; HALOPERIDOL; OXAZEPAM; PHENTOLAMINE; PUROMYCIN; TEMAZEPAM; TRIPROLIDINE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; DRUG DETERMINATION; DRUG SCREENING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

ANIMALS; BLOOD CHEMICAL ANALYSIS; CHROMATOGRAPHY, LIQUID; DOGS; MALE; MASS SPECTROMETRY; PAN TROGLODYTES; PHARMACOKINETICS;

EID: 0033957404     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac990769y     Document Type: Article

References (18)

1. Berman, J.; Halm, K.; Adkison, K.; Shaffer, J. J. Med. Chem. 1997, 40, 827-829.
2. Olah, T.; McLoughlin, D.; Gilbert, J. Rapid Commun. Mass Spectrom. 1997, 11, 17-23.
3. Bryant, M.; Korfmacher, W.; Wang, S.; Nardo, S.; Nomeir, A.; Lin, C. J. Chromatogr. 1997, 777, 61-66.
4. Hop, C.; Wang, Z,; Chen, Q.; Kwei, G. J. Pharm. Sci. 1998, 87, 901-903.
5. Allen, M. C.; Shah, T. S.; Day, W. W. Pharm. Res. 1998, 15, 93-97.
6. Henion, J.; Brewer, E.; Rule, G. Anal. Chem. 1998, 70, 650A-656A.
7. Simpson, H.; Berthemy, A.; Buhrman, D.; Burton, R.; Newton, J.; Kealy, M.; Wells, D.; Wu, D. Rapid Commun. Mass Spectrom. 1998, 12, 75-82.
8. Janiszewski, J.; Schneider, R. P.; Hoffmaster, K.; Swyden, M.; Wells, D.; Fouda, H. Rapid Commun. Mass Spectrom. 1997, 11, 1033-1037.
9. Allanson, J. P.; Biddlecombe, R. A.; Jones, A. E.; Pleasance, S. Rapid Commun. Mass Spectrom. 1996, 10, 811-816.
10. Cai, J.; Henion, J. D. J. Chromatogr., B. 1997, 691, 357-370.
11. van der Hoeven, R. A. M.; Hofte, A. J. P.; Frenay, M.; Irth, H.; Tjaden, U. R.; van der Greef, J.; Rudolphi, A.; Boos, K.-S.; Varga, G. M.; Edholm, L. E. J. Chromatogr. A 1997, 762, 193-200.
12. Beaudry, F.; LeBlanc, J.; Coutu, M.; Brown, N. Rapid Commun. Mass Spectrom. 1998, 1216-1222.
13. McLoughlin, D. A.; Olah, T. V.; Gilbert, J. D. J. Pharm. Biomed. Anal. 1997, 15, 1893-1901.
14. Needham, S. R.; Cole, M. J.; Fouda, H. G. J. Chromatogr., B 1998, 718, 87-94.
15. Pretorius, V.; Smuts, T. W. Anal. Chem. 1966, 38, 274-281.
16. Jemal, M.; Qing, Y.; Whigan, D. B. Rapid Commun. Mass Spectrom. 1998, 12, 1389-1399.
17. Ayrton, J.; Dear, G. J.; Leavens, W. J.; Mallett, D. N.; Plumb, R. S. Rapid Commun. Mass Spectrom. 1997, 11, 1953-1958.
18. Gulochon, G.; Martin, M. Anal. Chem. 1982, 54, 1533-1540.