Relationship of sequence-specific transactivation and p53-regulated apoptosis in interleukin 3-dependent hematopoietic cells

Cell Growth and Differentiation

Volumn 7, Issue 3, 1996, Pages 301-310

  Gottlieb, Eyal ^a   Lindner, Serge ^a   Oren, Moshe ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 3; PROTEIN P53; TRANSCRIPTION FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE ACTIVATION; GENETIC TRANSCRIPTION; HEMATOPOIETIC CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSACTIVATION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA, NEOPLASM; G1 PHASE; GENE EXPRESSION; INTERLEUKIN-3; LYMPHOCYTES; LYMPHOMA; MICE; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIATION, IONIZING; RNA, MESSENGER; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0029823623     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (80)

1. Oren, M. Relationship of p53 to the control of apoptotic cell death. Semin. Cancer Biol., 5: 221-227, 1994.
2. Lee, J. M., and Bernstein, A Apoptosis, cancer and the p53 tumor suppressor gene. Cancer Metastasis Rev., 14: 149-161, 1995.
3. Levine, A. J. The tumor suppressor genes. Ann. Rev. Biochem., 62: 623-651, 1993.
4. Haffner, R., and Oren, M. Biochemical properties and biological effects of p53. Curr. Opin. Genet. Dev., 5: 84-90, 1995.
5. Crook, T., Marston, N. J., Sara, E. A., and Vousden, K. H. Transcriptional activation by p53 correlates with suppression of growth but not transformation. Cell, 79: 817-827, 1994.
6. Ory, K , Legros, Y , Auguin, C., and Soussi, T. Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation. EMBO J., 13: 3496-3504, 1994.
7. Pietenpol, J. A., Tokino, T., Thiagalingam, S., El-Deiry, W. S., Kinzler, K. W , and Vogelstein, B Sequence-specific transcriptional activation is essential for growth suppression by p53. Proc. Natl. Acad. Sci. USA, 91: 1998-2002, 1994.
8. Cip1/Waf1 proteins following γ-irradiation of human lymphoma cells. Cancer Res., 55: 2387-2393, 1995.
9. Weinberg, W. C., Azzoli, C. G., Chapman, K., Levine, A. J., and Yuspa, S. H p53-mediated transcriptional activity increases in differentiating epidermal keratinocytes in association with decreased p53 protein. Oncogene, 10: 2271-2279, 1995.
10. Caelles, C., Helmberg, A., and Kann, M. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature (Lond.), 370: 220-223, 1994.
11. 1 arrest and apoptosis. Cancer Res., 54: 1169-1174, 1994.
12. Shen, Y. Q., and Shenk, T. Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular bcl-2 protein. Proc. Natl. Acad. Sci. USA, 91: 8940-8944, 1994.
13. Waf1/Cip1. Genes & Dev., 8: 2817-2830, 1994.
14. Haupt, Y., Rowan, S., Shaulian, E., Vousden, K. H., and Oren, M. Induction of apoptosis in HeLa cells by trans-activation deficient p53. Genes & Dev., 9: 2170-2183, 1995.
15. Ishioka, C., Englert, C., Winge, P., Yan, Y. X., Engelstein, M., and Friend, S. H. Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo. Oncogene, 10: 1485-1492, 1995.
16. Sabbatini, P., Chiou, S. K., Rao, L., and White, E. Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein. Mol. Cell. Biol., 15: 1060-1070, 1995.
17. Sabbatini, P., Lin, J., Levine, A. J., and White, E. Essential role for p53-mediated transcription in E1A-induced apoptosis. Genes & Dev., 9: 2184-2192, 1995.
18. Gottlieb, E., Haffner, R., Von Ruden, T., Wagner, E. F., and Oren, M. Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal. EMBO J., 13: 1368-1374, 1994
19. Gottlieb, E., Haffner, R., Yonish-Rouach, E , Von Ruden, T., Wagner, E. F., and Oren, M. Wild-type p53 activity contributes to dependence on hematopoietic survival factors. In. E. Mihich and R. T. Schimke (eds.), Apoptosis, pp. 31-41. New York: Plenum Publishing Corp., 1994
20. Lotem, J., and Sachs, L. Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents. Blood, 82: 1092-1096, 1993.
21. Zhu, Y. M., Bradbury, D. A., and Russell, N. H. Wild-type p53 is required for apoptosis induced by growth factor deprivation in factor-dependent leukaemic cells. Br. J. Cancer, 69: 468-472, 1994.
22. Blandino, G , Scardigli, R., Rizzo, M. G., Crescenzi, M., Soddu, S., and Sacchi, A. Wild-type p53 modulates apoptosis of normal, IL-3 deprived hematopoietic cells. Oncogene, 10: 731-737, 1995.
23. Canman, C E., Gilmer, T. M., Coutts, S. B., and Kastan, M. B. Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes & Dev., 9: 600-611, 1995.
