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1
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0031745571
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Signal transduction and signal modulation by cell adhesion receptors
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A broad-ranging review of signaling processes mediated by integrins, cadherins, selectins, and immunoglobulin family-CAMs. of special interest
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Aplin AE, Howe A, Alahari SK, Juliano RL. Signal transduction and signal modulation by cell adhesion receptors. of special interest Pharmacol Rev. 1998; A broad-ranging review of signaling processes mediated by integrins, cadherins, selectins, and immunoglobulin family-CAMs.
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(1998)
Pharmacol Rev
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Aplin, A.E.1
Howe, A.2
Alahari, S.K.3
Juliano, R.L.4
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2
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0030850248
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Integrins and anoikis
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of special interest. A timely review of anchorage regulation of apoptosis.
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Frisch SM, Ruoslahti E. Integrins and anoikis. of special interest Curr Opin Cell Biol. 9:1997;701-706 A timely review of anchorage regulation of apoptosis.
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(1997)
Curr Opin Cell Biol
, vol.9
, pp. 701-706
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Frisch, S.M.1
Ruoslahti, E.2
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3
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0029731588
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Focal adhesions, contractility, and signaling
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of special interest. A thought-provoking review on the structure and formation of focal contacts, suggesting the role of actomysosin-generated tension.
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Burridge K, Chrzanowska-Wodnicka M. Focal adhesions, contractility, and signaling. of special interest Annu Rev Cell Dev Biol. 12:1996;463-519 A thought-provoking review on the structure and formation of focal contacts, suggesting the role of actomysosin-generated tension.
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(1996)
Annu Rev Cell Dev Biol
, vol.12
, pp. 463-519
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Burridge, K.1
Chrzanowska-Wodnicka, M.2
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4
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0029870339
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Integrin activation by R-ras
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of special interest. The first report of G-protein regulation of integrin affinity by the process of 'inside-out' signaling.
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Zhang Z, Vuori K, Wang H-G, Reed JC, Ruoslahti E. Integrin activation by R-ras. of special interest Cell. 85:1996;61-69 The first report of G-protein regulation of integrin affinity by the process of 'inside-out' signaling.
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(1996)
Cell
, vol.85
, pp. 61-69
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Zhang, Z.1
Vuori, K.2
Wang H-G3
Reed, J.C.4
Ruoslahti, E.5
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5
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0030909050
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Suppression of integrin activation: A novel function of a Ras/Raf-initiated MAP kinase pathway
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of outstanding interest. An important paper that implicates elements of the Ras/MAPK pathway in modulation of integrin affinity.
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Hughes PE, Renshaw MW, Pfaff M, Forsyth J, Keivens VM, Schwartz MA, Ginsberg MH. Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. of outstanding interest Cell. 88:1997;521-530 An important paper that implicates elements of the Ras/MAPK pathway in modulation of integrin affinity.
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(1997)
Cell
, vol.88
, pp. 521-530
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Hughes, P.E.1
Renshaw, M.W.2
Pfaff, M.3
Forsyth, J.4
Keivens, V.M.5
Schwartz, M.A.6
Ginsberg, M.H.7
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6
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0030059222
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Role of Rho in chemoattractant-activated leukocyte adhesion through integrins
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Laudanna C, Campbell JJ, Butcher EC. Role of Rho in chemoattractant-activated leukocyte adhesion through integrins. Science. 271:1996;981-983.
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(1996)
Science
, vol.271
, pp. 981-983
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Laudanna, C.1
Campbell, J.J.2
Butcher, E.C.3
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7
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0031459917
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Cdc42 and Rac 1 induce integrin-mediated cell motility and invasiveness via PI 3-kinase
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of special interest. An interesting study illustrating the collaborating role of integrins and Rho-family proteins in control of tumor progression.
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Keely PJ, Westwick JK, Whitehead IP, Der CJ, Parise LV. Cdc42 and Rac 1 induce integrin-mediated cell motility and invasiveness via PI 3-kinase. of special interest Nature. 390:1997;632-636 An interesting study illustrating the collaborating role of integrins and Rho-family proteins in control of tumor progression.
