Dose-dependent brain penetration of SDZ PSC 833, a novel multidrug resistance-reversing cyclosporin, in rats

Cancer Chemotherapy and Pharmacology

Volumn 38, Issue 5, 1996, Pages 481-486

  Lemaire, Michel ^a   Bruelisauer, Armin ^a   Guntz, Pierrette ^a   Sato, Hitoshi ^b  

^a Sandoz Pharma Ltd   (Switzerland)

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Blood brain barrier; Dose dependence; Rats; SDZ PSC 833

Indexed keywords

CYCLOSPORIN A; CYCLOSPORIN DERIVATIVE; VALSPODAR; VINCRISTINE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG BRAIN LEVEL; INTRAVENOUS DRUG ADMINISTRATION; MALE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARY PERMEABILITY; CYCLOSPORINE; CYCLOSPORINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ENDOTHELIUM, VASCULAR; MALE; P-GLYCOPROTEIN; PERFUSION; RATS; RATS, WISTAR; TISSUE DISTRIBUTION; VINCRISTINE;

EID: 0029766804     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050515     Document Type: Article

References (32)

1. Begley DJ, Squires LK, Zlokovic BV, Mitrovic DM (1990) Permeability of blood-brain barrier to the immuno-suppressive cyclic peptide cyclosporin A. J Neurochem 55: 1222-1230
2. Castle MC, Mead JAR (1978) Investigations of the metabolic fate of tritiated vincristine in the rat by high-pressure liquid chromatography. Biochem Pharmacol 27:37-44
3. Cefalu WT, Pardridge WM (1985) Restrictive transport of a lipid soluble peptide (cyclosporin) through the blood-brain barrier. J Neurochem 44:1954-1956
4. Chikhale EG, Burton PS, Borchardt RT (1995) The effect of verapamil on the transport of peptides across the blood-brain barrier in rats: kinetic evidence for an apically polarized efflux mechanism. J Pharmacol Exp Ther 273:298-303
5. Colombo T, Zucchetti M, D'Incalci M (1994) Cyclosporin A markedly changes the distribution of doxorubicin in mice and rats. J Pharmacol Exp Ther 269: 22-27
6. Cordon-Cardo L, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR, Bertino JR (1989) Multi-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA 86:695-698
7. Croop JM, Raymond M, Hader D, Devault A, Arceci RJ, Gos P, Housman DE (1989) The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol Cell Biol 9:1346-1350
8. Fojo AT, Ueda K, Slamon DJ, Poplack DG, Gottesman MM, Pastan I (1987) Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci USA 84:265-269
9. Gaveriaux C, Boesch D, Jachez B, Bollinger P, Payne T, Loor F (1991) SDZ PSC 833, a non-immunosuppressive cyclosporin analog, is a very potent multidrug-resistance modifier. J Cell Pharmacol 2:225-234
10. Gonzalez O, Colombo T, De Fusco M, Imperatori L, Zucchetti M, D'Incalci M (1995) Changes in doxorubicin distribution and toxicity in mice pretreated with the cyclosporin analogue SDZ PSC 833. Cancer Chemother Pharmacol 36:335-340
11. Greenwood J (1992) Characterization of a rat retinal endothelial cell culture and the expression of P-glycoprotein in brain and retinal endothelium in vitro. J Neuroimmunol 39: 123-132
12. Greig NH, Soncranty TT, Shetty HU, Momma S, Smith QR, Rapoport SI (1990) Brain uptake and anticancer activitier of vincristince and vinblastine are restricted by their low cerebrovascular permeability and binding to plasma constituents in rat. Cancer Chemother Pharmacol 26:263-268
13. Guillot F, Misslin P, Lemaire M (1993) Comparison of fluvastatin and lovastatin blood-brain barrier transfer using in vitro and in vivo methods. J Cardiovasc Pharmacol 21:339-346
