Transforming growth factor β induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene-1 in rat insulinoma cells

European Journal of Biochemistry

Volumn 267, Issue 4, 2000, Pages 971-978

  Sayo, Yoshitaka ^a   Hosokawa, Hitoshi ^a   Imachi, Hitomi ^a   Murao, Koji ^a   Sato, Makoto ^a   Wong, Norman C W ^b   Ishida, Toshihiko ^a   Takahara, Jiro ^a  

^a KAGAWA UNIVERSITY   (Japan)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

FK506; Insulin; PDX 1; TGF ; Transcription

Indexed keywords

INSULIN; TACROLIMUS; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DUODENUM; GENE INDUCTION; HOMEOBOX; INSULIN SYNTHESIS; INSULINOMA; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROMOTER REGION; RAT; TRANSCRIPTION REGULATION;

ANIMALS; DNA; GLUCOSE; HOMEODOMAIN PROTEINS; IMMUNOPHILINS; INSULIN; INSULINOMA; ISLETS OF LANGERHANS; MUTATION; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RATS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RESPONSE ELEMENTS; RNA, MESSENGER; TACROLIMUS; TACROLIMUS BINDING PROTEINS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0033976650     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01080.x     Document Type: Article

References (52)

1. 1. Yamanaka, Y., Friess, H., Buchler, M., Beger, H.G., Gold, L.I. & Korc, M. (1993) Synthesis and expression of transforming growth factor β-1, β-2, and β-3 in the endocrine and exocrine pancreas. Diabetes 42, 746-756.
2. 2. Sjoholm, A., Hellerstrom, C. (1991) TGF-beta stimulates insulin secretion and blocks mitogenic response of pancreatic β-cells to glucose. Am. J. Physiol. 260, C1046-C1045.
3. 3. Totsuka, Y., Tabuchi, M., Kojima, I., Eto, Y., Shibai, H. & Ogata, E. (1989) Stimulation of insulin secretion by transforming growth factor-beta. Biochem. Biophys. Res. Commun. 158, 1060-1065.
4. 4. Furth, S., Neu, A., Colombani, P., Plotnick, L., Turner, M.E. & Fivush, B. (1996) Diabetes as a complication of tacrolimus (FK506) in pediatric renal transplant patients. Pediatr. Nephrol. 10, 64-66.
5. 5. Okadome, T., Oeda, E., Saitoh, M., Ichijo, H., Moses, H.L., Miyazono, K. & Kawabata, M. (1996) Characterization of the interaction of FKBP12 with the transforming growth factor-beta type I receptor in vivo. J. Biol. Chem. 271, 21687-21690.
6. 6. Wang, T., Li, B.Y., Danielson, P.D., Shah, P.C., Rockwell, S., Lechleider, R.J., Martin, J., Manganaro, T. & Donahoe, P.K. (1996) The immunophilin FKBP12 functions as a common inhibitor of the TGF β family type I receptors. Cell 86, 435-444.
7. 7. Stein, R. (1993) Factors regulating insulin gene transcription. Trends Endocrinol. Metab. 4, 96-100.
8. 8. Crowe, D.T. & Tsai, M.J. (1989) Mulagenesis of the rat insulin II 5'-flanking region defines sequences important for expression in HIT cells. Mol. Cell Biol. 9, 1784-1789.
9. 9. German, M.S., Moss, L.G., Wang, J. & Rutter, W.J. (1992) The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that hind identical beta-cell nuclear complexes. Mol. Cell Biol. 12, 1777-1788.
10. 10. Karlsson, O., Edlund, T., Moss, J.B., Rutter, W.J. & Walker, M.D. (1987) A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer. Proc. Natl Acad. Sci. USA 84, 8819-8823.
11. 11. Peshavaria, M., Gamer, L., Henderson, E., Teitelman, G., Wright, C.V. & Stein, R. (1994) X1Hbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. Mol. Endocrinol. 8, 806-816.
12. 12. Shieh, S.Y. & Tsai, M.J. (1991) Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene. J. Biol. Chem. 266, 16708-16714.
13. 13. Whelan, J., Poon, D., Weil, P.A. & Stein, R. (1989) Pancreatic β-cell-type specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elements. Mol. Cell Biol. 9, 3253-3259.