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(1997)
Nature
, vol.390
, pp. 632-636
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Keely, P.J.1
Westwick, J.K.2
Whitehead, I.P.3
Der, C.J.4
Parise, L.V.5
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8
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0030602819
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αlβ2 integrin/LFA1 binding to ICAM1 induced by cytohesin-1, a cytoplasmic regulatory molecule
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of special interest. The first report of a cytoplasmic protein that binds to integrin cytoplasmic tails and modulates integrin affinity.
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Kolanus W, Nagel W, Schiller B, Zeitlmann L, Godar S, Stockinger H, Seed B. αLβ2 integrin/LFA1 binding to ICAM1 induced by cytohesin-1, a cytoplasmic regulatory molecule. of special interest Cell. 86:1996;233-242 The first report of a cytoplasmic protein that binds to integrin cytoplasmic tails and modulates integrin affinity.
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(1996)
Cell
, vol.86
, pp. 233-242
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Kolanus, W.1
Nagel, W.2
Schiller, B.3
Zeitlmann, L.4
Godar, S.5
Stockinger, H.6
Seed, B.7
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9
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0030026679
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Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase
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of special interest. The initial description of an integrin-regulated kinase that may have a vital role in the control of cell growth and differentiation.
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Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, Bell JC, Dedhar S. Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase. of special interest Nature. 379:1996;91-96 The initial description of an integrin-regulated kinase that may have a vital role in the control of cell growth and differentiation.
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(1996)
Nature
, vol.379
, pp. 91-96
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Hannigan, G.E.1
Leung-Hagesteijn, C.2
Fitz-Gibbon, L.3
Coppolino, M.G.4
Radeva, G.5
Filmus, J.6
Bell, J.C.7
Dedhar, S.8
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10
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0030978516
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Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion
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of special interest. This work demonstrates that a protein that binds to alpha subunit cytoplasmic tails can have a striking effect on integrin mediated adhesion and signaling.
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Coppolino MG, Woodside MJ, Demaurex N, Grinsten S, St-Arnaud R, Dedhar S. Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion. of special interest Nature. 386:1997;843-847 This work demonstrates that a protein that binds to alpha subunit cytoplasmic tails can have a striking effect on integrin mediated adhesion and signaling.
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(1997)
Nature
, vol.386
, pp. 843-847
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Coppolino, M.G.1
Woodside, M.J.2
Demaurex, N.3
Grinsten, S.4
St-Arnaud, R.5
Dedhar, S.6
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11
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0031041536
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Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP ribosylation factor
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Meacci E, Tsai S-C, Adami R, Moss J, Vaughan M. Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP ribosylation factor. Proc Natl Acad Sci USA. 94:1997;1745-1748.
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(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 1745-1748
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Meacci, E.1
Tsai S-C2
Adami, R.3
Moss, J.4
Vaughan, M.5
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12
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0031042493
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Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton
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of special interest. An excellent review of Rho-family GTPases.
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Tapon N, Hall A. Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton. of special interest Curr Opin Cell Biol. 9:1997;86-92 An excellent review of Rho-family GTPases.
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(1997)
Curr Opin Cell Biol
, vol.9
, pp. 86-92
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Tapon, N.1
Hall, A.2
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13
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0030756973
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Role of actin polymerization and adhesion to extracellular matrix in Rac- And Rho-induced cytoskeletal reorganization
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Machesky LM, Hall A. Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganization. J Cell Biol. 138:1997;913-926.
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(1997)
J Cell Biol
, vol.138
, pp. 913-926
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MacHesky, L.M.1
Hall, A.2
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14
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0030968580
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Rho GTPases and signaling networks
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of special interest. A excellent and very comprehensive review of Rho-family GTPases.
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Van Aelst L, D'Souza-Schorey D. Rho GTPases and signaling networks. of special interest Genes Dev. 11:1997;2295-2322 A excellent and very comprehensive review of Rho-family GTPases.
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(1997)
Genes Dev
, vol.11
, pp. 2295-2322
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Van Aelst, L.1
D'Souza-Schorey, D.2
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15
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0030298138
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Rac and cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade
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Lamarche NN, Tapon L, Stowers PD, Burbelo P, Aspenstron T, Bridges J, Chant A, Hall A. Rac and cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. Cell. 87:1996;519-529.
