Role of programmed cell death in development

International Review of Cytology

Volumn 202, Issue , 2001, Pages 159-242

  Ranganath, R M ^a   Nagashree, N R ^a  

^a BANGALORE UNIVERSITY   (India)

Author keywords

Apoptosis; Embryonic development; Programmed cell death

Indexed keywords

APOPTOSIS INHIBITOR; ARABINOGALACTAN; CASPASE; CERAMIDE; DEOXYRIBONUCLEASE; FAS ANTIGEN; GENE PRODUCT; PROTEIN BCL 2; PROTEIN CED3; PROTEIN CED4; PROTEIN CED9; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; CAENORHABDITIS ELEGANS; CELL DEATH; DNA DEGRADATION; DROSOPHILA; DROSOPHILA MELANOGASTER; ENZYME MECHANISM; MOUSE; NONHUMAN; PHAGOCYTOSIS; PLANT GROWTH; PRIORITY JOURNAL; REVIEW;

ANIMALIA; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; EUKARYOTA; MELANOGASTER;

EID: 0035071672     PISSN: 00747696     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7696(01)02005-8     Document Type: Article

References (385)

1. Homology and developmental genes
2. Programmed cell death during Drosophila embryogenesis
3. The Bcl-2 protein family Arbiters of cell survival
4. Apoptosis, a general comment
5. Involvement of p53 in cell differentiation and development
6. The domains of death: Evolution of the apoptosis machinery
7. Tumor necrosis factor receptor-associated factors (TRAFs) - A family of adapter proteins that regulates life and death
8. Death receptors: Signaling and modulation
9. Apoptosis control by death and decoy receptors
10. The relation of programmed cell death to development and reproduction, comparative studies and an attempt at classification
11. p53 binds single stranded DNA through the C-terminal domain and internal segments via the middle domain
12. Suppression of human colorectal carcinoma cell growth by wild type p53
13. Transducers of life and death: TNF receptor super family and associated proteins
14. Is apoptosis key in Alzheimer's disease?
15. Identification of deoxyribonuclease II as an endonuclease involved in apoptosis
16. p53 in signaling checkpoint arrest or apoptosis
17. Microtubular configurations during meiosis and megasporogenesis in Gasteria verrucosa and Chamenerior angustifolium
18. Maturation of the megaspore in Marselia vestita
19. Megaspore abortion. A consequence of selective apoptosis?
20. 2+ concentration and DNA fragmentation
21. Cell fate in the Arabidospsis root meristem determined by directional signaling
22. Hormonal signaling in cereal aleurone
23. Reproductive development and nuclear DNA content in angiosperms
24. Induction of cell death by taxol: Evidence of p53 mediated apoptotis
25. Apoptotic cell death induced by c-myc is inhibited by bcl-2
26. Early signal transduction pathways in plant-pathogen interactions
27. Plant transmembrane receptors: New pieces in the signaling puzzle
28. Neural apotosis
29. Molecular genetics of DNA repair in higher plants
30. Pollen development in orchids. 3. A novel generative pole microtubule system predicts unequal pollen mitosis
31. Cell-death mechanisms in maize
32. Inhibition of ICE family of proteases by Baculovirus antiapoptotic protein p35
33. Programmed cell death in developing nervous system
34. Meiotic pairing and gametogenic failure
35. Unpaired sex chromosomes and gametogenic failure
36. Induction of the TRPM-2 gene in cell undergoing programmed cell death
37. p53 is a general repressor of RNA polymerase III transcription
38. Tracing tracheary element development
39. Genetic mechanisms of tumor supression by the human p53 gene
40. Grim, a novel cell death gene in Drosophila
41. The role of p53: Regulating genomic stability when DNA and RNA syntheses are inhibited
42. The cell death machine
43. Interaction of CED-4 with CED-3 and CED-9. A molecular framework for cell death
44. The Y134.5 gene of Herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristics of programmed cell death in neuronal cells
45. Thymocyte apoptosis induced by p53 dependent and independent pathways
46. p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following y-irradiation
47. Nineteenth centuary research on naturally occurring cell death and related phenomena
48. Interaction of the Asc locus in F8 paired lines of tomato with Alternaria alternate f. sp. lycopersici and AAL-toxin
49. Apoptosis
