-
1
-
-
0029980043
-
P53 in growth control and neoplasia
-
Gottlieb TM, Oren M. p53 in growth control and neoplasia. Biochim Biophys Acta. 1287:1996;77-102.
-
(1996)
Biochim Biophys Acta
, vol.1287
, pp. 77-102
-
-
Gottlieb, T.M.1
Oren, M.2
-
2
-
-
0029972806
-
P53: Puzzle and paradigm
-
Ko LJ, Prives C. p53: puzzle and paradigm. Genes Dev. 10:1996;1054-1072.
-
(1996)
Genes Dev
, vol.10
, pp. 1054-1072
-
-
Ko, L.J.1
Prives, C.2
-
3
-
-
9244232804
-
Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-tupe p53
-
Forrester K, Ambs S, Lupold SE, Kapust RB, Spillare EA, Weinberg WC, Felley-Bosco E, Wang XW, Geller DA, Tzeng E, et al. Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-tupe p53. Proc Natl Acad Sci USA. 93:1996;2442-2447.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 2442-2447
-
-
Forrester, K.1
Ambs, S.2
Lupold, S.E.3
Kapust, R.B.4
Spillare, E.A.5
Weinberg, W.C.6
Felley-Bosco, E.7
Wang, X.W.8
Geller, D.A.9
Tzeng, E.10
-
4
-
-
0029114967
-
P53 expression is required for thymocyte apoptosis induced by adenosine deaminase deficiency
-
Benveniste P, Cohen A. p53 expression is required for thymocyte apoptosis induced by adenosine deaminase deficiency. Proc Natl Acad Sci USA. 92:1995;8373-8377.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 8373-8377
-
-
Benveniste, P.1
Cohen, A.2
-
5
-
-
0030025773
-
Hypoxia-mediated selection of cells with diminished apoptotic potential insolid tumours
-
of outstanding interest. A demonstration that hypoxia induces p53-dependent apoptosis in transformed cells and, consequently, provides a selective pressure for the expansion of p53-deficient cells during tumourigenesis. This finding helps explain the high number of p53 mutations found in human tumours.
-
Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, Giaccia AJ. Hypoxia-mediated selection of cells with diminished apoptotic potential insolid tumours. of outstanding interest Nature. 379:1996;88-91 A demonstration that hypoxia induces p53-dependent apoptosis in transformed cells and, consequently, provides a selective pressure for the expansion of p53-deficient cells during tumourigenesis. This finding helps explain the high number of p53 mutations found in human tumours.
-
(1996)
Nature
, vol.379
, pp. 88-91
-
-
Graeber, T.G.1
Osmanian, C.2
Jacks, T.3
Housman, D.E.4
Koch, C.J.5
Lowe, S.W.6
Giaccia, A.J.7
-
6
-
-
0029964158
-
1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
-
of outstanding interest. This is the first evidence that p53 can arrest cell growth in response to metabolite deficiency. In contrast to the arrest caused in the same cells by DNA damage, this growth arrest is reversible.
-
1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. of outstanding interest Genes Dev. 10:1996;934-947 This is the first evidence that p53 can arrest cell growth in response to metabolite deficiency. In contrast to the arrest caused in the same cells by DNA damage, this growth arrest is reversible.
-
(1996)
Genes Dev
, vol.10
, pp. 934-947
-
-
Linke, S.P.1
Clarkin, K.C.2
Di Leonardo, A.3
Tsou, A.4
Wahl, G.M.5
-
7
-
-
0029007316
-
Identification of a novel p53 promoter element involved in genotoxic stress-inducible p53 gene expression
-
Sun X, Shimizu H, Yamamoto K-I. Identification of a novel p53 promoter element involved in genotoxic stress-inducible p53 gene expression. Mol Cell Biol. 15:1995;4489-4496.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 4489-4496
-
-
Sun, X.1
Shimizu, H.2
Yamamoto, K.-I.3
-
8
-
-
0029766553
-
Translation regulation of human p53 gene expression
-
Fu L, Minden MD, Benchimol S. Translation regulation of human p53 gene expression. EMBO J. 15:1996;4392-4401.
-
(1996)
EMBO J
, vol.15
, pp. 4392-4401
-
-
Fu, L.1
Minden, M.D.2
Benchimol, S.3
-
9
-
-
0029115918
-
Negative feedback regulation of wild-type p53 biosynthesis
-
Mosner J, Mummenbrauer T, Bauer C, Sczakiel G, Grosse F, Deppert W. Negative feedback regulation of wild-type p53 biosynthesis. EMBO J. 14:1995;4442-4449.
-
(1995)
EMBO J
, vol.14
, pp. 4442-4449
-
-
Mosner, J.1
Mummenbrauer, T.2
Bauer, C.3
Sczakiel, G.4
Grosse, F.5
Deppert, W.6
-
10
-
-
0029919728
-
Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion
-
Knippschild U, Oren M, Deppert W. Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion. Oncogene. 12:1996;1755-1765.
