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Volumn 20, Issue 6, 2000, Pages 2186-2197

Apoptotic and growth-promoting activity of E2F modulated by MDM2

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLINE; PROTEIN P53; TRANSCRIPTION FACTOR;

EID: 0033998439     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.6.2186-2197.2000     Document Type: Article
Times cited : (75)

References (54)
  • 1
    • 0030774301 scopus 로고    scopus 로고
    • Distinct mechanisms of nuclear accumulation regulate the functional consequence of E2F transcription factors
    • Allen, E. K., S. de la Luna, R. M. Kerkhoven, R. Bernards, and N. B. La Thangue. 1997. Distinct mechanisms of nuclear accumulation regulate the functional consequence of E2F transcription factors. J. Cell Sci. 110:2819-2831.
    • (1997) J. Cell Sci. , vol.110 , pp. 2819-2831
    • Allen, E.K.1    De La Luna, S.2    Kerkhoven, R.M.3    Bernards, R.4    La Thangue, N.B.5
  • 2
    • 0025040233 scopus 로고
    • Suppression of human colorectal-carcinoma cell-growth by wild type p53
    • Baker, S. J., S. Markowitz, E. R. Fearson, J. K. U. Willson, and B. Vogelstein. 1990. Suppression of human colorectal-carcinoma cell-growth by wild type p53. Science 249:912-915.
    • (1990) Science , vol.249 , pp. 912-915
    • Baker, S.J.1    Markowitz, S.2    Fearson, E.R.3    Willson, J.K.U.4    Vogelstein, B.5
  • 3
    • 0030828488 scopus 로고    scopus 로고
    • Apoptosis induced in mammalian cells by small peptides that functionally antagonize the Rb-regulated E2F transcription factor
    • Bandara, L. R., R. Girling, and N. B. La Thangue. 1997. Apoptosis induced in mammalian cells by small peptides that functionally antagonize the Rb-regulated E2F transcription factor. Nat. Biotechnol. 15:896-901.
    • (1997) Nat. Biotechnol. , vol.15 , pp. 896-901
    • Bandara, L.R.1    Girling, R.2    La Thangue, N.B.3
  • 4
    • 0027985749 scopus 로고
    • E2F4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo
    • Beijersbergen, R. L., R. M. Kerkoven, L. Zhu, L. Carlee, P. M. Voorhoeve, and R. Bernards. 1994. E2F4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev. 8:2680-2690.
    • (1994) Genes Dev. , vol.8 , pp. 2680-2690
    • Beijersbergen, R.L.1    Kerkoven, R.M.2    Zhu, L.3    Carlee, L.4    Voorhoeve, P.M.5    Bernards, R.6
  • 5
    • 0032939925 scopus 로고    scopus 로고
    • Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53
    • Blattner, C., A. Sparks, and D. Lane. 1999. Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53. Mol. Cell. Biol. 19:3704-3713.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3704-3713
    • Blattner, C.1    Sparks, A.2    Lane, D.3
  • 6
    • 0023339504 scopus 로고
    • Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3-cell line
    • Cahilly-Snyder, L., T. Yang-Feng, U. Francke, and D. L. George. 1987. Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3-cell line. Somat. Cell Mol. Genet. 13:235-244.
    • (1987) Somat. Cell Mol. Genet. , vol.13 , pp. 235-244
    • Cahilly-Snyder, L.1    Yang-Feng, T.2    Francke, U.3    George, D.L.4
  • 7
    • 0027222956 scopus 로고
    • Mapping of the p53 and mdm-2 interaction domains
    • Chen, J., V. Marechal, and A. J. Levine. 1993. Mapping of the p53 and mdm-2 interaction domains. Mol. Cell. Biol. 13:4107-4114.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4107-4114
    • Chen, J.1    Marechal, V.2    Levine, A.J.3
  • 8
    • 0029913730 scopus 로고    scopus 로고
    • 1 arrest and apoptosis functions of the p53 tumor suppressor protein
    • 1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol. Cell. Biol. 16:2445-2452.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2445-2452
    • Chen, J.1    Wu, X.2    Lin, J.3    Levine, A.J.4
  • 9
    • 0029912789 scopus 로고    scopus 로고
    • Nuclear accumulation of the E2F heterodimer regulated by subunit composition and alternative splicing of a nuclear localization signal
    • de la Luna, S., M. J. Burden, C.-W. Lee, and N. B. La Thangue. 1996. Nuclear accumulation of the E2F heterodimer regulated by subunit composition and alternative splicing of a nuclear localization signal. J. Cell. Sci. 109:2443-2452.
