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0027393734
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23
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0029912970
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Interspecies diversity of the occludin sequence: CDNA cloning of human, mouse, dog, and rat - Kangaroo homologues
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of outstanding interest. Report on the cDNA cloning of mammalian occludin, opening the way to studying its function in conventional epithelial and endothelial cell systems. Mammalian occludins are highly conserved at the amino acid level, but are considerably different from chicken occludin. This accounts for the difficulty in cloning the mammalian forms of this important junctional protein.
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of outstanding interest Ando-Akatsuka Y, Saitou Hirase T, Kishi M, Sakakibara A, Itoh M, Yonemura S, Furuse M, Tsukita S. Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat - kangaroo homologues. J Cell Biol. 133:1996;43-47 Report on the cDNA cloning of mammalian occludin, opening the way to studying its function in conventional epithelial and endothelial cell systems. Mammalian occludins are highly conserved at the amino acid level, but are considerably different from chicken occludin. This accounts for the difficulty in cloning the mammalian forms of this important junctional protein.
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Ando-Akatsuka, Y.1
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Tsukita, S.8
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24
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0026322983
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A cell culture model of the blood - Brain barrier
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Rubin LL, Hall DE, Porter S, Barbu K, Cannon C, Horner HC, Janatpour M, Liaw CW, Manning K, Morales J, Tanner LI, et al. A cell culture model of the blood - brain barrier. J Cell Biol. 115:1991;1725-1735.
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25
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of special interest. A good review of tight-junction protein architecture and implications for the regulation of permeability.
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of special interest Anderson JM. Cell signalling: MAGUK magic. Curr Biol. 6:1996;382-384 A good review of tight-junction protein architecture and implications for the regulation of permeability.
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Anderson, J.M.1
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26
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0028931103
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Evidence that tyrosine phosphorylation may increase tight junction permeability
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of special interest. This paper provides evidence that signalling is important in regulating tight-junction permeability. The activities of tyrosine kinases and phosphatases may be key determinants of junctional properties in normal and pathological conditions.
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of special interest Staddon JM, Herrenknecht K, Smales C, Rubin LL. Evidence that tyrosine phosphorylation may increase tight junction permeability. J Cell Sci. 108:1995;609-619 This paper provides evidence that signalling is important in regulating tight-junction permeability. The activities of tyrosine kinases and phosphatases may be key determinants of junctional properties in normal and pathological conditions.
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Staddon, J.M.1
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27
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0028922237
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Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells
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Van Itallie CM, Balda MS, Anderson JM. Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells. J Cell Sci. 108:1995;1735-1742.
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0029615381
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V-src shifts the cadherin-based cell adhesion from the strong to the weak state and β-catenin is not required for the shift
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of special interest. A chimaeric α-catenin - cadherin protein is used to show that β-catenin appears to be dispensable for the src-mediated decrease in cell - cell adhesion.
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of special interest Takeda H, Nagafuchi A, Yonemura S, Tsukita S, Behrens J, Birchmeier W, Tsukita S. V-src shifts the cadherin-based cell adhesion from the strong to the weak state and β-catenin is not required for the shift. J Cell Biol. 131:1995;1839-1847 A chimaeric α-catenin - cadherin protein is used to show that β-catenin appears to be dispensable for the src-mediated decrease in cell - cell adhesion.
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Takeda, H.1
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Tsukita, S.7
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0028953668
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Increased tyrosine phosphorylation of ZO-1 during modification of tight junctions between glomerular foot processes
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0028900299
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The molecular organization of endothelial cell to cell junctions: Differential association of plakoglobin, β-catenin, and α-catenin with vascular endothelial cadherin (VE-cadherin)
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of special interest. A description of catenins and their association with cadherin in ECs. This paper suggests that VE-cadherin (originally designated as cadherin-5) is a (or, perhaps, the) functional cadherin in peripheral ECs. The definitive identification of brain EC cadherins remains unresolved.
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of special interest Lampugnani MG, Corada M, Caveda L, Breviario F, Ayalon O, Geiger B, Dejana E. The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, β-catenin, and α-catenin with vascular endothelial cadherin (VE-cadherin). J Cell Biol. 129:1995;203-217 A description of catenins and their association with cadherin in ECs. This paper suggests that VE-cadherin (originally designated as cadherin-5) is a (or, perhaps, the) functional cadherin in peripheral ECs. The definitive identification of brain EC cadherins remains unresolved.
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Geiger, B.6
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33
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0029116142
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P120, a p120-related protein (p100) and the cadherin/catenin complex
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of outstanding interest. A clear description of the localization of the src substrate p120 at adherens junctions in brain ECs in culture and in vivo. See also annotation [43].
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of outstanding interest Staddon JM, Smales C, Schulze C, Esch FS, Rubin LL. p120, a p120-related protein (p100) and the cadherin/catenin complex. J Cell Biol. 130:1995;369-381 A clear description of the localization of the src substrate p120 at adherens junctions in brain ECs in culture and in vivo. See also annotation [43].
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Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junction where the level of tyrosine phosphorylation is elevated
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Tsukita S, Oishi K, Akiyama T, Yamanishi Y, Yamamoto T, Tsukita S. Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junction where the level of tyrosine phosphorylation is elevated. J Cell Biol. 113:1991;867-879.
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The non-receptor tyrosine kinase lyn is localised in the developing murine blood - Brain barrier
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Aachen MG, Clauss M, Schnürch H, Risau W. The non-receptor tyrosine kinase lyn is localised in the developing murine blood - brain barrier. Differentiation. 59:1995;15-24.
