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Mouse A-myb encodes a trans-activator and is expressed in mitotically active cells of the developing central nervous system, adult testis and B lymphocytes
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0025821494
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A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
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0030948537
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Arrest of spermatogenesis and defective breast development in mice lacking A-myb
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of special interest. Demonstration that A-myb plays a critical role in spermatogenesis and mammary gland development. Spermatogenesis is blocked at the early pachytene stage. During pregnancy, hormone-induced ductal proliferation and morphogenesis in mammary glands does not occur.
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Toscani A, Mettus R, Coupland R, Simpkins H, Litvin J, Orth J, Hatton K, Reddy E. Arrest of spermatogenesis and defective breast development in mice lacking A-myb. of special interest Nature. 386:1997;713-717 Demonstration that A-myb plays a critical role in spermatogenesis and mammary gland development. Spermatogenesis is blocked at the early pachytene stage. During pregnancy, hormone-induced ductal proliferation and morphogenesis in mammary glands does not occur.
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Nature
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Toscani, A.1
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Coupland, R.3
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Litvin, J.5
Orth, J.6
Hatton, K.7
Reddy, E.8
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Characterization and cell cycle-regulated expression of mouse B-myb
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Watson, R.3
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15
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0030988084
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1-to-S phase transition and cooperates with c-myc to mediate progression to S phase
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of special interest. The only demonstration that Myb proteins can drive resting cells into cycle. No cell death associated with c-Myc microinjection; suggests c-Myc and Mybs act respectively as competence and progression factors.
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1-to-S phase transition and cooperates with c-myc to mediate progression to S phase. of special interest Mol Cell Biol. 17:1997;2448-2457 The only demonstration that Myb proteins can drive resting cells into cycle. No cell death associated with c-Myc microinjection; suggests c-Myc and Mybs act respectively as competence and progression factors.
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Mol Cell Biol
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Marhamati, D.1
Bellas, R.2
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Sonenshein, G.5
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Bender, T.P.1
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1 progression and c-myb progression. Science. 233:1986;203-206.
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An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription
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Lam E, Watson R. An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription. EMBO J. 12:1993;2705-2713.
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Lam E, Morris J, Davies R, Crook T, Watson R, Vousden K. HPV16 E7 oncoprotein deregulates B-myb expression: correlation with targeting of p107/E2F complexes. EMBO J. 13:1994;871-878.
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Lam, E.1
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0029781223
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E2F binding is required but not sufficient for repression of B-myb transcription in quiescent fibroblasts
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Bennett J, Farlie P, Watson R. E2F binding is required but not sufficient for repression of B-myb transcription in quiescent fibroblasts. Oncogene. 13:1996;1073-1082.
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Bennett, J.1
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Watson, R.3
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24
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Cell cycle-regulated repression of B-myb transcription: Cooperation of an E2F site with a contiguous corepressor element
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Liu N, Lucibello F, Zwicker J, Engeland K, Muller R. Cell cycle-regulated repression of B-myb transcription: cooperation of an E2F site with a contiguous corepressor element. Nucleic Acids Res. 24:1996;2905-2910.
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Liu, N.1
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Muller, R.5
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25
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15444353328
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PRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes
-
of outstanding interest. Analysis of 21 E2F target genes in mice lacking Rb or both p107 and p130. B-myb expression is unchanged in the former but is constitutive in the latter. Demonstrates unequivocally that the data gathered in vitro and in transfection experiments are completely correct!
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Hurford RK, Cobrinik D, Lee M-H, Dyson N. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. of outstanding interest Genes Dev. 11:1997;1447-1463 Analysis of 21 E2F target genes in mice lacking Rb or both p107 and p130. B-myb expression is unchanged in the former but is constitutive in the latter. Demonstrates unequivocally that the data gathered in vitro and in transfection experiments are completely correct!
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Genes Dev
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Hurford, R.K.1
Cobrinik, D.2
Lee M-H3
Dyson, N.4
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26
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0030801039
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Regulatory domains of the A-Myb transcription factor and its interaction with the CBP/p300 adaptor molecules
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Facchinetti V, Loffarelli L, Schreek S, Oelgeschlager M, Luscher B, Introna M, Golay J. Regulatory domains of the A-Myb transcription factor and its interaction with the CBP/p300 adaptor molecules. Biochem J. 324:(3):1997;729-736.
