Glucagonlike peptide-1 agonist stimulation of β-cell growth and differentiation

Current Opinion in Endocrinology and Diabetes

Volumn 8, Issue 2, 2001, Pages 74-81

  Habener, J F ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON LIKE PEPTIDE 1;

ANIMAL CELL; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL MATURATION; DIABETES MELLITUS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; REVIEW; SIGNAL TRANSDUCTION; STEM CELL;

EID: 0035100815     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/00060793-200104000-00004     Document Type: Review

References (62)

1. Ontogeny, differentiation and growth of the endocrine pancreas
2. Islet growth and development in the adult
3. Perspective: Postnatal pancreatic beta cell growth
4. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development
5. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model
6. Islet cell precursors are neurones
7. Developmental biology of the pancreas
8. Control of early development of the pancreas in rodents and humans: Implications of signals from the mesenchyme
9. Transcribing pancreas
10. A newly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus
11. The glucagon-like peptides
12. Glucagon-like peptides
13. The incretin notion and its relevance to diabetes
14. Pancreas: How to get there from the gut?
15. Early-onset type-ii diabetes mellitus (mody4) linked to ipf1
16. Transcription factors involved in pancreatic islet development
17. Insulin-promoter-factor 1 is required for pancreas development in mice
18. Pdx-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
19. Pancreatic agenesis attributable to a single nucleotide deletion in the human ipf1 gene coding sequence
20. Regulatory factor linked to late-onset diabetes?
21. Beta-cell-specific inactivation of the mouse ipf1/pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
22. Defective mutations in the insulin promoter factor-1 (ipf-1) gene in late-onset type 2 diabetes mellitus
23. Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes
24. Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats
25. Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations
26. The homeodomain protein idx-1 increases after an early burst of proliferation during pancreatic regeneration
27. Glucagon-like peptide-1 regulates the beta cell transcription factor, pdx-1, in insulinoma cells
28. Glucagon-like peptide 1 and exendin-4 convert pancreatic ar42j cells into glucagon and insulin-producing cells
29. Pancreatic tumoral cell line ar42j: An amphicrine model
30. Molecular basis of transdifferentiation of pancreas to liver
31. Betacellulin and activin a coordinately convert amylase-secreting pancreatic ar42j cells into insulin-secreting cells
32. Formation of insulin-producing cells from pancreatic acinar ar42j cells by hepatocyte growth factor
33. Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide y, but not pancreatic polypeptide
34. Early pattern of differentiation in the human pancreas
35. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages
36. Developmental expression of the homeodomain protein idx-1 in mice transgenic for an idx-1 promoter/lacz transcriptional reporter
37. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein idx-1 and increase islet size in mouse pancreas
38. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
39. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
40. Insulinotropic glucagon-like peptide i receptor expression in glucagon- producing alpha-cells of the rat endocrine pancreas
41. Glucagon-like peptide i stimulates insulin gene expression and increases cyclic amp levels in a rat islet cell line
42. Pancreatic glucagon-like peptide-1 receptor couples to multiple g proteins and activates mitogen-activated protein kinase pathways in chinese hamster ovary cells
43. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (pdx-1) DNA binding activity in beta (ins-1)-cells
44. Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, ins-1
45. Glucose modulates the binding activity of the beta-cell transcription factor iuf1 in a phosphorylation-dependent manner
46. Insulin stimulates pancreatic-duodenal homeobex factor-1 (pdx1) DNA-binding activity and insulin promoter activity in pancreatic beta cells
47. The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells
48. Glucose-stimulated preproinsulin gene expression and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 mapk/sapk2
49. Possible involvement of atypical protein kinase c (pkc) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal hemeobox gene-1 (pdx-1) are enhanced via calphostin c-sensitive but phorbol 12-myristate 13-acetate (pma) and go 6976-insensitive pathway
50. Glucose stimulates the activation domain potential of the pdx-1 homeodomain transcription factor
51. Glucagon-like peptide 1 increases glucose-dependent activity of the homeoprotein idx-1 transactivating domain in pancreatic beta-cells
52. Expression of camp-regulated guanine nucleotide exchange factors in pancreatic beta-cells
53. A family of camp-binding proteins that directly activate rap1
54. Camp activates map kinase and elk-1 through a b-raf- and rap1-dependent pathway
55. Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells
56. In vitro cultivation of human islets from expanded ductal tissue
57. Multipotential nestin-positive stem-cells isolated from adult pancreatic islets differentiate, ex vivo, into pancreatic endocrine, exocrine and hepatic phenotypes
58. Neogenesis vs. Apoptosis as main components of pancreatic beta cell mass changes in glucose-infused normal and mildly diabetic adult rats
59. Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion
60. Initiation of increased pancreatic islet growth in young normoglycemic mice (umea +/?)
61. Expansion of pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha
62. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia