Hot-spot mutants of p53 core domain evince characteristic local structural changes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 15, 1999, Pages 8438-8442

  Wong, Kam B O ^a   DeDecker, Brian S ^a   Freund, Stefan M V ^a   Proctor, Mark R ^a   Bycroft, Mark ^a   Fersht, Alan R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Drug design; Dynamics; NMR; Suppressor; Tumor

Indexed keywords

ALANINE; DNA; MUTANT PROTEIN; PROTEIN P53; VALINE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DNA BINDING; HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN STRUCTURE;

BINDING SITES; DNA-BINDING PROTEINS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MUTATION; NEOPLASMS; PROTEIN STRUCTURE, SECONDARY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033587701     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.15.8438     Document Type: Article

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