14. 14. Ohlsson, H., Thor, S. & Edlund, T. (1991) Novel insulin promoter-and enhancer binding proteins that discriminate between pancreatic alpha-and beta cells. Mol. Endocrinol. 5, 897-904.
15. 15. Robinson, G.L., Peshavaria, M., Henderson, E., Shieh, S.Y., Tsai, M.J., Teitelman, G. & Stein, R. (1994) Expression of the trans-active factors that stimulate insulin control element-mediated activity appear to precede insulin gene transcription. J. Biol. Chem. 269, 2452-2460.
16. 16. Ohlsson, H., Karlsson, K. & Edlund, T. (1993) IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J. 12, 4251-4259.
17. 17. Miller, C.P., McGehee, R. Jr & Habener, J.F. (1994) IDX-I: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates thesomatostatin gene. EMBO J. 13, 1145-1156.
18. 18. Leonard, J., Peers, B., Johnson, T., Ferreri, K., Lee, S. & Montminy, M.R. (1993) Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic Islet cells. Mol. Endocrinol. 7, 1275-1283.
19. 19. Melloul, D., Ben-Neriah, Y. & Cerasi, E. (1993) Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters. Proc. Natl Acad. Sci. USA 90, 3865-3869.
20. 20. Petersen, H.V., Serup, P., Leonard, J., Michelsen, B.K. & Madsen, O.D. (1994) Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. Proc. Natl Acad. Sci. USA 91, 10465-10469.
21. 21. MacFarlane, W.M., Read, M.L., Gilligan, M., Bujalska, I. & Docherty, K. (1994) Glucose modulates the binding activity of the β-cell transcription factor IUFI in a phosphorylation-dependent manner. Biochem. J. 303, 625-631.
22. 22. Chomczynski, P. & Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
23. 23. Mizobuchi, M., Murao, K., Takeda, R. & Kakimoto, Y. (1994) Tissue-specific expression of isoaspartyl protein carboxyl methyltransferase gene in rat brain and testis. J. Neurochem. 62, 322-328.
24. 24. Tokunaga, K., Taniguchi, H., Yoda, K., Shimizu, M. & Sakiyama, S. (1986) Nucleotide sequence of a full-length cDNA for mouse cytoskeletal β-actin mRNA. Nucleic Acids Res. 14, 2829.
25. 25. Choi, M.E., Kim, E.G., Huang, Q. & Ballermann, B.J. (1993) Rat mesangial cell hypertrophy in response to transforming growth factor-beta 1. Kidney Int. 44, 948-958.
26. 26. Wikstrom, P., Bergh, A. & Dumber, J.E. (1997) Expression of transforming growth factor-beta receptor type I and typeII in rat ventral prostate and Dunning R3327 PAP adenocarcinoma in response to castration and oestrogen treatment. Uro. Res. 25, 103-111.
27. 27. Nelson, P.A., Lippke, J.A., Murcko, M.A., Rosborough, S.L. & Peattie, D.A. (1991) cDNA encoding murine FK506-binding protein (FKBP) nucleotide and deduced amino acid sequence. Gene 109, 255-258.
28. 28. Ullrich, A., Shine, J., Chirgwin, J.M., Pictet, R., Tischer, E., Rutter, W.J. & Goodman, H.M. (1977) Rat insulin genes: construction of plasmids containing the coding sequences. Science 196, 1313-1319.
29. 29. Murao, K., Wada, Y., Nakamura, T., Taylor, A.H., Mooradian, A.D. & Wong, N.C.W. (1998) Effects of glucose and insulin on rat apolipoprotein A-I gene expression. J. Biol. Chem 273, 18959-18965.
30. 30. Chen, C. & Okayama, H. (1987) High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell Biol. 7, 2745-2752.
31. 31. Herbomel, P., Bourachot, B. & Yaniv, M. (1984) Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma. Cell 39, 653-662.
32. 32. Ebner, R., Chen, R.H., Shum, L., Lawler, S., Zioncheck, T.F., Lee, A., Lopez, A.R. & Derynck, R. (1993) Cloning of a type I TGF-β receptor and its effect on TGF-β binding to the type II receptor. Science 260, 1344-1348.