-
(1996)
Oncogene
, vol.12
, pp. 1755-1765
-
-
Knippschild, U.1
Oren, M.2
Deppert, W.3
-
12
-
-
0029078067
-
The carboxy-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity
-
Bayle JH, Elenbaas B, Levine AJ. The carboxy-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity. Proc Natl Acad Sci USA. 92:1995;5729-5733.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5729-5733
-
-
Bayle, J.H.1
Elenbaas, B.2
Levine, A.J.3
-
13
-
-
0028673142
-
Regulating of the cryptic sequence-specific DNA binding function of p53 by protein kinases
-
Hupp TR, Lane DP. Regulating of the cryptic sequence-specific DNA binding function of p53 by protein kinases. Cold Spring Harb Symp Quant Biol. 59:1994;195-206.
-
(1994)
Cold Spring Harb Symp Quant Biol
, vol.59
, pp. 195-206
-
-
Hupp, T.R.1
Lane, D.P.2
-
14
-
-
0028966935
-
Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases
-
Takenaka I, Morin F, Seizinger BR, Kley N. Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases. J Biol Chem. 270:1995;5405-5411.
-
(1995)
J Biol Chem
, vol.270
, pp. 5405-5411
-
-
Takenaka, I.1
Morin, F.2
Seizinger, B.R.3
Kley, N.4
-
15
-
-
0030071548
-
Regulation of specific DNA binding by p53: Evidence for a role for O-glycosylation and charged residues at the carboxy-terminus
-
Shaw P, Freeman J, Bovey R, Iggo R. Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus. Oncogene. 12:1996;921-930.
-
(1996)
Oncogene
, vol.12
, pp. 921-930
-
-
Shaw, P.1
Freeman, J.2
Bovey, R.3
Iggo, R.4
-
16
-
-
0028845158
-
Small peptides activate the latent sequence-specific DNA binding function of p53
-
of outstanding interest. Latent forms of p53 can be activated artificially by peptides which bind the carboxy-terminal regulatory domain. This work suggests the potential for rescuing p53 function when upstream signaling pathway are defective.
-
Hupp TR, Sparks A, Lane DP. Small peptides activate the latent sequence-specific DNA binding function of p53. of outstanding interest Cell. 83:1995;237-245 Latent forms of p53 can be activated artificially by peptides which bind the carboxy-terminal regulatory domain. This work suggests the potential for rescuing p53 function when upstream signaling pathway are defective.
-
(1995)
Cell
, vol.83
, pp. 237-245
-
-
Hupp, T.R.1
Sparks, A.2
Lane, D.P.3
-
17
-
-
0029013273
-
P53 and its 14kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
-
of special interest. p53 is shown to recognize sites of damaged DNA directly through the binding of its carboxy-terminal domain. See also annotation [20].
-
Lee S, Elenbaas B, Levine A, Griffith J. p53 and its 14kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches. of special interest Cell. 81:1995;1013-1020 p53 is shown to recognize sites of damaged DNA directly through the binding of its carboxy-terminal domain. See also annotation [20].
-
(1995)
Cell
, vol.81
, pp. 1013-1020
-
-
Lee, S.1
Elenbaas, B.2
Levine, A.3
Griffith, J.4
-
18
-
-
0028862982
-
The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation
-
Reed M, Woelker B, Wang P, Wang Y, Anderson ME, Tegtmeyer P. The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation. Proc Natl Acad Sci USA. 92:1995;9455-9459.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9455-9459
-
-
Reed, M.1
Woelker, B.2
Wang, P.3
Wang, Y.4
Anderson, M.E.5
Tegtmeyer, P.6
-
19
-
-
0028987037
-
P53 binds single stranded DNA through the C-terminal domain and internal segments via the middle domain
-
Bakalkin G, Selivanova G, Yakelova T, Kiseleva E, Kashuba E, Magnussen KP, Szekely L, Klein G, Terenius L, Wiman KG. p53 binds single stranded DNA through the C-terminal domain and internal segments via the middle domain. Nucleic Acids Res. 23:1995;362-369.
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 362-369
-
-
Bakalkin, G.1
Selivanova, G.2
Yakelova, T.3
Kiseleva, E.4
Kashuba, E.5
Magnussen, K.P.6
Szekely, L.7
Klein, G.8
Terenius, L.9
Wiman, K.G.10
-
20
-
-
0029055808
-
Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus
-
of special interest. DNA damage - in the form of short single DNA strands - is shown to activate p53 through the binding of its carboxy-terminal regulatory domain. In conjunction with [17] and with subsequent reports [18,19], this study prompts the interesting possibility that p53 is directly involved in the primary recognition of DNA damage and that such recognition results in biochemical activation of p53.
