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Volumn 3, Issue 6, 1997, Pages 387-400

The entry of antiviral and antiretroviral drugs into the central nervous system

Author keywords

Antiretroviral; Antisense; Antiviral; Blood brain barrier; CSF; Nucleoside; Zidovudine

Indexed keywords

ACICLOVIR; ANTIRETROVIRUS AGENT; ANTISENSE OLIGONUCLEOTIDE; ANTIVIRUS AGENT; CYTARABINE; DIDANOSINE; GANCICLOVIR; LAMIVUDINE; NUCLEOSIDE ANALOG; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; VIDARABINE; ZALCITABINE; ZIDOVUDINE;

EID: 0031475151     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.3109/13550289709031185     Document Type: Review
Times cited : (102)

References (106)
  • 1
    • 0003429689 scopus 로고
    • Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS
    • Wickstrom E (cd): Wiley-Liss: New York
    • Agrawal S (1991). Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS. In Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS. Wickstrom E (cd): Wiley-Liss: New York, pp. 142-158.
    • (1991) Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS , pp. 142-158
    • Agrawal, S.1
  • 2
    • 0025743216 scopus 로고
    • Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice
    • Agrawal S, Temsamani J et al (1991). Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice. Proc Natl Acad Sci USA 88: 7595-7599.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7595-7599
    • Agrawal, S.1    Temsamani, J.2
  • 3
    • 0025267249 scopus 로고
    • Uptake kinetics of 2′,3′-dideoxyinosine into brain and cerebrospinal fluid of rats; intravenous infusion studies
    • Anderson BD, Hoesterey BL et al (1990). Uptake kinetics of 2′,3′-dideoxyinosine into brain and cerebrospinal fluid of rats; intravenous infusion studies. J Pharmacol Exp Ther 253: 113-118.
    • (1990) J Pharmacol Exp Ther , vol.253 , pp. 113-118
    • Anderson, B.D.1    Hoesterey, B.L.2
  • 4
    • 0023444615 scopus 로고
    • Cerebral blood volume is increased in dogs during administration of nitrous oxide or isoflurance
    • Archer DP, Labrecque P et al (1987). Cerebral blood volume is increased in dogs during administration of nitrous oxide or isoflurance. Anesthesiology 67: 642-648.
    • (1987) Anesthesiology , vol.67 , pp. 642-648
    • Archer, D.P.1    Labrecque, P.2
  • 5
    • 0023391975 scopus 로고
    • Reduction of cerebrospinal pressure by hypocapnia: Changes in cerebral blood volume, cerebrospinal fluid volume, and brain tissue water and electrolytes
    • Artru AA (1987). Reduction of cerebrospinal pressure by hypocapnia: changes in cerebral blood volume, cerebrospinal fluid volume, and brain tissue water and electrolytes. J Cereb Blood Flow Metab 7: 471-479.
    • (1987) J Cereb Blood Flow Metab , vol.7 , pp. 471-479
    • Artru, A.A.1
  • 7
    • 0017646359 scopus 로고
    • Methotrexate, cytosine arabinoside, and BCNU concentration in brain after ventriculocisternal perfusion
    • Blasberg RG (1977). Methotrexate, cytosine arabinoside, and BCNU concentration in brain after ventriculocisternal perfusion. Cancer Treat Rep 61: 625-631.
    • (1977) Cancer Treat Rep , vol.61 , pp. 625-631
    • Blasberg, R.G.1
  • 8
    • 0022622673 scopus 로고
    • Chemotherapy of brain tumors: Physiological and pharmacokinetic considerations
    • Blasberg RG, Groothuis DR (1986). Chemotherapy of brain tumors: physiological and pharmacokinetic considerations. Sem Oncol 13: 70-83.
    • (1986) Sem Oncol , vol.13 , pp. 70-83
    • Blasberg, R.G.1    Groothuis, D.R.2
  • 9
    • 0016816050 scopus 로고
    • Intrathecal chemotherapy: Brain tissue profiles after ventriculocisternal perfusion
    • Blasberg RG, Patlak C et al (1975). Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion. J Pharmacol Exp Ther 195: 78-83.
    • (1975) J Pharmacol Exp Ther , vol.195 , pp. 78-83
    • Blasberg, R.G.1    Patlak, C.2
  • 10
    • 0017704173 scopus 로고
    • Distribution of methotrexate in the cerebrospinal fluid and brain after intraventricular administration
    • Blasberg RG, Patlak CS et al (1977). Distribution of methotrexate in the cerebrospinal fluid and brain after intraventricular administration. Cancer Treat Rep 61: 633-641.
    • (1977) Cancer Treat Rep , vol.61 , pp. 633-641
    • Blasberg, R.G.1    Patlak, C.S.2
  • 11
    • 0020546311 scopus 로고
    • Selection of experimental conditions for the accurate determination of blood-brain transfer constants from single-time experiments: A theoretical analysis
    • Blasberg RG, Patlak CS et al (1983a). Selection of experimental conditions for the accurate determination of blood-brain transfer constants from single-time experiments: a theoretical analysis. J Cereb Blood Flow Metab 3: 215-225.