33. 33. Sharma, A. & Stein, R. (1994) Glucose-induced transcription of the insulin gene is mediated by factors required for β-cell-type-specific expression. Mol. Cell Biol. 14, 871-879.
34. 34. Sekine, N., Yamashita, N., Kojima, I., Miyazaki, J. & Ogata, E. (1994) Bimodal effect of transforming growth factor-beta on insulin secretion in MIN6 cells. Diabetes Res. Clin. Pract. 26, 7-14.
35. 35. Asfari, M., Janjic, D., Meda, P., Li, G., Halban, P.A. & Wollheim, C.B. (1992) Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130, 167-178.
36. 36. Janjic, D. & Wollheim, C.B. (1992) Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay. Diabetologia 35, 482-485.
37. 37. Sekine, N., Cirulli, V., Regazzi, R., Brown, L.J., Gine, E., Tamarit-Rodriguez, J., Girotti, M., Marie, S., MacDonald, M.J., Wollheim, C.B. & Rutter, G.A. (1994) Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic β-cells. Potential role in nutrient sensing. J. Biol. Chem. 269, 4895-4902.
38. 38. Philippe, J., Pacheco, I. & Meda, P. (1994) Insulin gene transcription is decreased rapidly by lowering glucose concentrations in rat islet cells. Diabetes 43, 523-528.
39. 39. Marie, S., Diaz-Guerra, M.J., Miquerol, L., Kahn, A. & Iynedjian, P.B. (1993) The pyruvate kinase gene as a model for studies of glucose-dependent regulation of gene expression in the endocrine pancreatic beta-cell type. J. Biol. Chem. 268, 23881-23990.
40. 40. Yasuda, H., Inoue, K., Shibata, H., Takeuchi, T., Eto, Y., Hasegawa, Y., Sekine, N., Totsuka, Y., Mine, T. & Ogata, E. (1993) Existence of activin-A in A-and D cells of rat pancreatic islet. Endocrinology 133, 624-630.
41. 41. Morgan, B.A. & Tabin, C.J. (1993) The role of Hox genes in limb development. Prog. Clin. Biol. Res. 383A, 1-9.
42. 42. Davis, A.P., Witte, D.P., Hsieh-Li, H.M., Potter, S.S. & Capecchi, M.R. (1995) Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature 375, 791-795.
43. 43. Redmon, J.B., Olson, L.K., Armstrong, M.B., Greene, M.J. & Robertson, R.P. (1996) Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells. J. Clin. Invest. 98, 2786-2793.
44. 44. Wang, T., Donahoe, P.K. & Zervos, A.S. (1994) Specific interaction of type I receptors of the TGF-β family with the immunophilin FKBP-12. Science 265, 674-676.
45. 45. Shou, W., Aghdasi, B., Armstrong, D.L., Guo, Q., Bao, S., Charng, M.J., Mathews, L.M., Schneider, M.D., Hamilton, S.L. & Matzuk, M.M. (1998) Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12. Nature 391, 489-492.
46. 46. Bassing, C.H., Shou, W., Muir, S., Heitman, J., Matzuk, M.M. & Wang, X.F. (1998) FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes. Cell Growth Differ. 9, 223-228.
47. 47. Massague, J. (1998) TGF-beta signal transduction. Annu. Rev. Biochem. 67, 753-791.
48. 48. Yamaguchi, K., Shirakabe, K., Shibuya, H., Irie, K., Oishi, I., Ueno, N., Taniguchi, T., Nishida, E. & Matsumoto, K. (1995) Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 270, 2008-2011.
49. 49. Rossi, P., Karsenty, G., Roberts, A.B., Roche, N.S., Sporn, M.B. & de Crombrugghe, B. (1988) A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta. Cell 52, 405-414.
50. 2+ flux. Cell 83, 463-472.
51. 51. Rafiq, I., Kennedy, H.J. & Rutter, G.A. (1998) Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 beta-cells. J. Biol. Chem. 273, 23241-23247.
52. 52. Macfarlane, W.M., McKinnon, C.M., Felton-Edkins, Z.A., Cragg, H., James, R.F. & Docherty, K. (1999) Glucose stimulates translocation of the homeodomain transcription factor PDXI from the cytoplasm to the nucleus in pancreatic beta-cells. J. Biol. Chem. 274, 1011-1016.