Roles of cytoskeletal and junctional plaque proteins in nuclear signaling

International Review of Cytology

Volumn 208, Issue , 2001, Pages 207-265

  Hubner S ^a   Jans, D A ^a   Drenckhahn, D ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Cell junctions; Cytoskeleton; Nuclear localization sequence; Nuclear protein import; Nuclear signaling; Plaque proteins

Indexed keywords

CELL PROTEIN; CYTOSKELETON PROTEIN; PLAQUE PROTEIN; UNCLASSIFIED DRUG;

CELL ADHESION; CELL JUNCTION; CELL MEMBRANE TRANSPORT; CELL NUCLEUS; CELLULAR DISTRIBUTION; HUMAN; NONHUMAN; PLAQUE FORMING CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION;

EID: 0034899717     PISSN: 00747696     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0074-7696(01)08005-6     Document Type: Article

References (341)

1. Beta-catenin is a target for the ubiquitin-proteasome pathway
2. Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors
3. A novel nuclear import pathway for the transcription factor TFIIS
4. Ultrastructural localization of filamentous actin within neuronal interphase nuclei in situ
5. Tissue-specific analogues of erythrocyte protein 4.1 retain functional domains
6. Identification of a widespread nuclear actin binding protein
7. Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ
8. Calmodulin-binding proteins in the nuclei of quiescent and proliferatively activated rat liver cells
9. Nuclear ribonucleoprotein release and nucleoside triphosphatase activity are inhibited by antibodies directed against one nuclear matrix glycoprotein
10. Two classes of tight junctions are revealed by ZO-1 isoforms
11. The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression
12. Importin alpha mediates steroid receptor interaction with microtubules during translocation
13. Nuclear localization of NFATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction
14. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
15. Golgi spectrin: Identification of an erythroid beta-spectrin homolog associated with the Golgi complex
16. Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11
17. Functional interaction of beta-catenin with the transcription factor LEF-1
18. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
19. Interaction of iodinated vinculin, metavinculin and alpha-actinin with cytoskeletal proteins
20. Characterization of the human talin (TLN) gene: Genomic structure, chromosomal localization, and expression pattern
21. A myosin heavy-chain-like polypeptide is associated with the nuclear envelope in higher eukaryotic cells
22. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1
23. Karyopherin beta2 mediates nuclear import of a mRNA binding protein
24. Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells
25. Evidence that pinin, reportedly a differentiation-specific desmosomal protein, is actually a widespread nuclear protein
26. Identification and characterization of a novel kind of nuclear protein occurring free in the nucleoplasm and in ribonucleoprotein structures of the speckle type
27. The cAMP-dependent protein kinase site (Ser312) enhances dorsal nuclear import through facilitating nuclear localization sequence/importin interaction
28. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
29. An interaction between vinculin and talin
30. Drosophila Tcf and Groucho interact to repress Wingless signalling activity
31. Differentiation-associated switches in protein 4.1 expression. Synthesis of multiple structural isoforms during normal human erythropoiesis
32. I-mf, a novel myogenic repressor, interacts with members of the MyoD family
33. Sequence and characterization of cytoplasmic nuclear protein import factor p9T
34. RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import
35. Differentiation dependent expression and distinct subcellular localization of the protooncogene product, PEBP2beta/CBFbeta, in muscle development
36. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein
37. Cloning of ALL-l, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations
38. Structure of importin-beta bound to the IBB domain of importin-alpha
39. Tight junction proteins
40. The molecular basis for the structure, function and regulation of tight junctions
41. Cingulin: Characterization and localization
42. Integrins and signal transduction pathways: The road taken
43. Diffusible and bound actin nuclei of Xenopus laevis oocytes
44. An actin filament matrix in hand-isolated nuclei of X. laevis oocytes
45. Structure, function, and molecular genetics of erythroid membrane skeletal protein 4.1 in normal and abnormal red blood cells
46. Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1
47. Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha
48. Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin
49. Characterization of isoforms of protein 4.1 present in the nucleus
50. Assembly of focal adhesions: Progress, paradigms, and portents
51. Purification and characterization of zyxin, an 82,000- dalton component of adherens junctions
