-
7
-
-
0033601346
-
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
-
(1999)
Science
, vol.286
, pp. 2528-2531
-
-
Bell, D.W.1
Varley, J.M.2
Szydlo, T.E.3
Kang, D.H.4
Wahrer, D.C.5
Shannon, K.E.6
Lubratovich, M.7
Verselis, S.J.8
Isselbacher, K.J.9
Fraumeni, J.F.10
Birch, J.M.11
Li, F.P.12
Garber, J.E.13
Haber, D.A.14
-
26
-
-
0027210981
-
Gain of function mutations in p53
-
(1993)
Nat. Genet.
, vol.4
, pp. 42-46
-
-
Dittmer, D.1
Pati, S.2
Zambetti, G.3
Chu, S.4
Teresky, A.K.5
Moore, M.6
Finaly, C.7
Levine, A.J.8
-
29
-
-
3543046171
-
Exclusion of a p53 germline mutation in a classic Li-Fraumeni syndrome family
-
(1998)
Hum. Genet.
, vol.102
, pp. 681-686
-
-
Evans, S.C.1
Mims, B.2
McMasters, K.M.3
Foster, C.J.4
DeAndrade, M.5
Amos, C.I.6
Strong, L.C.7
Lozano, G.8
-
30
-
-
0027498314
-
The mdm2 oncogene can overcome wild-type p53 suppression of transformed cell growth
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 301-306
-
-
Finlay, C.A.1
-
38
-
-
0030797585
-
Activation of sequence-specific binding by acetylation of the p53 C-terminal domain
-
(1997)
Cell
, vol.90
, pp. 595-606
-
-
Gu, W.1
Roeder, R.G.2
-
43
-
-
0034629072
-
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
-
(2000)
Science
, vol.287
, pp. 1824-1827
-
-
Hirao, A.1
Kong, Y.Y.2
Matsuoka, S.3
Wakeham, A.4
Ruland, J.5
Yoshida, H.6
Liu, D.7
Elledge, S.J.8
Mak, T.W.9
-
44
-
-
0344604528
-
Genomic instability in Gadd45a-deficient mice
-
(1999)
Nat. Genet.
, vol.23
, pp. 176-184
-
-
Hollander, M.C.1
Sheikh, M.S.2
Bulavin, D.V.3
Lundgren, K.4
Augeri-Henmueller, L.5
Shehee, R.6
Molinaro, T.A.7
Kim, K.E.8
Tolosa, E.9
Ashwell, J.D.10
Rosenberg, M.P.11
Zhan, O.12
Fernandez-Salguero, P.M.13
Morgan, W.F.14
Deng, C.X.15
Fornace A.J., Jr.16
-
45
-
-
0028108985
-
Database of p53 gene somatic mutations in human tumors and cell lines
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 3551-3555
-
-
Hollstein, M.1
Rice, K.2
Greenblatt, M.S.3
Soussi, T.4
Fuchs, R.5
Sorlie, T.6
Hovig, E.7
Smith-Sorensen, B.8
Montesano, R.9
Harris, C.C.10
-
54
-
-
0026496885
-
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
-
(1992)
Cell
, vol.71
, pp. 587-597
-
-
Kastan, M.B.1
Zhan, Q.2
El-Deiry, W.S.3
Carrier, F.4
Jacks, T.5
Walsh, W.V.6
Plunkett, B.S.7
Vogelstein, B.8
Fornace A.J., Jr.9
-
55
-
-
0000303499
-
ATM associates with and phosphorylates p53: Mapping the region of interaction
-
(1998)
Nat. Genet.
, vol.20
, pp. 398-400
-
-
Khanna, K.K.1
Keating, K.E.2
Kozlov, S.3
Scott, S.4
Gatei, M.5
Hobson, K.6
Taya, Y.7
Gabrielli, B.8
Chan, D.9
Lees-Miller, S.P.10
Lavin, M.F.11
-
60
-
-
0035140981
-
Regulation of p53 by hypoxia: Dissociation of transcriptional repression and apoptosis from p53-dependent transactivation
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1297-1310
-
-
Koumenis, C.1
Alarcon, R.2
Hammond, E.3
Sutphin, P.4
Hoffman, W.5
Murphy, M.6
Derr, J.7
Taya, Y.8
Lowe, S.W.9
Kastan, M.10
Giaccia, A.11
-
65
-
-
0024431245
-
High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene
-
(1989)
Mol. Cell. Biol.
