Intra-arterial administration of carboplatin and the blood brain barrier permeabilizing agent, RMP-7: A toxicologic evaluation in swine

Journal of Neuro-Oncology

Volumn 36, Issue 2, 1998, Pages 167-178

  Riley, M Gary I ^a   Kim, Norman N ^a   Watson, Vance E ^b,d   Gobin, Y Pierre ^b   LeBel, Carl P ^a,e   Black, Keith L ^b   Bartus, Raymond T ^a,c  

^a ALKERMES INC   (United States)

^b UCLA MEDICAL CENTER   (United States)

^c TUFTS MEDICAL CENTER   (United States)

^d GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^e AMGEN INC   (United States)

Author keywords

Blood brain barrier; Carboplatin; Chemotherapy; Drug delivery; Gliomas; Intracarotid administration; Neuropathology; Toxicity; Vascular pathology

Indexed keywords

ANTINEOPLASTIC METAL COMPLEX; BRADYKININ B2 RECEPTOR AGONIST; CARBOPLATIN; LOBRADIMIL;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD GAS; BODY WEIGHT; CANCER COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; GLIOMA; HEART RATE; INTRAARTERIAL DRUG ADMINISTRATION; MALE; NEUROTOXICITY; NONHUMAN; SWINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD-BRAIN BARRIER; BRADYKININ; CAPILLARY PERMEABILITY; CARBOPLATIN; CEREBROVASCULAR CIRCULATION; DRUG ADMINISTRATION SCHEDULE; HYPOTENSION; INFUSIONS, INTRA-ARTERIAL; MALE; MODELS, BIOLOGICAL; SWINE;

EID: 0031882705     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005751922174     Document Type: Article

References (57)

