Two independent domains of hDlg are sufficient for subcellular targeting: The PDZ1-2 conformational unit and an alternatively spliced domain

Journal of Cell Biology

Volumn 135, Issue 4, 1996, Pages 1125-1137

  Lue, Robert A ^a   Brandin, Eric ^a   Chan, Erick P ^a   Branton, Daniel ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROCYTE BAND 4.1 PROTEIN; EZRIN; GUANYLATE KINASE; MOESIN; RADIXIN;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSKELETON; DROSOPHILA; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE;

ANIMALIA; MURINAE;

EID: 0029846832     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.135.4.1125     Document Type: Article

References (54)

1. Adam, S.A., R. Sterne Marr, and L. Gerace. 1990. Nuclear import in permeabilized mammalian cells requires soluble cytoplasmic factors. J. Cell Biol. 111: 807-816.
2. Anderson, R.A., and E.F. Lovrien. 1984. Glycophorin is linked by band 4.1 protein to the human erythrocyte membrane skeleton. Nature (Lond.). 307:655-658.
3. Bar-Sagi, D., D. Rotin, A. Batzer, V. Mandiyan, and J. Schlessinger. 1993. SH3 domains direct cellular localization of signaling molecules. Cell. 74:83-91.
4. Beckers, C.J.M., D.S. Keller, and W.E. Balch. 1987. Semi-intact cells permeable to macromolecules: use in reconstitution of protein transport from the endoplasmic reticulum to the Golgi complex. Cell. 50:523-534.
5. Brenman, J.E., D.S. Chao, S.H. Gee, A.W. McGee, S.E. Craven, D.R. Santillano, Z. Wu, F. Huang, H. Xia, M.F. Peters, et al. 1996. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and O1-syntrophin mediated by PDZ domains. Cell. 84:757-767.
6. Bryant, P.J., K.L. Watson, R.W. Justice, and D.F. Woods. 1993. Tumor suppressor genes encoding proteins required for cell interactions and signal transduction in Drosophila. Development (Camb.). (Suppl.)239-249.
7. Byers, T.J., R. Dubreuil, D.P. Kiehart, L.S.B. Goldstein, and D. Branton. 1987. Drosophila spectrin II. Conserved features of the α-subunit are revealed by analysis of cDNA clones and fusion proteins. J. Cell Biol. 105:2103-2110.
8. Cho, K.-O., C.A. Hunt, and M.B. Kennedy. 1992. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron. 9:929-942.
9. Conboy, J.G., J.Y. Chan, J.A. Chasis, Y.W. Kan, and N. Mohandas. 1991. Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1. J. Biol. Chem. 266:8273-8280.
10. Fehon, R.G., I.A. Dawson, and S. Artavanis-Tsakonas. 1994. A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene. Development (Camb.). 120:545-557.
11. Ferguson, E.L., and H.R. Horvitz. 1985. Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. Genetics. 110:17-72.
12. Gary, R., and A. Bretscher. 1995. Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site. Mol. Biol. Cell. 6:1061-1075.
13. Goda, Y., and S. Pfeffer. 1989. Cell-free systems to study vesicular transport along the secretory and endocytic pathways. FASEB J. 3:2488-2495.
14. Gould, K.L., A. Bretscher, F.S. Esch and T. Hunter. 1989. cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1. EMBO (Eur. Mol. Biol. Organ.) J. 8:4133-4142.
15. Gu, M., J.D. York, I. Warshawsky, and P.W. Majerus. 1991. Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1. Proc. Natl. Acad. Sci. USA. 88:5867-5871.
16. Gumbiner, B., T. Lowenkopf, and D. Apatira. 1991. Identification of a 160 kD polypeptide that binds to the tight junction protein ZO-1. Proc. Natl. Acad. Sci. USA. 88:3460-3464.
17. Haas, T.A., and E.F. Plow. 1994. Integrin-ligand interactions: a year in review. Curr. Opin. Cell Biol. 6:656-662.
18. Hata, Y., S. Butz, and T.C. Sudhof. 1996. CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins. J. Neurosci. 16:2488-2494.
19. Horvitz, H.R., and J.E. Sulston. 1980. Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans. Genetics. 96: 435-454.
20. Hoskins, R., A.F. Hajnal, S.A. Harp, and S.K. Kim. 1996. The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins. Development (Camb.). 122:97-111.
21. Itoh, M., A. Nagafuchi, S. Yonemura, T. Kitani-Yasuda, S. Tsukita, and S. Tsukita. 1993. The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy. J.Cell Biol. 121:491-502.
22. Jesaitis, L.A., and D.A. Goodenough. 1994. Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein. J. Cell Biol. 124:949-961.
23. Kennedy, M.B. 1995. Origin of PDZ (DHR, GLGF) domains. TIBS (Trends Biochem. Sci.). 20:350.
24. + channels by interaction with a family of membrane-associated guanylate kinases. Nature (Lond.). 378:85-88.
25. Kistner, U., B.M. Wenzel, R.W. Veh, C. Cases-Langhoff, A.M. Garner, U. Appeltauer, B. Voss, E.D. Gundelfinger, and C.C. Garner. 1993. SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A. J. Biol. Chem. 268:4580-4583.
26. Kornau, H-C., L.T. Schenker, M.B. Kennedy, and P.H. Seeburg. 1995. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science (Wash. DC). 269:1737-1740.
27. Krezel, A.M., G. Wagner, J. Seymour-Ulmer, and R.A. Lazarus. 1994. Structure of the RGD protein decorsin: conserved motif and distinct function in Leech proteins that affect blood clotting. Science (Wash. DC). 264:1944-1947.
