Meiotic chromosomes: It takes two to tango

Genes and Development

Volumn 11, Issue 20, 1997, Pages 2600-2621

  Roeder, G Shirleen ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

BASE MISPAIRING; CHROMATIN; CHROMOSOME PAIRING; CHROMOSOME SEGREGATION; CROSSING OVER; DNA REPLICATION; GENETIC RECOMBINATION; HOLLIDAY JUNCTION; MEIOSIS; NONHUMAN; PRIORITY JOURNAL; PROPHASE; REVIEW; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SISTER CHROMATID; TELOMERE;

SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE;

EID: 0030767256     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.20.2600     Document Type: Review

References (232)

1. Afshar, K., N.R. Barton, R.S. Hawley, and L.S.B. Goldstein. 1995. DNA binding and meiotic chromosomal localization of the Drosophila Nod kinesin-like protein. Cell 81: 129-138.
2. Alani, E., R. Padmore, and N. Kleckner. 1990. Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination. Cell 61: 419-436.
3. Albini, S.M. and G.H. Jones. 1987. Synaptonemal complex spreading in Allium cepa and A. fistulosum. I. The initiation and sequence of pairing. Chromosoma 95: 324-338.
4. Anderson, L.K. and S.M. Stack. 1988. Nodules associated with axial cores and synaptonemal complexes during zygotene in Psilotum nudum. Chromosoma 97: 96-100.
5. Anderson, L.K., S.M. Stack, R.J. Todd, and R.P. Ellis. 1994. A monoclonal antibody to lateral element proteins in synaptonemal complexes of Lilium Iongiflorum. Chromosoma 103:357-367.
6. Anderson, L.K., H.H. Offenberg, W.M.H.C. Verkuijlen, and C. Heyting. 1997. RecA-like proteins are components of early meiotic nodules in lily. Proc. Natl. Acad. Sci. 94: 6868-6873.
7. Ashley, T. 1994. Mammalian meiotic recombination: A reexamination. Hum. Genet. 94: 587-593.
8. Ashley, T., A.W. Plug, J. Xu, A. Solari, G. Reddy, E.I. Golub, and D.C. Ward. 1995. Dynamic changes in Rad51 distribution on cbromatin during meiosis in male and female vertebrates. Chromosoma 104: 19-28.
9. Bahler, J., T. Wyler, J. Loidl, and J. Kohli. 1993. Unusual nuclear structures in meiotic prophase of fission yeast: A cytological analysis. J. Cell Biol. 121: 241-256.
10. Baker, B.S., A.T.C. Carpenter, M.S. Esposito, R.E. Esposito, and L. Sandler. 1976. The genetic control of meiosis. Annu. Rev. Genet. 10:53-134.
11. Baker, S.M., C.E. Bronner, L. Zhang, A.W. Plug, M. Robatzek, G. Warren, E.A. Elliott, J. Yu, T. Ashley, N. Arnheim, R.A. Flavell, and R.M. Liskay. 1995. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell 82:309-319.
12. Baker, S.M., A.W. Plug, T.A. Prolla, C.E. Bronner, A.C. Harris, X. Yao, D.M. Christie, C. Monell, N. Arnheim, A. Bradley, T. Ashley, and R.M. Liskay. 1996. Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nature Genet. 13:336-342.
13. Barlow, A.L. and M.A. Hulten. 1996. Combined immunocytogenetic and molecular cytogenetic analysis of meiosis I human spermatocytes. Chromosome Res. 4: 562-573.
14. Barlow, A.L., F.E. Benson, S.C. West, and M.A. Hulten. 1997. Distribution of the Rad51 recombinase in human and mouse spermatocytes. EMBO J. 16 (in press).
15. Barnes, T.M., Y. Kohara, A. Coulson, and S. Hekimi. 1995. Meiotic recombination, noncoding DNA and genomic organization in Caenorhabditis elegans. Genetics 141: 159-179.
16. Bass, H.W., W.F. Marshall, J.W. Sedat, D.A. Agard, and W.Z. Cande. 1997. Telomeres cluster de nova before the initiation of synapsis; a 3-dimensional spatial analysis of telomere positions before and during meiotic prophase. J. Cell Biol. 137:5-18.
17. Baudat, F. and A. Nicolas. 1997. Clustering of meiotic doublestrand breaks on yeast chromosome III. Proc. Natl. Acad. Sci. 94:5213-5218.
18. Bergerat, A., B. de Massy, D. Gadelle, P.-C. Varoutas, A. Nicolas, and P. Forterre. 1997. An atypical topoisomerase II from archaea with implications for meiotic recombination. Nature 386:414-417.
19. Bickel, S.E., D.W. Wyman, and T.L. Orr-Weaver. 1997. Mutational analysis of the Drosophila sister-chromatid cohesion protein ORD and its role in the maintenance of centromeric cohesion. Genetics 146: 1319-1331.
20. Bishop, D.K. 1994. RecA homologs Dmc1 and Rad51 interact to form discrete nuclear complexes prior to meiotic chromosome synapsis. Cell 79: 1081-1092.
21. Bishop, D., D. Park, L. Xu, and N. Kleckner. 1992. DMC1: A meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression. Cell 69: 439-456.
22. Bullard, S.A., S. Kim, A.M. Galbraith, and R.E. Malone. 1996. Double-strand breaks at the HIS2 recombination hot spot in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 93: 13054-13059.
23. Cao, L., E. Alani, and N. Kleckner. 1990. A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae. Cell 61: 1089-1101.
24. Carpenter, A.T.C. 1975. Electron microscopy of meiosis in Drosophila melanogaster females. II. The recombination nodule - a recombination-associated structure at pachytene? Proc. Natl. Acad. Sci. 72:3186-3189.
25. _. 1979. Recombination nodules and synaptonemal complex in recombination-defective females of Drosophila melanogaster. Chromosoma 75: 259-292.
26. _. 1984. Meiotic roles of crossing-over and of gene conversion. Cold Spring Harbor Symp. Quant. Biol. 49: 23-29.