-
Jayaraman L, Prives C. Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus. of special interest Cell. 81:1995;1021-1029 DNA damage - in the form of short single DNA strands - is shown to activate p53 through the binding of its carboxy-terminal regulatory domain. In conjunction with [17] and with subsequent reports [18,19], this study prompts the interesting possibility that p53 is directly involved in the primary recognition of DNA damage and that such recognition results in biochemical activation of p53.
-
(1995)
Cell
, vol.81
, pp. 1021-1029
-
-
Jayaraman, L.1
Prives, C.2
-
21
-
-
0029003061
-
1 cyclin-dependent kinases
-
2/M cell cycle phases is therefore suggested.
-
2/M cell cycle phases is therefore suggested.
-
(1995)
Nature
, vol.376
, pp. 88-91
-
-
Wang, Y.1
Prives, C.2
-
22
-
-
0029864618
-
Complex regulation of the DNA-binding activity p53 by phosphorylation: Differential effects of individual phosphorylation sites on the interaction with different binding motifs
-
Hecker D, Page G, Lohrum M, Weiland S, Scheidtmann KH. Complex regulation of the DNA-binding activity p53 by phosphorylation: differential effects of individual phosphorylation sites on the interaction with different binding motifs. Oncogene. 12:1996;953-961.
-
(1996)
Oncogene
, vol.12
, pp. 953-961
-
-
Hecker, D.1
Page, G.2
Lohrum, M.3
Weiland, S.4
Scheidtmann, K.H.5
-
23
-
-
0029122607
-
P53 dependent growth suppression by the c-Abl nuclear tyrosine kinase
-
Goga A, Liu X, Hambuch TM, Senechal K, Major E, Berk AJ, Witte ON, Sawyers CL. p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase. Oncogene. 11:1995;791-799.
-
(1995)
Oncogene
, vol.11
, pp. 791-799
-
-
Goga, A.1
Liu, X.2
Hambuch, T.M.3
Senechal, K.4
Major, E.5
Berk, A.J.6
Witte, O.N.7
Sawyers, C.L.8
-
24
-
-
0029973738
-
Role for c-Abl tyrosine kinase in growth arrest response to DNA damage
-
Yuan Z-M, Huang Y, Whang Y, Sawyers C, Weichselbaum R, Kharbanda S, Kufe D. Role for c-Abl tyrosine kinase in growth arrest response to DNA damage. Nature. 382:1996;272-274.
-
(1996)
Nature
, vol.382
, pp. 272-274
-
-
Yuan, Z.-M.1
Huang, Y.2
Whang, Y.3
Sawyers, C.4
Weichselbaum, R.5
Kharbanda, S.6
Kufe, D.7
-
25
-
-
0029615315
-
Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1
-
O'Conner DJ, Lam EW-F, Griffin S, Zhong S, Leighton LC, Burbidge SA, Lu X. Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1. EMBO J. 14:1995;6184-6192.
-
(1995)
EMBO J
, vol.14
, pp. 6184-6192
-
-
O'Conner, D.J.1
Lam, E.-F.2
Griffin, S.3
Zhong, S.4
Leighton, L.C.5
Burbidge, S.A.6
Lu, X.7
-
26
-
-
0029164446
-
The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis
-
of special interest. This report demonstrates that a protein interaction can selectively modulate certain functions of p53. WT1 stabilizes p53, increases transactivation, permits growth arrest, yet inhibits transrepression and apoptosis.
-
Maheswaran S, Englert C, Bennett P, Heinrich G, Haber DA. The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis. of special interest Genes Dev. 9:1995;2143-2156 This report demonstrates that a protein interaction can selectively modulate certain functions of p53. WT1 stabilizes p53, increases transactivation, permits growth arrest, yet inhibits transrepression and apoptosis.
-
(1995)
Genes Dev
, vol.9
, pp. 2143-2156
-
-
Maheswaran, S.1
Englert, C.2
Bennett, P.3
Heinrich, G.4
Haber, D.A.5
-
27
-
-
0028864667
-
Induction of the growth inhibitor IGF-binding protein 3 by p53
-
of outstanding interest. The transcriptional activation of IGF-BP3 by p53 may be another mechanism of suppressing cell growth and/or causing apoptosis, as this protein can inhibit both survival and mitogenic signals from IGF1.
-
Buckbinder L, Talbott R, Velasco-Miguel S, Takenaka I, Faha B, Seizinger BR, Kley N. Induction of the growth inhibitor IGF-binding protein 3 by p53. of outstanding interest Nature. 377:1995;646-649 The transcriptional activation of IGF-BP3 by p53 may be another mechanism of suppressing cell growth and/or causing apoptosis, as this protein can inhibit both survival and mitogenic signals from IGF1.