24. Qin, X. Q., Livingston, D. M., Kaelin, W. G., and Adams, P. D. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA, 91: 10918-10922, 1994.
25. Wu, X. W., and Levine, A. J. p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl. Acad. Sci. USA, 91: 3602-3606, 1994.
26. Haupt, Y., Rowan, S., and Oren, M. p53-mediated apoptosis in HeLa cells can be overcome by excess pRB. Oncogene, 10: 1563-1571, 1995.
27. Ihle, J N. Biochemical and biological properties of interteukin-3: a lymphokine mediating the differentiation of lineage of cells that includes prothymocytes and mastlike cells. Contemp. Topics Mol. Immunol., 10: 93-119, 1984.
28. Michalovitz, D., Halevy, O., and Oren, M. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell, 62: 671-680, 1990.
29. Shaulian, E., Zauberman, A., Ginsberg, D., and Oren, M. Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding. Mol. Cell Biol., 12: 5581-5592, 1992.
30. Maltzman, W., and Czyzyk, L. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol. Cell. Biol., 4: 1689-1694, 1984.
31. Kastan, M. B., Onyekwere, O , Sidransky, D., Vogelstein, B., and Craig, R W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res., 51: 6304-6311, 1991.
32. Kuerbitz, S. J., Plunkett, B. S., Walsh, W. V., and Kastan, M. B. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA, 89: 7491-7495, 1992.
33. Fritsche, M., Haessler, C., and Brandner, G. Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene, 8: 307-318, 1993.
34. Lu, X., and Lane, D. P. Differential induction of transcriptionally active p53 following UV or ionizing radiation - defects in chromosome instability syndromes? Cell, 75: 765-778, 1993.
35. Zhan, Q. M., Bae, I., Kastan, M. B., and Fomace, A. J. The p53-dependent γ-ray response of GADD45. Cancer Res., 54: 2755-2760, 1994.
36. Zhan, Q. M., Fan, S. J., Bae, I., Guillouf, C., Liebermann, D. A., O'Connor, P. M., and Fornace, A. J. Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis Oncogene, 9: 3743-3751, 1994.
37. Zhan, Q. M., El-Deiry, W., Bae, I., Alamo, I., Kastan, M B., Vogelstein, B., and Fornace, A. J. Similarity of the DMA-damage responsiveness and growth-suppressive properties of WAF1/CIP1 and GADD45. Int. J. Oncol., 6. 937-946, 1995.
38. Kern, S. E., Kinzler, K. W., Bruskin, A., Jarosz, D., Friedman, P., Prives, C., and Vogelstein, B. Identification of p53 as a sequence-specific DNA-binding protein. Science (Washington DC), 252: 1708-1711, 1991.
39. Juven, T., Barak, Y., Zauberman, A., George, D. L., and Oren, M. Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene, 8: 3411-3416, 1993.
40. El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E , Kinzler, K. W., and Vogelstein, B. WAF1, a potential mediator of p53 tumor suppression. Cell, 75: 817-825, 1993.
41. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K., and Elledge, S. J. The p21 CDK-interacting protein cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 75: 805-816, 1993
42. Xiong, Y., Zhang, H., and Beach, D. Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes & Dev., 7: 1572-1583, 1993.
43. Miyashita, T., Krajewski, S., Krajewska, M., Wang, H. G., Lin, H. K., Liebermann, D. A., Huffman, B., and Reed, J. C. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene, 9: 1799-1805, 1994.
44. Selvakumaran, M., Lin, H. K., Miyashita, T., Wang, H. G., Krajewski, S., Reed, J. C , Hoffman, B., and Liebermann, D. Immediate early up-regulation of bax expression by p53 but not TGF β1: a paradigm for distinct apoptotic pathways. Oncogene, 9: 1791-1798, 1994.
45. Miyashita, T., and Reed, J. C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell, 80: 293-299, 1995.
46. Oltvai, Z. N., Milliman, C. L., and Krosmeyer, S. J. Bcl-2 hetrodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell, 74: 609-619, 1993.
47. Apte, S. S., Mattei, M-G., and Olsen, B. R. Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAXδ. Genomics, 26: 592-594, 1995.
48. 1 arrest. Mol Cell Biol., 15: 6045-6054, 1995.
49. Askew, D. S., Ashmun, R. A., Simmons, B. C., and Cleveland, J. L. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene, 6: 1915-1922, 1991.
50. Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., and Wyllie, A. H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature (Lond.), 362: 849-852, 1993
51. Lowe, S W., Schmitt, E. M., Smith, S. W., Osborne, B. A., and Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (Lond.), 362. 847-849, 1993.
52. Collins, M. K L., Marvel, J., Malde, P., and Lopez-Rivas, A. Interleukin-3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents J. Exp. Med., 176: 1043-1051, 1992.
53. Maheswaran, S., Englert, C , Bennett, P., Heinrich, G., and Haber, D. A. The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis. Genes & Dev., 9: 2143-2156, 1995.