28. Leto, T.L., and V.T. Marchesi. 1984. A structural model of human erythrocyte protein 4.1. J. Biol. Chem. 259:4603-4608.
29. Leto, T.L., B.M. Pratt, and J.A. Madri. 1986. Mechanisms of cytoskeletal regulation: modulation of aortic endothelial cell protein band 4.1 by the extracellular matrix. J. Cell. Physiol. 127:423-431.
30. Lue, R.A., S.M. Marfatia, D. Branton, and A.H. Chishti. 1994. Cloning and characterization of hDlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. Proc. Natl. Acad. Sci. USA. 91: 9818-9822.
31. Main, A.L., T.S. Harvey., M. Baron, J. Boyd, and I.D. Campbell. 1992. The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions. Cell. 71:671-678.
32. Marfatia, S.M., R.A. Lue, D. Branton, and A.H. Chishti. 1994. In vitro binding studies suggest a membrane-associated complex between erythroid p55, protein 4.1 and glycophorin C. J. Biol. Chem. 269:8631-8634.
33. Marfatia, S.M., R.A. Lue, D. Branton, and A.H. Chishti. 1995. Identification of the protein 4.1 binding interface on glycophorin C and p55, a homologue of the Drosophila discs-large tumor suppressor protein. J. Biol. Chem. 270: 715-719.
34. Matsumine, A., A. Ogai, T. Senda, N. Okumura, K. Satoh, G-H. Baeg, T. Kawahara, S. Kobayashi, M. Okada, K. Toyoshima, and T. Akiyama. 1996. Binding of APC to the human homolog of the Drosophila Discs Large tumor suppressor protein. Science (Wash. DC). 272:1020-1023.
35. Mazoyer, S., S.A. Gayther, M.A. Nagai, S.A. Smith, A. Dunning, E.J. Van-Rensburg, H. Albertsen, R. White, and B.A. Ponder. 1995. A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dlg-A. Genomics. 28:25-31.
36. Montermini, L., F. Rodius, L. Pianese, M.D. Molto, M. Cossee, V. Campuzano, F. Cavalcanti, A. Monticelli, F. Palau, G. Gyapay, et al. 1995. The Friedreich ataxia critical region spans a 150-kb interval on chromosome 9q13. Am. J. Hum. Genet. 57:1061-1067.
37. Moore, M.S., and G. Blobel. 1992. The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors. Cell. 69:939-950.
38. Muller, B.M., U. Kistner, R.W. Veh, C. Cases-Langhoff, B. Becker, E.D. Gundelfinger, and C.C. Garner. 1995. Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein. J. Neurosci. 15:2354-2366.
39. Ponting, C.P., and C. Phillips. 1995. DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins. TIBS (Trends Biochem. Sci). 20: 102-103.
40. Rees, D.J.G., S.E. Ades, S.J. Singer, and R.O. Hynes. 1990. Sequence and domain structure of talin. Nature (Lond.). 347:685-689.
41. Rouleau, G.A., P. Merel, M. Lutchman, M. Sanson, J. Zucman, C. Marineau, K. Hoang-Xuan, S. Demczuk, C. Desmaze, B. Plougastel, et al. 1993. Alteration in a new gene encoding a putative membrane-organizing protein causes neurofibromatosis type 2. Nature (Lond.). 363:515-521.
42. Ruff, P., D.W. Speicher, and A. Husain-Chishti. 1991. Molecular identification of a major palmiloylated erythrocyte membrane protein containing the src homology 3 motif. Proc. Natl. Acad. Sci. USA. 88:6595-6599.
43. Sato, N., N. Funayama, A. Nagafuchi, S. Yonemura, S. Tsukita, and S. Tsukita. 1992. A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites. J. Cell Sci. 103: 131-143.
44. Sato, T., S. Irie, S. Kitada, and J.C. Reed. 1995. FAP-1: a protein tyrosine phosphatase that associates with Fas. Science (Wash. DC). 268:411-415.
45. Smith, D.B., and K.S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene. 67:31-40.
46. Stevenson, B.R., J.D. Siliciano, M.S. Mooseker, and D.A. Goodenough. 1986. Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J. Cell Biol. 103:755-766.
47. Trofatter, J.A., M.M. MacCollin, J.L. Rutter, J.R. Murrell, M.P. Duyao, D.M. Parry, R. Eldridge, N. Kley, A.G. Menon, K. Pulaski, et al. 1993. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell. 72:791-800.
48. Tsukita, S., M. Itoh, A. Nagafuchi, S. Yonemura, and S. Tsukita. 1993. Submembranous junctional plaque proteins include potential tumor suppressor molecules. J. Cell Biol. 123:1049-1053.
49. Tsukita, S., K. Oishi, N. Sato, J. Sagara, A. Kawai, and S. Tsukita. 1994. ERM family members us molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons. J. Cell Biol. 126:391-401.
50. Willott, E., M.S. Balda, A.S. Fanning, B. Jameson, C. Van Itallie, and J.M. Anderson. 1993. The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions. Proc. Natl. Acad. Sci. USA. 90:7834-7838.
51. Winckler, B., Ch. Gonzalez Agosti, M. Magendantz, and F. Solomon. 1994. Analysis of a cortical cytoskeletal structure: a role for ezrin-radixin-moesin (ERM proteins) in the marginal band of chicken erythrocytes. J. Cell Sci. 107:2523-2534.
52. Woods, D.F., and P.J. Bryant. 1991. The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell. 66:451-464.
53. Woods, D.F., and P.J. Bryant. 1993. ZO-1, DlgA and PSD-95/SAP90: homologous proteins in tight, septate and synaptic cell junctions. Mech. Dev. 44:85-89.
54. Yamada, K.M., and S. Miyamoto. 1995. Integrin transmembrane signaling and cytoskeletal control. Curr. Opin. Cell Biol. 7:681-689.