Defective glucose-regulated insulin gene expression associated with PDX-1 deficiency in the Psammomys obesus model of type 2 diabetes

Diabetes

Volumn 50, Issue SUPPL. 1, 2001, Pages

  Leibowitz, Gil ^a   Melloul, Danielle ^a   Yuli, Michal ^a   Gross, David J ^a   Apelqvist, Åsa ^a   Edlund, Helena ^a   Cerasi, Erol ^a   Kaiser, Nurit ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HOMEODOMAIN PROTEIN; INSULIN; MESSENGER RNA; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; CALORIC INTAKE; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HOMEOBOX; HYPERGLYCEMIA; INSULIN SYNTHESIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RODENT;

EID: 0035124999     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.2007.s138     Document Type: Conference Paper

References (7)

1. Lilly lecture 1987: The triumvirate: β-cell, muscle, liver: A collusion responsible for NIDDM
2. Type 2 diabetes: When insulin secretion fails to compensate for insulin resistance
3. Hyperproinsulinemia and insulin deficiency in the diabetic Psammomys obesus
4. Hyperglycemia-induced β-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes
5. Purification of the β-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells
6. Insulin promoter factor-1 is required for pancreas development in mice
7. Interaction between genetic and dietary factors determines β-cell function in Psammomys obesus, an animal model of type 2 diabetes