54. Yonish-Rouach, E , Resnitzky, D , Lotem, J., Sachs, L., Kimchi, A., and Oren, M. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature (Lond.), 352: 345-347, 1991
55. Shaw, P., Bovey, R , Tardy, S., Sahli, R., Sordat, B., and Costa, J. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl. Acad. Sci. USA, 89: 4495-4499, 1992
56. Johnson, P., Chung, S., and Benchimol, S. Growth suppression of Friend virus-transformed erythroleukemia cells by p53 protein is accompanied by hemoglobin production and is sensitive to erythropoietin. Mol. Cell. Biol., 13: 1456-1463, 1993.
57. Ramqvist, T., Magnusson, K. P., Wang, Y. S., Szekely, L , Klein, G., and Wiman, K. G. Wild-type p53 induced apoptosis in a burkitt lymphoma (BL) line that carries mutant p53. Oncogene, 8: 1495-1500, 1993.
58. Ryan, J. J., Danish, R., Gottlieb, C. A., and Clarke, M. F. Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells. Mol. Cell Biol., 13: 711-719, 1993.
59. Wang, Y. S., Szekely, L., Okan, I., Klein, G., and Wiman, K. G. Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma line. Oncogene, 8: 3427-3431, 1993.
60. Yonish-Rouach, E., Borde, J., Gotteland, M., Mishal, Z., Viron, A., and May, E. Induction of apoptosis by transiently transfected metabolically stable wt p53 in transformed cell lines. Cell Death Differ., 1: 39-47, 1994
61. Debbas, M., and White, E. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes & Dev., 7: 546-554, 1993.
62. Lowe, S. W , and Ruley, H. E. Stabilization of the p53 tumor suppressor is induced by adenovirus-5 E1A and accompanies apoptosis. Genes & Dev., 7: 535-545, 1993
63. Hiebert, S. W., Packham, G., Strom, D., Haffner, R., Oren, M., Zambetti, G., and Cleveland, J. L. E2F-1:DP-1 induces p53 and overrides survival factor to trigger apoptosis. Mol Cell. Biol., 15: 6864-6874, 1995
64. Gottlieb, T., and Oren, M. p53 in growth control and neoplasia. Biochim. Biophys. Acta. Rev. Cancer, in press, 1996.
65. CIP1/WAF1 undergo normal development but are defective in G1 checkpoint control. Cell, 82: 675-684, 1995.
66. Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T., and Hannon, G. J. Radiation-induced cell cycle arrest compromised by p21 deficiency Nature (Lond ), 377: 552-557, 1995
67. Sachs, L , and Lotem, J. Control of programmed cell death in normal and leukemic cells: new implications for therapy. Blood, 82: 15-21, 1993.
68. Lane, D. P p53, guardian of the genome. Nature (Lond.), 358. 15-16, 1992.
69. Oren, M. p53: the ultimate tumor suppressor gene. FASEB J., 6. 3169-3176, 1992.
70. Evan, G I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H , Brooks, M., Waters, C. M., Penn, L. Z., and Hancock, D. C. Induction of apoptosis in fibroblasts by c-myc protein. Cell, 69: 119-128, 1992.
71. Howes, K. A., Ransom, L N , Papermaster, D. S., Lasudry, J. G. H., Albert, D. M., and Windle, J. J. Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53. Genes & Dev., 8: 1300-1310, 1994.
72. Pan, H., and Griep, A. E. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes & Dev., 8: 1285-1299, 1994.
73. White, A. E., Livanos, E. M., and Tlsty, T. D. Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins. Genes & Dev., 8: 666-677, 1994.
74. Pan, H., and Griep, A E. Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development. Genes & Dev., 9: 2157-2169, 1995.
75. Yonish-Rouach, E., Grunwald, D., Wilder, S., Kimchi, A., May, E., Lawrence, J. J., May, P., and Oren, M. p53-mediated cell death: relationship to cell cycle control. Mol. Cell. Biol., 13: 1415-1423, 1993.
76. Levy, N., Yonish-Rouach, E., Oren, M., and Kimchi, A. Complementation by wild-type p53 of interleukin-6 effects on M1 cells: induction of cell cycle exit and cooperativity with c-myc suppression. Mol. Cell. Biol., 13. 7942-7952, 1993.
77. Arends, M. J., and Wyllie, A. H. Apoptosis: mechanisms and roles in pathology. Int. Rev. Exp. Pathol., 32: 223-254, 1991.
78. Raff, M. C Social controls on cell survival and cell death. Nature (Lond.), 356: 397-400, 1992
79. 1 arrest and long-term induction of cip1 in normal human fibroblasts. Genes & Dev., 8: 2540-2551, 1994.
80. Karasuyama, H., and Melchers, F. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDIMA expression vectors. Eur. J. Immunol., 18: 97-104, 1988.