    • (1983) J Cereb Blood Flow Metab , vol.3 , pp. 215-225
    • Blasberg, R.G.1    Patlak, C.S.2
  • 12
    • 0020522339 scopus 로고
    • The transport of alpha-aminoisobutyric acid across brain capillary and cellular membranes
    • Blasberg RG, Patlak CS et al (1983b). The transport of alpha-aminoisobutyric acid across brain capillary and cellular membranes. J Cereb Blood Flow Metab 3: 8-32.
    • (1983) J Cereb Blood Flow Metab , vol.3 , pp. 8-32
    • Blasberg, R.G.1    Patlak, C.S.2
  • 13
    • 0029066919 scopus 로고
    • Antisense drug delivery through the blood-brain barrier
    • Boado RJ (1995). Antisense drug delivery through the blood-brain barrier. Advanced Drug Deliv Rev 15: 73-107.
    • (1995) Advanced Drug Deliv Rev , vol.15 , pp. 73-107
    • Boado, R.J.1
  • 14
    • 0028857672 scopus 로고
    • Rapid plasma clearance and metabolism in vivo of a phosphorothioate oligodeoxynucleotide with a single, internal phosphodiester bond
    • Boado RJ, Kang Y-S, et al. (1995). Rapid plasma clearance and metabolism in vivo of a phosphorothioate oligodeoxynucleotide with a single, internal phosphodiester bond. Drug Metab Disp, 23, 1297-1300.
    • (1995) Drug Metab Disp , vol.23 , pp. 1297-1300
    • Boado, R.J.1    Kang, Y.-S.2
  • 15
    • 23444437213 scopus 로고
    • Convection enhanced delivery of macromolccules in the brain
    • Bobo RH, Laske DW et al (1994). Convection enhanced delivery of macromolccules in the brain. Proc Natl Acad Sci USA 91: 2076-2080.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2076-2080
    • Bobo, R.H.1    Laske, D.W.2
  • 19
    • 0026915854 scopus 로고
    • Magnetic resonance imaging in the evaluation of cerebrospinal fluid flow abnormalities
    • Bradley WG (1992). Magnetic resonance imaging in the evaluation of cerebrospinal fluid flow abnormalities. Magn Reson Quart 8: 169-196.
    • (1992) Magn Reson Quart , vol.8 , pp. 169-196
    • Bradley, W.G.1
  • 20
    • 0027214576 scopus 로고
    • The effect of dihydronicontinate N-substitution on the brain targeting efficacy of a zidovudine chemical delivery system
    • Brewster ME, Pop E et al (1993). The effect of dihydronicontinate N-substitution on the brain targeting efficacy of a zidovudine chemical delivery system. Pharm Res 10: 1356-1362.
    • (1993) Pharm Res , vol.10 , pp. 1356-1362
    • Brewster, M.E.1    Pop, E.2
  • 21
    • 0022148335 scopus 로고
    • Ten precepts for quantitative data acquisition and analysis
    • Budinger TF, Huesman RH (1985). Ten precepts for quantitative data acquisition and analysis. Circulation 72 (Suppl 4): 53-62.
    • (1985) Circulation , vol.72 , Issue.4 SUPPL. , pp. 53-62
    • Budinger, T.F.1    Huesman, R.H.2
  • 22
    • 0028950992 scopus 로고
    • Concise overview of the clinical pharmacokinetics of dideoxynucleoside antiretroviral agents
    • Burger DM Meenhorst PL et al (1995). Concise overview of the clinical pharmacokinetics of dideoxynucleoside antiretroviral agents. Pharm World Sci 17: 25-30.
    • (1995) Pharm World Sci , vol.17 , pp. 25-30
    • Burger, D.M.1    Meenhorst, P.L.2
  • 23
    • 0025175236 scopus 로고
    • Disposition and metabolism of oligodeoxynucleoside methylphosphonate following a single iv injection into mice
    • Chem T-L, Miller PS et al (1990). Disposition and metabolism of oligodeoxynucleoside methylphosphonate following a single iv injection into mice. Drug Metab Disp 18: 815-818.
    • (1990) Drug Metab Disp , vol.18 , pp. 815-818
    • Chem, T.-L.1    Miller, P.S.2
  • 24
    • 0010328794 scopus 로고    scopus 로고
    • Antisense therapeutics in the central nervous system: The induction of c-fos
    • Agrawal S (ed): Humana Press: Totowa, N.J.
    • Chlasson BJ, Hong M et al (1996). Antisense therapeutics in the central nervous system: the induction of c-fos. In Antisense Therapeutics. Agrawal S (ed): Humana Press: Totowa, N.J., pp. 225-246.
    • (1996) Antisense Therapeutics , pp. 225-246
    • Chlasson, B.J.1    Hong, M.2
  • 25
    • 0025290649 scopus 로고
    • Brain targeting of anti-HIV nucleosides: Synthesis and in vitro and in vivo studies of hihydropyridine derivatives of 3′-azido-2′,2′-dideoxyuridine and 3′-azido-3′-dideoxythymidine
    • Chu CK, Bhadti VS et al (1990). Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of hihydropyridine derivatives of 3′-azido-2′,2′-dideoxyuridine and 3′-azido-3′-dideoxythymidine. J Med Chem 33: 2188-2192.