-
(1995)
Nature
, vol.377
, pp. 646-649
-
-
Buckbinder, L.1
Talbott, R.2
Velasco-Miguel, S.3
Takenaka, I.4
Faha, B.5
Seizinger, B.R.6
Kley, N.7
-
28
-
-
0029094463
-
P53 stimulates transcription from the transforming growth factor α promoter: A potential growth stimulatory role for p53
-
Shin TH, Paterson AJ, Kudlow JE. p53 stimulates transcription from the transforming growth factor α promoter: a potential growth stimulatory role for p53. Mol Cell Biol. 15:1995;4694-4701.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 4694-4701
-
-
Shin, T.H.1
Paterson, A.J.2
Kudlow, J.E.3
-
29
-
-
0029917987
-
Identification and cloning of E124, a gene induced by p53 in etoposide-treated cells
-
Lehar SM, Nacht M, Jacks T, Valer CA, Chittenden T, Guild BC. Identification and cloning of E124, a gene induced by p53 in etoposide-treated cells. Oncogene. 12:1996;1181-1187.
-
(1996)
Oncogene
, vol.12
, pp. 1181-1187
-
-
Lehar, S.M.1
Nacht, M.2
Jacks, T.3
Valer, C.A.4
Chittenden, T.5
Guild, B.C.6
-
30
-
-
0028868432
-
Wild-type human p53 transactivates the human proliferating cell nuclear antigen promoter
-
Shivakumar CV, Brown DR, Deb S, Deb SP. Wild-type human p53 transactivates the human proliferating cell nuclear antigen promoter. Mol Cell Biol. 15:1995;6785-6793.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 6785-6793
-
-
Shivakumar, C.V.1
Brown, D.R.2
Deb, S.3
Deb, S.P.4
-
31
-
-
0030034524
-
Transcriptional activation of the human proliferating-cell nuclear antigen promoter by p53
-
Morris GF, Bischoff JR, Mathews MB. Transcriptional activation of the human proliferating-cell nuclear antigen promoter by p53. Proc Natl Acad Sci USA. 93:1996;895-899.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 895-899
-
-
Morris, G.F.1
Bischoff, J.R.2
Mathews, M.B.3
-
32
-
-
9244251506
-
Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: Activation of the vertebrate homologue of the Drosophila seven in absentia gene
-
Amson RB, Nemani M, Roperch J-P, Israeli D, Bougueleret L, Le Gall I, Medhioub M, Linares-Cruz G, Lethorsne F, Pasturaud P, et al. Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the Drosophila seven in absentia gene. Proc Natl Acad Sci USA. 93:1996;3953-3957.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 3953-3957
-
-
Amson, R.B.1
Nemani, M.2
Roperch, J.-P.3
Israeli, D.4
Bougueleret, L.5
Le Gall, I.6
Medhioub, M.7
Linares-Cruz, G.8
Lethorsne, F.9
Pasturaud, P.10
-
33
-
-
0029097759
-
Radiation-induced cell cycle arrest compromised by p21 deficiency
-
Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T, Hannon GJ. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature. 377:1995;552-557.
-
(1995)
Nature
, vol.377
, pp. 552-557
-
-
Brugarolas, J.1
Chandrasekaran, C.2
Gordon, J.I.3
Beach, D.4
Jacks, T.5
Hannon, G.J.6
-
35
-
-
0029060982
-
A temperature-sensitive mutant of the human p53, Val 138, arrests rat cell growth without induced expression of cip1/waf1/sdi1 after temperature shiftdown
-
Hirano Y, Yamato K, Tsuchida N. A temperature-sensitive mutant of the human p53, Val 138, arrests rat cell growth without induced expression of cip1/waf1/sdi1 after temperature shiftdown. Oncogene. 10:1995;1879-1885.
-
(1995)
Oncogene
, vol.10
, pp. 1879-1885
-
-
Hirano, Y.1
Yamato, K.2
Tsuchida, N.3
-
36
-
-
0029143395
-
Essential role for p53-mediated transcription in E1a-induced apoptosis
-
Sabbatini P, Lin J, Levine AJ, White E. Essential role for p53-mediated transcription in E1a-induced apoptosis. Genes Dev. 9:1995;2184-2192.
-
(1995)
Genes Dev
, vol.9
, pp. 2184-2192
-
-
Sabbatini, P.1
Lin, J.2
Levine, A.J.3
White, E.4
-
37
-
-
0028841560
-
Gas1-induced growth suppression requires a transactivation-independent p53 function
-
Del Sal G, Ruaro EM, Utrera R, Cole CN, Levine AJ, Schneider C. Gas1-induced growth suppression requires a transactivation-independent p53 function. Mol Cell Biol. 15:1995;7152-7160.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 7152-7160
-
-
Del Sal, G.1
Ruaro, E.M.2
Utrera, R.3
Cole, C.N.4
Levine, A.J.5
Schneider, C.6
-
38
-
-
0029766527
-
The growth-inhibitory function of p53 is separable from transactivation, apoptosis, and suppression of transformation by E1a and Ras
-
Hansen RS, Braithwaite AW. The growth-inhibitory function of p53 is separable from transactivation, apoptosis, and suppression of transformation by E1a and Ras. Oncogene. 13:1997;995-1007.