52. An interaction between zyxin and alpha-actinin
53. Focal adhesions - The cytoskeletal connection
54. Inhibition of nuclear accumulation of karyophilic proteins in living cells by microinjection of the lectin wheat germ agglutinin
55. Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins
56. The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor
57. The interphase nucleus as a dynamic structure
58. Protein 4.1 is a component of the nuclear matrix of mammalian cells
59. memA/DRS, a putative mediator of multiprotein complexes, is overexpressed in the metastasizing human melanoma cell lines BLM and MV3
60. Major nonhistone proteins of rat liver chromatin: Preliminary identification of myosin, actin, tubulin, and tropomyosin
61. Organization of the actin filament cytoskeleton in the intestinal brush border: A quantitative and qualitative immunoelectron microscope study
62. Identification and subcellular location of talin in various cell types and tissues by means of [125I]vinculin overlay, immunoblotting and immunocytochemistry
63. Kinetic characterization of the human retinoblastoma protein bipartite nuclear localization sequence (NLS) in vivo and in vitro. A comparison with the SV40 large T-antigen NLS
64. Nuclear localization signal-independent and importin/karyopherin -independent nuclear import of beta-catenin
65. Protein-protein interactions: PDZ domain networks
66. The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton
67. A monoclonal antibody against the nuclear pore complex inhibits nucleocytoplasmic transport of protein and RNA in vivo
68. Movement of a karyophilic protein through the nucleax pores of oocytes
69. Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1
70. Inhibition of in vitro nuclear transport by a lectin that binds to nuclear pores
71. Groucho proteins: Transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates
72. CRM1 is an export receptor for leucine-rich nuclear export signals
73. Significance of two desmosome plaque-associated polypeptides of molecular weights 75000 and 83000
74. CRM1 is responsible for intracellular transport mediated by the nuclear export signal
75. Nuclear actin bundles in Amoeba, Dictyostelium and human HeLa cells induced by dimethyl sulfoxide
76. Embryonic axis induction by the armadillo repeat domain of beta-catenin: Evidence for intracellular signaling
77. Occludin: A novel integral membrane protein localizing at tight junctions
78. Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions
79. Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
80. Inhibition of glucocorticoid receptor nucleocytoplasmic shuttling by okadaic acid requires intact cytoskeleton
81. Characterization of multiple isoforms of protein 4.1R expressed during erythroid terminal differentiation
82. Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R
83. Analysis of β-catenin aggregation and localization using GFP fusion proteins: Nuclear import of α-catenin by the β-catenin/Tcf complex
84. The enigma of LIM domains
85. ctn, is a common membrane-associated protein in various epithelial and non-epithelial cells and tissues
86. Conformational difference between nuclear and cytoplasmic actin as detected by a monoclonal antibody
87. Expression of the tight junction protein ZO-2 at the nuclei of subconfluent cells
88. Tight junction proteins ZO-1, ZO-2, and occludin along isolated renal tubules
89. Isolation of a protein that is essential for the first step of nuclear protein import
90. Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope
91. A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus
92. Identification of different roles for RanGDP and RanGTP in nuclear protein import
93. The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts
94. Involvement of contractile proteins in the changes in consistency ef oocyte nucleoplasm of the newt Pleurodeles waltlii
95. Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesion and spreading
96. Characterization of monoclonal antibodies to Acanthamoeba myosin-I that cross-react with both myosin-II and low molecular mass nuclear proteins
97. Targeting of E. coli beta-galactosidase to the nucleus in yeast
98. Homeodomain of yeast repressor alpha 2 contains a nuclear localization signal
99. The secretion-stimulated 80K phosphoprotein of parietal cells is ezrin, and has properties of a membrane cytoskeletal linker in the induced apical microvilli
100. Active nuclear import of single-stranded oligonucleotides and their complexes with non-karyophilic macromolecules
101. DNA-mediated transport of the intermediate filament protein vimentin into the nucleus of cultured cells
102. ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin
103. Band 6 protein and cytoskeletal organization
104. Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: Evidence for a subfamily of closely related proteins
105. Band 6 protein, a major constituent of desmosomes from stratified epithelia, is a novel member of the armadillo multigene family
106. The function of plakophilin 1 in desmosome assembly and actin filament organization
107. Vinculin is associated with the E-cadherin adhesion complex
108. Cell type-specific desmosomal plaque proteins of the plakoglobin family: Plakophilin 1 (band 6 protein)
109. Integrin associated proteins
110. Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site
111. Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit
112. Phosphorylation on protein kinase C sites inhibits nuclear import of lamin B2
113. Determination of the functional domain organization of the importin alpha nuclear import factor
114. Nuclear import in permeabilized protoplasts from higher plants has unique features
115. Transcriptional regulation by extracellular signals: Mechanisms and specificity
116. Expression of neurofibromatosis 2 protein in human brain tumors: An immunohistochemical study
117. SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin
118. Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion
119. The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus
120. Interaction of plasma membrane fibronectin receptor with talin - A transmembrane linkage
121. Detection of the tight junction-associated protein ZO-1 in astrocytes and other nonepithelial cell types
122. Integrin signaling and cell growth control
123. Efficiency of importin alpha/beta-mediated nuclear localization sequence recognition and nuclear import. Differential role of NTF2
124. Nuclear localization of beta-catenin by interaction with transcription factor LEF-1
125. The protein kinase CK2 site (Ser111/112) enhances recognition of the simian virus 40 large T-antigen nuclear localization sequence by importin
126. Plant importin alpha binds nuclear localization sequences with high affinity and can mediate nuclear import independent of importin beta
127. The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation
128. Integrins: Versatility, modulation, and signaling in cell adhesion
129. Reversible induction of actin rods in mouse C3H-2K cells by incubation in salt buffers and by treatment with non-ionic detergents
130. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
131. The nuclear pore-targeting complex binds to nuclear pores after association with a karyophile
132. Functional domains of alpha-catenin required for the strong state of cadherin-based cell adhesion
133. A 220-kD undercoat-constitutive protein: Its specific localization at cadherin-based cell-cell adhesion sites
134. The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: Cdna cloning and immunoelectron microscopy
135. Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments
136. Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin
137. The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus
138. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells
139. The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1
140. Nuclear targeting by growth factors, cytokines, and their receptors: A role in signaling?
141. Regulation of protein transport to the nucleus: Central role of phosphorylation
142. Negative charge at the casein kinase II site flanking the nuclear localization signal of the SV40 large T-antigen is mechanistically important for enhanced nuclear import
143. Cyclin-dependent kinase site-regulated signal-dependent nuclear localization of the SW15 yeast transcription factor in mammalian cells
144. The cytokine interleukin-5 (IL-5) effects cotransport of its receptor subunits to the nucleus in vitro
145. Signals mediating nuclear targeting and their regulation: Application in drug delivery
146. Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein
147. Slime mould actin: Homology to vertebrate actin and presence in the nucleus
148. Identification of the binding interface involved in linkage of cytoskeletal protein 4.1 to the erythrocyte anion exchanger
149. F-actin binding site masked by the intramolecular association of vinculin head and tail domains
150. The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus
151. Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121
152. Sequence requirements for nuclear location of simian virus 40 large-T antigen
153. A short amino acid sequence able to specify nuclear location
154. Identification of a basic protein of Mr 75,000 as an accessory desmosomal plaque protein in stratified and complex epithelia
155. Identification of a 55-kDa ezrin-related protein that induces cytoskeletal changes and localizes to the nucleolus
156. Molecular cloning of the human p120ctn catenin gene (CTNND 1): Expression of multiple alternatively spliced isoforms
157. Symplekin, a novel type of tight junction plaque protein
158. Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos
159. Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases
160. Vinexin: A novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization
161. Axin, a negative regulator of the Wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin
162. SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A
163. Plakophilin, armadillo repeats, and nuclear localization
164. Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin
165. Roles of phosphorylation sites in regulating activity of the transcription factor Pho4
166. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95
167. Making a connection: Direct binding between keratin intermediate filaments and desmosomal proteins
168. Analysis of desmosomal cadherin-adhesive function and stoichiometry of desmosomal cadherin-plakoglobin complexes
169. The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes
170. Desmosomes: Intercellular adhesive junctions specialized for attachment of intermediate filaments
171. The head domain of plakophilin-1 binds to desmoplakin and enhances its recruitment to desmosomes. Implications for cutaneous disease
172. Structural protein 4.1 in the nucleus of human cells: Dynamic rearrangements during cell division
173. Regulation of yAP-1 nuclear localization in response to oxidative stress
174. Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor
175. Transcription-dependent redistribution of nuclear protein 4.1 to SC35-enriched nuclear domains
176. Functional association of nuclear protein 4.1 with pre-mRNA splicing factors
177. Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha
178. Construction and characterization of an SV40 mutant defective in nuclear transport of T antigen
179. Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos
180. Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density
181. Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
182. Cytoplasmic retention of Xenopus nuclear factor 7 before the mid blastula transition uses a unique anchoring mechanism involving a retention domain and several phosphorylation sites
183. Novel low molecular weight microtubule-associated protein-2 isoforms contain a functional nuclear localization sequence
184. Cloning and characterization of hdlg: The human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1
185. Two independent domains of hDlg are sufficient for subcellular targeting: The PDZ1-2 conformational unit and an alternatively spliced domain
186. A constitutive region is responsible for nuclear targeting of 4.1R: Modulation by alternative sequences results in differential intracellular localization
187. An alternative domain determines nuclear localization in multifunctional protein 4.1
188. Nuclear localization of protein 4.1 and the MAGUK family members p55 and hDlg
189. Intestinal absorptive cell tight junctions are linked to cytoskeleton
190. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
191. Evolutionary specialization of the nuclear targeting apparatus
192. Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction
193. Ponsin/SH3P12: An 1-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions
194. ARVCF localizes to the nucleus and adherens junction and is mutually exclusive with p120(ctn) in E-cadherin complexes
195. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration
196. Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg 1 with plakoglobin
197. A nonerythroid isoform of protein 4.1R interacts with the nuclear mitotic apparatus (NuMA) protein
198. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
199. The basic helix-loop-helix/PAS factor Sim is associated with hsp90. Implications for regulation by interaction with partner factors
200. Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor
201. Two-hybrid analysis reveals fundamental differences in direct interactions between desmoplakin and cell type-specific intermediate filaments
202. Characterization of an F-actin-binding domain in the cytoskeletal protein vinculin
203. Plakophilins 2a and 2b: Constitutive proteins of dual location in the karyoplasm and the desmosomal plaque
204. Cytochemical localization of actin and myosin aggregates in interphase nuclei in situ
205. The cDNA sequence of a human placental alpha-actinin
206. Molecular architecture of tight junctions
207. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
208. The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
209. Purification of a Ran-interacting protein that is required for protein import into the nucleus
210. Organization, chemistry, and assembly of the cytoskeletal apparatus of the intestinal brush border
211. Talin requires beta-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans
212. Biochemical and immunological characterization of desmoplakins I and II, the major polypeptides of the desmosomal plaque
213. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
214. Deletion of an amino-terminal sequence beta-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein
215. A knowledge base for predicting protein localization sites in eukaryotic cells
216. Dephosphorylation of serine 3 regulates nuclear translocation of cofilin
217. Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein
218. Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin
219. Identification of functional domains in the cytoskeletal protein talin
220. Cofilin is a component of intranuclear and cytoplasmic actin rods induced in cultured cells
221. Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: A potential mechanism for communication between sites of cell adhesion and the nucleus
222. Functional studies of the domains of talin
223. Dephosphorylation of cofilin accompanies heat shock-induced nuclear accumulation of cofilin
224. The RCCI protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA
225. Nexilin: A novel actin filament-binding protein localized at cell-matrix adherens junction
226. gCap39 is a nuclear and cytoplasmic protein
227. Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin
228. An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling
229. An interaction between alpha actinin and the beta 1 integrin subunit in vitro
230. Detection of vinculin-binding proteins with an 125I-vinculin gel overlay technique
231. Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex
232. Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family
233. Nuclear actin filaments and their topological changes in frog oocytes
234. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62
235. Disruption of the actin cytoskeleton after microinjection of proteolytic fragments of alpha-actinin
236. Transport routes through the nuclear pore complex
237. Nuclear localization signal recognition causes release of importin-alpha from aggregates in the cytosol
238. Spc98p directs the yeast gamma tubulin-complex into the nucleus and is subject to cell cycle-dependent phosphorylation on the nuclear side of the spindle pole body
239. Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP
240. Supervillin (p205): A novel membrane-associated, F-actin-binding protein in the villin/gelsolin superfamily
241. LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity
242. A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor
243. The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B
244. The adenomatous polyposis coli (APC) tumor suppressor
245. A novel receptor-mediated nuclear protein import pathway
246. Mbh 1: A novel gelsolin/severin-related protein which binds actin in vitro and exhibits nuclear localization in vivo
247. Nuclear localization and formation of beta-catenin-lymphoid enhancer factor 1 complexes are not sufficient for activation of gene expression
248. Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions
249. Searching for a function for nuclear actin
250. Identification, purification, and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein)
251. Protein import into nuclei: Association and dissociation reactions involving transport substrate, transport factors, and nucleoporins
252. NTF2 mediates nuclear import of Ran
253. The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV40 T-antigen
254. Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex
255. Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence
256. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
257. A nuclear import pathway for a protein involved in tRNA maturation
258. A distinct nuclear import pathway used by ribosomal proteins
259. Association of the APC gene product with beta-catenin
260. Zyxin and cCRP: Two interactive LIM domain proteins associated with the cytoskeleton
261. Distribution of snRNPs, splicing factor SC-35 and actin in interphase nuclei: Immunocytochemical evidence for differential distribution during changes in functional states
262. Different behavior of and neurabin-II during the formation and destruction of cell-cell adherens junction
263. The LIM domain: A new structural motif found in zinc-finger-like proteins
264. Reversible translocation of cytoplasmic actin into the nucleus caused by dimethyl sulfoxide
265. PDZ domains bind carboxy-terminal sequences of target proteins
266. Microinjection of actin-binding proteins and actin antibodies demonstrates involvement of nuclear actin in transcription of lampbrush chromosomes
267. Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus
268. Molecular dissection of a LIM domain
269. LIM domains of cysteine-rich protein 1 (CRP1) are essential for its zyxin-binding function
270. Desmosomes and cytoskeletal architecture in epithelial differentiation: Cell type-specific plaque components and intermediate filament anchorage
271. Plakophilins 1a and 1b: Widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components
272. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
273. Dissection of protein linkage between keratines and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus
274. Pinin, a desmosome-associated protein and a potential tumor suppressor
275. The in vitro DNA-binding properties of purified nuclear lamin proteins and vimentin
276. The binding in vitro of the intermediate filament protein vimentin to synthetic oligonucleotides containing telomere sequences