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(1996)
Cell
, vol.87
, pp. 519-529
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Lamarche, N.N.1
Tapon, L.2
Stowers, P.D.3
Burbelo, P.4
Aspenstron, T.5
Bridges, J.6
Chant, A.7
Hall, A.8
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16
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0031026132
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Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways
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Westwick JK, Lambert QT, Clark GJ, Symons M, Van Aelst L, Pestell RG, Der CJ. Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways. Mol Cell Biol. 17:1997;1324-1335.
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(1997)
Mol Cell Biol
, vol.17
, pp. 1324-1335
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Westwick, J.K.1
Lambert, Q.T.2
Clark, G.J.3
Symons, M.4
Van Aelst, L.5
Pestell, R.G.6
Der, C.J.7
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17
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0031081425
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Signaling through focal adhesion kinase
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of special interest. An up to date and useful review of FAK and its role in focal contacts; this includes considerable detail that is omitted in the discussion of FAK in the current article.
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Hanks SK, Polte TR. Signaling through focal adhesion kinase. of special interest BioEssays. 19:1997;137-145 An up to date and useful review of FAK and its role in focal contacts; this includes considerable detail that is omitted in the discussion of FAK in the current article.
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(1997)
BioEssays
, vol.19
, pp. 137-145
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Hanks, S.K.1
Polte, T.R.2
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18
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0031032777
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Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: Involvement of the Grb2, p130cas, and Nck adaptor proteins
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Schlaepfer DD, Broome MA, Hunter T. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol Cell Biol. 17:1997;1702-1713.
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(1997)
Mol Cell Biol
, vol.17
, pp. 1702-1713
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Schlaepfer, D.D.1
Broome, M.A.2
Hunter, T.3
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19
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0029120440
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Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
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of special interest. This 'knockout' study is still a key to understanding the role of FAK.
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Ilic D, Furuta Y, Kanazawa S, Takeda N, Sobue K, Nakatsuji N, Nomura S, Fujimoto J, Okada M, Yamamoto T, et al. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. of special interest Nature. 377:1995;539-544 This 'knockout' study is still a key to understanding the role of FAK.
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(1995)
Nature
, vol.377
, pp. 539-544
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Ilic, D.1
Furuta, Y.2
Kanazawa, S.3
Takeda, N.4
Sobue, K.5
Nakatsuji, N.6
Nomura, S.7
Fujimoto, J.8
Okada, M.9
Yamamoto, T.10
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20
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0030953445
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Integrin-mediated activation of focal adhesion kinase is independent of focal adhesion formation or integrin activation. Studies with activated and inhibitory beta3 cytoplasmic domain mutants.
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Lyman S, Gilmore A, Burridge K, Gidwitz S, White GC II. Integrin-mediated activation of focal adhesion kinase is independent of focal adhesion formation or integrin activation. Studies with activated and inhibitory beta3 cytoplasmic domain mutants. J Biol Chem. 272:1997;22538-22547.
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(1997)
J Biol Chem
, vol.272
, pp. 22538-22547
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Lyman, S.1
Gilmore, A.2
Burridge, K.3
Gidwitz, S.4
White G.C. II5
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21
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0030845282
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Dissection of pathways implicated in integrin-mediated actin cytoskeleton assembly. Involvement of protein kinase C, Rho GTPase, and tyrosine phosphorylation
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Defilippi P, Venturino M, Gulino D, Duperray A, Boquet P, Fiorentini C, Volpe G, Palmieri M, Silengo L, Tarone G. Dissection of pathways implicated in integrin-mediated actin cytoskeleton assembly. Involvement of protein kinase C, Rho GTPase, and tyrosine phosphorylation. J Biol Chem. 272:1997;21726-21734.
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(1997)
J Biol Chem
, vol.272
, pp. 21726-21734
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Defilippi, P.1
Venturino, M.2
Gulino, D.3
Duperray, A.4
Boquet, P.5
Fiorentini, C.6
Volpe, G.7
Palmieri, M.8
Silengo, L.9
Tarone, G.10
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22
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0029971297
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A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK
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Richardson A, Parsons T. A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK. Nature. 380:1996;538-540.
