Nexilin: A novel actin filament-binding protein localized at cell- matrix adherens junction

Journal of Cell Biology

Volumn 143, Issue 5, 1998, Pages 1227-1238

  Ohtsuka, Toshihisa ^a   Nakanishi, Hiroyuki ^a   Ikeda, Wataru ^a   Satoh, Ayako ^b   Momose, Yumiko ^a   Nishioka, Hideo ^b   Takai, Yoshimi ^a,b,c  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Actin binding protein; Adherens junction; Focal contact; Integrin; Stress fiber

Indexed keywords

ACTIN BINDING PROTEIN; F ACTIN; INTEGRIN; NEXILIN; PAXILLIN; TALIN; UNCLASSIFIED DRUG; VINCULIN;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROBLAST; IMMUNOFLUORESCENCE MICROSCOPY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN; TESTIS;

ACTINS; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BRAIN; CARRIER PROTEINS; CELL ADHESION; CELL LINE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; EXTRACELLULAR MATRIX; IMMUNOHISTOCHEMISTRY; INTERCELLULAR JUNCTIONS; MALE; MICE; MICROFILAMENT PROTEINS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; RATS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0032583119     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.143.5.1227     Document Type: Article

References (81)

1. Abercrombie, M., and G.A. Dunn. 1975. Adhesions of fibroblasts to substratum during contact inhibition observed by interference reflection microscopy. Exp. Cell Res. 92:57-62.
2. Abercrombie, M., J.E. Heaysman, and S.M. Pegram. 1971. The locomotion of fibroblasts in culture. Exp. Cell Res. 67:359-367.
3. Allen, P.B., C.C. Quimet, and P. Greengard. 1997. Spinophilin: a novel protein phosphatase 1 binding protein localized to dendritic spines. Proc. Natl. Acad. Sci. USA. 94:9956-9961.
4. Beckerle, M.C. 1986. Identification of a new protein localized at sites of cell-substrate adhesion. J. Cell Biol. 103:1679-1687.
5. Behrens, J., J.P. von Kries, M. Kühl, L. Bruhn, D. Wedlich, R. Grosschedl, and W. Birchmeier. 1996. Functional interaction of β-catenin with the transcription factor LEF-1. Nature. 382:638-642.
6. Berger, B., D.B. Wilson, E. Wolf, T. Tonchev, M. Milla, and P.S. Kim. 1995. Predicting coiled coils by use of pairwise residue correlations. Proc. Natl. Acad. Sci. USA. 92:8259-8263.
7. Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
8. Bretscher, A., and K. Weber. 1980. Fimbrin, a new microfilament-associated protein present in microvilli and other cell surface structures. J. Cell Biol. 86: 335-340.
9. Bretscher, A. 1993. Microfilaments and membranes. Curr. Opin. Cell Biol. 5:653-660.
10. Burridge, K., and L. Connell. 1983. A new protein of adhesion plaques and ruffling membranes. J. Cell Biol. 97:359-367.
11. Burridge, K., and M. Chrzanowska-Wodnicka. 1996. Focal adhesions, contractility, and signaling. Annu. Rev. Cell Dev. Biol. 12:463-518.
12. Carlsson, L., L.E. Nystrom, I. Sundkvist, F. Markey, and U. Lindberg. 1977. Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells. J. Mol. Biol. 115:465-483.
13. Chia, C.P., A.L. Hitt, and E.J. Luna. 1991. Direct binding of F-actin to ponticulin, an integral plasma membrane glycoprotein. Cell Motil. Cytoskel. 18:164-179.
14. Chuang, J.-Z., D.C. Lin, and S. Lin. 1995. Molecular cloning, expression, and mapping of the high affinity actin-capping domain of chicken cardiac tensin. J. Cell Biol. 128:1095-1109.
15. Crawford, A.W., and M.C. Beckerle. 1991. Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions. J. Biol. Chem. 266: 5847-5853.
16. De Arruda, M.V., S. Watson, C.-S. Lin, J. Leavitt, and P. Matsudaira. 1990. Fimbrin is a homologue of the cytoplasmic phosphoprotein plasmin and has domains homologous with calmodulin and actin gelatin protein. J. Cell Biol. 111:1064-1079.