277. Differential nuclear translocation and transactivation potential of beta-catenin and plakoglobin
278. Identification of nuclear and subnuclear localization domains in the desmosome-associated and nuclear protein pinin
279. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins
280. Nuclear import of Ran is mediated by the transport factor NTF2
281. Defining the interactions between intermediate filaments and desmosomes
282. Nuclear localization signal receptor importin alpha associates with the cytoskeleton
283. Protein targeting to the nuclear pore. What can we learn from plants?
284. Importin alpha from Arabidopsis thaliana is a nuclear import receptor that recognizes three classes of import signals
285. Nuclear targeting of the transcription factor PTF1 is mediated by a protein subunit that does not bind to the PTF1 cognate sequence
286. Nuclear and cytoplasmic actin in dinoflagellates
287. Macromolecular domains within the cell nucleus
288. Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus
289. Exportin 1 (Crm1p) is an essential nuclear export factor
290. Functional analysis of desmoplakin domains: Specification of the interaction with keratin versus vimentin intermediate filament networks
291. Phosphorylation of the desmoplakin COOH terminus negatively regulates its interaction with keratin intermediate filament networks
292. The tight junction: Morphology to molecules
293. Identification of ZO-1: A high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia
294. Nuclear access and action of notch in vivo
295. Complex protein interactions within the human polyadenylation machinery identify a novel component
296. Nectin/PRR: An immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein
297. The protooncogene product, PEBP2beta/CBFbeta, is mainly located in the cytoplasm and has an affinity with cytoskeletal structures
298. Selective expression of an erythroid-specific isoform of protein 4.1
299. Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97
300. Intracellular processing of talin occurs within focal adhesions
301. The interaction in vitro of the intermediate filament protein vimentin with synthetic polyribo- and polydeoxyribonucleotides
302. Intermediate filament proteins: Cytoskeletal elements with generegulatory function?
303. Interaction in vitro of the neurofilament triplet proteins from porcine spinal cord with natural RNA and DNA
304. Identification of the plakoglobin-binding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage
305. Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation
306. The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals
307. Structural and signalling molecules come together at tight junctions
308. Monoclonal antibody against non-histone chromosomal protein high mobility group 1 co-migrates with high mobility group 1 into the nucleus
309. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
310. Nuclear localization of the p 120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression
311. Nucleic acid-binding activities of the intermediate filament subunit proteins desmin and glial fibrillary acidic protein
312. Specific interaction of vinculin with alpha-actinin
313. Nuclear export of actin: A novel mechanism regulating the subcellular localization of a major cytoskeletal protein
314. Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: Identification of unique and shared domains
315. Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling
316. Translocation of actin from the cytoplasm into the nucleus in mammalian cells exposed to demethylsulfoxide
317. Importins and exportins: How to get in and out of the nucleus
318. Vinculin is part of the cadherin-catenin junctional complex: Complex formation between alpha-catenin and vinculin
319. Morphological study of the mammalian stress response: Characterization of changes in cytoplasmic organelles, cytoskeleton, and nucleoli, and appearance of intranuclear actin filaments in rat fibroblasts after heat-shock treatment
320. Nucleo-cytoplasmic localization of influenza virus nucleoprotein depends on cell density and phosphorylation
321. The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions
322. Desmosomal cadherin binding domains of plakoglobin
323. The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions
324. Karyopherins and kissing cousins
325. LIM domain recognition of a tyrosine-containing tight turn
326. Domain analysis of supervillin, an F-actin bundling plasma membrane protein with functional nuclear localization signals
327. SV40 large tumor antigen nuclear import is regulated by the double-stranded DNA-dependent protein kinase site (serine 120) flanking the nuclear localization sequence
328. Analysis of molecular domains of epitope-tagged merlin isoforms in Cos-7 cells and primary rat Schwann cells
329. The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells
330. A role for the divergent actin gene, ACT2, in nuclear pore structure and function
331. Ezrin-calpain I interactions in gastric parietal cells
332. Cloning and characterization of human karyopherin beta3
333. Beta-catenin can be transported into the nucleus in a Ran-unassisted manner
334. The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
335. Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene
336. gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein
337. The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation
338. Localization of pre-mRNA splicing in mammalian nuclei
339. Nuclear transport of adenovirus DNA polymerase is facilitated by interaction with preterminal protein
340. NF-AT activation requires suppression of Crm 1-dependent export by calcineurin