HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter

Biochemistry

Volumn 37, Issue 11, 1998, Pages 3594-3601

  Lee, Caroline G L ^a   Gottesman, Michael M ^a   Cardarelli, Carol O ^a   Ramachandra, Muralidhara ^a,c   Jeang, Kuan Teh ^b   Ambudkar, Suresh V ^a   Pastan, Ira ^a   Dey, Saibal ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DAUNORUBICIN; GAG PROTEIN; GLYCOPROTEIN P; INDINAVIR; POL PROTEIN; PRAZOSIN; PROTEINASE INHIBITOR; RHODAMINE; RITONAVIR; SAQUINAVIR; VALSPODAR; VERAPAMIL; VINBLASTINE;

ANIMAL CELL; ARTICLE; DRUG ACCUMULATION; DRUG MECHANISM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INSECT; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; STRUCTURAL GENE; VIRUS REPLICATION; VIRUS RESISTANCE;

3T3 CELLS; ADENOSINE TRIPHOSPHATASES; AFFINITY LABELS; ANIMALS; AZIDES; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT; CARCINOMA, SQUAMOUS CELL; DRUG RESISTANCE, MULTIPLE; ENZYME ACTIVATION; GENES, MDR; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; IODINE RADIOISOTOPES; MICE; P-GLYCOPROTEIN; PRAZOSIN; SPODOPTERA; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED; VINBLASTINE;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; INSECTA; UNIDENTIFIED BACULOVIRUS;

EID: 0032540001     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi972709x     Document Type: Article

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