50. Apoptosis and programmed cell death in immunity
51. Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents
52. Rapid in vivo effects of glucocorticoids on the integrity of rat lymphocyte genomic deoxyribonucleic acid
53. Microfilament disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis
54. Recombinational cross roads: Eukaryotic enzymes and the limits of bacterial precedents
55. An apoptosis inhibiting baculovirus gene with a zinc finger-like motif
56. Protease to die for
57. Variable cell number in nematodes
58. Plants just say no to pathogens
59. Long view from a high plateau
60. Death don't have no mercy: Cell death programs in plant-microbe interactions
61. Influence of thyroid hormones on neuronal death and differentiation in larval Rana pipiens
62. A genetic tool used to identify thioredoxin as a mediator of growth inhibitory signal
63. Sex determination gene Tasselseed-2 of maize encodes a short chain alcohol dehydrogenase required for stage specific floral organ abortion
64. Caspases and programmed cell death in the hypersensitive response of plants to pathogens
65. Novel vascular cell-specific genes whose expression is regulated temporally and spatially during vascular system development
66. DNA damage triggers a prolonged p53 dependent G1 arrest and long term induction of Clp1 in normal human fibroblasts
67. Involvement of superoxide anion generation in the hypersensitive response of potato tuber tissues to infection with the incompatible race of Phytophthora infestans and to the hyphal components
68. 2-generation in membrane fractions isolated from wounded potato tubers inoculated with Phytophthora infestans
69. Mice deficient for p53 are developmentally normal but succeptible to spontaneous tumors
70. Why don't plants get cancer?
71. A conserved family of cellular genes related to the baculovirus IAP gene and encoding apoptosis inhibitor
72. Cytolysis mediated by ionoptiores and pore forming agents: Role of intracellular calcium in apoptosis
73. Protein ubiqutiination in diploid parthenogenesis and early somatic embryo genesis of Norway spruce
74. Latent diploid parthenogenesis and parthenote cleavage in egg equivalents of Norway Spruce
75. Nuclear changes in apoptosis
76. Apoptosis: Product of programmed and unprogrammed cell death
77. Life and death of p53
78. Two C. elegans genes control the programmed death of specific cells in the pharynx
79. Mechanisms and functions of cell death
80. Caspase-activated DNase that degrades DNA during apoptosis and its inhibitor ICAD
81. Cellular responses to DNA damage: Cell cycle checkpoints, apoptosis, and the roles of p53 and ATM
82. Apoptosis and the cell cycle
83. A matter of life and cell death
84. Apoptosis: Getting rid of the bodies
85. Cpp 32, a novel human apoptosis protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian Interleukin-1 beta-converting enzyme
86. Apoptotic hepatocytes become insoluble in detergents and chaotropic agents as a result of transglutaminase action
87. Rhizobium plant signal exchange
88. NF-κB to the rescue - RELs, apoptosis, and cellular transformation
89. A bad kinase makes good
90. A license to kill
91. Evidence for the role of endo-exonuclease in the chromatin DNA fragmentation which accompanies apoptosis
92. p53 inhibition by the LANA protein of KSHV protects against cell death
93. Translation regulation of human p53 gene expression
94. Xylogenesis: Initiation, progression and cell death
95. Tracheary element differentiation
96. Cytodifferentiation
97. Apoptosis meets signal transduction: Elimination of a BAD influence
98. Asymmetric cell division and cell fate in plants
99. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
100. Antisense RNA regulated programmed cell death
101. Normal meiotic recombination in p53-deficient mice
102. The complexity of p53 modulation: Emerging patterns from divergent signals
103. Cell deaths in normal vertebrate ontogeny
104. Action of cytochalasin D on cells of established lines-III. Zeiosis and movements at the cell surface
105. Anther development: Basic principles and practical applications
106. Controlling cell death
107. Modulation of cell signaling by ceramides