    • (1990) J Med Chem , vol.33 , pp. 2188-2192
    • Chu, C.K.1    Bhadti, V.S.2
  • 26
    • 2542535219 scopus 로고    scopus 로고
    • Antiviral Agents
    • Reese RE, Betts RF (ed): Little, Brown and Co.: Boston
    • Cohn SE, Nawaz T et al (1996). Antiviral Agents. In A Practical Approach to Infectious Diseases. Reese RE, Betts RF (ed): Little, Brown and Co.: Boston, pp. 967-1036.
    • (1996) A Practical Approach to Infectious Diseases , pp. 967-1036
    • Cohn, S.E.1    Nawaz, T.2
  • 27
    • 0020826160 scopus 로고
    • Distributed model for drug delivery to CSF and brain tissue
    • Collins JM, Dedrick RL (1983). Distributed model for drug delivery to CSF and brain tissue. Am J Physiol 14: R303-R310.
    • (1983) Am J Physiol , vol.14
    • Collins, J.M.1    Dedrick, R.L.2
  • 28
    • 0016836221 scopus 로고
    • Independent blood-brain barrier transport systems for nucleic acid precursors
    • Cornford EM, Oldendorf WH (1975). Independent blood-brain barrier transport systems for nucleic acid precursors. Biochim Biophys Acta 394: 211-219.
    • (1975) Biochim Biophys Acta , vol.394 , pp. 211-219
    • Cornford, E.M.1    Oldendorf, W.H.2
  • 29
    • 0027786912 scopus 로고
    • 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats
    • 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats. J Pharmacol Exp Ther 267: 1181-1190.
    • (1993) J Pharmacol Exp Ther , vol.267 , pp. 1181-1190
    • Cossum, P.A.1    Sasmor, H.2
  • 30
    • 0020966884 scopus 로고
    • Regional brain blood flow, blood volume and hematocrit values in the adult rat
    • Cremer JE, Seville MP (1983). Regional brain blood flow, blood volume and hematocrit values in the adult rat. J Cereb Blood Flow Metab 3: 254-256.
    • (1983) J Cereb Blood Flow Metab , vol.3 , pp. 254-256
    • Cremer, J.E.1    Seville, M.P.2
  • 31
    • 78651133453 scopus 로고
    • The permeability of capillaries in various organs as determined by the use of the 'indicator diffusion' method
    • Crone C (1963). The permeability of capillaries in various organs as determined by the use of the 'indicator diffusion' method. Acta Physiol Scand 59: 292-305.
    • (1963) Acta Physiol Scand , vol.59 , pp. 292-305
    • Crone, C.1
  • 32
    • 12644302203 scopus 로고    scopus 로고
    • Pharmacokinetic properties of several novel oligonucleotide analogs in mice
    • Crooke ST, Graham MJ et al (1996). Pharmacokinetic properties of several novel oligonucleotide analogs in mice. J Pharmacol Exp Ther 277: 923-937.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 923-937
    • Crooke, S.T.1    Graham, M.J.2
  • 33
    • 0017692459 scopus 로고
    • Flow of cerebral interstitial fluid as indicated by the removal of extracellular markers from rat caudate nucleus
    • Cserr HF, Cooper DN et al (1977). Flow of cerebral interstitial fluid as indicated by the removal of extracellular markers from rat caudate nucleus. Exp Eye Res 25 (Suppl): 461-473.
    • (1977) Exp Eye Res , vol.25 , Issue.SUPPL. , pp. 461-473
    • Cserr, H.F.1    Cooper, D.N.2
  • 34
    • 0019556901 scopus 로고
    • Efflux of radiolabeled polyethylene glycols and albumin from rat brain
    • Cserr HF, Cooper DN et al (1981). Efflux of radiolabeled polyethylene glycols and albumin from rat brain. Am J Physiol 240: F319-F328.
    • (1981) Am J Physiol , vol.240
    • Cserr, H.F.1    Cooper, D.N.2
  • 35
    • 0030988750 scopus 로고    scopus 로고
    • Biomedical applications of nanotechnology-implications for drug targeting and gene therapy
    • Davis SS (1997). Biomedical applications of nanotechnology-implications for drug targeting and gene therapy. TIBTECH 15: 217-224.
    • (1997) TIBTECH , vol.15 , pp. 217-224
    • Davis, S.S.1
  • 37
    • 0028815330 scopus 로고
    • The use of intracerebral microdialysis to determine changes in blood-brain barrier transport characteristics
    • de Lange EC, Hesselink MB et al (1995). The use of intracerebral microdialysis to determine changes in blood-brain barrier transport characteristics. Pharm Res 12, 129-133.
    • (1995) Pharm Res , vol.12 , pp. 129-133
    • De Lange, E.C.1    Hesselink, M.B.2
  • 38
    • 0030963109 scopus 로고    scopus 로고
    • Metabolism and disposition of the HIV-1 protease inhibitor ritonavir (ABT-538) in rats, dogs, and humans
    • Denissen JF, Grabowski BA et al (1997). Metabolism and disposition of the HIV-1 protease inhibitor ritonavir (ABT-538) in rats, dogs, and humans. Drug Metab Disp 25: 489-501.
    • (1997) Drug Metab Disp , vol.25 , pp. 489-501
    • Denissen, J.F.1    Grabowski, B.A.2
  • 39
    • 0028911385 scopus 로고
    • Clinical pharmacokinetics of nucleoside antiretroviral agents
    • Dudley MN (1995). Clinical pharmacokinetics of nucleoside antiretroviral agents. J Infect Dis 171: S99-112.