-
(1997)
Oncogene
, vol.13
, pp. 995-1007
-
-
Hansen, R.S.1
Braithwaite, A.W.2
-
39
-
-
0030013337
-
Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis
-
Attardi LD, Lowe SW, Brugarolas J, Jacks T. Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis. EMBO J. 15:1996;3693-3701.
-
(1996)
EMBO J
, vol.15
, pp. 3693-3701
-
-
Attardi, L.D.1
Lowe, S.W.2
Brugarolas, J.3
Jacks, T.4
-
40
-
-
0029585933
-
Transcriptional activation plays a role in the induction of apoptosis by transiently transfected wild-type p53
-
Yonish-Rouach E, Deguin V, Zaitchouk T, Breugnot C, Mishal Z, Jenkins JR, May E. Transcriptional activation plays a role in the induction of apoptosis by transiently transfected wild-type p53. Oncogene. 12:1996;2197-2205.
-
(1996)
Oncogene
, vol.12
, pp. 2197-2205
-
-
Yonish-Rouach, E.1
Deguin, V.2
Zaitchouk, T.3
Breugnot, C.4
Mishal, Z.5
Jenkins, J.R.6
May, E.7
-
41
-
-
0029092356
-
Induction of apoptosis in HeLa cells by trans-activation-deficient p53
-
In HeLa cells, two transactivation-defective mutants are shown to induce apoptosis, though at a slower rate than wild-type p53. This finding indicates the involvement of both transactivation-dependent and -independent mechanisms.
-
Haupt Y, Rowan S, Shaulian E, Vousden K, Oren M. Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev. 9:1995;2170-2183 In HeLa cells, two transactivation-defective mutants are shown to induce apoptosis, though at a slower rate than wild-type p53. This finding indicates the involvement of both transactivation-dependent and -independent mechanisms.
-
(1995)
Genes Dev
, vol.9
, pp. 2170-2183
-
-
Haupt, Y.1
Rowan, S.2
Shaulian, E.3
Vousden, K.4
Oren, M.5
-
42
-
-
0029985647
-
Cell type-specific inhibition of p53-mediated apoptosis by mdm2
-
Haupt Y, Barak Y, Oren M. Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J. 15:1996;1596-1606.
-
(1996)
EMBO J
, vol.15
, pp. 1596-1606
-
-
Haupt, Y.1
Barak, Y.2
Oren, M.3
-
43
-
-
0029742781
-
Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function
-
of special interest. See annotation [44].
-
Ludwig RL, Bates S, Vousden KH. Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function. of special interest Mol Cell Biol. 16:1996;4952-4960 See annotation [44].
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4952-4960
-
-
Ludwig, R.L.1
Bates, S.2
Vousden, K.H.3
-
44
-
-
0029783722
-
A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis
-
WAF1. Thus, p53 appears to activate distinct sets of target genes depending upon its cellular effect.
-
WAF1. Thus, p53 appears to activate distinct sets of target genes depending upon its cellular effect.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4961-4971
-
-
Friedlander, P.1
Haupt, Y.2
Prives, C.3
Oren, M.4
-
45
-
-
0029669929
-
T cells from baxa transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53
-
Brady HJM, Salomons GS, Bobeldijk RC, Berns AJM. T cells from baxa transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53. EMBO J. 15:1996;1221-1230.
-
(1996)
EMBO J
, vol.15
, pp. 1221-1230
-
-
Brady, H.J.M.1
Salomons, G.S.2
Bobeldijk, R.C.3
Berns, A.J.M.4
-
46
-
-
0001166257
-
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway
-
of special interest. This paper proposes a novel mechanism for p53-mediated apoptosis. Through interaction with helicases involved in nucleotide excision repair, p53 may provide a direct link between DNA damage and apoptosis.
-
Wang XW, Vermeulen W, Coursen JD, Gibson M, Lupold SE, Forrester K, Xu G, Elmore L, Yeh H, Hoeijmakers JHJ, Harris CC. The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. of special interest Genes Dev. 10:1996;1219-1232 This paper proposes a novel mechanism for p53-mediated apoptosis. Through interaction with helicases involved in nucleotide excision repair, p53 may provide a direct link between DNA damage and apoptosis.
-
(1996)
Genes Dev
, vol.10
, pp. 1219-1232
-
-
Wang, X.W.1
Vermeulen, W.2
Coursen, J.D.3
Gibson, M.4
Lupold, S.E.5
Forrester, K.6
Xu, G.7
Elmore, L.8
Yeh, H.9
Hoeijmakers, J.H.J.10
Harris, C.C.11
-
48
-
-
0029823623
-
Relationship of sequence-specific transactivation and p53-regulated apoptosis in interleukin 3-dependent hematopotetic cells
-
Gottlieb E, Linder S, Oren M. Relationship of sequence-specific transactivation and p53-regulated apoptosis in interleukin 3-dependent hematopotetic cells. Cell Growth Differ. 7:1996;301-310.
