Quantification and rapid metabolite identification in drug discovery using API time-of-flight LC/MS

Analytical Chemistry

Volumn 72, Issue 4, 2000, Pages 800-806

  Zhang, Nanyan ^a   Fountain, Scott T ^a   Bi, Honggang ^a   Rossi, David T ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPHENIRAMINE; DESIPRAMINE; DIPHENHYDRAMINE; LIDOCAINE; PHENYLBUTAZONE; TRIMIPRAMINE;

ARTICLE; DRUG CLEARANCE; DRUG METABOLISM; DRUG STRUCTURE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; PHARMACOKINETICS;

ANIMALS; CHROMATOGRAPHY, LIQUID; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS; RATS;

EID: 0034652244     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac9911701     Document Type: Article

References (14)

1. Gelpi, E. J. Chromatogr., A 1995, 703, 59-80.
2. Moeller, M. R.; Steinmeyer, S.; Kraemer, T. J. Chromatogr., B 1998, 713, 91-109.
3. Huang, H.; Kagel, J. R.; Rossi, D. T. J. Pharm. Biomed. Anal. 1999, 19, 613-620.
4. Bi, H.; Hoffman, K. L.; Pace, G.; Rossi, D. T. J. Pharm. Biomed. Anal., in press.
5. Olah, T. V.; McLoughlin, D. A.; Gilbert, J. D. Rapid. Commun. Mass Spectrom. 1997, 11, 17-23.
6. Wechter, W. J.; Murray, E. D. Exp. Nephrol. 1998, 6, 488-90.
7. McLuckey, S. A.; Van Berkel, G. J.; Goeringer, D. E.; Glish, G. L. Anal. Chem. 1994, 66, 689A.
8. McLuckey, S. A.; Van Berkel, G. J.; Goeringer, D. E.; Glish, G. L. Anal. Chem. 1994, 66, 737A.
9. Chernushevich, I. V.; Ens, W.; Standing, K. G. Anal. Chem. 1999, 71, 452A-461A.
10. Schultz, G.; Lowes, S.; Henion, J.; Hop, C.; Carlin, J. Comparison of a Triple Quadrupole Using SRM to a TOFMS for Quantitative LC-MS Support of Drug Discovery Programs; American Society of Mass Spectrometry: Orlando, FL, 1998.
11. Cotter, R. J. Anal. Chem. 1999, 71, 445A-451A.
12. Zhang, N.; Hoffman, K. L.; Li, W.; Rossi, D. T. J. Pharm. Biomed. Anal., in press.
13. Zhang, N.; Rogers, K.; Kagel, J. R.; Rossi, D. T. J. Pharm. Biomed. Anal., in press.
14. Constantopoulos, T. L.; Jackson, G. S.; Enke, C. G. J. Am. Soc. Mass. Spectrom. 1999, 10, 625-834.