Transducing signals of life and death

Current Opinion in Cell Biology

Volumn 9, Issue 2, 1997, Pages 247-251

  Yuan, Junying ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; INTERLEUKIN 1BETA CONVERTING ENZYME; TUMOR NECROSIS FACTOR RECEPTOR;

APOPTOSIS; CELL DEATH; CELL SURVIVAL; CYTOPLASM; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION;

EID: 0030987071     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(97)80069-5     Document Type: Article

References (31)

1. Yuan J: Molecular control of life and death. Curr Opin Cell Biol 1995, 7:211-214.
2. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, Hase A, Seto Y, Nagata S: The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 1991, 66:233-243.
3. Tartaglia LA, Weber RF, Figari IS, Reynolds C, Palladino MA Jr, Goeddel DV: The two different receptors for tumor necrosis factor mediate distinct cellular responses. Proc Natl Acad Sci USA 1991, 88:9292-9296.
4. Chinnaiyan AM, Yu GL, Lyons RH, Garg M, Duan DR, Xing L, Gentz R, Ni J, Dixit VM: Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 1996, 274:990-992.
5. Kitson Raven T, Jiang Y-P, Goeddel DV, Giles KM, Pun K-T, Grinham CJ, Brown R, Farrow SN: A death-domain-containing receptor that mediates apoptosis. Nature 1996, 384:372-375.
6. Itoh N, Nagata S: A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem 1993, 268:10932-10937.
7. Liu Z-G, Hsu H, Goeddel DV: Dissection of TNF receptor 1 effector function: JNK activation is not linked to apoptosis while NFκB activation prevents cell death. Cell 1996, 87:565-576. This elegant analysis of the TNF-R1 signaling complex showed that the recruitment of FADD to TNF-R1 mediates apoptosis and that the recruitment of RIP and TRAF2 to the TNF-R1 signaling complex mediates NFKB activation which protects against TNF-induced apoptosis.
8. Van Antwerp DJ, Martin SJ, Kafri T, Green DR, Verma IM: Suppression of TNF-α-induced apoptosis by NF-κB. Science 1996, 274:787-789.
9. Beg AA, Baldwin AS: An essential role for NF-κB in preventing TNF-α-induced cell death. Science 1996, 274:782-784.
10. Wang C-Y, Mayo MW, Baldwin AS Jr: TNF- and cancer therapy-induced apoptosis potentiation by inhibition of NF-κB. Science 1996, 274:784-787.
11. Hsu H, Xiong J, Goeddel DV: The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 1995, 81:495-504. The authors of this paper demonstrated beautifully that TRADD is an adapter protein for both apoptosis and survival.
12. Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM: FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995, 81:505-512. The authors of this paper identified FADD as a critical mediator of CD95-induced apoptosis.
13. Boldin MP, Varfolomeev EE, Pancer Z, Mett IL, Camonis JH, Wallach D: A novel protein that interacts with the death domain of Fas/AP01 contains a sequence motif related to the death domain. J Biol Chem 1995, 270:7795-7798. This paper identified MACH, a novel MORT1/FADD-interacting ICE-like protease with homology to FADD/MORT1.
14. Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH, Peter ME: Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J 1995, 14:5579-5588. Instantaneous association of the components, CAP1-4, of a death-inducing signaling complex (DISC) upon cross-linking of CD95 was detected by two-dimensional electrophoresis.
15. Chinnaiyan AM, Tepper CG, Seldin MF, O'Rourke K, Kischkel FC, Hellbardt S, Krammer PH, Peter ME, Dixit VM: FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J Biol Chem 1996, 271:4961-4965. Using a FADD mutant, this work demonstrated that FADD is involved in both CD95- and TNF-mediated signaling.
16. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R et al.: FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 1996, 85:817-827 See annotation [17••].
17. Boldin MP, Goncharov TM, Goltsev YV1 Wallach D: Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 1996, 85:803-815. These two papers [16••,17••] identified FLICE/MACH as a potential direct linkage between activation of CD95 and TNF-R and the ICE-like proteases.
18. Stanger BZ, Leder P, Lee TH, Kim E, Seed B: RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 1995, 81:513-523. This work identified RIP as a death domain containing kinase that interacts with CD95.
19. Peter ME, Kischkel FC, Hellbardt S, Chinnaiyan AM, Krammer PH, Dixit VM: CD95 (APO-1/Fas)-associating signalling proteins. Cell Death Differ 1996, 3:161-170.
20. Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV: TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 1996, 4:387-396. This work showed that RIP may be a component of the TNF-R complex.
21. Ting AT, Pimentel-Muinos FX, Seed B: RIP mediates tumor necrosis factor receptor 1 activation of NF-κB but not Fas/APO-1-initiated apoptosis. EMBO J 1996, 15:6189-6196.
22. Rothe M, Wong SC, Henzel WJ, Goeddel DV: A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 1994, 78:681-692.
23. Hsu H, Shu HB, Pan MG, Goeddel DV: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 1996, 84:299-308. TRADD is a bifurcating point in the TNF-R1 signaling pathway that interacts with TRAF2 to mediate NFκB activation and with FADD to induce apoptosis.
24. Rothe M, Sarma V, Dixit VM, Goeddel DV: TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science 1995, 269:1424-1427. A truncated mutant of TRAF2 lacking an amino-terminal RING-finger domain is a dominant-negative inhibitor of NFκB activation by TNF-R2 and CD40. Thus, TRAF2 is a common mediator of TNF-R2 and CD40 signaling.
25. Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D: Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science 1995, 267:1494-1498.
26. Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J: TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proc Natl Acad Sci USA 1996, 93:9437-9442.
27. Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV: TRAF6 is a signal transducer for interleukin-1. Nature 1996, 383:443-446.
28. Regnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC: Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. J Biol Chem 1995, 270:25715-25721.
29. Sato T, Irie S, Kitada S, Reed JC: FAP-1: a protein tyrosine phosphatase that associates with Fas. Science 1995, 268:411-415.
30. Clem RJ, Fechheimer M, Miller LK: Prevention of apoptosis by a baculovirus gene during infection of insect cells. Science 1991, 254:1388-1390.
31. Uren AG, Pakusch M, Hawkins CJ, Puls KL, Vaux DL: Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. Proc Natl Acad Sci USA 1996, 93:4974-4978.