27. _. 1988. Thoughts on recombination nodules, meiotic recombination, and chiasmata. In Genetic recombination (eds. R. Kucherlapati and G.R. Smith), pp. 529-548. American Society for Microbiology, Washington, DC.
28. Chen, Q., R.E. Pearlman, and P.B. Moens. 1992. Isolation and characterization of a cDNA encoding a synaptonemal complex protein. Biochem. Cell. Biol. 70: 1030-1038.
29. Chikashige, Y., D.-Q. Ding, H. Funabiki, T. Haraguchi, S. Yanagida, and Y. Hiraoka. 1994. Telomere-led premeiotic chromosome movement in fission yeast. Science 264: 270-273.
30. Chikashige, Y., D.Q. Ding, Y. Imai, M. Yamamoto, T. Haraguchi, and Y. Hiraoka. 1997. Meiotic nuclear reorganization: Switching the position of centromeres and telomeres in fission yeast Schizosaccharomyces pombe. EMBO J. 16: 193-200.
31. Chua, P.R. and G.S. Roeder. 1997. Taml, a telomere-associated meiotic protein, functions in chromosome synapsis and crossover interference. Genes & Dev. 11: 1786-1800.
32. Civardi, L., T. Xia, K.J. Edwards, P.S. Schnable, and B.J. Nikolau. 1994. The relationship between genetic and physical distances in the cloned a1-sh2 interval of Zea mays L. genome. Proc. Natl. Acad. Sci. 91: 8268-8272.
33. Connelly, J.C. and D.R.F. Leach. 1996. The sbcC and sbcD genes of Escherichia coli encode a nuclease involved in palindrome inviability and genetic recombination. Genes Cells 1:285-291.
34. Conrad, M.N., A.M. Dominguez, and M.E. Dresser. 1997. Ndj1, a meiotic telomere protein required for normal chromosome synapsis and segregation in yeast. Science 276: 1252-1255.
35. de Massy, B., F. Baudat, and A. Nicolas. 1994. Initiation of recombination in Saccharomyces cerevisiae haploid meiosis. Proc. Natl. Acad. Sci. 91: 11929-11933.
36. de Massy, B., V. Rocco, and A. Nicolas. 1995. The nucleotide mapping of DNA double-strand breaks at the CYS3 initiation site of meiotic recombination in Saccharomyces cerevisiae. EMBO J. 14: 4589-4598.
37. Dernburg, A.F., J.W. Sedat, W.Z. Cande, and H.W. Bass. 1995. Cytology of telomeres. In Telomeres (ed. E.H. Blackburn and C.W. Grieder), pp. 295-337. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
38. Dernburg, A.F., K.W. Broman, J.C. Fung, W.F. Marshall, J. Philips, D.A. Agard, and J.W. Sedat. 1996a. Perturbation of nuclear architecture by long-distance chromosome interactions. Cell 85: 745-759.
39. Dernburg, A.F., J.W. Sedat, and R.S. Hawley. 1996b. Direct evidence of a role for heterochromatin in meiotic chromosome segregation. Cell 86: 135-146.
40. Dobson, M.J., R.E. Pearlman, A. Karaiskakis, B. Spyropoulos, and P.B. Moens. 1994. Synaptonemal complex proteins: occurrence, epitope mapping, and chromosome disjunction. J. Cell Sci. 107: 2749-2760.
41. Dolganov, G.M., R.S. Maser, A. Novikov, L. Tosto, S. Chong, D.A. Bressan, and J.H.J. Petrini. 1996. Human Rad50 is physically associated with human Mre11: Identification of a conserved multiprotein complex implicated in recombinational DNA repair. Mol. Cell. Biol. 16: 4832-4841.
42. Dresser, M., D. Ewing, M. Conrad, A. Dominguez, R. Barstead, H. Jiang, and T. Kodadek. 1997. DMC1 functions in a meiotic pathway that is largely independent of the RAD51 pathway. Genetics 147 (in press).
43. Earnshaw, W.C., B. Halligan, C.A. Cooke, M.M.S. Heck, and L.F. Liu. 1985. Topoisomerase II is a structural component of mitotic chromosome scaffolds. J. Cell Biol. 100: 1706-1715.
44. Edelmann, W., P.E. Cohen, M. Kane, K. Lau, B. Morrow, S. Bennett, A. Umar, T. Kunkel, G. Cattoretti, R. Chaganti, J. Pollard, R. Kolodner, and R. Kucherlapati. 1996. Meiotic pachytene arrest in MLH1-deficient mice. Cell 85: 1125-1134.
45. Egel, R. 1995. The synaptonemal complex and the distribution of meiotic recombination events. Trends Genet. 11: 206-208.
46. Egel-Mitam, M., L.W. Olson, and R. Egel. 1982. Meiosis in Aspergillus nidulans: Another example for lacking synaptonemal complexes in the absence of crossover interference. Hereditas 97: 179-187.
47. Engebrecht, J., J. Hirsch, and G.S. Roeder. 1990. Meiotic gene conversion and crossing over: Their relationship to each other and to chromosome synapsis and segregation. Cell 62: 927-937.
48. Fan, Q.Q. and T.D. Petes. 1996. Relationship between nucleasehypersensitive sites and meiotic recombination hot spot activity at the HIS4 locus of Saccharomyces cerevisiae. Mol. Cell Biol. 16: 2037-2043.
49. Fox, M.E., J.B. Virgin, J. Metzger, and G.R. Smith. 1997. Position- and orientation-independent activity of the Schizosaccharomyces pombe meiotic recombination hot spot M26. Proc. Natl. Acad. Sci. 94: 7446-7451.
50. Friedman, D.B., N.M. Hollingsworth, and B. Byers. 1994. Insertional mutations in the yeast HOP1 gene: evidence for multimeric assembly in meiosis. Genetics 136: 449-464.
51. Gilbertson, L.A. and F.W. Stahl. 1994. Initiation of meiotic recombination is independent of interhomologue interactions. Proc. Natl. Acad. Sci. 91: 11934-11937.
52. _. 1996. A test of the double-strand break repair model for meiotic recombination in Saccharomyces cerevisiae. Genetics 144:27-41.