    • (1995) J Infect Dis , vol.171
    • Dudley, M.N.1
  • 40
    • 0027768971 scopus 로고
    • Microdialysis study of zidovudine (AZT) transport in rat brain
    • Dykstra KH, Arya A et al (1993). Microdialysis study of zidovudine (AZT) transport in rat brain. J Pharm Exp Ther 267: 1227-1236.
    • (1993) J Pharm Exp Ther , vol.267 , pp. 1227-1236
    • Dykstra, K.H.1    Arya, A.2
  • 42
    • 0019783061 scopus 로고
    • Methods for quantifying the transport of drugs across brain barrier systems
    • Fenstermacher JD, Blasberg RG et al (1981). Methods for quantifying the transport of drugs across brain barrier systems. Pharmacology and Therapeutics 14: 217-248.
    • (1981) Pharmacology and Therapeutics , vol.14 , pp. 217-248
    • Fenstermacher, J.D.1    Blasberg, R.G.2
  • 43
    • 0002438046 scopus 로고
    • Ventriculocisternal perfusion as a technique for analysis of brain capillary permeability and extra-cellular transport
    • Crone C, Lassen NA (ed): Academic Press; New York
    • Fenstermacher JD, Rall DP et al (1970). Ventriculocisternal perfusion as a technique for analysis of brain capillary permeability and extra-cellular transport. In: Capillary Permeability. Crone C, Lassen NA (ed): Academic Press; New York, pp. 484-490.
    • (1970) Capillary Permeability , pp. 484-490
    • Fenstermacher, J.D.1    Rall, D.P.2
  • 44
    • 0029925070 scopus 로고    scopus 로고
    • Gene transfer to neurons using herpes simplex virus-based vectors
    • Fink DJ, DeLuca NA et al (1996). Gene transfer to neurons using herpes simplex virus-based vectors. Ann Rev Neurosci 19: 265-287.
    • (1996) Ann Rev Neurosci , vol.19 , pp. 265-287
    • Fink, D.J.1    DeLuca, N.A.2
  • 46
    • 0002233432 scopus 로고    scopus 로고
    • Pharmacology of antiretroviral agents
    • DeVita VT, Hellman S, Roxenberg SA (ed): Lippincott-Raven: Philadelphia
    • Flexner C, Hendrix C (1997). Pharmacology of antiretroviral agents. In AIDS: Biology, Diagnosis, Treatment and Prevention. DeVita VT, Hellman S, Roxenberg SA (ed): Lippincott-Raven: Philadelphia, pp. 479-493.
    • (1997) AIDS: Biology, Diagnosis, Treatment and Prevention , pp. 479-493
    • Flexner, C.1    Hendrix, C.2
  • 47
    • 0025140975 scopus 로고
    • Brain and cerebrospinal fluid uptake of zidovudine (AZT) in rats after intravenous injection
    • Galinsky RE, Hoesterey BL et al (1990). Brain and cerebrospinal fluid uptake of zidovudine (AZT) in rats after intravenous injection. Life Sci 47: 781-788.
    • (1990) Life Sci , vol.47 , pp. 781-788
    • Galinsky, R.E.1    Hoesterey, B.L.2
  • 48
    • 26844438159 scopus 로고
    • Pharmacokinetic models for anticancer and antiviral drugs following administrations as novel drug delivery systems
    • D'Argenio DZ (ed): Plenum Press: New York
    • Gallo JM (1991). Pharmacokinetic models for anticancer and antiviral drugs following administrations as novel drug delivery systems. In Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis. D'Argenio DZ (ed): Plenum Press: New York, pp. 21-36.
    • (1991) Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis , pp. 21-36
    • Gallo, J.M.1
  • 49
    • 0028457103 scopus 로고
    • Delivery of anti-HIV nucleosides to the central nervous system
    • Gallo JM (1994). Delivery of anti-HIV nucleosides to the central nervous system. Advanced Drug Deliv Rev 14: 299-309.
    • (1994) Advanced Drug Deliv Rev , vol.14 , pp. 299-309
    • Gallo, J.M.1
  • 50
    • 0030297788 scopus 로고    scopus 로고
    • Rapid distribution of intraventricularly administered sucrose into cerebrospinal fluid cisterns via subarachnoid velae in rat
    • Ghersi-Egea JF, Finnegan W, et al. (1996). Rapid distribution of intraventricularly administered sucrose into cerebrospinal fluid cisterns via subarachnoid velae in rat. Neuroscience, 75, 1271-1288.
    • (1996) Neuroscience , vol.75 , pp. 1271-1288
    • Ghersi-Egea, J.F.1    Finnegan, W.2
  • 51
    • 0030925046 scopus 로고    scopus 로고
    • Drug delivery systems: Anticancer prodrugs and their polymeric conjugates
    • Greenwald RB (1997). Drug delivery systems: anticancer prodrugs and their polymeric conjugates. Exp Opin Ther Patents 7: 601-609.
    • (1997) Exp Opin Ther Patents , vol.7 , pp. 601-609
    • Greenwald, R.B.1
  • 52
    • 0027343882 scopus 로고
    • Cerebrospinal fluid circulation and associated intracranial dynamics
    • Greitz D (1993). Cerebrospinal fluid circulation and associated intracranial dynamics. Acta Radiol 34 (Suppl): 1-23.
