Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells

Journal of Clinical Investigation

Volumn 100, Issue 7, 1997, Pages 1840-1846

  Kajimoto, Yoshitaka ^a   Watada, Hirotaka ^a   Matsuoka, Taka Aki ^a   Kaneto, Hideaki ^a   Fujitani, Yoshio ^a   Miyazaki, Jun Ichi ^a   Yamasaki, Yoshimitsu ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Antisense oligodeoxynucleotide; Gene expression regulation; Homeodomain protein; Transcription factors

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; HOMEODOMAIN PROTEIN; INSULIN; MESSENGER RNA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL CULTURE; DNA BINDING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

EID: 0030931645     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119712     Document Type: Article

References (39)

1. Porte, D., Jr. 1991. Banting lecture 1990: β-cells in type II diabetes mellitus. Diabetes. 40:166-180.
2. Tokuyama, Y., J. Sturis, A.M. DePaoli, J. Takeda, M. Stroffel, J. Tang, X. Sun, K.S. Polonsky, and G.I. Bell. 1995. Evolution of β-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes. 44:1447-1457.
3. Hummel, K.P., D.L. Coleman, and P.W. Lane. 1972. The influence of genetic background of expression of mutations at the diabetes locus in the mouse. I. C57BL/KsJ and C57BL/6J strains. Biochem. Genet. 7:1-13.
4. Eizirik, D.L., G.S. Korbutt, and C. Hellerstrom. 1992. Prolonged exposure of human pancreatic islets to high glucose concentration in vtlro impairs the β-cell function. J. Clin. Invest. 90:1263-1268.
5. Zhang, H.J., T.F Walseth, and R.P. Robertson. 1989. Insulin secretion and cAMP metabolism in HIT cells. Reciprocal and serial passage-dependent relationships. Diabetes. 38:44-48.
6. Robertson, R.P., H.J. Zhang, K.L. Pyzdrowski, and T.F. Walseth. 1992. Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations. J. Clin. Invest. 90:320-325.
7. Olson, L.K., J.B. Redmon, H.C. Towle, and R.P. Robertson. 1993. Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein. J. Clin. Invest. 92:514-519.
8. Matsuoka, T., Y. Kajimoto, H. Watada, H. Kaneto, M. Kishimoto, Y. Umayahara, Y. Fujitani, T. Kamada, R. Kawamori, and Y. Yamasaki. 1997. Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells. J. Clin. Invest. 99:144-150.
9. Ohlsson, H., K. Karlsson, and T. Edlund. 1993. IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO (Eur. Mol. Biol. Organ.) J. 12:4251-4259.
10. Leonard, J., B. Peers, T. Johnson, K. Ferreri, S. Lee, and M.R. Montminy. 1993. Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol. Endocrinol. 7:1275-1283.
11. Miller, C.P., R.E. McGehee, and J.F. Habener. 1994. IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO (Eur. Mol. Biol. Organ.) J. 13:1145-1156.
12. Zangen, D.H., S.B. Weir, C.H. Lee, J.B. Latimer, C.P. Miller, J.F. Habener, and G.C. Weir. 1997. Reduced insulin, GLUT2, and IDX-1 in β-cells after partial pancreatectomy. Diabetes. 46:258-264.
13. German, M., S. Ashcroft, K. Docherty, H. Edlund, T. Edlund, S. Goodison, H. Imura, G. Kennedy, O. Madsen, D. Melloul, et al. 1995. The insulin gene promoter. A simplified nomenclature. Diabetes. 44:1002-1004.
14. Jonsson, J., L. Carlsson, T. Edlund, and H. Edlund. 1994. Insulin-promoter-factor 1 is required for pancreatic development in mice. Nature (Lond.). 371:606-609.
15. Guz, Y., M.R. Montminy, R. Stein, J. Leonard, L.W. Gamer, C.V. Wright, and G. Teitelman. 1995. Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development (Camb.). 121:11-18.
16. Watada, H., Y. Kajimoto, Y. Umayahara, T. Matsuoka, H. Kaneto, Y. Fujitani, T. Kamada, R. Kawamori, and Y. Yamasaki. 1996. The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1 (IPF1)/PDX-1 in its activation in HIT-T15 cells. Diabetes. 45:1478-1488.
17. Watada, H., Y. Kajimoto, H. Kaneto, T. Matsuoka, Y. Fujitani, J. Miyazaki, and Y. Yamasaki. 1996. Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription. Biochem. Biophys. Res. Commun. 229:746-751.
