Effects of a potent and specific P-glycoprotein inhibitor on the blood- brain barrier distribution and antinoclceptive effect of morphine in the rat

Drug Metabolism and Disposition

Volumn 27, Issue 7, 1999, Pages 827-834

  Letrent, Stephen P ^a,c   Pollack, Gary M ^a   Brouwer, Kenneth R ^b   Brouwer, Kim L R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b GLAXOSMITHKLINE   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELACRIDAR; GLYCOPROTEIN P; MORPHINE DERIVATIVE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG HALF LIFE; EXTRACELLULAR FLUID; INTRAVENOUS DRUG ADMINISTRATION; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ACRIDINES; ANALGESICS, OPIOID; ANIMALS; AREA UNDER CURVE; BLOOD-BRAIN BARRIER; CEREBRAL CORTEX; ISOQUINOLINES; MALE; MICRODIALYSIS; MORPHINE; P-GLYCOPROTEIN; RATS; RATS, SPRAGUE-DAWLEY; TETRAHYDROISOQUINOLINES;

ANIMALIA;

EID: 0033060742     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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