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Luscher, B.5
Introna, M.6
Golay, J.7
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27
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0030919599
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B-Myb function can be markedly enhanced by cyclin A-dependent kinase and protein truncation
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of outstanding interest. This and the following paper [28] lay to rest past controversy as to whether B-Myb activates transcription or not. Both papers show that the B-Myb transcription activation domain can be unmasked by losing the protein's carboxyl terminus, or by phosphorylating it.
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Lane S, Farlie P, Watson R. B-Myb function can be markedly enhanced by cyclin A-dependent kinase and protein truncation. of outstanding interest Oncogene. 14:1997;2445-2453 This and the following paper [28] lay to rest past controversy as to whether B-Myb activates transcription or not. Both papers show that the B-Myb transcription activation domain can be unmasked by losing the protein's carboxyl terminus, or by phosphorylating it.
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Oncogene
, vol.14
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Lane, S.1
Farlie, P.2
Watson, R.3
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28
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0031128118
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Phosphorylation and activation of B-Myb by cyclin A-Cdk2
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of outstanding interest. See annotation [27].
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Ziebold U, Bartsch O, Marais R, Ferrari S, Klempnauer K. Phosphorylation and activation of B-Myb by cyclin A-Cdk2. of outstanding interest Curr Biol. 7:1997;253-260 See annotation [27].
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Curr Biol
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Ziebold, U.1
Bartsch, O.2
Marais, R.3
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Klempnauer, K.5
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29
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0030769239
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Linking Myb to the cell cycle; Cyclin-dependent phosphorylation and regulation of A-Myb activity
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1/S, giving further support to the idea that all Myb proteins are tightly regulated during the cell cycle.
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1/S, giving further support to the idea that all Myb proteins are tightly regulated during the cell cycle.
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Ziebold, U.1
Klempnauer K-H2
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30
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Activation of human B-MYB by cyclins
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Sala A, Kundu M, Casella I, Engelhard A, Calabretta B, Grasso L, Paggi M, Giordano A, Watson R, Khalili K, Peschle C. Activation of human B-MYB by cyclins. Proc Natl Acad Sci USA. 94:1997;532-536.
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Sala, A.1
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Calabretta, B.5
Grasso, L.6
Paggi, M.7
Giordano, A.8
Watson, R.9
Khalili, K.10
Peschle, C.11
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31
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0029076963
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Modulation of c-Myb-induced transcription activation by a phosphorylation site near the negative regulatory domain
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Aziz N, Miglarese M, Hendrickson R, Shabanowitz J, Sturgill T, Hunt D, Bender T. Modulation of c-Myb-induced transcription activation by a phosphorylation site near the negative regulatory domain. Proc Natl Acad Sci USA. 92:1995;6429-6433.
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Aziz, N.1
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Taylor SJ, Shalloway D. Cell-cycle-dependent activation of Ras. Curr Biol. 6:1996;1621-1627.
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Oncogenic activation of c-Myb by carboxyl-terminal truncation leads to decreased proteolysis by the ubiquitin-26S proteasome pathway
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Bies J, Wolff L. Oncogenic activation of c-Myb by carboxyl-terminal truncation leads to decreased proteolysis by the ubiquitin-26S proteasome pathway. Oncogene. 14:1997;203-212.
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Oncogene
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Bies, J.1
Wolff, L.2
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34
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0030012002
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CBP as a transcriptional coactivator of c-Myb
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of special interest. This paper and the next [35] were the first to show that c-Myb could interact directly with another protein involved in transcription, and that this modulated the activity of c-Myb.
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Dai P, Akimaru H, Tanaka Y, Hou D-X, Yasukawa T, Kanei-Ishii C, Takahashi T, Ishii S. CBP as a transcriptional coactivator of c-Myb. of special interest Genes Dev. 10:1996;528-540 This paper and the next [35] were the first to show that c-Myb could interact directly with another protein involved in transcription, and that this modulated the activity of c-Myb.
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(1996)
Genes Dev
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Dai, P.1
Akimaru, H.2
Tanaka, Y.3
Hou D-X4
Yasukawa, T.5
Kanei-Ishii, C.6
Takahashi, T.7
Ishii, S.8
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35
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0029886810
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Interaction of the co-activator CBP with Myb proteins: Effects on Myb-specific transactivation and on the cooperativity with NF-M
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of special interest. See annotation [34].
-
Oelgeschlager M, Janknecht R, Krieg J, Schreek S, Luscher B. Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M. of special interest EMBO J. 15:1996;2771-2780 See annotation [34].