53. Gill, K.S., B.S. Gill, T.R. Endo, and E.V. Boyko. 1996. Identification and high-density mapping of gene-rich regions in chromosome group 5 of wheat. Genetics 143: 1011-1012.
54. Gillies, C.B. 1985. An electron microscopic study of synaptonemal complex formation at zygotene in rye. Chromosoma 92: 165-175.
55. Goldway, M., A. Sherman, D. Zenvirth, T. Arbel, and G. Simchen. 1993. A short chromosomal region with major roles in yeast chromosome III meiotic disjunction, recombination and double-strand breaks. Genetics 133: 159-169.
56. Gorbsky, G.G. 1995. Kinetochores, microtubules and the metaphase checkpoint. Trends Cell Biol. 5: 143-148.
57. Goyon, C. and M. Lichten. 1993. Timing of molecular events in meiosis in Saccharomyces cerevisiae: Stable heteroduplex DNA is formed late in meiotic prophase. Mol. Cell. Biol. 13: 373-382.
58. Hari, K.L., A. Santerre, J.J. Sekelsky, K.S. McKim, J.B. Boyd, and R.S. Hawley. 1995. The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene. Cell 82: 815-821.
59. Hassold, T.H., M. Abruzzo, K. Adkins, D. Griffin, M. Merrill, E. Millie, D. Saker, J. Shen, and M. Zaragoza. 1996. Human aneuploidy: Incidence, origin, and etiology. Environ. Mol. Mutagen. 28: 167-175.
60. Havekes, F.W., J.H. de Jong, C. Heyting, and M.S. Ramanna. 1994. Synapsis and chiasma formation in four meiotic mutants of tomato (Lycopersicon esculentum). Chromosome Res. 2:315-325.
61. Hawley, R.S. 1979. Chromosomal sites necessary for normal levels of meiotic recombination in Drosophila melanogaster. Genetics 94: 625-646.
62. _. 1988. Exchange and chromosomal segregation in eucaryotes. In Genetic recombination (ed. R. Kucherlapati and G.R. Smith), pp. 497-527. American Society for Microbiology, Washington, DC.
63. Hawley, R.S. and W.E. Theurkauf. 1993. Requiem for distributive segregation: Achiasmate segregation in Drosophila females. Trends Genet. 9:310-317.
64. Hawley, R.S., H. Irick, A.E. Zitron, D.A. Haddox, A. Lohe, C. New, M.D. Whitley, T. Arbel, J. Jang, K. McKim, and G. Childs. 1993. There are two mechanisms of achiasmate segregation in Drosophila females, one of which requires heterochromatic homology. Dev. Genet. 13: 440-467.
65. Hays, S.L., A.A. Firmenich, and P. Berg. 1995. Complex formation in yeast double-strand break repair: Participation of Rad51, Rad52, Rad55, and Rad57 proteins. Proc. Natl. Acad. Sci. 92: 6925-6929.
66. Heng, H.H.Q., L.-C. Tsui, and P.B. Moens. 1994. Organization of heterologous DNA inserts on the mouse meiotic chromosome core. Chromosoma 103: 401-407.
67. Heng, H.H.Q., J.W. Chamberlain, X.-M. Shi, B. Spyropoulos, L.-C. Tsui, and P.B. Moens. 1996. Regulation of meiotic chromatin loop size by chromosomal position. Proc. Natl. Acad. Sci. 93: 2795-2800.
68. Heyting, C. 1996. Synaptonemal complexes: Structure and function. Curr. Opin. Cell Biol. 8: 389-396.
69. Hiraoka, Y., A.F. Dernburg, S.J. Parmalee, M.C. Rykowski, D.A. Agard, and J.W. Sedat. 1993. The onset of homologous chromosome pairing during Drosophila melanogaster embryogenesis. J. Cell Biol. 120: 591-600.
70. Hollingsworth, N.M. and B. Byers. 1989. HOP1: a yeast meiotic pairing gene. Genetics 121: 445-462.
71. Hollingsworth, N.M. and A.D. Johnson. 1993. A conditional allele of the Saccharomyces cerevisiae HOP1 gene is suppressed by overexpression of two other meiosis-specific genes: RED1 and REC104. Genetics 133: 785-797.
72. Hollingsworth, N.M., L. Goetsch, and B. Byers. 1990. The HOP1 gene encodes a meiosis-specific component of yeast chromosomes. Cell 61: 73-84.
73. Hollingsworth, N.M., L. Ponte, and C. Halsey. 1995. MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair. Genes &. Dev. 9: 1728-1739.
74. Hollingsworth, N.M., T. de los Santos, and L. Ponte. 1997. Genetic interactions between HOP1, RED1, and MEK1 suggest that MEK1 regulates assembly of axial element components during meiosis in the yeast, Saccharomyces cerevisiae. Genetics 147: 33-42.
75. Hunt, P., R. Lemaire, P. Embury, L. Sheean, and K. Mroz. 1995. Analysis of chromosome behavior in intact mammalian oocytes: Monitoring the segregation of a univalent chromosome during female meiosis. Hum. Mol. Genet. 4:2007-2012.
76. Hunter, N. and R.H. Borts. 1997. Mlh1 is unique among mismatch repair proteins in its ability to promote crossing over during meiosis. Genes &. Dev. 11: 1573-1582.
77. Ikeya, T., A. Shinohara, S. Sato, S. Tabata, and T. Ogawa. 1996. Localization of mouse Rad51 and Lim15 proteins on meiotic chromosomes at late stages of prophase I. Genes Cells 1: 379-389.
78. Ivanov, E.L., V.G. Korolev, and F. Fabre. 1992. XRS2, a DNA repair gene of Saccharomyces cerevisiae, is needed for meiotic recombination. Genetics 132: 651-664.
79. Ivanov, E.L., N. Sugawara, C.I. White, F. Fabre, and J.E. Haber. 1994. Mutations in XRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiae. Mol. Cell. Biol. 14: 3414-3425.
80. Jinks-Robertson, S. and T.D. Petes. 1985. High-frequency meiotic gene conversion between repeated genes on nonhomologous chromosomes in yeast. Proc. Natl. Acad. Sci. 82: 3350-3354.