-
(1996)
Cell Growth Differ
, vol.7
, pp. 301-310
-
-
Gottlieb, E.1
Linder, S.2
Oren, M.3
-
49
-
-
0030031757
-
Induction of HL-60 cells to undergo apoptosis is determined by high levels of wild-type p53 protein whereas differentiation of the cell is mediated by lower p53 levels
-
Ronen D, Schwartz D, Teitz Y, Goldfinger N, Rotter V. Induction of HL-60 cells to undergo apoptosis is determined by high levels of wild-type p53 protein whereas differentiation of the cell is mediated by lower p53 levels. Cell Growth Differ. 7:1996;21-30.
-
(1996)
Cell Growth Differ
, vol.7
, pp. 21-30
-
-
Ronen, D.1
Schwartz, D.2
Teitz, Y.3
Goldfinger, N.4
Rotter, V.5
-
50
-
-
0029814061
-
Anti-apoptotic activity of low levels of wild-type p53
-
Lassus P, Ferlin M, Piette J, Hibner U. Anti-apoptotic activity of low levels of wild-type p53. EMBO J. 15:1996;4566-4573.
-
(1996)
EMBO J
, vol.15
, pp. 4566-4573
-
-
Lassus, P.1
Ferlin, M.2
Piette, J.3
Hibner, U.4
-
51
-
-
0029811984
-
Genetic determinants of p53-induced apoptosis and growth arrest
-
of special interest. Although an intact growth arrest pathway protects cells from p53-dependent apoptosis, cell hybrid studies show that in some cells the apoptotic signal is dominant over that which induces growth arrest.
-
Polyak K, Waldmann T, He T-C, Kinzler KW, Vogelstein B. Genetic determinants of p53-induced apoptosis and growth arrest. of special interest Genes Dev. 10:1996;1945-1952 Although an intact growth arrest pathway protects cells from p53-dependent apoptosis, cell hybrid studies show that in some cells the apoptotic signal is dominant over that which induces growth arrest.
-
(1996)
Genes Dev
, vol.10
, pp. 1945-1952
-
-
Polyak, K.1
Waldmann, T.2
He, T.-C.3
Kinzler, K.W.4
Vogelstein, B.5
-
52
-
-
0028860556
-
E2F-1 : DP-1 induces p53 and overrides survival factors to trigger apoptosis
-
Hiebert SW, Packham G, Strom DK, Haffner R, Oren M, Zambetti G, Cleveland JC. E2F-1 : DP-1 induces p53 and overrides survival factors to trigger apoptosis. Mol Cell Biol. 15:1995;6864-6874.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 6864-6874
-
-
Hiebert, S.W.1
Packham, G.2
Strom, D.K.3
Haffner, R.4
Oren, M.5
Zambetti, G.6
Cleveland, J.C.7
-
53
-
-
0029129088
-
Cell-specific transcriptional activation of the mdm2-gene by ectopically expressed wild-type form of temperature-sensitive mutant p53
-
of special interest. In this report, mdm2 is shown to be differentially transactivated in cells which either do or do not undergo growth arrest by p53. Thus, signals which modulate the transcriptional selectivity of p53 also alter its cellular effects.
-
Knippschild U, Kolzau T, Deppert W. Cell-specific transcriptional activation of the mdm2-gene by ectopically expressed wild-type form of temperature-sensitive mutant p53. of special interest Oncogene. 11:1995;683-690 In this report, mdm2 is shown to be differentially transactivated in cells which either do or do not undergo growth arrest by p53. Thus, signals which modulate the transcriptional selectivity of p53 also alter its cellular effects.
-
(1995)
Oncogene
, vol.11
, pp. 683-690
-
-
Knippschild, U.1
Kolzau, T.2
Deppert, W.3
-
54
-
-
0029111404
-
Increased activity of p53 in senescing fibroblasts
-
of special interest. Although low-and high-passage fibroblasts express similar levels of p53, the activity of p53 is shown to be increased in the high passage cells. A role for activated p53 in cell senescence is therefore suggested.
-
Atadja P, Wong H, Garkavtsev I, Veillette C, Riabowol K. Increased activity of p53 in senescing fibroblasts. of special interest Proc Natl Acad Sci USA. 92:1995;8348-8352 Although low-and high-passage fibroblasts express similar levels of p53, the activity of p53 is shown to be increased in the high passage cells. A role for activated p53 in cell senescence is therefore suggested.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 8348-8352
-
-
Atadja, P.1
Wong, H.2
Garkavtsev, I.3
Veillette, C.4
Riabowol, K.5
-
55
-
-
0029024691
-
Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1
-
Bond JA, Blaydes JP, Rowson J, Haughton MF, Smith JR, Wynford-Thomas D, Wyllie FS. Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1. Cancer Res. 55:1995;2404-2409.