    • (1993) Acta Radiol , vol.34 , Issue.SUPPL. , pp. 1-23
    • Greitz, D.1
  • 53
    • 17144436717 scopus 로고
    • Pharmacology and toxicology of phosphorothioate oligonucleotides in the mouse, rat, monkey and man
    • Iversen PL, Copple BL et al (1995). Pharmacology and toxicology of phosphorothioate oligonucleotides in the mouse, rat, monkey and man. Toxicol Letters 82/83: 425-430.
    • (1995) Toxicol Letters , vol.82-83 , pp. 425-430
    • Iversen, P.L.1    Copple, B.L.2
  • 54
    • 0028896853 scopus 로고
    • 32P]-labeled phosphodiester oligonucleotide coupled to a neutral avidin/monoclonal antibody conjugate
    • 32P]-labeled phosphodiester oligonucleotide coupled to a neutral avidin/monoclonal antibody conjugate. Drug Metab Disp 23: 55-59.
    • (1995) Drug Metab Disp , vol.23 , pp. 55-59
    • Kang, Y.-S.1    Boado, R.J.2
  • 55
    • 0017294792 scopus 로고
    • Spinal subarachnoid perfusion of rhesus monkeys
    • Kessler JA, Fenstermacher JD et al (1976). Spinal subarachnoid perfusion of rhesus monkeys. Am J Physiol 230: 614-618.
    • (1976) Am J Physiol , vol.230 , pp. 614-618
    • Kessler, J.A.1    Fenstermacher, J.D.2
  • 56
    • 0029051270 scopus 로고
    • Assays for antiviral drug resistance
    • Kimberlin DW, Spector SA et al (1995). Assays for antiviral drug resistance. Antiviral Res 26: 403-413.
    • (1995) Antiviral Res , vol.26 , pp. 403-413
    • Kimberlin, D.W.1    Spector, S.A.2
  • 57
    • 0018843019 scopus 로고
    • Local cerebral blood volume in head-injured patients
    • Kuhl DE, Alavi A et al (1980). Local cerebral blood volume in head-injured patients. J Neurosurg 52: 309-320.
    • (1980) J Neurosurg , vol.52 , pp. 309-320
    • Kuhl, D.E.1    Alavi, A.2
  • 58
    • 0014810671 scopus 로고
    • Blood volume, hematocrit and pressure relationship in the isolated perfused dog brain
    • Levin VA, Gilboe DD (1970). Blood volume, hematocrit and pressure relationship in the isolated perfused dog brain. Stroke 1: 270-277.
    • (1970) Stroke , vol.1 , pp. 270-277
    • Levin, V.A.1    Gilboe, D.D.2
  • 59
    • 0030919747 scopus 로고    scopus 로고
    • Alternative delivery systems for antiviral nucleosides and antisense oligonucleotides to the brain
    • Levy RM, Ward S, et al. (1997). Alternative delivery systems for antiviral nucleosides and antisense oligonucleotides to the brain. J Neurovirol, 3, S74-S75.
    • (1997) J Neurovirol , vol.3
    • Levy, R.M.1    Ward, S.2
  • 60
    • 0029974065 scopus 로고    scopus 로고
    • Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor
    • Lin JH, Chiba M et al (1996). Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor. Drug Metab Disp 1111-1120.
    • (1996) Drug Metab Disp , pp. 1111-1120
    • Lin, J.H.1    Chiba, M.2
  • 61
    • 0028960524 scopus 로고
    • Delivery of angiotensin II type 1 receptor antisense inhibits angiotensin action in neurons from hypertensive rat brain
    • Lu D, Raizada MK (1995). Delivery of angiotensin II type 1 receptor antisense inhibits angiotensin action in neurons from hypertensive rat brain. Proc Natl Acad Sci USA 92: 2914-2918.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2914-2918
    • Lu, D.1    Raizada, M.K.2
  • 62
    • 0028299612 scopus 로고
    • In vitro and in vivo transport of zidovudine (AZT) across the blood brain barrier and the effect of transport inhibitors
    • Masereeuw R, Jaehde U et al (1994). In vitro and in vivo transport of zidovudine (AZT) across the blood brain barrier and the effect of transport inhibitors. Pharm Res 11: 324-330.
    • (1994) Pharm Res , vol.11 , pp. 324-330
    • Masereeuw, R.1    Jaehde, U.2
  • 63
    • 0028876310 scopus 로고
    • Antisense oligonucleotide inhibition of tryptophan hydroxylase activity in mouse brain
    • McCarthy MM, Nielsen DA et al (1995). Antisense oligonucleotide inhibition of tryptophan hydroxylase activity in mouse brain. Regulatory Peptides 59: 163-170.
    • (1995) Regulatory Peptides , vol.59 , pp. 163-170
    • McCarthy, M.M.1    Nielsen, D.A.2
  • 64
    • 0027169360 scopus 로고
    • Enduring consequences of neonatal treatment with antisense oligodeoxynucleotides to estrogen receptor messenger ribonucleic acid on sexual differentiation of rat brain
    • McCarthy MM, Schlenker EH et al (1993). Enduring consequences of neonatal treatment with antisense oligodeoxynucleotides to estrogen receptor messenger ribonucleic acid on sexual differentiation of rat brain. Endocrinology 133: 433-439.