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Multiple defects in the immune system of lyn-deficient mice, culminating in autoimmune disease
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Hibbs ML, Tarlinton DM, Armes J, Grail D, Hodgson G, Maglitto R, Stacker SA, Dunn AR. Multiple defects in the immune system of lyn-deficient mice, culminating in autoimmune disease. Cell. 83:1995;301-311.
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Hibbs, M.L.1
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0025376378
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Monoclonal antibodies to individual tyrosine phosphorylated protein substrates of oncogene-encoded tyrosine kinases
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0028266975
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Peifer MS, Berg S, Reynolds AB. A repeating amino acid motif shared by proteins with diverse cellular roles. Cell. 76:1994;789-791.
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Peifer, M.S.1
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41
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0029035676
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The E-cadherin complex contains the src substrate p120
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of outstanding interest. See annotation [43].
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of outstanding interest Aghib DF, McCrea PD. The E-cadherin complex contains the src substrate p120. Exp Cell Res. 218:1995;359-369 See annotation [43].
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Exp Cell Res
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Aghib, D.F.1
McCrea, P.D.2
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42
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0029116143
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Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia
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of outstanding interest. See annotation [43].
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of outstanding interest Kinch MS, Clark GJ, Der CJ, Burridge K. Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. J Cell Biol. 130:1995;461-471 See annotation [43].
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J Cell Biol
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Kinch, M.S.1
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Der, C.J.3
Burridge, K.4
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43
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0028930736
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Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes
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of outstanding interest. This paper and others [33,40-42] demonstrate that the src substrate p120 is associated with the cadherin - catenin complex. Since src-like kinases are also thought to be associated with the adherens junctions, it seems likely that these proteins will form part of a system that regulates events that depend on cell - cell contact, such as junctional permeability and cell growth.
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of outstanding interest Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson KR, Wheelock MJ, Matsuyoshi N, Takeichi M, Ito F. Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes. J Cell Biol. 128:1995;949-957 This paper and others [33,40-42] demonstrate that the src substrate p120 is associated with the cadherin - catenin complex. Since src-like kinases are also thought to be associated with the adherens junctions, it seems likely that these proteins will form part of a system that regulates events that depend on cell - cell contact, such as junctional permeability and cell growth.
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(1995)
J Cell Biol
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Shibamoto, S.1
Hayakawa, M.2
Takeuchi, K.3
Hori, T.4
Miyazawa, K.5
Kitamura, N.6
Johnson, K.R.7
Wheelock, M.J.8
Matsuyoshi, N.9
Takeichi, M.10
Ito, F.11
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44
-
-
0029149746
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Receptor protein tyrosine phosphatase PTPμ associates with cadherins and catenins in vivo
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of special interest. Further evidence of a connection between signalling and the regulation of cell - cell adhesion, although one other group has failed to confirm the association of this phosphatase with the cadherin - catenin complex (see main text).
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of special interest Brady-Kalnay SM, Rimm DL, Tonks NK. Receptor protein tyrosine phosphatase PTPμ associates with cadherins and catenins in vivo. J Cell Biol. 130:1995;977-986 Further evidence of a connection between signalling and the regulation of cell - cell adhesion, although one other group has failed to confirm the association of this phosphatase with the cadherin - catenin complex (see main text).
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Lack of association between receptor protein tyrosine phosphatase RPTPμ and cadherins
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Zondag GCM, Moolenaar WH, Gebbink MFBG. Lack of association between receptor protein tyrosine phosphatase RPTPμ and cadherins. J Cell Biol. 134:1996;1513-1517.
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Gebbink MFBG, Zondag GCM, Koningstein GM, Feiken E, Wubbolts RW, Moolenaar WH. Cell surface expression of receptor protein tyrosine phosphatase RPTPμ is regulated by cell - cell contact. J Cell Biol. 131:1995;251-260.
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47
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0028786658
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Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia
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of special interest. An investigation of the role of rho in tight-junction permeability control. Rho is suggested to regulate permeability by influencing the assembly of filamentous actin at the tight junction.
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of special interest Nusrat A, Giry M, Turner JR, Colgan SP, Carnes D, Lemichez E, Bouquet P, Madara JL. Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia. Proc Natl Acad Sci USA. 92:1995;10629-10633 An investigation of the role of rho in tight-junction permeability control. Rho is suggested to regulate permeability by influencing the assembly of filamentous actin at the tight junction.
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48
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0029119895
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Myosin light chain kinase-regulated endothelial cell contraction: The relationship between isometric tension, actin polymerization, and myosin phosphorylation
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of special interest. A careful study investigating the role of myosin light-chain phosphorylation in EC contraction.
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of special interest Goeckeler ZM, Wysolmerski RB. Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation. J Cell Biol. 130:1995;613-627 A careful study investigating the role of myosin light-chain phosphorylation in EC contraction.
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of special interest. An excellent overview of cell adhesion and its regulation.
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of special interest Garcia JG, Davis HW, Patterson CE. Regulation of endothelial cell gap formation and barrier dysfunction: role of myosin light chain phosphorylation. J Cell Physiol. 163:1995;510-522 An excellent overview of cell adhesion and its regulation.
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Moolenaar WH. Lysophosphatidic acid, a multifunctional phospholipid messenger. J Biol Chem. 270:1995;12949-12952.
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