108. Relationship of sequence specific trans-activation and p53 regulated apoptosis in interleukin-3 dependent hematopoietic cells
109. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors
110. Pathways of p53-dependent apoptosis
111. Mitochondria and apoptosis
112. Programmed cell death. A way of life for plants
113. Programmed cell death in plant-pathogen interactions
114. Programmed cell death in plants: A pathogen triggered response activated coordinatedly with multiple defence functions
115. Cell proliferation and apoptosis
116. Dead end for neurodegradation?
117. Viral, worm and radical implications for apoptosis
118. Quickguide-p53 tumor suppressor
119. Role of free radicals and catalytic metal ions in human disease: An overview
120. Naturally occuring death in vertebrates
121. Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with BAX
122. Functions of ceramide in coordinating cellular responses to stress
123. Functions of ceramide in coordinating cellular responses to stress
124. Functions of sphingolipids and sphingolipid breakdown products in cellular regulation
125. Ceramide: An intracellular signal for apoptosis
126. p53: From inductive signal to cellular effect
127. Incompatible pathogen infection results in enhanced reactive oxygen and cell death responses in transgenic tobacco expressing a hyperactive mutant calmodulin
128. Modulation of Myc induced apoptosis by specific cytokines
129. Clinical implications of the p53 tumor suppressor gene
130. Papilloma virus and p53
131. Apoptosis during diploid parthenogenesis and early somatic embryogenesis of Norway spruce
132. CED-4 is a stranger no more
133. Death cycle and swiss army knives
134. C. elegans cell survival gene Ced-9 encodes a functional homolog of the mammalian protooncogene Bcl-2
135. Caenorhabaditis elegans gene Ced-9 protects cell from programmed cell death
136. From pollination to fertilization in fruit trees
137. Sex, cell death and the genome of C. elegans
138. A new player in cell death
139. The CARD domain: A new apoptotic signaling motif
140. Ceramide in apoptosis. Does it really matter?
141. Caspases: A treatment target for neurodegeneratire disease?
142. Programmed cell death in nematode development
143. The Ced-4 homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis
144. The extraction and estimation of nucleotides and nucleic acids from plant material
145. CLARP, a death effector domain containing protein interacts with caspase-8 and regulates apoptosis
146. Why plant cells divide?
147. Reactive oxygen species and programmed cell death
148. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA
149. Role of CED-3/ICE family proteases in staurospore-induced programmed cell death
150. Programmed cell death in animal development
151. Asymmetric cell division
152. DNA-dependent protein kinase is not required for the p53 dependent response to DNA damage
153. Molecular mechanisms of developmental neuronal death
154. Neuronal death in developmental models: Possible implications in neuropathology
155. 53-related protein that can induce apoptosis
156. Another p53 Doppelganger?
157. Ultrastructure and biology of female gametophyte in flowering plants
158. On the TRAIL from p53 to apoptosis
159. Cellular dissection of the degradation pattern of cortical cell death during aerenchyma formation of rice roots
160. Shrinkage necrosis: A distinct mode of cell death
161. Apoptosis
162. An electron microscope study of cell deletion in the anuran tadpole tail during spontaneous metamorphosis with special reference to apoptosis of striated muscle fibres
163. Apoptosis: A basic biological phenomenon with wide ranging implication in tissue kinetics
164. Akt is more than just a bad kinase
165. Proteolytic activities that mediate apoptosis
166. The Rhizobium infection process
167. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
168. Cell cycle regulation and apoptosis
169. Salicylic acid-mediated signal transduction in plant disease resistance
170. Involvement of calmodulin and calmodulin binding proteins in the differentiation of tracheary elements in Zinnia cells
171. Selfishness and death: Raison de etre of restriction, recombination and mitochondria
172. Elicitor-induced cell death and phytoalexin synthesis in Daucus carola
173. Regulators of cell death
