Role of apoptosis of renal tubular cells in acute renal failure: Therapeutic implications

Apoptosis

Volumn 6, Issue 1-2, 2001, Pages 83-102

  Rana, A ^a   Sathyanarayana, P ^b   Lieberthal, W ^c  

^a Cardiovascular Research Institute   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute renal failure; Apoptosis; Bcl 2; MAPK; Necrosis

Indexed keywords

PROTEIN BCL 2;

ACUTE KIDNEY FAILURE; APOPTOSIS; CELL VIABILITY; HUMAN; KIDNEY ISCHEMIA; KIDNEY TUBULE EPITHELIUM; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

APOPTOSIS; HUMANS; KIDNEY FAILURE, ACUTE; SIGNAL TRANSDUCTION;

EID: 0035083846     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009680229931     Document Type: Review

References (171)

1. Acute renal failure
2. Biology of acute renal failure: Therapeutic implications
3. Hospital-acquired renal insufficiency: A prospective study
4. Treatment of acute tubular necrosis
5. Acute renal failure complicating muscle crush injury
6. Iron, heme oxygenase, and glutathione: Effects on myoglobinuric proximal tubular injury
7. Necrosis and apoptosis in acute renal failure
8. Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia
9. Apoptosis and cell desquamation in repair process of ischemic tubular necrosis
10. Apoptotic cell death of renal tubules in experimental severe acute pancreatitis
11. Ciprofloxicin overdos: Acute renal failure with prominant apoptotic changes
12. Frequent apoptosis in human kidneys after renal hypoperfusion
13. Apoptosis: A basic biologic phenomenon with wide ranging implications in tissue kinetics
14. Apoptosis, oncosis, and necrosis: An overview of cell death
15. Mechanisms of apoptosis and its potential role in renal tubular epithelial cell injury
16. Nuclear changes in apoptosis
17. Suicidal tendencies: Apoptotic cell death by caspase family proteases
18. Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular sythnesis
19. A caspase-activated endonuclease that degrades DNA during apoptosis, and its inhibitor ICAD
20. Caspases: Enemies within
21. Proteolytic activities that mediate apoptosis
22. The cell biology of ischemic renal injury
23. Physiology of renal hypoxia
24. Acute renal failure. I. Relative importance of proximal vs. distal tubular injury
25. Lactate production in isolated segments of the rat nephron
26. Oxygen and renal metabolism
27. Adenosine triphosphate depletion induces a rise in cytosolic free calcium in canine renal epithelial cells
28. Evidence for a role of cytosolic free calcium in hypoxia-induced proximal tubular injury
29. The role of calcium in cell injury
30. Source of oxygen free radicals produced by rat hepatocytes during postanoxic reoxygenation
31. The 85-kD cytosolic phospholipase A2 knockout mouse: A new tool for physiology and cell biology
32. Reduced fertility and postischemic brain injury in mice deficient in cytosolic phospholipase A2
33. Antibodies against type II phospholipase A2 prevent renal injury due to ischemia and reperfusion in rats
34. Phospholipase A2: A potentially important determinant of adenosine triphosphate levels during hypoxic-reoxygenation tubular injury
35. Role of free radicals and catalytic metal ions in human disease
36. Nitric oxide, superoxide and peroxynitrite: The good, the bad, and the ugly
37. The hydroxyl radical: From chemistry to human disease
38. Oxidant stress in acute renal failure
39. Protein damage and degradation by oxygen radicals. IV. Degradation of denatured proreins
40. Apoptosis in the pathogenesis and treatment of disease
41. Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: Apoptosis vs. necrosis
42. Graded ATP depletion can induce apoptosis or necrosis of cultured mouse proximal tubular cells
43. Reperfusion injury induces apoptosis in rabbit cardiomyocytes
44. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia
45. Reactive oxygen species and programmed cell death
46. Role of superoxide in apoptosis induced by growth factor withdrawal
47. Oxygen radicals and signaling
48. Epidermal growth factor (EGF)-induced generation of hydrogen peroxide
49. Participation of reactive oxygen species in the lysophosphatidic acid-stimulated mitogen-activated protein kinase kinase activation pathway
50. A redox-triggered ras-effector interaction. Recruitment of phosphatidylinositol 3′-kinase to Ras by redox stress
51. Redox regulation of apoptotic cell death
52. ASK1 mediqates apoptotic cell death induced by genotoxic stress
53. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
54. Apoptosis by death factor
55. Induction of apoptosis in ischemia-reperfusion model of mouse kidney: Possible involvement of Fas
56. Pathogenesis of renal failure in sepsis
57. Social controls on cell survival and cell death
58. The extracellular matrix as a survival factor
59. Lysophosphatidic acid: A novel growth and survival factor for renal proximal tubular cells
60. Regulation of transcription by the rat EGF gene promoter in normal and ischemic murine kidney cells
61. Potential role of growth factors in the prophylaxis and treatment of acute renal failure
62. Insulin-like growth factor I-enhanced renal expression of osteopontin after acute ischemic injury in rats
63. Functional and cytoskeletal changes induced by sublethal injury in proximal tubular epithelial cells
64. β integrin-mediated adhesion between renal tubular cells following anoxic injury
65. Dissociation of tubular cell detachment and tubular cell death in clinical and experimental "acute tubular necrosis"
66. Alterations in human proximal tubule attachment in response to hypoxia
67. Mouse proximal tubular cell-cell adhesion inhibits apoptosis by a cadherin-dependent mechanism
68. Asynchrony and commitment to die during apoptosis
69. Mechanisms and genes of cellular suicide
70. Proteases to die for
71. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
72. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
73. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
74. Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis
75. The mitochondrial death/life regulator in apoptosis and necrosis
76. Mitochondria and apoptosis
77. Induction of apoptotic program in cell-free exttacts: Requirement for dATP and cytochrome c
78. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
79. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
80. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