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EMBO J
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Oelgeschlager, M.1
Janknecht, R.2
Krieg, J.3
Schreek, S.4
Luscher, B.5
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36
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0029786902
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The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb
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of outstanding interest. First demonstration of a protein interaction with the c-Myb negative regulatory domain which might affect c-Myb's activity. These observations may be the key to one aspect of c-Myb regulation.
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Dash A, Orrico F, Ness S. The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb. of outstanding interest Genes Dev. 10:1996;1858-1869 First demonstration of a protein interaction with the c-Myb negative regulatory domain which might affect c-Myb's activity. These observations may be the key to one aspect of c-Myb regulation.
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Genes Dev
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Dash, A.1
Orrico, F.2
Ness, S.3
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37
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Biophysical characterization of the c-Myb DNA-binding domain
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Ebneth A, Schweers O, Thole H, Fagin U, Urbanke C, Maass G, Wolfes H. Biophysical characterization of the c-Myb DNA-binding domain. Biochemistry. 33:1994;14586-14593.
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Ebneth, A.1
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FAETL motif required for leukemic transformation by v-Myb
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Fu S, Lipsick J. FAETL motif required for leukemic transformation by v-Myb. J Virol. 70:1996;5600-5610.
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Lipsick, J.2
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0026598268
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Kanei-Ishii C, MacMillan EM, Nomura T, Sarai A, Ramsay RG, Aimoto S, Ishii S, Gonda TJ. Transactivation and transformation by Myb are negatively regulated by a leucine-zipper structure. Proc Nat Acad Sci USA. 89:1992;3088-3092.
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Kanei-Ishii, C.1
MacMillan, E.M.2
Nomura, T.3
Sarai, A.4
Ramsay, R.G.5
Aimoto, S.6
Ishii, S.7
Gonda, T.J.8
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40
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0027426095
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Negative autoregulation of c-Myb activity by homodimer formation through the leucine zipper
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Nomura T, Sakai N, Sarai A, Sudo T, Kanei-Ishii C, Ramsay RG, Favier D, Gonda TJ, Ishii S. Negative autoregulation of c-Myb activity by homodimer formation through the leucine zipper. J Biol Chem. 268:1993;21914-21923.
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Nomura, T.1
Sakai, N.2
Sarai, A.3
Sudo, T.4
Kanei-Ishii, C.5
Ramsay, R.G.6
Favier, D.7
Gonda, T.J.8
Ishii, S.9
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41
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0028054699
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Detection of proteins that bind to the leucine zipper motif of c-Myb
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Favier D, Gonda TJ. Detection of proteins that bind to the leucine zipper motif of c-Myb. Oncogene. 9:1994;305-311.
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Oncogene
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Favier, D.1
Gonda, T.J.2
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0029001621
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The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism
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Burgess TL, Fisher EF, Ross SL, Bready JV, Qian YX, Bayewitch LA, Cohen AM, Herrera CJ, Hu SS, Kramer TB, et al. The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism. Proc Natl Acad Sci USA. 92:1995;4051-4055.
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Burgess, T.L.1
Fisher, E.F.2
Ross, S.L.3
Bready, J.V.4
Qian, Y.X.5
Bayewitch, L.A.6
Cohen, A.M.7
Herrera, C.J.8
Hu, S.S.9
Kramer, T.B.10
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43
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0029959522
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Inhibition of vascular smooth muscle cell proliferation by ribozymes that cleave c-myb mRNA
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of special interest. An interesting and well-controlled study suggesting an efficient and potentially very powerful method for inhibiting Myb activity. Nuclease-resistant ribozymes were constructed which specifically inhibited c-Myb mRNA production. The ribozymes were more active and exhibited fewer non-specific effects than did comparable antisense oligonucleotides.
-
Jarvis T, Alby L, Beaudry A, Wincott F, Beigelman L, McSwiggen J, Usman N, Stinchcomb D. Inhibition of vascular smooth muscle cell proliferation by ribozymes that cleave c-myb mRNA. of special interest RNA. 2:1996;419-428 An interesting and well-controlled study suggesting an efficient and potentially very powerful method for inhibiting Myb activity. Nuclease-resistant ribozymes were constructed which specifically inhibited c-Myb mRNA production. The ribozymes were more active and exhibited fewer non-specific effects than did comparable antisense oligonucleotides.
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RNA
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Jarvis, T.1
Alby, L.2
Beaudry, A.3
Wincott, F.4
Beigelman, L.5
McSwiggen, J.6
Usman, N.7
Stinchcomb, D.8
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45
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0029924478
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B-myb promotes S phase and is a downstream target of the negative regulator p107 in human cells
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