81. Johnson, R.D. and L.S. Symington. 1995. Functional differences and interactions among the putative RecA homologs Rad51, Rad55, and Rad57. Mol. Cell Biol. 15: 4842-4850.
82. Johzuka, K. and H. Ogawa. 1995. Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosisspecific double-strand break formation in Saccharomyces cerevisiae. Genetics 139: 1521-1532.
83. Jones, G.H. 1984. The control of chiasma distribution. In Controlling events in meiosis (ed. C.W. Evans and H.G. Dickinson), pp. 293-320. The Company of Biologists, Ltd., Cambridge, UK.
84. Kaback, D.B., H.Y. Steensma, and P. deJonge. 1989. Enhanced meiotic recombination on the smallest chromosome of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 86:3694-3698.
85. Kaback, D.B., V. Guacci, D. Barber, and J.W. Mahon. 1992. Chromosome size-dependent control of meiotic recombination. Science 256: 228-232.
86. Karpen, G.H., M.H. Le, and H. Le. 1996. Centric heterochromatin and the efficiency of achiasmate disjunction in Dro-sophila female meiosis. Science 273: 118-122.
87. Keegan, K.S., D.A. Holtzman, A.W. Plug, E.R. Christenson, E.E. Brainerd, G. Flaggs, N.J. Bentley, E.M. Taylor, M.S. Meyn, S.B. Moss, A.M. Carr, T. Ashley, and M.F. Hoekstra. 1996. The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes & Dev. 10: 2423-2437.
88. Keeney, S. and N. Kleckner. 1995. Covalent protein-DNA complexes at the 5′ termini of meiosis-specific double-strand breaks in yeast. Proc. Natl. Acad. Sci. 92: 11274-11278.
89. Keeney, S., C.N. Giroux, and N. Kleckner. 1997. Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell 88: 375-384.
90. Kerrebrock, A.W., W.Y. Miyazaki, D. Birnby, and T.L. OrrWeaver. 1992. The Drosophila mei-S332 gene promotes sister-chromatid cohesion in meiosis following kinetochore differentiation. Genetics 130:827-841.
91. Kerrebrock, A.W., O.P. Moore, J.S. Wu, and T.L. Orr-Weaver. 1995. Mei-S332, a Drosophila protein required for sister-chromatid cohesion, can localize to meiotic centromeric regions. Cell 83: 247-256.
92. Klapholz, S., C.S. Waddell, and R.E. Esposito. 1985. The role of the SPO11 gene in meiotic recombination in yeast. Genetics 110: 187-216.
93. Kleckner, N. 1996. Meiosis: How could it work? Proc. Natl. Acad. Sci. 93: 8167-8174.
94. Kleckner, N. and B.M. Weiner. 1993. Potential advantages of unstable interactions for pairing of chromosomes in meiotic, somatic, and premeiotic cells. Cold Spring Harb. Symp. Quant. Biol. 58: 553-565.
95. Klein, S., D. Zenvirth, V. Dror, A.B. Barton, D.B. Kaback, and G. Simchen. 1996. Patterns of meiotic double-strand breakage on native and artificial yeast chromosomes. Chromosoma 105: 276-284.
96. Koehler, K.E., C.L. Boulton, H.E. Collins, R.L. French, K.C. Herman, S.M. Lacefield, L.D. Madden, C.D. Schuetz, and R.S. Hawley. 1996. Spontaneous X chromosome MI and MII non-disjunction events in Drosophila melanogaster oocytes have different recombinational histories. Nature Genet. 14: 406-414.
97. Kohli, J. and J. Bahler. 1994. Homologous recombination in fission yeast: Absence of crossover interference and synaptonemal complex. Experientia 50: 295-306.
98. Kolodner, R. 1996. Biochemistry and genetics of eukaryotic mis-match repair. Genes & Dev. 10: 1433-1442.
99. Lamb, N.E., S.B. Freeman, A. Savage-Austin, D. Pettay, L. Taft, J. Hersey, Y. Gu, J. Shen, D. Saker, K.M. May, D. Avramopoulos, M.B. Petersen, A. Hallberg, M. Mikkelsen, T.J. Hassold, and S.L. Sherman. 1996. Susceptible chiasmate configurations of chromosome 21 predispose to non-disjunction in both maternal meiosis I and meiosis II. Nature Genet. 14: 400-405.
100. Lammers, J.H.M., H.H. Offenberg, M. van Aalderen, A.C.G. Vink, A.J.J. Dietrich, and C. Heyting. 1994. The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyteregulated genes. Mol. Cell Biol. 14: 1137-1146.
101. Lammers, J.H.M., M. van Aalderen, A.H.F.M. Peters, A.A.M. van Pelt, I.C. Gaemmers, D.G. de Rooij, P. de Boer, H.H. Offenberg, A.J.J. Dietrich, and C. Heyting. 1995. A change in the phosphorylation pattern of the 30000-33000 M, synaptonemal complex proteins of the rat between early and midpachytene. Chromosoma 104: 154-163.
102. Li, X. and R.B. Nicklas. 1995. Mitotic forces control a cell-cycle checkpoint. Nature 373: 630-632.
103. Lichten, M. and A.S.H. Goldman. 1995. Meiotic recombination hotspots. Annu. Rev. Genet. 29: 423-444.
104. Lichten, M., R.H. Borts, and J.E. Haber. 1987. Meiotic gene conversion and crossing over between dispersed homologous sequences occurs frequently in Saccharomyces cerevisiae. Genetics 115:233-246.
105. Lifschytz, E. and D. Haraven. 1982. Heterochromatin markers: Arrangement of obligatory heterochromatin, histone genes and multisite gene families in the interphase nucleus of D. melanogaster. Chromosoma 86: 443-455.
106. Lin, Y. and G.R. Smith. 1994. Transient, meiosis-induced expression of the rec6 and rec12 genes of Schizosaccharomyces pombe. Genetics 136: 769-779.
107. Liu, J., T.-C. Wu, and M. Lichten. 1995. The location and structure of double-strand DNA breaks induced during yeast meiosis: Evidence for a covalently linked DNA-protein intermediate. EMBO J. 14: 4599-4608.