1. Walker AE, Robins M, Weinfield FD: Epidemiology of brain tumors: the national survey of intracranial neoplasms. Neurology 35: 219-226, 1985
2. Tomatis L: Cancer: causes, occurrence and control. In: Tomatis L (ed) Vol. 100. Lyon, France, International Agency for Research on Cancer, pp 352, 1990
3. Nelson DF, Mcdonald JV, Lapham LW, Qazi R, Rubin P: Central nervous system tumors. In: Rubin P (ed) Clinical Oncology: A Multidisciplinary Approach for Physicians and Students. 7th edition. W.B. Saunders Company, Philadelphia 617-644, 1993
4. Groothuis DR, Fischer JM, Lapin G, Bigner DD, Vick NA: Permeability of different experimental brain tumor models to horseradish peroxidase. J Neuropathol Exp Neurol 41(2): 164-185, 1982
5. Long DM: Capillary ultrastructure and the blood-brain barrier in human malignant brain tumors. J Neurosurg 32: 127-144, 1970
6. Neuwelt EA, Barnett PA, Bigner DD, Frenkel EP: Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier. Proc Natl Acad Sci USA 79: 4420-4423, 1982
7. Shibata S: Ultrastructure of capillary walls in human brain tumors. Acta Neuropathol 78: 561-571, 1989
8. Warnick R, Prados M, Mack E, Chandler K, Doz F, Rabbitt J, Malec M: A phase II study of intravenous carboplatin for the treatment of recurrent gliomas. J Neuro-Oncol 19: 69-74, 1994
9. Hall JM: Bradykinin receptors: pharmacological properties and biological roles. Pharmacol Ther 56: 131-190, 1992
10. Brightman MW, Reese TS: Junctions between intimately apposed cell membranes in the vertebrate brain. J Cell Biol 40: 648-677, 1969
11. Brightman MW, Hori M, Rapoport SI, Reese TS, Westergaard E: Osmotic opening of tight junctions in cerebral endothelium. J Comp Neurol 152: 317-325, 1973
12. Dorovini-Zis K, Bowman PD, Betz AL, Goldstein GW: Hyperosmotic arabinose solutions open tight junctions between brain capillary endothelial cells in tissue culture. Brain Res 302: 383-386, 1984
13. Butt AM: Electrical resistance measurements of blood-brain barrier permeability. In: Greenwood J, Begley D, Segal M (eds) New Concepts of a Blood-Brain Barrier. Plenum Press, London 33-46, 1996
14. Wahl M, Unterberg A, Baethmann A, Schilling L: Mediators of blood-brain barrier dysfunction and formation of vasogenic brain edema. J Cereb Blood Flow Metab 8: 621-634, 1988
15. Sanovich E, Bartus R, Friden P, Dean R, Le H, Brightman M: Pathway across blood-brain barrier opened by the bradykinin agonist, RMP-7. Brain Res 705: 125-135, 1995
16. Inamura T, Nomura T, Bartus RT, Black K: Intracarotid infusion of RMP-7, a bradykinin analog: a method for selective drug delivery to brain tumors. J Neurosurg 81: 752-758, 1994
17. Elliott P, Hayward N, Dean R, Blunt D, Black K, Bartus R: Intravenous RMP-7 selectively increases uptake of carbo-platin into rat brain tumors. Cancer Research 1996, in press
18. Bartus RT, Elliott P, Hayward N, Dean R, Fisher S: Permeability of the BBB by the B2 agonist RMP-7: evidence for a sensitive, auto-regulated, receptor-mediated system. Immunopharmacology 33: 270-278, 1996
19. Bartus RT, Elliott PJ, Dean RL, Hayward NJ, Nagle TL, Huff MR, Snodgrass PA, Blunt DG: Controlled modulation of BBB permeability using the bradykinin agonist, RMP-7. Exp Neurol 142: 14-28, 1996
20. Matsukado K, Inamura T, Fukui M, Bartus R, Black K: Enhanced tumor uptake of carboplatin and survival in gliomabearing rats by intracarotid infusion of bradykinin analog, RMP-7. Neurosurgery 39(1): 125-134, 1996
21. Ichimura K, Ohno K, Aoyai M, Tamaki M, Suzuki R, Hirakawa K: Capillary permeability in experimental rat glioma and effects of intracarotid CDDP administration on tumor drug delivery. J Neuro-Oncol 16: 211-215, 1993
22. Lelieveld P, Van der Vijgh JF, Veldhuizen RW, Van Velzen D, Van Putten LM, Atassi G, Danguy A: Preclinical studies on toxicity, antitumor activity and pharmacokinetics of cisplatin and three recently developed derivatives. Eur J Cancer Clin Oncol 20(8): 1087-1104, 1984
23. Neuwelt E, Glasberg M, Frenkel E, Barnett P: Neurotoxicity of chemotherapeutic agents after blood-brain barrier modification: neuropathological studies. Ann Neurol 14: 316-324, 1983
24. Fujiwara T, Matsumoto Y, Honma Y, Kuyama H, Nagao S, Ohkawa M: A comparison of intraarterial carboplatin and ACNU for the treatment of gliomas. Surg Neurol 44(2): 145-150, 1995
25. Larner JM, Phillips CD, D ion JE, Jensen ME, Newman SA, Jane JA: A phase 1-2 trial of superselective carboplatin, low-dose infusional 5-fluorouracil and concurrent radiation for high-grade gliomas. Am J Clin Oncol 18(1): 1-7, 1995
26. Stewart DJ, Belanger JM, Grahovac Z, Curuvija S, Gionet LR, Aitken SE, Hugenholz H, Benoit BG, DaSilva VF: Phase I study on intracarotid administration of carboplatin. Neurosurgery 30(4): 512-517, 1992
27. Farmer SG, Burch RM: The pharmacology of bradykinin receptors. In: Burch RM (ed) Bradykinin Antagonists: Basic and Clinical Research. Marcel Dekker, New York 1-31, 1991
28. Wahl M, Unterberg A, Baethmann A, Schilling L: Mediators of blood-brain barrier dysfunction and formation of vasogenic brain edema. J Cereb Blood Flow Metab 8: 621-634, 1988
29. Saxena PR, Verdouw PD: Redistribution of 5-hydroxytryptamine of carotid arterial blood at the expense of arteriovenous anastomotic blood flow. J Physiol 332: 501-520, 1982