-
(1995)
Cancer Res
, vol.55
, pp. 2404-2409
-
-
Bond, J.A.1
Blaydes, J.P.2
Rowson, J.3
Haughton, M.F.4
Smith, J.R.5
Wynford-Thomas, D.6
Wyllie, F.S.7
-
56
-
-
0029013310
-
Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes
-
of special interest. A direct role for p53 in senescence is suggested by the observation that p53-deficient cells exhibit a very high rate of oncogene-induced immortalization.
-
Metz T, Harris AW, Adams JM. Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes. of special interest Cell. 82:1995;29-36 A direct role for p53 in senescence is suggested by the observation that p53-deficient cells exhibit a very high rate of oncogene-induced immortalization.
-
(1995)
Cell
, vol.82
, pp. 29-36
-
-
Metz, T.1
Harris, A.W.2
Adams, J.M.3
-
57
-
-
0028981380
-
INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts
-
INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts. Mol Cell Biol. 15:1995;4745-4753.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 4745-4753
-
-
Rogan, E.M.1
Bryan, T.M.2
Hukku, B.3
MacLean, K.4
Chang, A.C.M.5
Moy, E.L.6
Englezou, A.7
Warneford, S.G.8
Dalla-Pozza, L.9
Reddel, R.R.10
-
58
-
-
0029007405
-
A subset of p53-deficient embryos exhibit exencephaly
-
Sah VP, Attardi LD, Mulligan GJ, Williams BO, Bronson RT, Jacks T. A subset of p53-deficient embryos exhibit exencephaly. Nat Genet. 10:1995;175-180.
-
(1995)
Nat Genet
, vol.10
, pp. 175-180
-
-
Sah, V.P.1
Attardi, L.D.2
Mulligan, G.J.3
Williams, B.O.4
Bronson, R.T.5
Jacks, T.6
-
60
-
-
0029006469
-
A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice
-
Nicol CJ, Harrison ML, Laposa RR, Gimelshtein IL, Wells PG. A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice. Nat Genet. 10:1995;181-187.
-
(1995)
Nat Genet
, vol.10
, pp. 181-187
-
-
Nicol, C.J.1
Harrison, M.L.2
Laposa, R.R.3
Gimelshtein, I.L.4
Wells, P.G.5
-
61
-
-
0029874308
-
P53-dependent apoptosis suppresses radiation-induced teratogenesis
-
Norimura T, Nomoto S, Katsuki M, Gondo Y, Kondo S. p53-dependent apoptosis suppresses radiation-induced teratogenesis. Nat Med. 2:1996;577-580.
-
(1996)
Nat Med
, vol.2
, pp. 577-580
-
-
Norimura, T.1
Nomoto, S.2
Katsuki, M.3
Gondo, Y.4
Kondo, S.5
-
62
-
-
0029944241
-
A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation
-
of special interest. Teratocarcinoma cells (resembling cells of the early embryo) are found to maintain p53 in a latent form. Activation of this latent p53 occurs with DNA damage and results in apoptosis. Alternatively, biochemical activation of p53 can be achieved by merely inducing differentiation.
-
Lutzker SG, Levine AJ. A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation. of special interest Nat Med. 2:1996;804-810 Teratocarcinoma cells (resembling cells of the early embryo) are found to maintain p53 in a latent form. Activation of this latent p53 occurs with DNA damage and results in apoptosis. Alternatively, biochemical activation of p53 can be achieved by merely inducing differentiation.
-
(1996)
Nat Med
, vol.2
, pp. 804-810
-
-
Lutzker, S.G.1
Levine, A.J.2
-
63
-
-
0029029741
-
Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance
-
Ford JM, Hanawalt PC. Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance. Proc Natl Acad Sci USA. 92:1995;8876-8880.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 8876-8880
-
-
Ford, J.M.1
Hanawalt, P.C.2
-
64
-
-
0028989236
-
P53 modulation of TFIIH-associated nucleotide excision repair activity
-
Wang XW, Yeh H, Schaeffer L, Roy R, Moncollin V, Egly J-M, Wang Z, Friedberg EC, Evans MK, Taffe BG, et al. p53 modulation of TFIIH-associated nucleotide excision repair activity. Nat Genet. 10:1995;188-195.
-
(1995)
Nat Genet
, vol.10
, pp. 188-195
-
-
Wang, X.W.1
Yeh, H.2
Schaeffer, L.3
Roy, R.4
Moncollin, V.5
Egly, J.-M.6
Wang, Z.7
Friedberg, E.C.8
Evans, M.K.9
Taffe, B.G.10
-
65
-
-
0028919069
-
Involvement of the p53 tumor suppressor in repair of UV-type DNA damage
-
Smith ML, Chen I-T, Zhan Q, O'Conner PM, Fornace AJ. Involvement of the p53 tumor suppressor in repair of UV-type DNA damage. Oncogene. 10:1995;1053-1059.
-
(1995)
Oncogene
, vol.10
, pp. 1053-1059
-
-
Smith, M.L.1
Chen, I.-T.2
Zhan, Q.3
O'Conner, P.M.4
Fornace, A.J.5
-
66
-
-
0029029938
-
P53 inactivation by HPV16 results in increased mutagenesis in human cells
-
Havre PA, Yuan J, Hedrick L, Cho KR, Glazer PM. p53 inactivation by HPV16 results in increased mutagenesis in human cells. Cancer Res. 55:1995;4420-4424.
-
(1995)
Cancer Res
, vol.55
, pp. 4420-4424
-
-
Havre, P.A.1
Yuan, J.2
Hedrick, L.3
Cho, K.R.4
Glazer, P.M.5
-
67
-
-
0028980495
-
P53 deficiency does not affect the accumulation of point mutations in a transgene target
-
Sands AT, Suraokar MB, Sanchez A, Marth JE, Donehower LA, Bradley A. p53 deficiency does not affect the accumulation of point mutations in a transgene target. Proc Natl Acad Sci USA. 92:1995;8517-8521.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 8517-8521
-
-
Sands, A.T.1
Suraokar, M.B.2
Sanchez, A.3
Marth, J.E.4
Donehower, L.A.5
Bradley, A.6
-
68
-
-
0029156729
-
P53 wild-type and p53 nullizygous Big Blue transgenic mice have similar frequencies and patterns of observed mutation in liver, spleen and brain
-
Nishino H, Knoll A, Buettner VL, Frisk CS, Maruta Y, Haavik J, Sommer SS. p53 wild-type and p53 nullizygous Big Blue transgenic mice have similar frequencies and patterns of observed mutation in liver, spleen and brain. Oncogene. 11:1995;263-270.
-
(1995)
Oncogene
, vol.11
, pp. 263-270
-
-
Nishino, H.1
Knoll, A.2
Buettner, V.L.3
Frisk, C.S.4
Maruta, Y.5
Haavik, J.6
Sommer, S.S.7
-
69
-
-
0029969418
-
P53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction
-
Sturzbecher H-W, Donzelmann B, Henning W, Knippschild U, Buchhop S. p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. EMBO J. 15:1996;1992-2002.
-
(1996)
EMBO J
, vol.15
, pp. 1992-2002
-
-
Sturzbecher, H.-W.1
Donzelmann, B.2
Henning, W.3
Knippschild, U.4
Buchhop, S.5
-
70
-
-
0030604728
-
P53 protein exhibit 3′-to-5′ exonuclease activity
-
Mummenbrauer T, Janus F, Muller B, Weismuller L, Deppert W, Grosse F. p53 protein exhibit 3′-to-5′ exonuclease activity. Cell. 85:1996;1089-1099.
-
(1996)
Cell
, vol.85
, pp. 1089-1099
-
-
Mummenbrauer, T.1
Janus, F.2
Muller, B.3
Weismuller, L.4
Deppert, W.5
Grosse, F.6
-
71
-
-
0029881977
-
Abnormal centrosome amplification in the absence of p53
-
of outstanding interest. This report demonstrates that p53 has a role in maintaining mitotic integrity by ensuring that centrosome duplication occurs only once per cell cycle. See also annotation [72].
-
Fukasawa K, Choi T, Kuriyama R, Rulong S, Vande Woude GF. Abnormal centrosome amplification in the absence of p53. of outstanding interest Science. 271:1996;1744-1747 This report demonstrates that p53 has a role in maintaining mitotic integrity by ensuring that centrosome duplication occurs only once per cell cycle. See also annotation [72].
-
(1996)
Science
, vol.271
, pp. 1744-1747
-
-
Fukasawa, K.1
Choi, T.2
Kuriyama, R.3
Rulong, S.4
Vande Woude, G.F.5
-
72
-
-
0028913739
-
A p53-dependent mouse spindle checkpoint
-
of outstanding interest. p53 is shown participate in a checkpoint which ensures that DNA synthesis does not occur without proper chromosome segregation in mitosis. This report and [71] are the first to indicate that p53 contribute to the maintenance of genomic by overseeing mitotic events, which may explain the accumulation of karyotypic aberrations in cells lacking functional p53.
-
Cross SM, Sanchez CA, Morgan CA, Schimke MK, Ramel S, Idzerda RK, Raskind WH, Reid BJ. A p53-dependent mouse spindle checkpoint. of outstanding interest Science. 267:1995;1353-1356 p53 is shown participate in a checkpoint which ensures that DNA synthesis does not occur without proper chromosome segregation in mitosis. This report and [71] are the first to indicate that p53 contribute to the maintenance of genomic by overseeing mitotic events, which may explain the accumulation of karyotypic aberrations in cells lacking functional p53.
-
(1995)
Science
, vol.267
, pp. 1353-1356
-
-
Cross, S.M.1
Sanchez, C.A.2
Morgan, C.A.3
Schimke, M.K.4
Ramel, S.5
Idzerda, R.K.6
Raskind, W.H.7
Reid, B.J.8
|