108. Liu, J.-G., L. Yuan, E. Brundell, B. Bjorkroth, B. Daneholt, and C. Hoog. 1996. Localization of the N-terminus of SCP1 to the central element of the synaptonemal complex and evidence for direct interactions between the N-termini of SCP1 molecules organized head-to-head. Exp. Cell Res. 226: 11-19.
109. Loidl, J. 1990. The initiation of meiotic chromosome pairing: The cytological view. Genome 33: 759-778.
110. Loidl, J. and K. Nairz. 1997. Karyotype variability in yeast caused by nonallelic recombination in haploid meiosis. Genetics 146: 79-88.
111. Loidl, J., F. Klein, and H. Scherthan. 1994. Homologous pairing is reduced but not abolished in asynaptic mutants of yeast. J. Cell Biol. 125: 1191-1200.
112. Loidl, J., H. Scherthan, J.T.D. Dunnen, and F. Klein. 1995. Morphology of a human-derived YAC in yeast meiosis. Chromosoma 104: 183-188.
113. Lydall, D., Y. Nikolsky, D.K. Bishop, and T. Weinert. 1996. A meiotic recombination checkpoint controlled by mitotic checkpoint genes. Nature 383: 840-843.
114. Maguire, M.P. 1986. The pattern of pairing that is effective for crossing over in complex B-A chromosome rearrangements in maize. Chromosoma 94: 71-85.
115. _. 1990. Sister chromatid cohesiveness: Vital function, obscure mechanism. Biochem. Cell Biol. 68: 1231-1242.
116. _. 1995. Is the synaptonemal complex a disjunction machine? J. Hered. 86: 330-340.
117. Maguire, M.P. and R.W. Riess. 1994. The relationship of homologous synapsis and crossing over in a maize inversion. Genetics 137:281-288.
118. Maguire, M.P., A.M. Paredes, and R.W. Riess. 1991. The desynaptic mutant of maize as a combined defect of synaptonemal complex and chiasma maintenance. Genome 34: 879-887.
119. Marsischky, G.T., N. Filosi, M.F. Kane, and R. Kolodner. 1996. Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair. Genes & Dev. 10: 407-420.
120. McKee, A.H.Z. and N. Kleckner. 1997a. A general method for identifying recessive diploid-specific mutations in Saccharomyces cerevisiae, its application to the isolation of mutants blocked at intermediate stages of meiotic prophase and characterization of a new gene SAE2. Genetics 146: 797-816.
121. _. 1997b. Mutations in Saccharomyces cerevisiae that block meiotic prophase chromosome metabolism and confer cell cycle arrest at pachytene identify two new meiosis-specific genes SAE1 and SAE3. Genetics 146: 817-834.
122. McKee, B.D. 1996. The license to pair: Identification of meiotic pairing sites in Drosophila. Chromosoma 105: 135-141.
123. McKee, B.D., X.-j. Ren, and C.-s. Hong. 1996. A recA-like gene in Drosophila melanogaster that is expressed at high levels in female but not male meiotic tissues. Chromosoma 104: 479-488.
124. Menees, T.M. and G.S. Roeder. 1989. MEI4, a yeast gene required for meiotic recombination. Genetics 123: 675-682.
125. Meuwissen, R.L.J., H.H. Offenberg, A.J.J. Dietrich, A. Riesewijk, M. van Iersel, and C. Heyting. 1992. A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes. EMBO J. 11: 5091-5100.
126. Meuwissen, R.L.J., I. Meerts, J.M.N. Hoovers, N.J. Leschot, and C. Heyting. 1997. Human synaptonemal complex protein 1 (SCP1): Isolation and characterization of the cDNA and chromosomal localization of the gene. Genomics 39: 377-384.
127. Meyn, M.S. 1995. Ataxia-telangiectasia and cellular response to DNA damage. Cancer Res. 55: 5991-6000.
128. Milne, G.T. and D.T. Weaver. 1993. Dominant negative alleles of RAD52 reveal a DNA repair/recombination complex including Rad51 and Rad52. Genes & Dev. 7: 1755-1765.
129. Miyazaki, W.Y. and T.L. Orr-Weaver. 1992. Sister-chromatid misbehavior in Drosophila ord mutants. Genetics 342:1047-1061.
130. _. 1994. Sister-chromatid cohesion in mitosis and meiosis. Annu. Rev. Genet. 28: 167-187.
131. Mizuno, K.I., Y. Emura, M. Baur, J. Kohli, K. Ohta, and T. Shibata. 1997. The meiotic recombination hot spot created by the single-base substitution ade6-M26 results in remodeling of chromatin structure in fission yeast. Genes & Dev. 11:876-886.
132. Moens, P.B. 1969a. The fine structure of meiotic chromosome polarization and pairing in Locusta migratoria spermatocytes. Chromosoma 28: 1-25.
133. _. 1969b. Genetic and cytological effects of three desynaptic genes in the tomato. Can. J. Genet. Cytol. 11: 857-869.
134. Moens, P. and W.C. Earnshaw. 1989. Anti-topoisomerase II recognizes meiotic chromosome cores. Chromosoma 98:317-322.
135. Moens, P.B. and R.E. Pearlman. 1988. Chromatin organization at meiosis. BioEssays 9: 151-153.
136. _. 1990. Telomere and centromere DNA are associated with the cores of meiotic prophase chromosomes. Chromosoma 100: 8-14.
137. Moens, P.B. and B. Spyropoulos. 1995. Immunocytology of chiasmata and chromosomal disjunction at mouse meiosis. Chromosoma 104: 175-182.
138. Moens, P.B., D.J. Chen, Z. Shen, N. Kolas, M. Tarsounas, H.H.Q. Heng, and B. Spyropoulos. 1997. Rad51 immunocytology in rat and mouse spermatocytes and oocytes. Chromosoma (in press).
139. Molnar, M., J. Bahler, M. Sipiczki, and J. Kohli. 1995. The rec8 gene of Schizosaccharomyces pombe is involved in linear element formation, chromosome pairing, and sister-chromatid cohesion during meiosis. Genetics 141: 61-73.