    • (1996) J. Cell. Sci. , vol.109 , pp. 2443-2452
    • De La Luna, S.1    Burden, M.J.2    Lee, C.-W.3    La Thangue, N.B.4
  • 10
    • 0030753963 scopus 로고    scopus 로고
    • Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence
    • Dobbelstein, M., J. Roth, W. T. Kimberly, A. J. Levine, and T. Shenk. 1997. Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence. EMBO J. 16:4276-4284.
    • (1997) EMBO J. , vol.16 , pp. 4276-4284
    • Dobbelstein, M.1    Roth, J.2    Kimberly, W.T.3    Levine, A.J.4    Shenk, T.5
  • 11
    • 0029590161 scopus 로고
    • MDM2 transformation in the absence of p53 and abrogation of the p107 cell-cycle arrest
    • Dubs-Poterszman, C., B. Tocque, and B. Wasylyk. 1995. MDM2 transformation in the absence of p53 and abrogation of the p107 cell-cycle arrest. Oncogene 11:2445-2449.
    • (1995) Oncogene , vol.11 , pp. 2445-2449
    • Dubs-Poterszman, C.1    Tocque, B.2    Wasylyk, B.3
  • 12
    • 0032146274 scopus 로고    scopus 로고
    • The regulation of E2F by pRB-family proteins
    • Dyson, N. 1998. The regulation of E2F by pRB-family proteins. Genes Dev. 12:2245-2262.
    • (1998) Genes Dev. , vol.12 , pp. 2245-2262
    • Dyson, N.1
  • 13
    • 0029760621 scopus 로고    scopus 로고
    • The MDM2 oncoprotein binds specifically to RNA through its RING finger domain
    • Elenbaas, B., M. Dobbelstein, J. Roth, T. Shenk, and A. J. Levine. 1996. The MDM2 oncoprotein binds specifically to RNA through its RING finger domain. Mol. Med. 2:439-451.
    • (1996) Mol. Med. , vol.2 , pp. 439-451
    • Elenbaas, B.1    Dobbelstein, M.2    Roth, J.3    Shenk, T.4    Levine, A.J.5
  • 14
    • 0025853776 scopus 로고
    • Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
    • Fakharzadeh, S. S., S. P. Trusko, and D. L. George. 1991. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J. 10:1565-1569.
    • (1991) EMBO J. , vol.10 , pp. 1565-1569
    • Fakharzadeh, S.S.1    Trusko, S.P.2    George, D.L.3
  • 17
    • 0029797841 scopus 로고    scopus 로고
    • Degradation of E2F by the ubiquitin-proteasome pathway: Regulation by retinoblastoma family proteins and adenovirus transforming proteins
    • Hateboer, G., R. M. Kerkhoven, A. Shvarts, R. Bernards, and R. L. Beijersbergen. 1996. Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins. Genes Dev. 10:2960-2970.
    • (1996) Genes Dev. , vol.10 , pp. 2960-2970
    • Hateboer, G.1    Kerkhoven, R.M.2    Shvarts, A.3    Bernards, R.4    Beijersbergen, R.L.5
  • 18
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt, Y., R. Maya, A. Kazaz, and M. Oren. 1997. Mdm2 promotes the rapid degradation of p53. Nature 387:296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 19
    • 0029820095 scopus 로고    scopus 로고
    • The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway
    • Hoffman, F., F. Martelli, D. M. Livingston, and Z. Wang. 1996. The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway. Genes Dev. 10:2949-2959.