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(1996)
Nature
, vol.380
, pp. 538-540
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Richardson, A.1
Parsons, T.2
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23
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0029948080
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Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn
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Cary LA, Chang JF, Guan J-L. Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J Cell Sci. 109:1996;1787-1794.
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(1996)
J Cell Sci
, vol.109
, pp. 1787-1794
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Cary, L.A.1
Chang, J.F.2
Guan J-L3
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24
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0028609382
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Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
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of special interest. The first report suggesting that FAK could recruit Grb2 and thus possibly signal to the MAPK pathway.
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Schlaepfer DD, Hanks SK, Hunter T, van der Geer P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. of special interest Nature. 372:1994;786-791 The first report suggesting that FAK could recruit Grb2 and thus possibly signal to the MAPK pathway.
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(1994)
Nature
, vol.372
, pp. 786-791
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Schlaepfer, D.D.1
Hanks, S.K.2
Hunter, T.3
Van Der Geer, P.4
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25
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0030926774
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Focal adhesion kinase overexpression enhances Ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src
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Schlaepfer DD, Hunter T. Focal adhesion kinase overexpression enhances Ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. J Biol Chem. 272:1997;13189-13195.
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(1997)
J Biol Chem
, vol.272
, pp. 13189-13195
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Schlaepfer, D.D.1
Hunter, T.2
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26
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0031047981
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Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs
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Polte TR, Hanks SK. Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs. J Biol Chem. 272:1997;5501-5509.
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(1997)
J Biol Chem
, vol.272
, pp. 5501-5509
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Polte, T.R.1
Hanks, S.K.2
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27
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0029664531
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Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: A role for Src family kinases
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Vuori K, Hirai H, Aizawa S, Ruoslahti E. Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Mol Cell Biol. 16:1996;2606-2613.
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(1996)
Mol Cell Biol
, vol.16
, pp. 2606-2613
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Vuori, K.1
Hirai, H.2
Aizawa, S.3
Ruoslahti, E.4
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28
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0029739950
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Control of adhesion-dependent cell survival by focal adhesion kinase
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of special interest. This study showed that FAK has a key role in anoikis; it also suggested that FAK might not be involved in adhesion regulation of MAPK.
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Frisch SM, Vuori K, Ruoslahti E, Chan-Hui PY. Control of adhesion-dependent cell survival by focal adhesion kinase. of special interest J Cell Biol. 134:1996;793-799 This study showed that FAK has a key role in anoikis; it also suggested that FAK might not be involved in adhesion regulation of MAPK.
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(1996)
J Cell Biol
, vol.134
, pp. 793-799
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Frisch, S.M.1
Vuori, K.2
Ruoslahti, E.3
Chan-Hui, P.Y.4
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29
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0030874021
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Integrin-mediated activation of MAP kinase is independent of FAK: Evidence for dual integrin signaling pathways in fibroblasts
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of special interest. This report supports the existence of integrin signaling paths to MAPK that do not involve FAK. It makes use of the C-terminal domain of FAK as a dominant negative for FAK activation.
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Lin TH, Aplin AE, Shen Y, Chen Q, Schaller M, Romer L, Aukhil I, Juliano RL. Integrin-mediated activation of MAP kinase is independent of FAK: Evidence for dual integrin signaling pathways in fibroblasts. of special interest J Cell Biol. 136:1997;1385-1395 This report supports the existence of integrin signaling paths to MAPK that do not involve FAK. It makes use of the C-terminal domain of FAK as a dominant negative for FAK activation.
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(1997)
J Cell Biol
, vol.136
, pp. 1385-1395
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Lin, T.H.1
Aplin, A.E.2
Shen, Y.3
Chen, Q.4
Schaller, M.5
Romer, L.6
Aukhil, I.7
Juliano, R.L.8
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30
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0030584077
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The adaptor protein Shc couples a class of integrins to the control of cell cycle progression
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of outstanding interest. This report indicates the existence of a novel and important signaling pathway from integrins, through caveolin and Shc, and then to the Ras/MAPK cascade.
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Wary KK, Mainiero F, Isakoff SJ, Marcantonio EE, Giancotti FG. The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. of outstanding interest Cell. 87:1996;733-743 This report indicates the existence of a novel and important signaling pathway from integrins, through caveolin and Shc, and then to the Ras/MAPK cascade.
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(1996)
Cell
, vol.87
, pp. 733-743
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Wary, K.K.1
Mainiero, F.2
Isakoff, S.J.3
Marcantonio, E.E.4
Giancotti, F.G.5
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31
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0030960332
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Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth
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Engleman JA, Wykoff CC, Yasuhara S, Song KS, Okamoto T, Lisanti MP. Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth. J Biol Chem. 272:1997;16374-16381.
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(1997)
J Biol Chem
, vol.272
, pp. 16374-16381
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Engleman, J.A.1
Wykoff, C.C.2
Yasuhara, S.3
Song, K.S.4
Okamoto, T.5
Lisanti, M.P.6
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32
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17544364168
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Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization
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of special interest. this report provided evidence in favor of a role for Ras in integrin signaling to MAPK. It makes use of N17 Ras as a dominant negative.
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Clark EA, Hynes RO. Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization. of special interest J Biol Chem. 271:1996;14814-14818 this report provided evidence in favor of a role for Ras in integrin signaling to MAPK. It makes use of N17 Ras as a dominant negative.
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(1996)
J Biol Chem
, vol.271
, pp. 14814-14818
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Clark, E.A.1
Hynes, R.O.2
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33
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0030839766
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Phosphatidyl 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation
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King WG, Mattaliano MD, Chan TO, Tsichlis PN, Brugge JS. Phosphatidyl 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation. Mol Cell Biol. 17:1997;4406-4418.
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(1997)
Mol Cell Biol
, vol.17
, pp. 4406-4418
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King, W.G.1
Mattaliano, M.D.2
Chan, T.O.3
Tsichlis, P.N.4
Brugge, J.S.5
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34
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0029994358
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Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras
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of special interest. This report provided evidence in favor of a Ras-independent pathway for integrin signaling to MAPK. It makes use of an amino-terminal domain of Raf as a dominant negative.
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Chen Q, Lin TH, Der CJ, Juliano RL. Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras. of special interest J Biol Chem. 271:1996;18122-18127 This report provided evidence in favor of a Ras-independent pathway for integrin signaling to MAPK. It makes use of an amino-terminal domain of Raf as a dominant negative.
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(1996)
J Biol Chem
, vol.271
, pp. 18122-18127
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Chen, Q.1
Lin, T.H.2
Der, C.J.3
Juliano, R.L.4
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35
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0030898415
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The complexity of Raf regulation
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of special interest. This is a timely review of the intricacies of Raf activation.
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Cutler RE, Morrison DK. The complexity of Raf regulation. of special interest Curr Opin Cell Biol. 9:1997;174-179 This is a timely review of the intricacies of Raf activation.
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(1997)
Curr Opin Cell Biol
, vol.9
, pp. 174-179
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Cutler, R.E.1
Morrison, D.K.2
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36
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0030931217
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Regulation of cell motility by mitogen-activated protein kinase
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of special interest. An important study showing that MAPK can regulate MLCK and thus influence actinomyosin contractility and cell motility.
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Klemke RL, Cai S, Giannini AL, Gallagher PJ, de Lanerolle P, Cheresh DA. Regulation of cell motility by mitogen-activated protein kinase. of special interest J Cell Biol. 137:1997;481-492 An important study showing that MAPK can regulate MLCK and thus influence actinomyosin contractility and cell motility.
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(1997)
J Cell Biol
, vol.137
, pp. 481-492
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Klemke, R.L.1
Cai, S.2
Giannini, A.L.3
Gallagher, P.J.4
De Lanerolle, P.5
Cheresh, D.A.6
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37
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0031022256
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Anchorage-dependent cell cycle progression
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of special interest. An important review of the role of anchorage in regulation of the cell-cycle machinery.
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Assoian RK. Anchorage-dependent cell cycle progression. of special interest J Cell Biol. 136:1997;1-4 An important review of the role of anchorage in regulation of the cell-cycle machinery.