140. Moreau, P.J.F., D. Zickler, and G. Leblon. 1985. One class of mutants with disturbed centromere cleavage and chromosome pairing in Sordaria macrospora. Mol. Gen. Genet. 198: 189-197.
141. Mortensen, U.H., C. Bendixen, I. Sunjevaric, and R. Rothstein. 1996. DNA strand annealing is promoted by the yeast Rad52 protein. Proc. Natl. Acad. Sci. 93: 10729-10734.
142. Murti, J.R., M. Bumbulis, and J.C. Schimenti. 1994. Gene conversion between unlinked sequences in the germline of mice. Genetics 137: 837-843.
143. Nag, D.K. and T.D. Petes. 1993. Physical detection of heteroduplexes during meiotic recombination in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 13: 2324-2331.
144. Nag, D.K., H. Scherthan, B. Rockmill, J. Bhargava, and G.S. Roeder. 1995. Heteroduplex DNA formation and homolog pairing in yeast meiotic mutants. Genetics 141: 75-86.
145. Nairz, K. and F. Klein. 1997. mre11S-A yeast mutation that blocks double-strand break processing and permits nonhomologous synapsis in meiosis. Genes &Dev. 11: 2272-2290.
146. Nicklas, R.B. 1974. Chromosome segregation mechanisms. Genetics 78: 205-213.
147. Nicklas, R.B., S.C. Ward, and G.J. Gorbsky. 1995. Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint. J. Cell Biol. 130: 929-939.
148. Ogawa, T., A. Shinohara, A. Navetani, T. Ikeya, X. Yu, E.H. Egelman, and H. Ogawa. 1993a. RecA-like recombination proteins in eukaryotes: Functions and structure of RAD51 genes. Cold Spring Harb. Symp. Quant. Biol. 58: 567-576.
149. Ogawa, T., X. Yu, A. Shinohara, and E.H. Egelman. 1993b. Similarity of the yeast RAD51 filament to the bacterial RecA filament. Science 259: 1896-1899.
150. Ohta, K., T. Shibata, and A. Nicolas. 1994. Changes in chromatin structure at recombination initiation sites during yeast meiosis. EMBO J. 13: 5754-5763.
151. Padmore, R., L. Cao, and N. Kleckner. 1991. Temporal comparison of recombination and synaptonemal complex formation during meiosis in S. cerevisiae. Cell 66: 1239-1256.
152. n and LINE/SINE sequences. Genetics 130: 865-872.
153. Petes, T.D. and P.J. Pukkila. 1995. Meiotic sister chromatid recombination. Adv. Genet. 33:41-62.
154. Petrini, J.H.J., M.E. Walsh, C. Di Mare, J.R. Korenberg, X.-N. Chen, and D.T. Weaver. 1995. Isolation and characterization of the human MRE11 homologue. Genomics 29: 80-86.
155. Porter, S.E., M.A. White, and T.D. Petes. 1993. Genetic evidence that the meiotic recombination hotspot at the HIS4 locus of Saccharomyces cerevisiae does not represent a site for a symmetrically processed double-strand break. Genetics 134:5-19.
156. Prinz, S., A. Amon, and F. Klein. 1997. Isolation of COM1, a new gene required to complete meiotic double-strand break induced recombination in Saccharomyces cerevisiae. Genetics 146: 781-795.
157. Prolla, T.A., D.-M. Christie, and R.M. Liskay. 1994a. Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene. Mol. Cell. Biol. 14:407-415.
158. Prolla, T.A., Q. Pang, E. Alani, R.D. Kolodner, and R.M. Liskay. 1994b. MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast. Science 265: 1091-1093.
159. Pukkila, P.J., C. Skrzyma, and B.C. Lu. 1992. The rad3-1 mutant is defective in axial core assembly and homologous chromosome pairing during meiosis in the basidiomycete Coprinus cinereus. Dev. Genet. 13:403-410.
160. Ramesh, M.A. and M.E. Zolan. 1995. Chromosome dynamics in rad12 mutants of Coprinus cinereus. Chromosoma 104: 189-202.
161. Rappold, G.A. 1993. The pseudoautosomal regions of the human sex chromosomes. Hum. Genet. 92: 315-324.
162. Ren, X.J., L. Eisenhour, C.S. Hong, Y. Lee, and B.D. McKee. 1997. Roles of rDNA spacer and transcription unit-sequences in X-Y meiotic chromosome pairing in Dmsphila melanogaster males. Chromosoma 106: 29-36.
163. Rocco, V. and A. Nicolas. 1996. Sensing of DNA non-homology lowers the initiation of meiotic recombination in yeast. Genes Cells 1: 645-661.
164. Rockmill, B. and G.S. Roeder. 1990. Meiosis in asynaptic yeast. Genetics 126: 563-574.
165. _.1991. A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination. Genes & Dev. 5: 2392-2404.
166. Rockmill, B., J. Engebrecht, H. Scherthan, J. Loidl, and G.S. Roeder. 1995a. The yeast MER2 gene is required for meiotic recombination and chromosome synapsis. Genetics 141: 49-59.
167. Rockmill, B., M. Sym, H. Scherthan, and G. S. Roeder. 1995b. Roles for two RecA homologs in promoting meiotic chromosome synapsis. Genes & Dev. 9: 2684-2695.
168. Ross, L.O., R. Maxfield, and D. Dawson. 1996. Exchanges are not equally able to enhance meiotic chromosome segregation in yeast. Proc. Natl. Acad. Sci. 93: 4979-4983.
169. Ross-Macdonald, P. and G.S. Roeder. 1994. Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction. Cell 79: 1069-1080.
170. Rossignol, J.-L. and G. Faugeron. 1994. Gene inactivation triggered by recognition between DNA repeats. Experientia 50:307-317.
171. Scherthan, H., J. Bahler, and J. Kohli. 1994. Dynamics of chromosome organization and pairing during meiotic prophase in fission yeast. J. Cell Biol. 127: 273-285.
