Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells

Endocrinology

Volumn 140, Issue 10, 1999, Pages 4904-4907

  Wang, X ^a   Cahill, C M ^a   Pineyro, M A ^a   Zhou, J ^a   Doyle, M E ^a   Egan, J M ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCOKINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; ELECTROPHORESIS; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; INSULIN SYNTHESIS; INSULINOMA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL TUMOR; PRIORITY JOURNAL; PROTEIN BINDING; RAT;

EID: 0033305746     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.10.7158     Document Type: Article

References (13)

1. Glucagon-like peptide-1 7-36: A physiological incretin in man
2. Glucagon-like peptide can reverse the age-related decline in glucose tolerance in rats
3. Glucagon-like peptide-1 affects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-38 cells
4. Insulin-promoter-factor 1 is required for pancreas development in mice
5. Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes
6. IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene
7. Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
8. Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells
9. Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression
10. Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 beta-cells
11. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells
12. Transcriptional repression of the prointerleukin 1 beta gene by heat shock factor 1
13. Glucose stimulates the activation domain potential of the PDX-1 homeodomain transcription factor