17. 125I)vinculin overlay, immunoblotting, and immunocytochemistry. Eur J. Cell Biol. 46:513-522.
18. Elisei, R., D. Weightman, P. Kendall-Taylor, G. Vassart, and M. Ludgate. 1993. Muscle autoantigens in thyroid-associated ophthalmopathy: the limits of molecular genetics. J. Endocrinol. Invest. 16:533-540.
19. Endo, T., and T. Masaki. 1982. Molecular properties and functions in vitro of chicken smooth-muscle α-actinin in comparison with those of striated-muscle α-actinins. J. Biochem. (Tokyo). 92:1457-1468.
20. Fannon, A.M., and D.R. Colman. 1996. A model for central synaptic junctional complex formation based on the differential adhesive specificities of the cadherins. Neuron. 17:423-434.
21. Fraser, A.B., E. Eisenberg, W.W. Kielley, and F.D. Carlson. 1975. The interaction of heavy meromyosin and subfragment 1 with actin. Physical measurements in the presence and absence of adenosine triphosphate. Biochemistry. 14:2207-2214.
22. Geiger, B. 1979. A 130K protein from chicken gizzard: its localization at the termini of microfilament bundles in cultured chicken cells. Cell. 18:193-205.
23. Geiger, B. 1983. Membrane-cytoskeleton interaction. Biochim. Biophys. Acta. 737:305-341.
24. Geiger, B. 1989. Cytoskeleton-associated cell contacts. Curr. Opin. Cell Biol. 1:103-109.
25. Geiger, B., and D. Ginsberg. 1991. The cytoplasmic domain of adherens-type junctions. Cell Motil. Cytoskel. 20:1-6.
26. Geiger, B., T. Volk, and T. Volberg. 1985. Molecular heterogeneity of adherens junctions. J. Cell. Biol. 101:1523-1531.
27. Gottardi, C.J., M. Arpin, A.S. Fanning, and D. Louvard. 1996. The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts. Proc. Natl. Acad. Sci. USA. 93:10779-10784.
28. Hartwig, J.H., and D.J. Kwiatkowski. 1991. Actin-binding proteins. Curr. Opin. Cell Biol. 3:87-97.
29. Hata, Y., and T.C. Südhof. 1995. A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic. J. Biol. Chem. 270: 13022-13028.
30. Heath, J.P., and G.A. Dunn. 1978. Cell to substratum contacts of chick fibroblasts and their relation to the microfilament system: a correlated interference-reflexion and high-voltage electron-microscope study. J. Cell Sci. 29: 197-212.
31. Imazumi, K., T. Sasaki, K. Takahashi, and Y. Takai. 1994. Identification of a rabphilin-3A-interacting protein as GTP cyclohydrolase I in PC12 cells. Biochem. Biophys. Res. Commun. 205:1409-1416.
32. Itoh, M., S. Yonehara, A. Nagafuchi, Sa. Tsukita, and Sh. Tsukita. 1991. A 220-kD undercoat-constitutive protein: its specific localization at cadherin-based cell-cell adhesion sites. J. Cell Biol. 115:1449-1462.
33. Itoh, M., A. Nagafuchi, S. Moroi, and Sh. Tsukita. 1997. Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to α-catenin and actin filaments. J. Cell Biol. 138:181-192.
34. Izzard, C.S., and L.R. Lochner. 1976. Cell-to-substrate contacts in living fibroblasts: an interference reflexion study with an evaluation of the technique. J. Cell Sci. 21:129-159.
35. Jockusch, B.M., P. Bubeck, K. Giehl, M. Kroemker, J. Moschner, M. Rothkegel, M. Rüdiger, K. Schlüter, G. Stanke, and J. Winkler. 1995. The molecular architecture of focal adhesions. Annu. Rev. Cell Dev. Biol. 11:379-416.
36. Kato, M., T. Sasaki, T. Ohya, H. Nakanishi, H. Nishioka, M. Imamura, and Y. Takai. 1996. Physical and functional interaction of rabphilin-3A with α-actinin. J. Biol. Chem. 271:31775-31778.
37. Keely, P., L. Parise, and R. Juliano. 1998. Integrins and GTPases in tumour cell growth, motility, and invasion. Trends Cell Biol. 8:101-107.
38. Knudsen, K.A., A.P. Soler, K.R. Johnson, and M.J. Wheelock. 1995. Interaction of α-actinin with the cadherin/catenin cell-cell adhesion complex via α-catenin. J. Cell Biol. 130:67-77.