, vol.9
, pp. 3982-3991
-
-
Lavigueur, A.1
Maltby, V.2
Mock, D.3
Rossant, J.4
Pawson, T.5
Berstein, A.6
-
66
-
-
0030941458
-
p53, the cellular gatekeeper for growth and division
-
(1997)
Cell
, vol.88
, pp. 323-331
-
-
Levine, A.J.1
-
68
-
-
7344252500
-
Mutant p53 protein expression interferes with p53-independent apoptotic pathways
-
(1998)
Oncogene
, vol.16
, pp. 3269-3277
-
-
Li, R.1
Sutphin, P.D.2
Schwartz, D.3
Matas, D.4
Almog, N.5
Wolkowicz, R.6
Goldfinger, N.7
Pei, H.8
Prokocimer, M.9
Rotter, V.10
-
69
-
-
0029062595
-
Two critical hydrophobic amino acids in the N-terminal domain of the p53 protein are required for the gain of function phenotypes of human p53 mutants
-
(1995)
Oncogene
, vol.10
, pp. 2387-2390
-
-
Lin, J.1
Teresky, A.K.2
Levine, A.J.3
-
70
-
-
0018760324
-
Characterization of a 54 K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
-
(1979)
Cell
, vol.17
, pp. 43-52
-
-
Linzer, D.I.H.1
Levine, A.J.2
-
75
-
-
0027944206
-
p53 status and the efficacy of cancer therapy in vivo
-
(1994)
Science
, vol.266
, pp. 807-810
-
-
Lowe, S.W.1
Bodis, S.2
McClatchey, A.3
Remington, L.4
Ruley, H.E.5
Fisher, D.E.6
Housman, D.E.7
Jacks, T.8
-
79
-
-
0025633582
-
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
-
(1990)
Science
, vol.250
, pp. 1233-1238
-
-
Malkin, D.1
Li, F.-P.2
Strong, L.C.3
Fraumeni J.F., Jr.4
Nelson, C.E.5
Kim, D.H.6
Hassel, J.7
Gryka, M.A.8
Bischoff, F.Z.9
Tainsky, M.A.10
Friend, S.H.11
-
81
-
-
0028883179
-
Tumor suppressor p53 is a direct transcriptional activator of the human Bax gene
-
(1995)
Cell
, vol.80
, pp. 293-299
-
-
Miyashita, T.1
Reed, J.C.2
-
82
-
-
0028335717
-
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
-
(1994)
Oncogene
, vol.9
, pp. 1799-1805
-
-
Miyashita, T.1
Krajewski, S.2
Krajewski, M.3
Wang, H.G.4
Lin, H.K.5
Liebermann, D.A.6
Hoffman, B.7
Reed, J.C.8
-
90
-
-
0033215387
-
Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a
-
(1999)
Genes Dev.
, vol.13
, pp. 2490-2501
-
-
Murphy, M.1
Ahn, J.2
Walker, K.K.3
Hoffman, W.H.4
Evans, R.M.5
Levine, A.J.6
George, D.L.7
-
93
-
-
0034640281
-
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
-
(2000)
Science
, vol.288
, pp. 1053-1058
-
-
Oda, E.1
Ohki, R.2
Murasawa, H.3
Nemoto, J.4
Shibue, T.5
Yamashita, T.6
Tokino, T.7
Taniguchi, T.8
Tanaka, N.9
-
94
-
-
0029003501
-
Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 3032-3040
-
-
Owen-Schaub, L.B.1
Zhang, W.2
Cusack, J.C.3
Angelo, L.S.4
Santee, S.M.5
Fujiwara, T.6
Roth, J.A.7
Deisseroth, A.B.8
Zhang, W.W.9
Kruzel, E.10
-
98
-
-
0032475878
-
Signaling to p53: Breaking the MDM2-p53 circuit
-
(1998)
Cell
, vol.95
, pp. 5-8
-
-
Prives, C.1
-
101
-
-
0027175653
-
Base transitions are the most frequent genetic changes at P53 in gastric cancer
-
(1993)
Cancer Res.
, vol.53
, pp. 2614-2617
-
-
Renault, B.1
Van den Broek, M.2
Fodde, R.3
Wijnen, J.4
Pellegata, N.S.5
Amadori, D.6
Khan, P.M.7
Ranzani, G.N.8
-
104
-
-
0032530486
-
DNA damage activates p53 through a phosphorylation-acetylation cascade
-
(1998)
Genes Dev.
, vol.12
, pp. 2831-2841
-
-
Sakaguchi, K.1
Herrera, J.E.2
Saito, S.3
Miki, T.4
Bustin, M.5
Vassilev, A.6
Anderson, C.W.7
Apella, E.8
-
107
-
-
0030961889
-
Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain
-
(1997)
Nat. Med.
, vol.3
, pp. 632-638
-
-
Selivanova, G.1
Iotsova, V.2
Okan, I.3
Fritsche, M.4
Strom, M.5
Groner, B.6
Grafstrom, R.C.7
Wiman, K.G.8
-
110
-
-
0027050648
-
Wild-type p53 binds to the TATA-binding protein and represses transcription
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 12028-12032
-
-
Seto, E.1
Usheva, A.2
Zambetti, G.P.3
Momand, J.4
Horikoshi, N.5
Weinmann, R.6
Levine, A.J.7
Shenk, T.8
-
117
-
-
0033118933
-
DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization
-
(1999)
EMBO J.
