p53-Independent role of MDM2 in TGF-β1 resistance

Science

Volumn 282, Issue 5397, 1998, Pages 2270-2272

  Sun, Peiqing ^a   Dong, Ping ^a   Dai, Kang ^a,c   Hannon, Gregory J ^a   Beach, David ^b  

^a Watson School of Biological Sciences   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; PROTEIN P53; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; BREAST TUMOR; CANCER CELL; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GENETIC SCREENING; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; MUTATION; ONCOGENE C MYC; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; BREAST NEOPLASMS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; E2F TRANSCRIPTION FACTORS; GENE EXPRESSION; GENES, P53; GENES, RETINOBLASTOMA; GENETIC VECTORS; HUMANS; MICE; MINK; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

MURINAE; MUSTELA VISON;

EID: 0032545222     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.282.5397.2270     Document Type: Article

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35. We thank B. Vogelstein, D. Livingston, A. Levine, and M. Roussel for reagents; Berlex, Inc. for TGF-β; and R. Maestro and D. Conklin for helpful comments. Supported in part by grants from NIH (D.B. and G.J.H.), the Helen Hay Whitney Foundation (P.S.), the U.S. Army (C.J.H.), and the Pew Foundation (G.J.H.). D.B. is supported by the Hugh and Catherine Stevenson Fund.