p53 in signaling checkpoint arrest or apoptosis

Current Opinion in Genetics and Development

Volumn 6, Issue 1, 1996, Pages 12-18

  Bates, Stewart ^a   Vousden, Karen H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; TRANSCRIPTION FACTOR;

APOPTOSIS; CELL CYCLE; CELL CYCLE G1 PHASE; CELL DEATH; CELL DIVISION; CELL TYPE; DNA DAMAGE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSCRIPTION INITIATION;

EID: 0029670589     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(96)90004-0     Document Type: Article

References (16)

1. Lane DP: p53, guardian of the genome. Nature, 1992, 358:15-16.
2. Dameron KM, Volpert OV, Tainsky MA, Bouck N: Control of anglogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 1994, 265:1582-1584.
3. Aloni-Grinstein R, Schwartz D, Rotter V: Accumulation of wild-type p53 protein upon γ-irradiation induces a 62 arrest-dependent immunoglobulin κlight chain gene expression. EMBO J 1995, 14:1392-1401.
4. Atadja P, Wong H, Garkavtsev I, Veillette C, Riabowol K: increased activity of p53 in senescing fibroblasts. Proc Natl Acad Sci USA 1995, 92:8348-8352.
5. Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M: Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 1991, 353:345-347.
6. Shaw P, Bovey R, Tardy S, Sahli R, Sordat R, Costa J: induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc Natl Acad Sci USA 1992, 89:4495-4499.
7. Hermeking H, Eick D: Mediation of c-myc-induced apoptosis by p53. Science 1994, 265:2091-2093.
8. Lows SW, Schmitt EM, Smith SW, Osborne BA, Jacks T: p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 1993, 362:847-849.
9. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, Wyllie AH: Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 1993, 362:849-852.
10. waf1/cip1. Genes and Dev 1994, 8:2817-2830. These findings [7**,10**] establish a role for p53 in the activation of apoptosis by Myc, one of the most commonly activated oncogenes in human tumorigenesis.
11. Lowe SW, Jacks T, Housman DE, Ruley HE: Abrogation of oncogene-associated apoptosis allows transformation of p53 deficient cells. Proc Natl Acad Sci USA 1994, 91:2026-2030.
12. Symonds H, Krall L, Remington L, Saenzrobles M, Lowe S, Jacks T, Van Dyke T: p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 1994, 78:703-711.
13. Pan HC, Griep AE: Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development Genes Dev 1994, 8:1285-1299.
14. Howes KA, Ransom LN, Papermaster DS, Lasudry JGH, Albert DM, Windle JJ: Apoptosis or retinoblastoma: Alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53. Genes and Dev 1994, 8:1300-1310.
15. Morgenbesser SD, Williams BO, Jacks T, DePinho RA: p53-dependent apoptosis produced by -deficiency in the developing mouse lens. Nature 1994, 371:72-74. These four papers [12**-15**] all use transgenic mice that either express viral proteins or are deficient for the expression of pRB to illustrate the importance of the apoptotic function of p53 in tumour suppression.
16. Kastan MB, Zhan Q, El Deiry W-S, Carrier F, Jacks T, Walsh VW, Plunkett BS, Vogelstein B, Fornace AJ: A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 1992, 71:587-597.