, vol.18
, pp. 1815-1823
-
-
Shieh, S.-Y.1
Taya, Y.2
Prives, C.3
-
119
-
-
0028569767
-
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen
-
(1994)
Science
, vol.266
, pp. 1376-1380
-
-
Smith, M.L.1
Chen, I.T.2
Zhan, Q.3
Bae, I.4
Chen, C.Y.5
Gilmer, T.M.6
Kastan, M.B.7
O'Connor, P.M.8
Fornace A.J., Jr.9
-
120
-
-
0035843169
-
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
-
(2001)
Nature
, vol.409
, pp. 207-211
-
-
Soengas, M.S.1
Capodieci, P.2
Polsky, D.3
Mora, J.4
Esteller, M.5
Opitz-Araya, X.6
McCombie, R.7
Herman, J.G.8
Gerald, W.L.9
Lazebnik, Y.A.10
Cordon-Cardo, C.11
Lowe, S.W.12
-
123
-
-
0032169516
-
ARF, participates in a regulatory feedback loop with p53 and MDM2
-
(1998)
EMBO J.
, vol.17
, pp. 5001-5014
-
-
Stott, F.J.1
Bates, S.2
James, M.C.3
McConnell, B.B.4
Starborg, M.5
Brookes, S.6
Palmero, I.7
Ryan, K.8
Hara, E.9
Vousden, K.H.10
Peters, G.11
-
128
-
-
0033555260
-
A role for ATR in the DNA damage-induced phosphorylation of p53
-
(1999)
Genes Dev.
, vol.13
, pp. 152-157
-
-
Tibbetts, R.S.1
Brumbaugh, K.M.2
Williams, J.M.3
Sarkaria, J.N.4
Cliby, W.A.5
Shieh, S.Y.6
Taya, Y.7
Prives, C.8
Abraham, R.T.9
-
132
-
-
0033553505
-
Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 13760-13767
-
-
Wadgaonkar, R.1
Collins, T.2
-
135
-
-
0027990725
-
p53 domains: Structure, oligomerization, and transformation
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 5182-5191
-
-
Wang, P.1
Reed, M.2
Wang, Y.3
Mayr, G.4
Stenger, J.E.5
Anderson, M.E.6
Schwedes, J.F.7
Tegtmeyer, P.8
-
136
-
-
0027744051
-
p53 domains: Identification and characterization of two autonomous DNA-binding regions
-
(1993)
Genes Dev.
, vol.7
, pp. 2575-2586
-
-
Wang, Y.1
Reed, M.2
Wang, P.3
Stenger, J.E.4
Mayr, G.5
Anderson, M.E.6
Schwedes, J.F.7
Tegtmeyer, P.8
-
137
-
-
0032500106
-
Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis
-
(1998)
Oncogene
, vol.17
, pp. 35-45
-
-
Wang, X.-J.1
Greenhalgh, D.A.2
Jiang, A.3
He, D.4
Zhong, L.5
Medina, D.6
Brinkley, B.R.7
Roop, D.R.8
-
139
-
-
0033616501
-
GADD45 induction of a G2/M cell cycle checkpoint
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3706-3711
-
-
Wang, X.W.1
Zhan, Q.2
Coursen, J.D.3
Khan, M.A.4
Kontny, H.U.5
Yu, L.6
Hollander, M.C.7
O'Connor, P.M.8
Fornace A.J., Jr.9
Harris, C.C.10
-
141
-
-
0034665749
-
ARF tumor suppressor
-
(2000)
Genes Dev.
, vol.14
, pp. 2358-2365
-
-
Weber, J.D.1
Jeffers, J.R.2
Rehg, J.E.3
Randle, D.H.4
Lozano, G.5
Roussel, M.F.6
Sherr, C.J.7
Zambetti, G.P.8
-
142
-
-
0021746318
-
Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene
-
(1984)
Cell
, vol.38
, pp. 119-126
-
-
Wolf, D.1
Harris, N.2
Rotter, V.3
-
145
-
-
0031253977
-
KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene
-
(1997)
Nat. Genet.
, vol.17
, pp. 141-143
-
-
Wu, G.S.1
Burns, T.F.2
McDonald III, E.R.3
Jiang, W.4
Meng, R.5
Krantz, I.D.6
Kao, G.7
Gan, D.D.8
Zhou, J.Y.9
Muschel, R.10
Hamilton, S.R.11
Spinner, N.B.12
Markowitz, S.13
Wu, G.14
El-Deiry, W.S.15
-
149
-
-
0027983521
-
Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 7013-7024
-
-
Xiao, H.1
Pearson, A.2
Coulombe, B.3
Truant, R.4
Zhang, S.5
Regier, J.L.6
Triezenberg, S.J.7
Reinberg, D.8
Flores, O.9
Ingles, C.J.10
Greenblatt, J.11
-
155
-
-
0345059361
-
COOH-terminal domain of p53 modulates p53-mediated transcriptional transactivation, cell growth, and apoptosis
-
(1999)
Cancer Res.
, vol.59
, pp. 843-848
-
-
Zhou, X.1
Wang, X.W.2
Xu, L.3
Hagiwara, K.4
Nagashima, M.5
Wolkowicz, R.6
Zurer, I.7
Rotter, V.8
Harris, C.C.9
|