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(1997)
J Cell Biol
, vol.136
, pp. 1-4
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Assoian, R.K.1
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38
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0030661566
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Integrins, oncogenes and anchorage independence
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of special interest. An unique and interesting viewpoint on the relationship between oncogenes and anchorage regulation of cell growth.
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Schwartz MA. Integrins, oncogenes and anchorage independence. of special interest J Cell Biol. 139:1997;575-578 An unique and interesting viewpoint on the relationship between oncogenes and anchorage regulation of cell growth.
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(1997)
J Cell Biol
, vol.139
, pp. 575-578
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Schwartz, M.A.1
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39
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0029670904
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Stimulation of β1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF β-receptors
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Sundberg C, Rubin K. Stimulation of β1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF β-receptors. J Cell Biol. 132:1996;741-752.
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(1996)
J Cell Biol
, vol.132
, pp. 741-752
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Sundberg, C.1
Rubin, K.2
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40
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0031039771
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Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs
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41
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of special interest. An excellent recent example of integrin modulation of the activation of a RTK (PDGFb receptor). It also recapitulates earlier work on integrin effects on insulin receptor and IRS-1.
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Schneller M, Vuori K, Ruoslahti E. αvβ3 integrin associates with activated insulin and PDGFβ receptors and potentiates the biological activity of PDGF. of special interest EMBO J. 16:1997;5600-5607 An excellent recent example of integrin modulation of the activation of a RTK (PDGFb receptor). It also recapitulates earlier work on integrin effects on insulin receptor and IRS-1.
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42
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of special interest. A key early report demonstrating that integrin clustering could enhance growth factor signaling.
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Miyamoto, S.1
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of special interest
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Lin TH, Chen Q, Howe A, Juliano R.L. Cell anchorage permits efficient signal transduction between Ras and its downstream kinases. J Biol Chem. 272:1997;8849-8852. of special interest.
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44
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of special interest. Lin, 1997 [43] and the paper above investigate the role of integrin-mediated anchorage in regulating downstream events in the MAPK cascade triggered by peptide mitogens. They come to somewhat different specific conclusions, but both show integrins affecting coupling between upstream and downstream events.
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Renshaw MW, Ren X-D, Schwartz MA. Growth factor activation of MAP kinase requires cell adhesion. of special interest EMBO J. 16:1997;5592-5599 Lin, 1997 [43] and the paper above investigate the role of integrin-mediated anchorage in regulating downstream events in the MAPK cascade triggered by peptide mitogens. They come to somewhat different specific conclusions, but both show integrins affecting coupling between upstream and downstream events.
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60
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of special interest. A key analysis of the cell-cycle events regulated by cell anchorage.
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Zhu X, Ohtsubo M, Bohmer RM, Roberts JM, Assoian RK. Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, phosphorylation of the retinoblastoma protein. of special interest J Cell Biol. 133:1996;391-403 A key analysis of the cell-cycle events regulated by cell anchorage.
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Dependence of cyclin E-CDK2 kinase activity on cell anchorage
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of special interest. This report emphasizes the role of p21 and p27 inhibitor proteins in anchorage regulation of the cell cycle.
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Fang F, Orend G, Watanabe N, Hunter T, Ruoslahti E. Dependence of cyclin E-CDK2 kinase activity on cell anchorage. of special interest Science. 271:1996;499-502 This report emphasizes the role of p21 and p27 inhibitor proteins in anchorage regulation of the cell cycle.
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waf1 pathway in response to disruption of cell-matrix interactions. J Biol Chem. 272:1997;29091-29098.
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64
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Yang JJ, Krauss RS. Extracellular ATP induces anchorage-independent expression of cyclin A and rescues the transformed phenotype of a ras-resistant mutant cell line. J Biol Chem. 272:1997;3103-3108.
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Wen L-P, Fahrni JA, Troie S, Guan J-L, Orth K, Rosen GD. Cleavage of focal adhesion kinase by caspases during apoptosis. J Biol Chem. 272:1997;26056-26061.
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79
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Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein
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Affinity modulation of platelet integrin αllbβ3 by β3 endonexin, a selective binding partner of the β3 integrin cytoplasmic tail
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