81. The caspase-3 precursor has a cytosolic and mitochondrial distribution: Implications for apoptotic signaling
82. The Bcl-2 protein family: Arbiters of cell survival
83. Double identity for proteins of the Bcl-2 family
84. Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines
85. Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species
86. Bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs
87. Caspase-9, Bcl-xL and Apaf- 1 form a ternary complex
88. Bcl-xL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
89. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
90. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
91. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
92. Bd-x(L) forms an ion channel in synthetic lipid membranes
93. Inhibition of Bax channel-forming activity by Bcl-2
94. Regulation of neuronal survival by the serine-threonine protein kinase Akt
95. Conversion of Bcl-2 to a Bax-like death effector by caspases
96. Structure, regulation and function of NF-kappa B
97. Inhibition of TNF-induced apoptosis ny NDκB
98. An essential role for NF-κB in preventing TNF-a-induced cell death
99. Death receptors: Signaling and modulation
100. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
101. NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
102. The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis
103. IEX-1L, an apoptosis inhibitor involved in NF-κB-mediated cell survival
104. Transcriptional cross talk between NF-kappaB and p53
105. Evidence for a role of NF-kappaB in the survival of hematopoietic cells mediated by interleukin 3 and the oncogenic TEL/platelet-derived growth factor receptor beta fusion protein
106. A role for nuclear factor kappaB in the antiapoptotic function of insulin
107. A matter of life and cell death
108. PI3K: Downstream AK-Tion blocks apoptosis
109. Mechanisms and consequences of activation of protein kinase B/Akt
110. The akt proto-oncogene links ras to pak and cell survival signals
111. Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the phosphatidylinositol 3-kinase signaling pathway
112. Phosphatidylinositol 3-kinase is required for integrinstimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation
113. Signalling through the lipid products of phosphoinositide-3-OH kinase
114. Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase
115. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
116. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
117. Dual role of phosphatidyinositol-3,4,5-trisphosphate in the activation of protein kinase B
118. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
119. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
120. Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK
121. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
122. Renal stress response and acute renal failure
123. MAPK activation determines renal epithelial cell survival during oxidative injury
124. Sounding the alarm: Protein kinase cascades activated by stress and inflammation
125. Protein kinase cascades activated by stress and inflammatory cytokines
126. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms
127. Making the connection: Coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses
128. Cell signal transduction through the mitogen-activated protein kinase pathway
129. Integrin function: Molecular heirarchies of cytoskeletal and signaling molecules
130. GTP-dependent association of Raf-1 with Ha-Ras: Identification of Raf as a target downstream of Ras in mammalian cells
131. Control of the ERK MAP kinase cascade by Ras and Raf
132. The MAPK signaling cascade
133. Tyrosine phosphorylation of extracellular signal-regulated protein kinase 4 in response to growth factors
134. The stress-activated protein kinase subfamily of c-jun kinases
135. The stress activated protein kinases are major c-jun amino-terminal kinases activated by ischemia and reperfusion
136. Phosphorylation of c-jun mediated by MAP kinases
137. Selective interaction of JNK protein kinase isoforms with transcription factors
138. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
139. Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
140. The mixed lineage kinase SPRK phosphorylares and activates the stress-activated protein kinase activator, SEK-1
141. MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase
142. Dual leucine zipper-bearing kinase (DLK) activates p46SAPK and p38mapk but not ERK2
143. Tp1-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase
144. Activation of MEK-1 and SEK-1 by Tp1-2 proto-oncoprotein, a novel MAP kinase kinase kinase
145. Role of SAPKERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
146. Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase
147. Transcription factor ATF2 regulation by the JNK signal transduction pathway
148. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
149. The primary structure of p38 gamma: A new member of p38 group of MAP kinases
150. Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver
151. Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stressand cytokine-stimulated monocytes and epithelial cells
152. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
153. Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation
154. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1
155. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
156. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
157. Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein
158. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase
159. Serine/threonine protein kinases and apoptosis
160. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
161. Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: Involvement of MEK upstream of Bad phosphorylation
162. B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway
163. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase
164. A cytoplasmic inhibitor of the JNK signal transduction pathway
165. Neglected oppotunities in apoptosis research
166. Inhibition of death receptor signals by cellular FLIP
167. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitiors of apoptosis
168. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
169. Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35
170. Role of caspases (ICE/CED3 proteases) in DNA damage and cell death in response to a mitochondrial inhibitor, antimycin A
171. Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue BAK