    • (1993) Endocrinology , vol.133 , pp. 433-439
    • McCarthy, M.M.1    Schlenker, E.H.2
  • 65
    • 0016763145 scopus 로고
    • The third circulation revisited
    • Milhorat TH (1975). The third circulation revisited. J Neurosurg 42: 628-645.
    • (1975) J Neurosurg , vol.42 , pp. 628-645
    • Milhorat, T.H.1
  • 66
    • 0030435368 scopus 로고    scopus 로고
    • Quantitative assessment of blood-brain barrier damage during microdialysis
    • Morgan ME, Singhal D et al (1996). Quantitative assessment of blood-brain barrier damage during microdialysis. J Pharmacol Exp Ther 277: 1167-1176.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1167-1176
    • Morgan, M.E.1    Singhal, D.2
  • 67
    • 0028144703 scopus 로고
    • High flow microinfusion: Tissue penetration and pharmacodynamics
    • Morrison PF, Laske DW et al (1994). High flow microinfusion: tissue penetration and pharmacodynamics. Am J Physiol 266: R292-305.
    • (1994) Am J Physiol , vol.266
    • Morrison, P.F.1    Laske, D.W.2
  • 68
    • 0023778704 scopus 로고
    • Dexamethasone effects on vascular volume and tissue hematocrit in experimental RG-2 gliomas and adjacent brain
    • Nakagawa H, Groothuis DR et al (1988). Dexamethasone effects on vascular volume and tissue hematocrit in experimental RG-2 gliomas and adjacent brain. J Neurooncol 6: 157-168.
    • (1988) J Neurooncol , vol.6 , pp. 157-168
    • Nakagawa, H.1    Groothuis, D.R.2
  • 69
    • 0027380431 scopus 로고
    • Pharmacokinetic quantification of the exchange of drugs between blood and cerebrospinal fluid in man
    • Nau R, Zysk G et al (1993). Pharmacokinetic quantification of the exchange of drugs between blood and cerebrospinal fluid in man. Europ J Clin Pharmacol 45, 469-475.
    • (1993) Europ J Clin Pharmacol , vol.45 , pp. 469-475
    • Nau, R.1    Zysk, G.2
  • 70
    • 0018237164 scopus 로고
    • Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat
    • Ohno K, Pettigrew KD et al (1978). Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat. Am J Physiol 235: H299-H307.
    • (1978) Am J Physiol , vol.235
    • Ohno, K.1    Pettigrew, K.D.2
  • 71
    • 0014888279 scopus 로고
    • Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard
    • Oldendorf WH (1970). Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard. Brain Res 24: 372-376.
    • (1970) Brain Res , vol.24 , pp. 372-376
    • Oldendorf, W.H.1
  • 72
    • 0027982389 scopus 로고
    • Quantitative approaches to in vivo brain microdialysis
    • Parsons LH, Justice JB (1994). Quantitative approaches to in vivo brain microdialysis. Critical Rev Neurobiol 8: 189-220.
    • (1994) Critical Rev Neurobiol , vol.8 , pp. 189-220
    • Parsons, L.H.1    Justice, J.B.2
  • 73
    • 0016714197 scopus 로고
    • Measurements of dog blood-brain transfer constants by ventriculocisternal perfusion
    • Patlak CS, Fenstermacher JD (1975). Measurements of dog blood-brain transfer constants by ventriculocisternal perfusion. Am J Physiol 229: 877-884.
    • (1975) Am J Physiol , vol.229 , pp. 877-884
    • Patlak, C.S.1    Fenstermacher, J.D.2
  • 74
    • 0020956774 scopus 로고
    • Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data
    • Patlak CS, Blasberg RG et al (1983). Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3: 1-7.
    • (1983) J Cereb Blood Flow Metab , vol.3 , pp. 1-7
    • Patlak, C.S.1    Blasberg, R.G.2
  • 77
    • 0012033401 scopus 로고
    • Passage of proteins from blood to cerebrospinal fluid. Model for transfer by pores and vesicles
    • Wood JH (ed): Plenum Press: New York
    • Rapoport SI (1983). Passage of proteins from blood to cerebrospinal fluid. Model for transfer by pores and vesicles. In Neurobiology of Cerebrospinal Fluid. Wood JH (ed): Plenum Press: New York, pp. 233-246.
    • (1983) Neurobiology of Cerebrospinal Fluid , pp. 233-246
    • Rapoport, S.I.1
  • 78
    • 13344292421 scopus 로고
    • Transport of potassium-42 from blood to tissue in isolated mammalian skeletal muscle
    • Renkin EM (1959). Transport of potassium-42 from blood to tissue in isolated mammalian skeletal muscle. Am J Physiol 197: 1205-1210.
    • (1959) Am J Physiol , vol.197 , pp. 1205-1210
    • Renkin, E.M.1
  • 79
    • 0025214285 scopus 로고
    • Model for drug uptake by brain tumors: Effect of osmotic treatment and of diffusion in brain
    • Robinson PJ, Rapoport SI (1990). Model for drug uptake by brain tumors: effect of osmotic treatment and of diffusion in brain. J Cereb Blood Flow Metab 10: 153-161.