    • (1996) Genes Dev. , vol.10 , pp. 2949-2959
    • Hoffman, F.1    Martelli, F.2    Livingston, D.M.3    Wang, Z.4
  • 20
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • Honda, R., H. Tanaka, and H. Yasuda. 1997 Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420:25-27.
    • (1997) FEBS Lett. , vol.420 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 21
    • 0030850752 scopus 로고    scopus 로고
    • E2F-1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction
    • Hsieh, J.-K., S. Fredersdorf, T. Kouzarides, K. Martin, and X. Lu. 1997. E2F-1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 11:1840-1852.
    • (1997) Genes Dev. , vol.11 , pp. 1840-1852
    • Hsieh, J.-K.1    Fredersdorf, S.2    Kouzarides, T.3    Martin, K.4    Lu, X.5
  • 22
    • 0027491775 scopus 로고
    • Expression of E2F-1 induces quiescent cells to enter S phase
    • Johnson, D. G., J. K. Schwarz, W. D. Cress, and J. R. Nevins. 1993. Expression of E2F-1 induces quiescent cells to enter S phase. Nature 365:349-352.
    • (1993) Nature , vol.365 , pp. 349-352
    • Johnson, D.G.1    Schwarz, J.K.2    Cress, W.D.3    Nevins, J.R.4
  • 23
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones, S. N., A. E. Roe, L. A. Donehower, and A. Bradley. 1995. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378: 206-208.
    • (1995) Nature , vol.378 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 24
    • 0028960617 scopus 로고
    • E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis
    • Kowalik, T. F., J. DeGregori, J. K. Schwarte, and J. R. Nevins. 1995. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J. Virol. 69:2491-2500.
    • (1995) J. Virol. , vol.69 , pp. 2491-2500
    • Kowalik, T.F.1    DeGregori, J.2    Schwarte, J.K.3    Nevins, J.R.4
  • 25
    • 0031992159 scopus 로고    scopus 로고
    • E2F-1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2
    • Kowalik, T. F., J. DeGregori, G. Leone, L. Jakoi, and J. R. Nevins. 1998. E2F-1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ. 9:113-118.
    • (1998) Cell Growth Differ. , vol.9 , pp. 113-118
    • Kowalik, T.F.1    DeGregori, J.2    Leone, G.3    Jakoi, L.4    Nevins, J.R.5
  • 26
    • 0028362359 scopus 로고
    • Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase
    • Krek, W., M. E. Ewen, S. Shirodkar, Z. Arany, W. G. Kaelin, and D. M. Livingston. 1994. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell 78:161-172.
    • (1994) Cell , vol.78 , pp. 161-172
    • Krek, W.1    Ewen, M.E.2    Shirodkar, S.3    Arany, Z.4    Kaelin, W.G.5    Livingston, D.M.6
  • 27
    • 0029559027 scopus 로고
    • Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint
    • Krek, W., G. Xu, and D. M. Livingston. 1995. Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Cell 83:1149-1158.
    • (1995) Cell , vol.83 , pp. 1149-1158
    • Krek, W.1    Xu, G.2    Livingston, D.M.3
  • 28
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • Kubbutat, M. H. G., S. N. Jones, and K. H. Vousden. 1997. Regulation of p53 stability by Mdm2. Nature 387:299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.G.1    Jones, S.N.2    Vousden, K.H.3
  • 29
    • 0027986982 scopus 로고
    • DP and E2F proteins: Co-ordinating transcription with cell cycle progression
    • Lam, E., and N. B. La Thangue. 1994. DP and E2F proteins: co-ordinating transcription with cell cycle progression. Curr. Opin. Cell. Biol. 6:859-866.
    • (1994) Curr. Opin. Cell. Biol. , vol.6 , pp. 859-866
    • Lam, E.1    La Thangue, N.B.2
  • 30
    • 0028267869 scopus 로고
    • DRTF1/E2F: An expanding family of heterodimeric transcription factors implicated in cell-cycle control
    • La Thangue, N. B. 1994. DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci. 19:108-114.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 108-114
    • La Thangue, N.B.1
  • 31
    • 0032575079 scopus 로고    scopus 로고
    • Functional interplay between p53 and E2F through co-activator p300
    • Lee, C.-W., T. S. Sørensen, N. Shikama, and N. B. La Thangue. 1998. Functional interplay between p53 and E2F through co-activator p300. Oncogene 16:2695-2710.