14. Hegmann EJ, Bauer HC, Kerbel RS (1992) Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells. Cancer Res 52 6969-6975
15. Keller RP, Altermatt HJ, Donatsch P, Zihlmann H, Laissue JA, Hiestand PC (1992) Pharmacologic interactions between the resistance-modifying cyclosporine SDZ PSC 833 and etoposide (VP 16-213) enhance in vivo cytostatic activity and toxicity. Int J Cancer 51:433-438
16. Lemaire M, Tillement JP (1982) Role of lipoproteins and erythrocytes in the in vitro binding and distribution of cyclosporin A in the blood. J Pharm Pharmacol 34:715-718
17. Lemaire M, Pardridge WM, Chaudhuri G (1988) Influence of blood components on the tissue uptake indices of cyclosporin in rats. J Pharmacol Exp Ther 244:740-743
18. Levin VA (1980) Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J Med Chem 23:682-684
19. Niederberger W, Lemaire M, Maurer G, Nussbaumer K, Wagner O (1983) Distribution and binding of cyclosporin in blood and tissues. Transplant Proc 15:2419-2421
20. Pardridge WM (1991) Peptide lipidization and liposomes. In: Pardridge WM (ed) Peptide drug delivery to the brain. Raven. New-York, pp 123-148
21. Pardridge WM, Triguero D, Yang J, Cancilla PA (1990) Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier. J Pharmacol Exp Ther 253:884-889
22. Sakata A, Tamai I, Kawazu K, Deguchi Y, Ohnishi T, Saheki A, Tsuji A (1994) In vivo evidence for ATP-dependent and P-glycoprotein mediated transport of cyclosporin A at the blood-brain barrier. Biochem Pharmacol 48:1989-1992
23. Schinkel AH, Smit JJM, Van Tellingen O, Beijnen JH, Wagenaar E, Van Deemter L, Mol CAAM, Van Der Valk MA, Robanus-Mandaag EC, Te Riele HPJ, Berns AJM, Borst P (1994) Disruption of the mouse mdr la P-glycoprotcin gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drug. Cell 77:491-502
24. Shirai A, Naito M, Tatsuta T, Dong J, Hanaoka K, Mikami K, Oh-Hara T, Tsuruo T (1994) Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein. Biochim Biophys Acta 1222:400-404
25. Takasato Y, Rapoport SI, Smith QR (1984) An in situ brain perfusion technique to study cerebrovascular transport in the rat. Am J Physiol 247:H484-H493
26. Tatsuta T, Naito M, Oh-Hara T, Sugawara I, Tsuruo T (1992) Functional involvement of P-glycoprotein in blood-brain barrier. J Biol Chem 267:20383-20391
27. Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC (1989) Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and cross-reactivity of one antibody with a muscle protein. J Histochem Cytochem 37: 159-164
28. Triguero D, Buciak JB, Pardridge WM (1990) Capillary depletion method for quantifying the blood-brain barrier transcytosis of circulating peptides and plasma proteins. J Neurochem 54:1882-1888
29. Tsuji A, Tamai I, Sakata A, Tenda Y, Terasaki T (1993) Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein. Biochem Pharmacol 46:1096-1099
30. Van Der Valk P, Van Kalken CK, Ketelaars H, Broxterman HJ, Scheffer G, Kuiper CM, Tsuruo T, Lankelma J, Meijer CJLM, Pinedo HM, Scheper RJ (1990) Distribution of multi-drug resistance associated P-glycoprotein in normal and neoplastic human tissues. Ann Oncol 1:56-54
31. Wagner O, Schreier E, Heitz F, Maurer G (1987) Tissue distribution, disposition, and metabolism of cyclosporine in rats. Drug Metab Dispos 15:377-383
32. Zhou XJ, Martin M, Placidi M, Cano JP, Rahmani R (1990) In vivo and in vitro pharmacokinetics and metabolism of vinca alkaloids in rat. II. Vinblastine and vincristine. Eur J Drug Metab Pharmacokinet 15:323 332