메뉴 건너뛰기




Volumn 26, Issue 6, 2000, Pages 449-462

The blood-brain barrier and oncology: New insights into function and modulation

Author keywords

Blood brain barrier; Brain metastasis; Cytoarchitecture; Modulation; Multidrug resistance; Multidrug resistance associated protein; Organic anion transporter; P glycoprotein; Visualization

Indexed keywords

2,4 BIS(ALLYLAMINO) 6 [4 [[2,2 BIS(4 FLUOROPHENYL)ETHYL]AMINO]PIPERIDINO] 1,3,5 TRIAZINE; 5 (4,6 DIMETHYL 1,3,2 DIOXAPHOSPHORINAN 2 YL) 2,6 DIMETHYL 4 (3 NITROPHENYL) 3 PYRIDINECARBOXYLIC ACID 2 (4 BENZHYDRYL 1 PIPERAZINYL)ETHYL ESTER P OXIDE; ANTIEMETIC AGENT; ANTINEOPLASTIC AGENT; BIRICODAR; BRADYKININ RECEPTOR AGONIST; CARDIOVASCULAR AGENT; CARRIER PROTEIN; CYCLOSPORIN A; CYTOTOXIC AGENT; DAUNORUBICIN; DOXORUBICIN; ELACRIDAR; GLUCURONIDE; GLUTATHIONE; GLYCOPROTEIN P; IMMUNOSUPPRESSIVE AGENT; METHOTREXATE; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; MIFEPRISTONE; MULTIDRUG RESISTANCE PROTEIN; NEW DRUG; OPIATE; PACLITAXEL; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALSPODAR; VERAPAMIL; VERLUKAST; ZOSUQUIDAR;

EID: 0034500036     PISSN: 03057372     EISSN: None     Source Type: Journal    
DOI: 10.1053/ctrv.2000.0194     Document Type: Review
Times cited : (172)