39. Kotani, H., K. Takaishi, T. Sasaki, and Y. Takai. 1997. Rho regulates association of both the ERM family and vinculin with the plasma membranes in MDCK cells. Oncogene. 14:1705-1713.
40. Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:680-685.
41. Lewis, J.M., R. Baskaran, S. Taagepera, M.A. Schwartz, and J.Y. Wang. 1996. Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport. Proc. Natl. Acad. Sci. USA. 93:15174-15179.
42. Lo, S.H., Q. An, S. Bao, W.-K. Wong, Y. Liu, P.A. Janmey, J.H. Hartwig, and L.B. Chen. 1994. Molecular cloning of chick cardiac muscle tensin. J. Biol. Chem. 269:22310-22319.
43. Luna, E.J., and A.L. Hitt. 1992. Cytoskeleton-plasma membrane interactions. Science. 258:955-964.
44. Lupas, A. 1996. Coiled coils: new structures and new functions. Trends Biochem. Sci. 21:375-382.
45. Lupas, A., M. Van Dyke, and J. Stock. 1991. Predicting coiled coils from protein sequences. Science. 252:1162-1164.
46. Mandai, K., H. Nakanishi, A. Satoh, H. Obaishi, M. Wada, H. Nishioka, M. Itoh, A. Mizoguchi, T. Aoki, T. Fujimoto, et al. 1997. Afadin: a novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J. Cell Biol. 139:517-528.
47. Matsudaira, P. 1991. Modular organization of actin crosslinking proteins. Trends Biochem. Sci. 16:87-92.
48. Mizoguchi, A., S. Kim, T. Ueda, A. Kikuchi, H. Yorifuji, N. Hirooka, and Y. Takai. 1990. Localization and subcellular distribution of smg p25A, a ras p21-like GTP-binding protein, in rat brain. J. Biol. Chem. 91:257-269.
49. Molenaar, M., M. van de Wetering, M. Oosterwegel, J. Peterson-Maduro, S. Godsave, V. Korinek, J. Roose, O. Destree, and H. Clevers. 1996. XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos. Cell. 86:391-399.
50. Nagafuchi, A., M. Takeichi, and Sh. Tsukita. 1991. The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression. Cell. 65:849-857.
51. Nakai, K., and M. Kanehisa. 1992. A knowledge base for predicting protein localization sites in eukaryotic cells. Genomics. 14:897-911.
52. Nakanishi, H., M. Obaishi, A. Satoh, M. Wada, K. Mandai, K. Satoh, H. Nishioka, Y. Matsuura, A. Mizoguchi, and Y. Takai. 1997. Neurabin: a novel neural tissue-specific actin filament-binding protein involved in neurite formation. J. Cell Biol. 139:951-961.
53. Nix, D.A., and M.C. Beckerle. 1997. Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus. J. Cell Biol. 138:1139-1147.
54. Obaishi, H., H. Nakanishi, K. Mandai, K. Satoh, A. Satoh, K. Takahashi, M. Miyahara, H. Nishioka, K. Takaishi, and Y. Takai. 1998. Frabin, a novel FGD1-related actin filament-binding protein capable of changing cell shape and activating c-Jun N-terminal kinase. J. Biol. Chem. 273:18697-18700.
55. Ozawa, M., H. Baribault, and R. Kemler. 1989. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO (Eur. Mol. Biol. Organ.) J. 8:1711-1717.
56. Pardee, J.D., and J.A. Spudich. 1982. Purification of muscle actin. Methods Enzymol. 85:164-181.
57. Pasteris, N.G., A. Cadle, L.J. Losie, M.E.M. Porteous, C.E. Shwarts, R.E. Stevenson, T.W. Glover, R.S. Wilroy, and J.L. Gorski. 1994. Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: a putative Rho/Rac guanine nucleotide exchange factor. Cell. 79:669-678.
58. Pestonjamasp, K., M.R. Amieva, CP. Strassel, W.M. Nauseef, H. Furthmayr, and E.J. Luna. 1995. Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranes. Mol. Biol. Cell. 6:247-259.
59. Philp, N.J., M.Y. Yoon, and R.S. Hock. 1990. Identification and localization of talin in chick retinal pigment epithelial cells. Exp. Eye Res. 51:191-198.
60. Pollard, T.D., and J.A. Cooper. 1982. Methods to characterize actin filament networks. Methods Enzymol. 85:211-233.
