High-throughput quantitative bioanalysis by LC/MS/MS

Biomedical Chromatography

Volumn 14, Issue 6, 2000, Pages 422-429

  Jemal, Mohammed ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATMOSPHERIC IONIZATION; ATMOSPHERIC PRESSURE; BIOMOLECULES; DRUG PRODUCTS; EXTRACTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHASE SEPARATION; SENSITIVITY ANALYSIS; THROUGHPUT;

96-WELL; BIOLOGICAL MATRIXES; DRUG METABOLITES; HIGH-THROUGHPUT; HIGH-THROUGHPUT APPROACHES; HIGH-THROUGHPUT BIOANALYSIS; INTRODUCTION AND IMPLEMENTATIONS; LC-MS-MS; QUANTITATIVE BIO-ANALYSIS; SAMPLE PREPARATION;

METABOLITES;

ACETONITRILE; BIOMATERIAL; DRUG; DRUG METABOLITE; FORMIC ACID; METHANOL; PROTEIN;

ATMOSPHERIC PRESSURE; AUTOMATION; CAPILLARY CHROMATOGRAPHY; CONTROLLED STUDY; FLOW RATE; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; MATERIALS HANDLING; METABOLITE; METHODOLOGY; PRECIPITATION; QUANTITATIVE ASSAY; REVIEW; SAFETY; SAMPLING; SOLID PHASE EXTRACTION; TUBE; VELOCITY;

EID: 0033824707     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-0801(200010)14:6<422::AID-BMC25>3.0.CO;2-I     Document Type: Review

References (54)