References (180)
  • 20
    • 0031691947 scopus 로고    scopus 로고
    • P-glycoprotein-mediated efflux transport of anti-cancer drugs at the blood-brain barrier
    • (1998) Ther Drug Monit , vol.20 , pp. 588-590
    • Tsuji, A.1
  • 23
    • 0030841332 scopus 로고    scopus 로고
    • Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
    • (1997) Cancer Res , vol.57 , pp. 3537-3547
    • Kool, M.1    De Haas, M.2    Scheffer, G.L.3
  • 28
    • 0032874193 scopus 로고    scopus 로고
    • Kinetic and biochemical analysis of carrier-mediated efflux of drugs through the blood-brain and blood-cerebrospinal fluid barriers: Importance in the drug delivery to the brain
    • (1999) J Controlled Release , vol.62 , pp. 179-186
    • Sugiyama, Y.1    Kusuhara, H.2    Suzuki, H.3
  • 34
    • 0019798883 scopus 로고
    • Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: A study using quail - Chick transplantation chimeras
    • (1981) Dev Biol , vol.84 , pp. 183-192
    • Stewart, P.A.1    Wiley, M.J.2
  • 43
    • 0020074071 scopus 로고
    • Human central nervous system distribution of cis-diamminedichloroplatinum and use as a radiosensitizer in malignant brain tumors
    • (1982) Cancer Res , vol.42 , pp. 2474-2479
    • Stewart, D.J.1    Leavens, M.2    Maor, M.3
  • 47
    • 0019124032 scopus 로고
    • Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability
    • (1980) J Med Chem , vol.23 , pp. 682-684
    • Levin, V.A.1
  • 48
    • 0033053207 scopus 로고    scopus 로고
    • In vitro models of the blood-brain barrier to polar permeants: Comparison of transmonolayer flux measurements and cell uptake kinetics using cultured cerebral capillary endothelial cells
    • (1999) J Pharm Sci , vol.88 , pp. 620-625
    • Johnson, M.D.1    Anderson, B.D.2
  • 52
    • 0029983195 scopus 로고    scopus 로고
    • High level expression of the multidrug resistance (MDR1) gene in the normal bladder urothelium: A potential involvement in protection against carcinogens?
    • (1996) Carcinogenesis , vol.17 , pp. 601-604
    • Clifford, S.C.1    Neal, D.E.2    Lunec, J.3
  • 55
  • 59
    • 0022993652 scopus 로고
    • Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins
    • (1986) Cell , vol.47 , pp. 371-380
    • Gros, P.1    Croop, J.2    Housman, D.3
  • 67
    • 0003041614 scopus 로고    scopus 로고
    • A novel hypothesis for the mechanism of action of P-glycoprotein as a multidrug transporter
    • (1999) Mol Carcinog , vol.25 , pp. 1-13
    • Zhu, B.T.1
  • 71
    • 0345084436 scopus 로고    scopus 로고
    • The multidrug resistance modulator valspodar (PSC 833) is metabolized by human cytochrome P450 3A. Implications for drug-drug interactions and pharmacological activity of the main metabolite
    • (1998) Drug Metab Dispos , vol.26 , pp. 802-811
    • Fischer, V.1    Rodriguez-Gascon, A.2    Heitz, F.3
  • 73
    • 0025105779 scopus 로고
    • Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues. Analysis with 3 monoclonal antibodies recognizing different epitopes of the P-glycoprotein molecule
    • (1990) Ann Oncol , vol.1 , pp. 56-64
    • Van der Valk, P.1    Van Kalken, C.K.2    Ketelaars, H.3
  • 79
  • 92
    • 0001308329 scopus 로고    scopus 로고
    • Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA
    • (1998) J Clin Invest , vol.101 , pp. 1310-1319
    • Evers, R.1    Kool, M.2    Van Deemter, L.3
  • 103
    • 4444224892 scopus 로고    scopus 로고
    • Human ATP Binding Cassette transporters
    • (2000)
    • Muller, M.1
  • 104
    • 0033551671 scopus 로고    scopus 로고
    • pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells
    • (1999) J Biol Chem , vol.274 , pp. 23541-23548
    • McAleer, M.A.1    Breen, M.A.2    White, N.L.3    Matthews, N.4
  • 112
    • 0032902957 scopus 로고    scopus 로고
    • Enhanced delivery of carboplatin into brain tumours with intravenous Cereport (RMP-7): Dramatic differences and insight gained from dosing parameters
    • (1999) Br J Cancer , vol.80 , pp. 964-970
    • Emerich, D.F.1    Snodgrass, P.2    Dean, R.3
  • 118
    • 0031882705 scopus 로고    scopus 로고
    • Intra-arterial administration of carboplatin and the blood brain barrier permeabilizing agent, RMP-7: A toxicologic evaluation in swine
    • (1998) J Neurooncol , vol.36 , pp. 167-178
    • Riley, M.G.1    Kim, N.N.2    Watson, V.E.3
  • 126
    • 0031686969 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of paclitaxel in combination with biricodar, a novel agent that reverses multidrug resistance conferred by overexpression of both MDR1 and MRP
    • (1998) J Clin Oncol , vol.16 , pp. 2964-2976
    • Rowinsky, E.K.1    Smith, L.2    Wang, Y.M.3
  • 127
    • 0031819596 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein: Rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier
    • (1998) Pharm Res , vol.15 , pp. 993-1000
    • Fenart, L.1    Buee, S.V.2    Descamps, L.3
  • 128
    • 0031963639 scopus 로고    scopus 로고
    • Results of a phase III, double-blind, placebo-controlled trial of megestrol acetate modulation of P-glycoprotein-mediated drug resistance in the first-line management of small-cell lung carcinoma
    • (1998) Br J Cancer , vol.77 , pp. 627-631
    • Wood, L.1    Palmer, M.2    Hewitt, J.3
  • 132
    • 0033378748 scopus 로고    scopus 로고
    • Modulation of multidrug resistance (MDR) in hematological malignancies
    • (1999) Ann Oncol , vol.10 , Issue.SUPPL. 6
    • Covelli, A.1
  • 133
    • 0032924631 scopus 로고    scopus 로고
    • Treatment of refractory and relapsed acute myelogenous leukemia with combination chemotherapy plus the multidrug resistance modulator PSC 833 (Valspodar)
    • (1999) Blood , vol.93 , pp. 787-795
    • Advani, R.1    Saba, H.I.2    Tallman, M.S.3
  • 134
    • 0003185435 scopus 로고    scopus 로고
    • Phase III study of PSC-833 modulation of multidrug resistance (MDR) in previously untreated acute myeloid leukamia (AML) patients 60 years (CALGB 9720)
    • (1999) Blood , vol.94 , Issue.10 SUPPL. 1
    • Baer, M.R.1    George, S.L.2    Dodge, R.K.3
  • 138
  • 140
  • 144
    • 0033060248 scopus 로고    scopus 로고
    • Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein
    • (1999) J Biol Chem , vol.274 , pp. 15420-15426
    • Hipfner, D.R.1    Mao, Q.2    Qiu, W.3
  • 156
    • 0030762796 scopus 로고    scopus 로고
    • Preirradiation paclitaxel in glioblastoma multiforme: Efficacy, pharmacology, and drug interactions. New Approaches to Brain Tumor Therapy Central Nervous System Consortium
    • (1997) J Clin Oncol , vol.15 , pp. 3121-3128
    • Fetell, M.R.1    Grossman, S.A.2    Fisher, J.D.3
  • 161
    • 0031474750 scopus 로고    scopus 로고
    • The ins and outs of antiviral drug transport in the brain
    • (1997) J Neurovirol , vol.3 , pp. 385-386
    • Gallo, J.M.1
  • 179
    • 0032753749 scopus 로고    scopus 로고
    • Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter
    • (1999) Mol Pharmacol , vol.56 , pp. 1219-1228
    • Chen, Z.S.1    Kawabe, T.2    Ono, M.3
  • 180


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.