174. Endosperm development in maize
175. Mitochondria and germ-cell death
176. The mitochondrial death/life regulator in apoptosis and necrosis
177. Decreased apoptosis in the brain and premature lethality in CPP32 deficient mice
178. ICE-like proteases in apoptosis
179. Nuclear changes during differentiation of xylem vessel elements
180. DP and E2F proteins: Coordinating transcription with cell cycle progression
181. A death in the life of p53
182. Awakening angels
183. Licence to kill
184. Membrane expressions of HIV envelop glycoproteins trigger apoptosis in CD4 cells
185. Nuclear events of apoptosis in vitro in cell free mitotic extracts: A model system for analysis of the active phase of apoptosis
186. Apoptosis and signal transduction: Clues to a molecular mechanism
187. p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
188. Identification and cloning of E124 gene induced by p53 in etopside treated cells
189. The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repair
190. Developmental neurobiology and the natural history of nerve growth factor
191. Calcium mediated apoptosis in a plant hypersensitive disease resistance response
192. Space flight alters microtubules and increases apoptosis in human lymphocytes (jurkat)
193. Deciphering the pathways of life and death
194. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
195. Induction of apoptotic program in cell-free extracts: Requirement of dATP and cytochrome-c
196. Programmed cell death II. Endocrine potentiation of the breakdown of the intersegmental muscles of silkmoths
197. Rhizobium symbiosis: Nod factors in perspective
198. Endosperm: Origin, development and function
199. p53 is required for radiation induced apoptosis in mouse thymocytes
200. Increased disease succeptibility of transgenic tobacco plants with suppressed levels of preformed phenyl proponoid products
201. Apoptosis, oncosis and necrosis. An overview of cell death
202. Apoptotic features of selective neuronal death in ischemia, epilepsy and glends
203. Dying with death, dissecting the components of apoptotis machinery
204. Key to the mitochondrial gate
205. Tracheary element formation: Building up to a dead end
206. Facing death in the fly: Genetic analysis of apoptosis in Drosophila
207. How p53 binds DNA as a tetramer
208. Apoptosis: Ras to the rescue in the fly eye
209. Life and death in a FLASH
210. Active oxygen species in plant defence against pathogens
211. Caspases find a new place to hide
212. SARPs: A family of apoptosis-related proteins
213. Enzymes of ceramide biosynthesis
214. Genetic control of cell division patterns in developing plants
215. Genetics of programmed cell death in C. elegans: Past, present and future
216. p63 is a p53 homolog required for limb and epidermal morphogenesis
217. Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation
218. Transient and specific expression of a cysteine endopeptidase during autolysis in differentiating tracheary elements from Zinnia mesophyll cells
219. In situ detection of nDNA fragmentation during the differentiation of tracheary elements in higher plants
220. Coordinated activation of programmed cell death and defence mechanisms in transgenic tobacco plants expressing a bacterial proton pump
221. Induction of apoptosis in fibroblast by IL-1 beta converting enzyme, a mammalian homolog of the C. elegans cell death gene Ced-3
222. Isolation and identification of substances inducing formation of tracheary elements in cultured carrot-root slices
223. Negative feedback regulation of wild type p53 biosynthesis
224. The regulation of apoptosis by microbial pathogens
225. p53 protein exhibits 3′-5′ endonuclease activity
226. Cell cycle checkpoints and apoptosis. Potential for improving radiation therapy
227. Modularity in the TNF receptor family
228. Caspase-12 mediates endoplasmic reticulum-specific apoptosis and cytotoxicity by amyloid-β
229. The role of morphogenetic cell death during Drosophila embryonic head development
230. The p53 binding protein 53BP2 also interacts with Bcl-2 and impedes cell cycle progression at G2/M
231. Inactivation of MAP kinases
232. The Bcl-2 family and cell death regulation
233. L, and procaspase-8 associated protein in the endoplasmic reticulum