1. Comparison of conventional, narrow-bore and capillary liquid chromatography/mass spectrometry for electrospray ionization mass spectrometry: Practical considerations
2. The use of automated solid phase extraction in the '96 well' format for high throughput bioanalysis using liquid chromatography coupled to tandem mass spectrometry
3. The use of turbulent flow chromatography/mass spectrometry for the rapid, direct analysis of a novel pharmaceutical compound in plasma
4. Optimisation and routine use of generic ultra-high flow-rate liquid chromatography with mass spectrometric detection for the direct on-line analysis of pharmaceuticals in plasma
5. Ultra-high flow rate capillary liquid chromatography with mass spectrometric detection for the direct analysis of pharmaceuticals in plasma at sub-nanogram per millilitre concentrations
6. High throughput liquid chromatography/mass spectrometric analyses using a novel multiplexed electrospray interface
7. Automated protein precipitation by filtration in the 96-well format
8. The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds
9. Quantitation of SR 27417 in human plasma using electrospray liquid chromatography-tandem mass spectrometry: A study of ion suppression
10. Matrix-related modification of ionization in bioanalytical liquid chromatography-atmospheric pressure ionization tandem mass spectrometry
11. A new approach to the effective preparation of plasma samples for rapid drug quantitation using online solid phase extraction mass spectrometry
12. Determination of tetracylines in bovine kidney by liquid chromatography/tandem mass spectrometry with on-line extraction and clean-up
13. The use of capillary high performance liquid chromatography with electrospray mass spectrometry for the analysis of small volume blood samples from serially bled mice to determine the pharmacokinetics of early discovery compounds
14. Effect of the sample matrix on the determination of indinavir in human urine by HPLC with turbo ion spray tandem mass spectrometric detection
15. Automated 96-well solid phase extraction for the determination of doramectin in cattle plasma
16. Fast liquid chromatographic-mass spectrometric determination of pharmaceutical compounds
17. High-throughput solid-phase extraction for the determination of cimetidine in human plasma
18. Analysis of nucleic acids by capillary ion-pair reversed-phase HPLC coupled to negative-ion electrospray ionization mass spectrometry
19. Evaluation of volatile eluents and electrolytes for high-performance liquid chromatography-electrospray ionization mass spectrometry and capillary electrophoresis-electrospray ionization mass spectrometry of proteins: I. Liquid chromatogra
20. Effect of high performance liquid chromatography mobile phase (methanol versus acetonitrile) on the positive and negative ion electrospray response of a compound that contains both an unsaturated lactone and a methyl sulfone group
21. The need for adequate chromatographic separation in the quantitative determination of drugs in biological samples by high performance liquid chromatography with tandem mass spectrometry
22. Negative ion electrospray high-performance liquid chromatography-mass spectrometry method development for determination of a highly polar phosphonic acid/sulfonic acid compound in plasma: Optimization of ammonium acetate concentration and
23. +
24. The use of high-flow high performance liquid chromatography coupled with positive and negative ion electrospray tandem mass spectrometry for quantitative bioanalysis via direct injection of the plasma/serum samples
25. High performance liquid chromatography mobile phase composition optimization for the quantitative determination of a carboxylic acid compound in human plasma by negative ion electrospray high performance liquid chromatography tandem mass s
26. Comparison of plasma sample purification by manual liquid-liquid extraction, automated 96-well liquid-liquid extraction and automated 96-well solid-phase extraction for analysis by high-performance liquid chromatography with tandem mass sp
27. A versatile system of high-flow high performance liquid chromatography with tandem mass spectrometry for rapid direct-injection analysis of plasma samples for quantitation of a β-lactam drug candidate and its open-ring biotransformation p
28. Direct injection versus liquid-liquid extraction for plasma sample analysis by high performance liquid chromatography with tandem mass spectrometry
29. Liquid chromatography-electrospray tandem mass spectrometry method for the quantitation of fosinoprilat in human serum using automated 96-well SPE for sample preparation
30. Direct-injection LC-MS-MS method for high-throughput simultaneous quantitation of simvastatin and simvastatin acid in human plasma
31. Effects of mobile-phase additives, solution pH, ionization constant, and analyte concentration on the sensitivities and electrospray ionization mass spectra of nucleoside antiviral agents
32. 'Wrong-way-round' electrospray ionization of amino acids
33. Matrix effect in quantitative LC/MS/MS analyses of biological fluids: A method for determination of finasteride in human plasma at picogram per milliliter concentrations
34. Simultaneous assay of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human plasma using normal-phase liquid chromatography-tandem mass spectrometry with a silica column and an aqueous organic mobile phase
35. 2, 12-hydroxyeicosatetraenoic acid and arachidonic acid using high performance liquid/electrospray ionization mass spectrometry
36. 4 in whole blood by liquid chromatography/mass spectrometry
37. Automated high-throughput liquid-liquid extraction for initial purification of combinatorial libraries
38. The application of fast gradient capillary liquid chromatography/mass spectrometry to the analysis of pharmaceuticals in biofluids
39. Effect of high-performance liquid chromatography mobile phase components on sensitivity in negative atmospheric pressure chemical ionization liquid chromatography-mass spectrometry
40. High throughput liquid/mass spectrometry bioanalysis using 96-well disk solid phase extraction plate for the sample preparation
41. Liquid-liquid extraction in the 96-well plate format with SRM LC/MS quantitative determination of methotrexate and its major metabolite in human plasma
42. An automated method of sample preparation of biofluids using pierceable caps to eliminate the uncapping of the sample tubes during sample transfer
43. The effect of LC eluent composition on MS responses using electrospray ionization
44. Higher throughput bioanalysis by automation of a protein precipitation assay using a 96-well format with detection by LC-MS/MS
45. 96-well plate products for solid-phase extraction
46. Accessory products for SPE using 96-well plates
47. Direct plasma sample injection in multiple-component LC-MS/MS assays for high-throughput pharmacokinetic screening
48. Ternary-column system for high-throughput direct-injection bioanalysis by liquid chromatography/tandem mass spectrometry
49. Low picogram determination of Ro 48-6791 and its major metabolite, Ro 48-6792, in plasma with column-switching microbore high-performance liquid chromatography coupled to ion spray tandem mass spectrometry
50. Quantitative and qualitative determination of estrogen sulfates in human urine by liquid chromatography/tandem mass spectrometry using 96-well technology
51. Effects of solvent composition on molecular ion response in electrospray mass spectrometry: Investigation of the ionization process
52. Quasilinear gradients for capillary liquid chromatography with mass and tandem mass spectrometry
53. Comparison of turbulent-flow chromatography with automated solid-phase extraction win 96-well plates and liquid-liquid extraction used as plasma sample preparation techniques for liquid chromatography-tandem mass spectrometry
54. High-throughput bioanalytical LC/MS/MS determination of benzodiazepines in human urine: 1000 samples per 12 hours