Kinetic and biochemical analysis of carrier-mediated efflux of drugs through the blood-brain and blood-cerebrospinal fluid barriers: Importance in the drug delivery to the brain

Journal of Controlled Release

Volumn 62, Issue 1-2, 1999, Pages 179-186

  Sugiyama, Yuichi ^a   Kusuhara, Hiroyuki ^a   Suzuki, Hiroshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Blood brain barrier; Blood cerebrospinal fluid barrier; MRP; oatp

Indexed keywords

4 AMINOHIPPURIC ACID; CEFODIZIME; ESTRADIOL 17 GLUCURONIDE; GLUTATHIONE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; QUINIDINE;

ARTICLE; BLOOD BRAIN BARRIER; BLOOD CEREBROSPINAL FLUID BARRIER; BRUSH BORDER; CHOROID PLEXUS; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG TRANSPORT; HEMISPHERE; IMMUNOBLOTTING; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSPORT KINETICS;

ANIMALS; BLOOD-BRAIN BARRIER; CEFOTAXIME; CEPHALOSPORINS; CHOROID PLEXUS; DRUG DELIVERY SYSTEMS; MICE; P-GLYCOPROTEIN; PHARMACOKINETICS; QUINIDINE; RATS;

EID: 0032874193     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(99)00036-X     Document Type: Article

References (21)

1. Tsuji A., Tamai I. Blood-brain barrier function of P-glycoprotein. Adv. Drug Deliv. Rev. 25:1997;287-298.
2. Schinkel A.H. The physiological function of drug-transporting P-glycoproteins. Semin. Cancer Biol. 8:1997;161-170.
3. Harashima H., Sawada Y., Sugiyama Y., Iga T., Hanano M. Analysis of nonlinear tissue distribution of quinidine in rats by physiologically based pharmacokinetics. J. Pharmacokinet. Biopharm. 13:1985;425-440.
4. Kusuhara H., Suzuki H., Terasaki T., Kakee A., Lemaire L., Sugiyama Y. P-glycoprotein mediates the efflux of quinidine across the blood-brain barrier. J. Pharmacol. Exp. Ther. 283:1987;574-580.
5. Matsushita H., Suzuki H., Sugiyama Y., Sawada Y., Iga T., Kawaguchi Y., Hanano M. Facilitated transport of cefodizime into the rat central nervous system. J. Pharmacol. Exp. Ther. 259:1991;620-625.
6. Suzuki H., Terasaki T., Sugiyama Y. Role of efflux transport across the blood-brain barrier and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the central nervous system. Adv. Drug Deliv. Rev. 25:1997;257-285.
7. Collins J.M., Dedrick R.L. Distributed model for drug delivery to CSF and brain tissue. Am. J. Physiol. 245:1983;R303-R310.
8. Kakee A., Terasaki T., Sugiyama Y. Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier. J. Pharmacol. Exp. Ther. 277:1996;1550-1559.
9. Kakee A., Terasaki T., Sugiyama Y. Selective brain to blood efflux transport of para-aminohippuric acid across the blood-brain barrier: in vivo evidence by use of the brain efflux index method. J. Pharmacol. Exp. Ther. 283:1997;1018-1025.
10. Leininger B., Ghersi-Egea J.F., Siest G., Minn A. In vivo study of the elimination from rat brain of an intracerebrally formed xenobiotic metabolite, 1-naphthyl-β-D-glucuronide. J. Neurochem. 56:1991;1163-1168.
11. Kusuhara H., Suzuki H., Sugiyama Y. The role of P-glycoprotein and canalicular multispecific organic anion transporter (cMOAT) in the hepatobiliary excretion of drugs. J. Pharm. Sci. 87:1998;1025-1040.
12. Suzuki H., Sugiyama Y. Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2. Semin. Liv. Dis. 18:1998;359-376.
13. Tatsuta T., Naito M., Oh-hara T., Sugawara I., Tsuruo T. Functional involvement of P-glycoprotein in blood-brain barrier. J. Biol. Chem. 267:1992;20383-20391.
14. Kusuhara H., Suzuki H., Naito M., Tsuruo T., Sugiyama Y. Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line. J. Pharmacol. Exp. Ther. 285:1998;1260-1265.
15. Ogawa M., Suzuki H., Sawada Y., Hanano M., Sugiyama Y. Kinetics of active efflux via choroid plexus of β-lactam antibiotics from the CSF into the circulation. Am. J. Physiol. 266:1994;R392-R399.
16. Angeletti R.H., Novikoff P.M., Juvvadi S.R., Fritschy J.M., Meier P.J., Wolkoff A.W. The choroid plexus epithelium is the site of the organic anion transport protein in the brain. Proc. Natl. Acad. Sci. USA. 94:1997;283-286.
17. Kouzuki H., Suzuki H., Ohashi R., Ito K., Sugiyama Y. Contribution of organic anion transporting polypeptide to the uptake of ligands into rat hepatocytes. J. Pharmacol. Exp. Ther. 288:1999;627-634.
18. Ooie T., Terasaki T., Suzuki H., Sugiyama Y. Kinetic evidence for active transport at the blood-brain barrier of quinolone antibiotics. J. Pharmacol. Exp. Ther. 283:1997;293-304.
19. Takasawa K., Terasaki T., Suzuki H., Ooie T., Sugiyama Y. Distributed model analysis of 3′-azido-3′-deoxythymidine and 2′,3′-dideoxyinosine distribution in brain tissue and CSF. J. Pharmacol. Exp. Ther. 282:1997;1509-1517.
20. Takasawa K., Terasaki T., Suzuki H., Sugiyama Y. In vivo evidence for carrier-mediated efflux transport of 3′-azido-3′-deoxythymidine and 2′,3′-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system. J. Pharmacol. Exp. Ther. 281:1997;369-375.
21. Kitazawa T., Terasaki T., Suzuki H., Kakee A., Sugiyama Y. Efflux of taurocholic acid across the blood-brain barrier: Interaction with cyclic peptides. J. Pharmacol. Exp. Ther. 286:1998;890-895.