234. L cooperatively associates with the Bap31 complex in the endoplasmic reticulum, dependent on procaspase-8 and Ced-4 adaptor
235. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
236. Caspases: Killer proteases
237. IL-2 protects T-lymphocytes from glucocorticoid induced DNA fragmentation and cell death
238. Cytogenetics of neoplasia
239. Condensation of the chromatin at the membrane of an apoptotic nucleus is not associated with activation of an endonuclease
240. Major changes in chromatin condensation suggest the presence of apoptotic pathway in cells
241. The primary xylem
242. The meiotic checkpoint monitoring synapsis eliminates supermatocytes via p53-independent apoptosis
243. Directing cell division during development
244. Checkpoints of dueling dimers foil death wishes
245. Bcl-2 heterodimerizes in vivo with a conserved homolog Bax that accelerates programmed cell death
246. Cell death in vertebrates: Lessons from the worm
247. Cell death suffers a TKO
248. G1 events and regulation of cell proliferation
249. Programmed cell death in plants
250. Identification of a trasitional cell state in the developmental pathway to carrot somatic embryogenesis
251. Evidence of apoptosis cell death in HIV encephalitis
252. Raf revealed in life or death decisions
253. Fools rush in
254. Extreme sensitivity of some intestinal crypt cells to x- and y-irradiation
255. Inhibition of platal epithelial cell death by altered protein synthesis
256. Signaling to p53: Breaking the MDM2-p53 circuit
257. Structure and growth of infection threads in the legume symbiosis inth Rhizobium leguminosarum
258. Social controls on cell survival and cell death
259. Cell suicide for beginners
260. Programmed cell death and control of cell survival: Lessons from the nervous system
261. Selective cell elimination during microsporogenesis in sedges
262. Bcl-2 and the ICE family of apoptotic regulators: Making a connection
263. Identification and characterization of the enzymatic activity of S-crystallin from guinea pig lens
264. Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1-beta converting enzyme
265. Mini review: Cellular mechanisms of disease series. Bcl-2 and regulation of programmed cell death
266. The C-terminal domain of p53 recognizes DNA damaged by ioniozing radiation
267. Signal transduction: Fast lane to transcriptional activation
268. Rise in chlorotetracycline accompanies tracheary element differentiation in suspension cultures of Zinnia
269. Morphology of programmed cell death in the ventral nerve cord of Caenorhabditis elegans larvae
270. Meiotic chromosomes: It takes two to tango
271. Mice with reduced levels of p53 protein exhibit the testicular gaint cell degenerative syndrome
272. Fine structure of megagametophyte development in Zea mays
273. Cleavage of nuclear DNA into oligonucleosomal fragments during cell death induced by fungal infection or by abiotic treatments
274. Programmed cell death in development
275. Death in embryonic systems
276. Phagocytic docking without shocking
277. Phagocyte recognition of cell undergoing apoptosis
278. The production of auxin by tobacco internode tissues
279. Arabinogalactin proteins in maize coleoptiles: Developmental relationship in cell death during xylem differentiation but not to extension growth
280. The role of lipo-chito-oligosaccharides in root nodule organogeneis and plant cell growth
281. Hormone induced signaling during moss development
282. Gene activation is required for developmentally programmed cell death
283. Cold thoughts of death: The role of ICE proteases in neuronal cell death
284. Death defying yeast identify novel apoptosis genes
285. Induction of apoptosis by wild type p53 in human colon tumor-derived cell line
286. Role for c-myc in activation induced apoptotic cell death in T-cell hybridomas
287. The phloem sieve element. A river runs through it
288. MAP kinases and plant defences
289. Pathogen defence in plants - A paradigm of biological complexity
290. Death by design: Mechanism of control of apoptosis
291. Coupling cell division and cell death to microtubule dynamics
292. Regulation of plant morphogenesis by lipo-chitin oligosaccharides
293. T-lymphocytes and thymus
294. Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis
295. Mechanisms and genes of cellular suicide
296. Ultrastructure of the developing megaspore mother cell of Ginkgo bitoba
297. Signaling across membranes: A one and a two and a,...
298. p53 is linked directly to homologous recombination process via RAD 51/Rec. A protein interaction
299. Post-embryonic cell lineages of the nematode Caenorhabditis elegans
300. Bcl-2 inhibits the mitochondrial release of an apoptotic protease
301. Ubiquitin tag for sperm mitochondria
302. Downregulation of Fas ligand by shedding
303. Requirement for RNA and protein synthesis for induced regression of tadpole tail in organ culture
304. Sphingomyelin breakdown and cell fate
305. Recent advances in tumor necrosis factor and CD signaling
306. Apoptosis in the pathogenesis and treatment of disease
307. Special topic: Apoptosis
308. The many roles of c-Myc in apoptosis
309. Caspases: Enemies within
310. Introduction to apoptosis: The molecular basis of cell death
311. Apoptosis in C3HIOT 1/2 mouse embryonic cells: Evidence for internucleosomal DNA modification in the absence of double strand cleavage
312. Xylem formation: A paradigm of cytodifferentiation in higher plants
313. Cell death and the disease process. The role of calcium
314. The fight of viruses against apoptosis
315. Apoptosis: Silencing the death receptors
316. Involvement of the Bcl-2 gene in human follicular lymphoma
317. Genome digestion is a dispensible consequence of physiological cell death mediated by cytotoxic T-lymphocytes
318. Viral inhibitors of apoptosis
319. Metabolic transport across symbiotic membranes of legume nodules
320. Biosynthesis of rhizobial exopolysaccharides and their role in the root nodule synthesis of leguminous plants
321. CED-4 - The third horseman of apoptosis
322. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
323. Prevention of programmed cell death in Caenorhaabditis elegans by human Bcl-2
324. An evolutionary perspective on apoptosis
325. Caspases and caspase inhibitors
326. Immunosuppressive effects of apoptotic cells
327. Detection of the onitial stages of DNA fragmentation in apoptosis
328. Apoptosis: Placing death under control
329. Fumonisins and AAI toxins, Sphinganine analog mycotoxins induce apoptosis in monkey kidney cells
330. Apoptosis: A functional paradigm for programmed plant cell death induced by host selective phytotoxin and invoked during development
331. Cell biology of embryosac development in Arabidopsis
332. Constitutive expression of the machinery for programmed cell death
333. Diverse molecular provocation of programmed cell death
334. Myb proteins in life, death and differentiation
335. Function of the adenovirus EIB oncogene in infected and transformed cells
336. Life, death and pursuit of apoptosis
337. Genetic control of programmed cell death in Drosophila
338. Programmed cell death: A fundamental protective response to pathogen
339. Thyroid disease: A case of cell suicide?
340. DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
341. Features of the ultrastructure of the female gametophyte of Myosurus minimus
342. The C. elegans cell corpse engulfment gene Ced-7 endcodes a protein similar to ABC transporters
343. Apoptosis - Death gets a brake
344. Clues in the p53 murder mystery
345. An endonuclease at last
346. Cell injury and death
347. Cell death: The significance of apoptosis
348. p63 is essential for regenerative proliferation in limb, craneofacial and epithelial development
349. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with bax
350. Fas-mediated cell death promoted by opioids
351. Wild type p53 induces apoptosis in myeloid leaukaemic cells that is inhibited by interleukin-6
352. Ethylene mediated programmed cell death during maize endosperm development of wild type and shrunken2 genotypes
353. Transducing signals of life and death
354. The Caenorhabditis elegans genes Ced-3 and Ced-4 act cell autonomously to cause programmed cell death
355. The C. elegans cell death gene Ced-3 encodes a protein similar to mammalian interleukin-1 beta converting enzyme
356. All's well that ends dead
357. Apaf-1, a human protein homologous to C. elegans Ced-4 participates in cytochrome-c dependent activation of caspase-3