    • (1990) J Cereb Blood Flow Metab , vol.10 , pp. 153-161
    • Robinson, P.J.1    Rapoport, S.I.2
  • 80
    • 0018903891 scopus 로고
    • Bulk flow of brain interstitial fluid under normal and hyperosmolar conditions
    • Rosenberg GA, Kyner WT et al (1980). Bulk flow of brain interstitial fluid under normal and hyperosmolar conditions. Am J Physiol 238: F42-F49.
    • (1980) Am J Physiol , vol.238
    • Rosenberg, G.A.1    Kyner, W.T.2
  • 81
    • 0028117635 scopus 로고
    • Pharmacokinetics, tissue distribution, and stability of antisense oligonucleotide phosphorothioate ISIS 3466 in mice
    • Saijo Y, Perlaky L et al (1994). Pharmacokinetics, tissue distribution, and stability of antisense oligonucleotide phosphorothioate ISIS 3466 in mice. Oncol Res 6: 243-249.
    • (1994) Oncol Res , vol.6 , pp. 243-249
    • Saijo, Y.1    Perlaky, L.2
  • 82
    • 0021963338 scopus 로고
    • Regional cerebral blood volume and hematocrit measured in normal human volunteers by single-photon emission computed tomography
    • Sakai F, Nakazawa K et al (1985). Regional cerebral blood volume and hematocrit measured in normal human volunteers by single-photon emission computed tomography. J Cereb Blood Flow Metab 5: 207-213.
    • (1985) J Cereb Blood Flow Metab , vol.5 , pp. 207-213
    • Sakai, F.1    Nakazawa, K.2
  • 83
    • 0028180664 scopus 로고
    • Intracerebroventricular administration of AT1 receptor antisense oligonucleotides inhibits the behavioral actions of angiotensin II
    • Sakai RR, He PF et al (1994). Intracerebroventricular administration of AT1 receptor antisense oligonucleotides inhibits the behavioral actions of angiotensin II. J Neurochem 62: 2053-2056.
    • (1994) J Neurochem , vol.62 , pp. 2053-2056
    • Sakai, R.R.1    He, P.F.2
  • 84
    • 0028788962 scopus 로고
    • Intracerebroventricular administration of angiotensin type 1 (AT1) receptor antisense oligonucleotides attenuate thirst in the rat
    • Sakai RR, Ma LY et al (1995). Intracerebroventricular administration of angiotensin type 1 (AT1) receptor antisense oligonucleotides attenuate thirst in the rat. (Regulatory Peptides 59: 183-192.
    • (1995) Regulatory Peptides , vol.59 , pp. 183-192
    • Sakai, R.R.1    Ma, L.Y.2
  • 86
    • 0017359125 scopus 로고
    • Model for transport in the CNS
    • Spector R, Spector AZ et al (1977). Model for transport in the CNS. Am J Physiol 232: R73-R79.
    • (1977) Am J Physiol , vol.232
    • Spector, R.1    Spector, A.Z.2
  • 87
    • 0019126174 scopus 로고
    • Thymidine transport in the CNS
    • Spector R (1980). Thymidine transport in the CNS. J Neurochem 35: 1092-1098.
    • (1980) J Neurochem , vol.35 , pp. 1092-1098
    • Spector, R.1
  • 88
    • 0019986123 scopus 로고
    • Pharmacokinetics and metabolism of cytosine arabinoside in the central nervous system
    • Spector R (1982). Pharmacokinetics and metabolism of cytosine arabinoside in the central nervous system. J Pharmacol Exp Ther 222: 1-6.
    • (1982) J Pharmacol Exp Ther , vol.222 , pp. 1-6
    • Spector, R.1
  • 89
    • 0021328577 scopus 로고
    • Deoxynucleoside and vitamin transport into the central nervous system
    • Spector R, Eells J (1984). Deoxynucleoside and vitamin transport into the central nervous system. Fed Proc 43: 196-200.
    • (1984) Fed Proc , vol.43 , pp. 196-200
    • Spector, R.1    Eells, J.2
  • 90
    • 0021933963 scopus 로고
    • Thymidine transport and metabolism in choroid plexus: Effect of diazepam and thiopental
    • Spector R (1985a). Thymidine transport and metabolism in choroid plexus: effect of diazepam and thiopental. J Pharmacol Exp Ther 235: 16-19.
    • (1985) J Pharmacol Exp Ther , vol.235 , pp. 16-19
    • Spector, R.1
  • 91
    • 0022235662 scopus 로고
    • Uridine transport and metabolism in the central nervous system
    • Spector R (1985b). Uridine transport and metabolism in the central nervous system. J Neurochem 45: 1411-1418.
    • (1985) J Neurochem , vol.45 , pp. 1411-1418
    • Spector, R.1
  • 92
    • 0027232178 scopus 로고
    • Microdialysis in pharmacokinetics
    • Stahle L (1993). Microdialysis in pharmacokinetics. Europ J Drug Metab Pharmacokin 18: 89-96.
    • (1993) Europ J Drug Metab Pharmacokin , vol.18 , pp. 89-96
    • Stahle, L.1
  • 93
    • 0029146043 scopus 로고
    • Antisense oligodeoxyribonucleotides: Stability and distribution after intracerebral injection into rat brain
    • Szklarczyk A, Kaczmarek L (1995). Antisense oligodeoxyribonucleotides: stability and distribution after intracerebral injection into rat brain. J Neurosci Methods 60: 181-187.