18. Watada, H., Y. Kajimoto, J. Miyagawa, T. Hanafusa, K. Hamaguchi, T. Matsuoka, K. Yamamoto, Y. Matsuzawa, R. Kawamori, and Y. Yamasaki. 1996. PDX-1 induces insulin and glucokinase gene expressions in αTC1 clone 6 cells in the presence of betacellulin. Diabetes. 45:1826-1831.
19. Miyazaki, J., K. Araki, E. Yamato, H. Ikegami, T. Asano, Y. Shibasaki, Y. Oka, and K. Yamamura. 1990. Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology. 127:126-132.
20. Hamaguchi, K., and E.H. Leiter. 1990. Comparison of cytokine effects on mouse pancreatic α-cell and β-cell lines. Viability, secretory function, and MHC antigen expression. Diabetes. 39:415-425.
21. Vierra, C.A., and C. Nelson. 1995. The pan basic helix-loop-helix proteins are required for insulin gene expression. Mol. Endocrinol. 9:64-71.
22. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
23. Sadowski, H B., and M.Z. Gilman. 1993. Cell-free activation of a DNA-binding protein by epidermal growth factor. Nature (Lond.). 362:79-83.
24. Andreone, T.L., R.L. Printz, S.J. Pilkis, M.A. Magnuson, and D.K. Granner. 1989. The amino acid sequence of rat liver glucokinase deduced from cloned cDNA. J. Biol. Chem. 264:363-369.
25. Nishi, M., S.J. Chan, S. Nagamatsu, G.I. Bell, and D.F. Steiner. 1989. Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone. Proc. Natl. Acad. Sci. USA. 86:5738-5742.
26. Probst, J.C., and T. Skutella. 1996. Elevated messenger RNA levels after antisense oligodeoxynucleotide treatment in vitro and in vivo. Biochem. Biophys. Res. Commun. 225:861-868.
27. Welsh, M., A.N. David, A.J. MacKrell, and D.F. Steiner. 1985. Control of insulin gene expression in pancreatic β-cells and in an insulin-producing cell line. RIN-5F cells. J. Biol. Chem. 260:13590-13594.
28. Poitout, V., L.K. Olson, and R.P. Robertson. 1996. Chronic exposure of βTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator. J. Clin. Invest. 97:1041-1046.
29. Olson, L.K., A. Sharma, M. Peshavaria, C.V.E. Wright, H.C. Towle, R.P. Robertson, and R. Stein. 1995. Reduction of insulin gene transcription in HIT-T15 β-cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression. Proc. Natl. Acad. Sci. USA. 92:9127-9131.
30. Serup, P., J. Jensen, F.G. Andersen, M.C. Jorgensen, N. Blume, J.J. Holst, and O.D. Madsen. 1996. Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1. Proc. Natl. Acad. Sci. USA. 93:9015-9020.
31. Moran, A., H. Zhang, L.K. Olson, J.S. Harmon, V. Poitout, and R.P. Robertson. 1997. Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15. J. Clin. Invest. 99:534-539.
32. Naya, F.J., C.M. Stellrecht, and M.J. Tsai. 1995. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev. 15:1009-1019.
33. Lee, J.E., S.M. Hollenberg, L. Snider, D.L. Turner, N. Lipnick, and H. Weintraub. 1995. Conservation of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science (Wash. DC). 268:836-844.
34. Ohlsson, H., O. Karlsson, and T. Edlund. 1988. A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer. Proc. Natl. Acad. Sci. USA. 85:4228-4231.
35. Boam, D.S., A.R. Clark, and K. Docherty. 1990. Positive and negative regulation of the human insulin gene by multiple transacting factors. J. Biol. Chem. 265:8285-8296.
36. Morgan, B.A., and C. Tabin. 1993. The role of Hox genes in limb development. Prog. Clin. Biol. Res. 383A:1-9.
37. Davis, A.P., D.P. Witte, H.M. Hsieh-Li, S.S. Potter, and M.R. Capecchi. 1995. Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature (Lond.). 375:791-795.
38. Sharma, A., L.K. Olson, R.P. Robertson, and R. Stein. 1995. The reduction of the insulin gene transcription in HIT-T15 β cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression. Mol. Endocrinol. 9:1127-1134.
39. Melloul, D., Y. Ben-Neriah, and E. Cerasi. 1993. Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoter. Proc. Natl. Acad. Sci. USA. 90:3865-3869.