    • (1998) Oncogene , vol.16 , pp. 2695-2710
    • Lee, C.-W.1    Sørensen, T.S.2    Shikama, N.3    La Thangue, N.B.4
  • 32
    • 0028938539 scopus 로고
    • The human oncoprotein MDM2 binds to the human TATA-binding protein in vivo and in vitro
    • Leng, P., D. R. Brown, S. Debs, and S. P. Deb. 1995. The human oncoprotein MDM2 binds to the human TATA-binding protein in vivo and in vitro. Int. J. Oncol. 6:251-259.
    • (1995) Int. J. Oncol. , vol.6 , pp. 251-259
    • Leng, P.1    Brown, D.R.2    Debs, S.3    Deb, S.P.4
  • 33
    • 0028823020 scopus 로고
    • Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
    • Luna, R. M., D. S. Wagner, and G. Lozano. 1995. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378:203-206.
    • (1995) Nature , vol.378 , pp. 203-206
    • Luna, R.M.1    Wagner, D.S.2    Lozano, G.3
  • 35
    • 0029910628 scopus 로고    scopus 로고
    • Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
    • Macleod, K. F., Y. Hu, and T. Jacks. 1996. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J. 15:6178-6188.
    • (1996) EMBO J. , vol.15 , pp. 6178-6188
    • Macleod, K.F.1    Hu, Y.2    Jacks, T.3
  • 36
    • 0029991715 scopus 로고    scopus 로고
    • Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members
    • Magae, J., C. L. Wu, S. Illenye, E. Harlow, and N. H. Heintz. 1996. Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. J. Cell Sci. 109:1717-1726.
    • (1996) J. Cell Sci. , vol.109 , pp. 1717-1726
    • Magae, J.1    Wu, C.L.2    Illenye, S.3    Harlow, E.4    Heintz, N.H.5
  • 37
    • 0027999512 scopus 로고
    • The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes
    • Marechal, V., B. Elenbaas, J. Piette, J. C. Nicolas, and A. J. Levine. 1994. The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes. Mol. Cell. Biol. 14:7414-7420.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7414-7420
    • Marechal, V.1    Elenbaas, B.2    Piette, J.3    Nicolas, J.C.4    Levine, A.J.5
  • 39
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with p53 and inhibits p53-mediated transactivation
    • Momand, J., G. P. Zambetti, D. C. Olson, D. L. George, and A. J. Levine. 1992. The mdm-2 oncogene product forms a complex with p53 and inhibits p53-mediated transactivation. Cell 69:1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.L.4    Levine, A.J.5
  • 40
    • 0027934570 scopus 로고
    • p53 dependent apoptosis produced by Rb-deficiency in the developing lens
    • Morgenbesser, S. D., B. O. Williams, T. Williams, and R. A. DePinho. 1994. p53 dependent apoptosis produced by Rb-deficiency in the developing lens. Nature 371:72-74.
    • (1994) Nature , vol.371 , pp. 72-74
    • Morgenbesser, S.D.1    Williams, B.O.2    Williams, T.3    DePinho, R.A.4
  • 42
    • 0028787278 scopus 로고
    • A new member of the DP family, DP-3, with distinct protein products suggests a regulatory role for alternative splicing in the cell cycle transcription factor DRTF/E2F
    • Ormondroyd, E., S. de la Luna, and N. B. La Thangue. 1995. A new member of the DP family, DP-3, with distinct protein products suggests a regulatory role for alternative splicing in the cell cycle transcription factor DRTF/E2F. Oncogene 11:1437-1446.
    • (1995) Oncogene , vol.11 , pp. 1437-1446
    • Ormondroyd, E.1    De La Luna, S.2    La Thangue, N.B.3
  • 43
    • 0030739355 scopus 로고    scopus 로고
    • Induction of DNA synthesis and apoptosis are separable functions of E2F-1
    • Phillips, A. C., S. Bates, K. M. Ryan, K. Helin, and K. H. Vousden. 1997. Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev. 11:1853-1856.
    • (1997) Genes Dev. , vol.11 , pp. 1853-1856
    • Phillips, A.C.1    Bates, S.2    Ryan, K.M.3    Helin, K.4    Vousden, K.H.5
  • 44
    • 0030800922 scopus 로고    scopus 로고
    • Mdm2: Keeping p53 under control
    • Piette, J., H. Neel, and V. Maréchal. 1997. Mdm2: keeping p53 under control. Oncogene 15:1001-1010.
    • (1997) Oncogene , vol.15 , pp. 1001-1010
    • Piette, J.1    Neel, H.2    Maréchal, V.3
  • 45
    • 0027947383 scopus 로고
    • Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
    • Qin, X.-Q., D. M. Livingston, W. G. Kaelin, and P. D. Adams. 1994. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. 91:10918-10922.
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 10918-10922
    • Qin, X.-Q.1    Livingston, D.M.2    Kaelin, W.G.3    Adams, P.D.4
  • 46
    • 0032518917 scopus 로고    scopus 로고
    • Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
    • Roth, J., M. Dobbelstein, D. A. Freedman, T. Shenk, and A. J. Levine. 1998. Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J. 17:554-564.
    • (1998) EMBO J. , vol.17 , pp. 554-564
    • Roth, J.1    Dobbelstein, M.2    Freedman, D.A.3    Shenk, T.4    Levine, A.J.5
  • 47
    • 0029805888 scopus 로고    scopus 로고
    • The molecular basis of E2F-1/DP-1 induced S-phase entry and apoptosis
    • Shan, B., A. A. Farmer, and W.-H. Lee. 1996. The molecular basis of E2F-1/DP-1 induced S-phase entry and apoptosis. Cell Growth Differ. 7:689-697.
    • (1996) Cell Growth Differ. , vol.7 , pp. 689-697
    • Shan, B.1    Farmer, A.A.2    Lee, W.-H.3
  • 48
    • 0028061670 scopus 로고
    • Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
    • Shan, B., and W. H. Lee. 1994. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell. Biol. 14:8166-8173.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 8166-8173
    • Shan, B.1    Lee, W.H.2
  • 49
    • 0029824669 scopus 로고    scopus 로고
    • Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming abilities and frequent detection in human cancer
    • Sigalas, I., A. H. Calvert, J. J. Anderson, D. E. Neal, and J. Lunec. 1997. Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming abilities and frequent detection in human cancer. Nat. Med. 2:912-915.
    • (1997) Nat. Med. , vol.2 , pp. 912-915
    • Sigalas, I.1    Calvert, A.H.2    Anderson, J.J.3    Neal, D.E.4    Lunec, J.5
  • 50
    • 11944270727 scopus 로고    scopus 로고
    • Introduction to the E2F family: Protein structure and gene regulation
    • Slansky, J. E., and P. J. Farnham. 1996. Introduction to the E2F family: protein structure and gene regulation. Curr. Top. Microbiol. Immunol. 208: 1-30.
    • (1996) Curr. Top. Microbiol. Immunol. , vol.208 , pp. 1-30
    • Slansky, J.E.1    Farnham, P.J.2
  • 51
    • 0028222124 scopus 로고
    • p53 and E2F-1 co-operate to mediate apoptosis
    • Wu, X., and A. J. Levine. 1994. p53 and E2F-1 co-operate to mediate apoptosis. Proc. Natl. Acad. Sci. USA 91:3602-3606.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3602-3606
    • Wu, X.1    Levine, A.J.2
  • 54
    • 0026645529 scopus 로고
    • Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor
    • Zamanian, M., and N. B. La Thangue. 1992. Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor. EMBO J. 11:2603-2610.
    • (1992) EMBO J. , vol.11 , pp. 2603-2610
    • Zamanian, M.1    La Thangue, N.B.2


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