30. van Gelderen EM, De Bruijne ELE, Agteresch HJ, Saxena PR: The effect of nitric oxide donors on haemodynamics and blood flow distribution in the porcine carotid circulation. Br J Pharmacol 114(6): 1303-1309, 1995
31. Hariri RS, Firlick AD, Shepard SR, Cohen DS, Barie PS, Emery JM, Ghajar JB: Traumatic brain injury, hemorrhagic shock, and fluid resuscitation: effects on intracranial pressure and brain compliance. J Neurosurgery 79(3): 421-477, 1993
32. Ross DT, Meaney DF, Sabol MK, Smith DH, Gennarelli TA: Distribution of forebrain diffuse axonal injury following inertial closed head injury in miniature swine. Exp Neurol 126(2): 291-299, 1994
33. Lentner C: Nomogram for determination of body surface from height and mass. In: Lentner C (ed) Geigy Scientific Tables, Volume 1: Units of Measurement, Body Fluids, Composition of the Body, Nutrition. 8th edition. Ciba-Geigy Limited, Basle pp. 227, 1981
34. Lee D, Wriedt C, Kaufmann J, Pelz D, Fox A, Vinuela F: Evaluation of three embolic agents in pig rete. AmJ Neuroradiology 10(4): 773-776, 1989
35. Duckwiler G, Dion J, Vinuela F, Tabour B, Martin N, Bentson J: Intravascular microcatheter pressure monitoring: experimental results and early clinical evaluation. Am J Neuroradiology 11: 169-175, 1990
36. Elliott P, Hayward N, Dean R, Bartus R: Dissociation of blood-brain barrier permeability and the hypotensive effects of the bradykinin B2 agonist, RMP-7. Immunopharmacology 33: 205-208, 1996
37. Chason JL, Landers JW, Swanson RE: Cotton fiber embolism: a frequent complication of cerebral angiography. Neurology 13: 558-560, 1963
38. Silberman J, Cravioto H, Feigin I: Foreign body emboli following cerebral angiography. Arch Neurol 3: 711-717, 1960
39. Dimmick JE, Bove KE, McAdams AJ, Benzing G: Fiber embolization - a hazard of cardiac surgery and catheterization. N E J Med 292(13): 685-687, 1975
40. Vinters H, Kaufman J, Drake C: 'Foreign' particles in encephalic vascular malformations. Arch Neurol 40: 221-225, 1983
41. Bhoola KD, Figueroa CD, Worthy K: Bioregulation of kinins:kallikreins, kininogens, and kinases. Pharmacol Rev 44 (1): 1-80, 1992
42. Betz AL: An overview of the multiple functions of the blood-brain barrier. In: Frankenheim J, Brown RM (eds) Bioavailability of Drugs to the Brain and Blood-Brain Barrier. CNIDA Research Monograph 120: 54-72, 1992
43. Abbott NJ, Revest PA: Control of brain endothelial permeability. Cerebrovascular and Brain Metabolism Reviews 3(1): 39-72, 1991
44. Rapoport SI: A model for brain edema. In: Inaba Y, Klatzo I, Spitz M (eds) Brain Edema. Springer-Verlag, Berlin 59-71, 1985
45. Wahl M, Schilling L, Unterberg A, Baethmann A: Mediators of vascular and parenchymal mechanisms in secondary brain damage. Acta Neurochir Suppl 57: 64-72, 1993
46. Ikeda Y, Wang M, Nakazawa S: Simple quantitative evaluation of blood-brain barrier disruption in vasogenic brain edema. Acta Neurochir Suppl 60: 119-120, 1994
47. Inamura T, Black KL: Bradykinin selectively opens blood-tumor barrier in experimental brain tumor. J Cereb Blood Flow Metab 14: 862-870, 1994
48. Haasemann M, Muller-Esterl, Cartaud J, Dunia I: Agonist induced redistribution of kinin B2 receptors into caveolae. Fourteenth International Symposium Kinins, Denver, CO, Sept. 1995, Abstract #L-31
49. Munoz CM, Lee-LundbergLMF: Receptor-mediated internalization of bradykinin. J Biol Chem 267(1): 303-309, 1992
50. Millay R, Klein M, Shults W, Dahlborg S, Neuwelt E: Maculopathy associated with combination chemotherapy and osmotic opening of the blood-brain barrier. Am J Ophthalmol 102: 626-632, 1986
51. Williams PC, Henner WD, Roman-Goldstein S, Dahlborg SA, Brummett RE, Tableman M, Dana BW, Neuwelt EA: Toxicity and efficacy of carboplatin and etoposide in conjunction with disruption of the blood-brain tumor barrier in the treatment of intracranial neoplasms. Neurosurgery 37: 17-28, 1995
52. Fike JR, Gobbel GT, Nakagawa M, Mesiwala AH, Seilhan TM: Effect of bradykinin agonist RMP-7 on normal and abnormal blood-brain barrier. Proceedings of the American Association of Neurological Surgeons 1994 Annual Meeting, San Diego, CA, April 13, 1994
53. Warnke PC, Weyerbrock A, Ostertag CB: Effect of the synthetic bradykinin RMP-7 on capillary permeability in glioblastoma multiforme. Proceedings of the Cerebral Vascular Biology Conference, Paris, July 10-12, 1995
54. Bleehen NM, Ford JM, Miles KA, Barton T, Osborn C: A phase I dose rising study of RMP-7 and carboplatin in patients with recurrent malignant glioma. Proceedings of the European Assoc. of Neuro-Oneology, Wurzburg, October 6-9, 1996
55. Norman D, Moseley M, DeCrespigny AJ, Rabbitt J, Prados M, Graney WF: Effects of RMP-7 on enhancing volume by MRI in glioma. Proceedings of the 2nd U.S.-Japan Symposium on Drug Delivery Systems, Maui, Hawaii, December 13, 1993
56. Alavi A, Shao L, Lattanaud C, Duncan D, Loessner A, O'Toole T, Grous J: Brain tumor permeability enhanced by RMP-7, a novel bradykinin agonist. Proceedings of the 19th Internation Congress of Chemotherapy, Montreal, Quebec, Canada, July 16-21, 1995
57. Black K, Huang S, Gobin P, Hoh C, Farahani K, Vinela F: Open-label study of the effects of intraarterial (IA) RMP-7 and carboplatin on tumor permeability and for the treatment of malignant recurrent glioma. Proceedings of the American Academy of Neurology Meeting, March 1996