172. Scherthan, H., J. Loidl, T. Schuster, and D. Schweizer. 1992. Meiotic chromosome condensation and pairing in Saccharomyces cerevisiae studied by chromosome painting. Chromosoma 101: 590-595.
173. Scherthan, H., S. Weich, H. Schwegler, C. Heyting, M. Harle, and T. Cremer. 1996. Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing. J. Cell Biol. 134: 1109-1125.
174. Schmekel, K. and B. Daneholt. 1995. The central region of the synaptonemal complex revealed in three dimensions. Trends Cell Biol 5: 239-242.
175. Schmekel, K., R.L.J. Meuwissen, A.J.J. Dietrich, A.C.G. Vink, J. van Marle, H. van Veen, and C. Heyting. 1996. Organization of SCP1 protein molecules within synaptonemal complexes of the rat. Exp. Cell Res. 227: 20-30.
176. Schuchert, P., M. Langsford, E. Kaslin, and J. Kohli. 1991. A specific DNA sequence is required for high frequency of recombination in the ade6 gene of fission yeast. EMBO J. 10:2157-2163.
177. Schwacha, A. and N. Kleckner. 1994. Identification of joint molecules that form frequently between homologs but rarely between sister chromatids during yeast meiosis. Cell 76: 51-63.
178. _. 1995. Identification of double Holliday junctions as intermediates in meiotic recombination. Cell 83: 783-791.
179. _. 1997. Interhomolog bias during meiotic recombination: Meiotic functions promote a highly differentiated interhomolog-only pathway. Cell (in press).
180. Sears, D.D., J.H. Hegemann, and P. Hieter. 1992. Meiotic recombination and segregation of human-derived artificial chromosomes in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 89: 5296-5300.
181. Sharples, G.J. and D.R.F. Leach. 1995. Structural and functional similarities between the SbcCD proteins of Escherichia coli and the Rad50 and Mre11 (Rad32) recombination and repair proteins of yeast. Mol. Microbiol. 17: 1215-1220.
182. +, is required for the formation of meiotic prophasespecific nuclear architecture. Mol. & Gen. Genet. 254: 238-249.
183. Shinohara, A., H. Ogawa, and T. Ogawa. 1992. Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein. Cell 69: 457-470.
184. Shinohara, A., H. Ogawa, Y. Matsuda, N. Ushio, K. Ikeo, and T. Ogawa. 1993. Cloning of human, mouse, and fission yeast recombination genes homologous to RAD51 and recA. Nature Genet. 4: 239-243.
185. Shinohara, M., E. Seta-Yamaguchi, J.-M. Buerstedde, and H. Ogawa. 1997. Characterization of S. cerevisiae mutants in RAD54 and a homolog of RAD54, RDH54/TID1, recombination genes in mitosis and meiosis. Genetics (in press).
186. Smith, A. and R. Benavente. 1992. Identification of a structural protein component of rat synaptonemal complexes. Exp. Cell Res. 198:291-297.
187. Smith, A.V. and G.S. Roeder. 1997. The yeast Red1 protein localizes to the cores of meiotic chromosomes. J. Cell Biol. 136: 957-967.
188. Smithies, O. and P.A. Powers. 1986. Gene conversions and their relation to homologous chromosome pairing. Phil. Trans. R. Soc. Land. B 312: 291-302.
189. Stack, S.M. and D. Soulliere. 1984. Rhoea spathacea. I. The relationship between synapsis and chiasma formation. Chromosoma 90: 72-83.
190. Stassen, N.Y., J.M. Logsdon, Jr., G.J. Vora, H.H. Offenberg, J.D. Palmer, and M.E. Zolan. 1997. Isolation and characterization of rad51 orthologs from Coprinus cinereus and Lycopersicon esculentum, and phylogenetic analysis of eukaryotic recA homologs. Curr. Genet. 31: 144-157.
191. Storlazzi, A., L. Xu, L. Cao, and N. Kleckner. 1995. Crossover and noncrossover recombination during meiosis: Timing and pathway relationships. Proc. Natl. Acad. Sci. 92: 8512-8516.
192. Storlazzi, A., L. Xu, A. Schwacha, and N. Kleckner. 1996. Synaptonemal complex (SC) component Zip1 plays a role in meiotic recombination independent of SC polymerization along the chromosomes. Proc. Natl. Acad. Sci. 93: 9043-9048.
193. Sturzbecher, H.-W., B. Donzelmann, W. Henning, U. Knippschild, and S. Buchhop. 1992. p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. EMBO J. 15: 1992-2002.
194. Suja, J.A., C. Antonio, and J.S. Rufas. 1992. Involvement of chromatid cohesiveness at the centromere and chromosome arms in meiotic chromosome segregation: A cytological approach. Chromosoma 101:493-501.
195. Sun, H., D. Treco, N.P. Schultes, and J.W. Szostak. 1989. Double-strand breaks at an initiation site for meiotic gene conversion. Nature 338: 87-90.
196. Sun, H., D. Treco, and J.W. Szostak. 1991. Extensive 3′-overhanging, single-stranded DNA associated with the meiosisspecific double-strand breaks at the ARG4 recombination initiation site. Cell 64: 1155-1161.
197. Sung, P. 1994. Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein. Science 265: 1241-1243.
198. _. 1997. Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase. Genes &. Dev. 11: 1111-1121.
199. Svoboda, A., J. Bahler, and J. Kohli. 1995. Microtubule-driven nuclear movements and linear elements as meiosis-specific characteristics of the fission yeasts Schizosaccharomyces versatilis and Schizosaccharomyces pombe. Chromosoma 104:203-214.
200. Sym, M. and G.S. Roeder. 1994. Crossover interference is abolished in the absence of a synaptonemal complex protein. Cell 79: 283-292.
201. _. 1995. Zip1-induced changes in synaptonemal complex structure and polycomplex assembly. J. Cell Biol. 128: 455-466.
202. Sym, M., J. Engebrecht, and G.S. Roeder. 1993. ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis. Cell 72:365-378.
203. Szostak, F.W., T.L. Orr-Weaver, R.J. Rothstein, and F.W. Stahl. 1983. The double-strand-break repair model for recombination. Cell 33: 25-35.