61. Rayment, I., H.M. Holder, M. Whittaker, C.B. Yohn, M. Lorenz, K.C. Holmes, and R.A. Milligan. 1993. Structure of the actin-myosin complex and its implications for muscle contraction. Science. 261:58-65.
62. Rimm, D.L., E.R. Koslov, P. Kebriaei, C.D. Cianci, and J.S. Morrow. 1995. α1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex. Proc. Nail. Acad. Sci. USA. 92:8813-8817.
63. Robbins, J., S.M. Dilworth, R.A. Laskey, and C. Dingwall. 1991. Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell. 64:615-623.
64. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. 2nd edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
65. Satoh, A., H. Nakanishi, H. Obaishi, M. Wada, K. Takahashi, K. Satoh, K. Hirao, H. Nishioka, Y. Hata, A. Mizoguchi, and Y. Takai. 1998. Neurabin-II/ spinophilin: an actin filament-binding protein with one PDZ domain localized at cadherin-based cell-cell adhesion sites. J. Biol. Chem. 273:3470-3475.
66. Schaller, M.D., C.A. Borgman, B.S. Cobbs, R.R. Vines, A.B. Reynolds, and J.T. Parsons. 1992. pp125FAK: a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc. Natl. Acad. Sci. USA. 89:5192-5196.
67. Schröder, R.R., D.J. Manstein, W. Jahn, H. Holden, I. Rayment, K.C. Holmes, and J.A. Spudich. 1993. Three-dimensional atomic model of F-actin decorated with Dictyostelium myosin S1. Nature. 364:171-174.
68. Schwartz, M.A., M.D. Schaller, and M.H. Ginsberg. 1995. Integrins: emerging paradigms of signal transduction. Annu. Rev. Cell Dev. Biol. 11:549-599.
69. Takeichi, M. 1988. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development (Camb.). 102:639-655.
70. Takeichi, M. 1991. Cadherin cell adhesion receptors as a morphogenetic regulator. Science. 251:1451-1455.
71. Takeuchi, M., Y. Hata, K. Hirao, A. Toyoda, M. Irie, and Y. Takai. 1997. SAPAPs: a family of PSD-95/SAP90-associated proteins localized at postsynaptic density. J Biol. Chem. 272:11943-11951.
72. Tidball, J.G., T. O'Halloran, and K. Burridge. 1986. Talin at myotendinous junctions. J. Cell Biol. 103:1465-1472.
73. Tsukita, Sa., S. Yonemura, and Sh. Tsukita. 1997. ERM proteins: head-to-tail regulation of actin-plasma membrane interaction. Trends Biochem. Sci. 22: 53-58.
74. Tsukita, Sh., Sa. Tsukita, A. Nagafuchi, and S. Yonemura. 1992. Molecular linkage between cadherins and actin filaments in cell-eell adherens junctions. Curr. Opin. Cell Biol. 4:834-839.
75. Turner, C.E., and K. Burridge. 1991. Transmembrane molecular assemblies in cell-extracellular matrix interactions. Curr. Opin. Cell Biol. 3:849-853.
76. Turner, C.E., J. Glenney, Jr., and K. Burridge. 1990. Paxillin: a new vinculin-binding protein present in focal adhesions. J. Cell Biol. 111:1059-1068.
77. Uchida, N., Y. Honjo, K.R. Johnson, M.J. Wheelock, and M. Takeichi. 1996. The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones. J. Cell Biol. 135:767-779.
78. Wang, E., H.L. Yin, J.G. Krueger, L.A. Caliguiri, and I. Tamm. 1984. Unphosphorylated gelsolin is localized in regions of cell-substratum contact or attachment in Rous sarcoma virus-transformed rat cells. J. Cell Biol. 98:761-771.
79. Wilkins, J.A., M.A. Risinger, and S. Lin. 1986. Studies on proteins that copurify with smooth muscle vinculin: identification of immunologically related species in focal adhesions of nonmuscle and Z-lines of muscle cells. J. Cell Biol. 103:1483-1494.
80. Yang, Y., J. Dowling, Q.C. Yu, P. Kouklis, D.W. Cleveland, and E. Fuchs. 1996. An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments. Cell. 86:655-665.
81. Zheng, Y., D.J. Fisher, M.F. Santos, G. Tigyi, N.G. Fastens, J.L. Gorski, and Y. Xu. 1996. The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific guanine nucleotide exchange factor. J. Biol. Chem. 271: 33169-33172.