    • (1995) J Neurosci Methods , vol.60 , pp. 181-187
    • Szklarczyk, A.1    Kaczmarek, L.2
  • 94
    • 0030977086 scopus 로고    scopus 로고
    • In vivo evidence for carrier-mediated efflux transport of 3′-azido-3′-deoxythymidine and 2′,3′-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system
    • Takasawa K, Terasaki T et al (1997). In vivo evidence for carrier-mediated efflux transport of 3′-azido-3′-deoxythymidine and 2′,3′-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system. J Pharmacol Exp Ther 369-375.
    • (1997) J Pharmacol Exp Ther , pp. 369-375
    • Takasawa, K.1    Terasaki, T.2
  • 95
    • 0023820733 scopus 로고
    • Restricted transport of 3′-azido-3′-deoxythymidine and dideoxynucleosides through the blood-brain barrier
    • Terasaki T, Pardridge WM (1988). Restricted transport of 3′-azido-3′-deoxythymidine and dideoxynucleosides through the blood-brain barrier. J Infect Dis 158: 630-632.
    • (1988) J Infect Dis , vol.158 , pp. 630-632
    • Terasaki, T.1    Pardridge, W.M.2
  • 96
    • 0030294795 scopus 로고    scopus 로고
    • Drug delivery to brain tumors
    • Walker WL, Cook J (1996). Drug delivery to brain tumors. Bull Mathemat Biol 58: 1047-1074.
    • (1996) Bull Mathemat Biol , vol.58 , pp. 1047-1074
    • Walker, W.L.1    Cook, J.2
  • 97
    • 0030029362 scopus 로고    scopus 로고
    • In vivo biodistribution, pharmacokinetic parameters, and brain uptake of 5-halo-y-methoxy (or ethoxy)-5,6-dihydro-3′-azido-3′-deoxythymidine diastereomers as potential prodrugs of 3′-azido-3′-deoxythymidine
    • Wang L, Morin KW et al (1996). In vivo biodistribution, pharmacokinetic parameters, and brain uptake of 5-halo-y-methoxy (or ethoxy)-5,6-dihydro-3′-azido-3′-deoxythymidine diastereomers as potential prodrugs of 3′-azido-3′-deoxythymidine. J Med Chem 826-833.
    • (1996) J Med Chem , pp. 826-833
    • Wang, L.1    Morin, K.W.2
  • 98
    • 0029013672 scopus 로고
    • Zidovudine transport in the rabbit brain during intravenous and intracerebroventricular infusion
    • Wang Y, Sawchuk RJ (1995). Zidovudine transport in the rabbit brain during intravenous and intracerebroventricular infusion. J Pharm Sci 84: 871 -876.
    • (1995) J Pharm Sci , vol.84 , pp. 871-876
    • Wang, Y.1    Sawchuk, R.J.2
  • 99
    • 0028986487 scopus 로고
    • Targeting HIV-1 protease: A test of drug-design methodologies
    • West ML, Fairlie DP (1995). Targeting HIV-1 protease: a test of drug-design methodologies. Trend in Pharm Sci 16: 67-75.
    • (1995) Trend in Pharm Sci , vol.16 , pp. 67-75
    • West, M.L.1    Fairlie, D.P.2
  • 100
    • 0028873172 scopus 로고
    • Intracerebral dialysis and the blood brain barrier
    • Westergren I, Nystrom B et al (1995). Intracerebral dialysis and the blood brain barrier. J Neurochem 64, 229-234.
    • (1995) J Neurochem , vol.64 , pp. 229-234
    • Westergren, I.1    Nystrom, B.2
  • 101
    • 0027298897 scopus 로고
    • Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: Implications for therapeutic application with the central nervous system
    • Whitesell L, Geselowitz D et al (1993). Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: Implications for therapeutic application with the central nervous system. Proc Natl Acad Sci USA 90: 4665-4669.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4665-4669
    • Whitesell, L.1    Geselowitz, D.2
  • 102
    • 0027769788 scopus 로고
    • Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: Investigation of the inhibitory effect of probenecid utilizing microdialysis
    • Wong SL, Van Belle K et al (1993). Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: investigation of the inhibitory effect of probenecid utilizing microdialysis. J Pharm Exp Ther 264: 899-909.
    • (1993) J Pharm Exp Ther , vol.264 , pp. 899-909
    • Wong, S.L.1    Van Belle, K.2
  • 104
    • 0029925704 scopus 로고    scopus 로고
    • 3H]-biotinylated phosphorothioate oligodeoxynucleotide conjugated to a vector-mediated drug delivery system
    • 3H]-biotinylated phosphorothioate oligodeoxynucleotide conjugated to a vector-mediated drug delivery system. J Pharmacol Exp Ther 276: 206-211.
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 206-211
    • Wu, D.1    Boado, R.J.2
  • 105
    • 0028884696 scopus 로고
    • Distribution of phosphodiester and phosphorothioate oligonucleotides in rat brain after intraventricular and intrahippocampal administration determined by in situ hybridization
    • Yaida Y, Nowak TS (1995). Distribution of phosphodiester and phosphorothioate oligonucleotides in rat brain after intraventricular and intrahippocampal administration determined by in situ hybridization. Regulatory Peptides 59: 193-199.
    • (1995) Regulatory Peptides , vol.59 , pp. 193-199
    • Yaida, Y.1    Nowak, T.S.2


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