204. Tarsounas, M., R.E. Pearlman, P.J. Gasser, M.S. Park, and P.B. Moens. 1997. Protein-protein interactions in the synaptonemal complex. Mol. Biol. Cell (in press).
205. Tavassoli, M., M. Shayeghi, A. Nasium, and F.Z. Watts. 1995. Cloning and characterization of the Schizosaccharomyces pombe rad32 gene: A gene required for repair of doublestrand breaks and recombination. Nucleic Acids Res. 23: 383-388.
206. Terasawa, M., A. Shinohara, Y. Hotta, H. Ogawa, and T. Ogawa. 1995. Localization of RecA-like recombination proteins on chromosomes of the lily at various meiotic stages. Genes & Dev. 9: 925-934.
207. Theurkauf, W.E. and R.S. Hawley. 1992. Meiotic spindle assembly in Drosophila females: Behavior of nonexchange chromosomes and the effects of mutations in the nod kinesinlike protein. J. Cell Biol. 116: 1167-1180.
208. Tishkoff, D.X., A.L. Boerger, P. Bertrand, N. Filosi, G.M. Gaida, M.F. Kane, and R.D. Kolodner. 1997. Identification and characterization of Saccharomyces cerevisiae EX01, a gene encoding an exonuclease that interacts with MSH2. Proc. Natl. Acad. Sci. 94: 7487-7492.
209. Tu, J., W. Song, and M. Carlson. 1996. Protein phosphatase type 1 interacts with proteins required for meiosis and other cellular processes in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:4199-4206.
210. Vazquez Nin, G.H., E. Flores, O.M. Echerverria, H. Merkert, R. Wettstein, and R. Benavente. 1993. Immunocytochemical localization of DNA in synaptonemal complexes of rat and mouse spermatocytes, and of chick oocytes. Chromosoma 102: 457-463.
211. Villeneuve, A.M. 1994. A cis-acting locus that promotes crossing over between X chromosomes in Caenorhabditis elegans. Genetics 136: 887-902.
212. Vincent, J.E. and G.H. Jones. 1993. Meiosis in autopolyploid Crepis capillaris. Chromosoma 102: 195-206.
213. von Wettstein, D., S.W. Rasmussen, and P. B. Holm. 1984. The synaptonemal complex in genetic segregation. Annu. Rev. Genet. 18:331-413.
214. Wagstaff, J.E., S. Klapholz, C.S. Waddell, L. Jensen, and R.E. Esposito. 1985. Meiotic exchange within and between chromosomes requires a common rec function in Saccharomyces cerevisiae. Mol. Cell. Biol. 5: 3532-3544.
215. Wahls, W.P. and G.R. Smith. 1994. A heterodimeric protein that binds to a meiotic homologous recombination hot spot: Correlation of binding and hot spot activity. Genes & Dev. 8: 1693-1702.
216. Wallace, B.M.N. and M.A. Hulten. 1985. Meiotic chromosome pairing in the normal human female. Ann. Hum. Genet. 49:215-226.
217. Wandall, A. and A. Svendsen. 1985. Transition from somatic to meiotic pairing and progressional changes of the synaptonemal complex in spermatocytes of Andes aegypti. Chromosoma 92: 254-264.
218. Weiner, B.M. and N. Kleckner. 1994. Chromosome pairing via multiple interstitial interactions before and during meiosis in yeast. Cell 77: 977-991.
219. West, S.C. 1992. Enzymes and molecular mechanisms of genetic recombination. Annu. Rev. Biochem. 61: 603-640.
220. White, M.A., P. Detloff, M. Strand, and T.D. Petes. 1992. A promoter deletion reduces the rate of mitotic, but not meiotic, recombination at the HIS4 locus in yeast. Curr. Genet. 21: 109-116.
221. Wu, T.-C. and M. Lichten. 1994. Meiosis-induced double-strand break sites determined by yeast chromatin structure. Science 263:515-518.
222. _. 1995. Factors that affect the location and frequency of meiosis-induced double-strand breaks in Saccharomyces cerevisiae. Genetics 140: 55-66.
223. Xu, F. and T.D. Petes. 1996. Fine-structure mapping of meiosisspecific double-strand DNA breaks at a recombination hotspot associated with an insertion of telomeric sequences upstream of the HIS4 locus in yeast. Genetics 143: 1115-1125.
224. Xu, L. and N. Kleckner. 1995. Sequence non-specific double-strand breaks and interhomolog interactions prior to double-strand break formation at a meiotic recombination hot spot in yeast. EMBO J. 14: 5115-5128.
225. Xu, Y., T. Ashley, E.E. Brainerd, R.T. Bronson, M.S. Meyn, and D. Baltimore. 1996. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes & Dev. 10:2411-2422.
226. Xu, L., B.M. Weiner, and N. Kleckner. 1997. Meiotic cells monitor the status of the interhomolog recombination complex. Genes & Dev. 11: 106-118.
227. Zahn-Zabal, M., E. Lehmann, and J. Kohli. 1995. Hotspots of recombination in fission yeast: Inactivation of the M26 hotspot by deletion of the ade6 promoter, and the novel hotspot ura3-aim. Genetics 140: 469-478.
228. Zetka, M. and A. Rose. 1995a. The genetics of meiosis in Caenorhabditis elegans. Trends Genet. 11:27-31.
229. _. 1995b. Mutant rec-1 eliminates the meiotic pattern of crossing over in Caenorhabditis elegans. Genetics 141: 1339-1349.
230. Zhang, P., B.A. Knowles, L.S.B. Goldstein, and R.S. Hawley. 1990. A kinesin-like protein required for distributive chromosome segregation in Drosophila. Cell 62: 1053-1062.
231. Zickler, D. 1977. Development of the synaptonemal complex and the "recombination nodules" during meiotic prophase in the seven bivalents of the fungus Sordaria macrospora auersw. Chromosoma 61: 289-316.
232. Zickler, D., P.J.F. Moreau, A.D. Huynh, and A. Slezec. 1992. Correlation between pairing sites, recombination nodules and meiotic recombination in Sordaria macrospora. Genetics 132: 135-148.