Evidence for different ABC transporters in Caco-2 cells modulating drug uptake

Pharmaceutical Research

Volumn 16, Issue 3, 1999, Pages 402-407

  Gutmann, Heike ^a   Fricker, Gert ^b   Török, Michael ^a   Michael, Susanne ^b   Beglinger, Christoph ^a   Drewe, Jürgen ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b Inst for Pharmaceut/Biopharm   (Germany)

Author keywords

Caco 2 cells; MDR; MRP; Multidrug resistance related protein; P glycoprotein

Indexed keywords

ABC TRANSPORTER; CYCLOSPORIN A; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; VALSPODAR; VERLUKAST;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG UPTAKE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INTESTINE ABSORPTION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0032905375     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018825819249     Document Type: Article

References (30)

1. 1. A. Lorico, G. Rappa, R. A. Finch, D. Yang, R. A. Flavell, and A. C. Sartorelli. Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione. Cancer Res. 57:5238-5242 (1997).
2. 2. M. M. Gottesman and I. Pastan. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62:385-427 (1993).
3. 3. D. Keppler, I. Leier, and G. Jedlitschky. Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2. Biol. Chem. 378:787-791 (1997).
4. 4. T. Fujita, H. Yamada, M. Fukuzumi, A. Nishimaki, A. Yamamoto, and S. Muranishi. Calcein is excreted from the intestinal mucosal cell membrane by the active transport system. Life Sci. 60:307-313 (1997).
5. 5. A. Tsuji and I. Tamai. Carrier-mediated intestinal transport of drugs. Pharm. Res. 13:963-977 (1996).
6. 6. G. Fricker, J. Drewe, J. Huwyler, H. Gutmann, and C. Beglinger. Relevance of P-glycoprotein for the enterai absorption of cyclosporin A: in vitro-in vivo correlation. Br. J. Pharmacol. 118:1841-1847 (1996).
7. 7. A. Sparreboom, J. van-Asperen, U. Mayer, A. H. Schinkel, J. W. Smit, D. K. Meijer, P. Borst, W. J. Nooijen, J. H. Beijnen, and O. van Tellingen. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc. Natl. Acad. Sci. USA. 94:2031-2035 (1997).
8. 8. R. B. Kim, M. F. Fromm, C. Wandel, B. Leake, A. J. Wood, D. M. Roden, and G. R. Wilkinson. The drug transporter p-glycoprotein limits oral absorption and brain entry of HIV-1 proteinase inhibitors. J. Clin. Invest. 101:289-294 (1998).
9. 9. J. Alsenz, H. Steffen, and R. Alex. Active apical scretory efflux of the HIV-protease inhibitors saquinavir and ritonavir in Caco-2 cell monolayers. Pharm. Res. 15:423-428 (1998).
10. 10. J. Karlsson, S. M. Kuo, J. Ziemniak, and P. Artursson. Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein. Br. J. Pharmacol. 110:1009-1016 (1993).
11. 11. H. Lennernas. Human jejunal effective permeability and its correlation with preclinical drug absorption models. J. Pharm. Pharmacol. 49:627-638 (1997).
12. 12. P. Anderle, E. Nederer, W. Rubas, C. Hilgendorf, H. Spahn-Langguth, H. Wunderli-Allenspach, H. P. Merkle, and P. Langguth. P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels. J Pharm. Sci. 87:757-762 (1998).
13. 13. P. Artursson. Epithelial transport of drugs in cell culture. I.: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells. J. Pharm. Sci. 79:476-482 (1990).
14. 14. A. R. Hilgers, R. A. Conradi, and P. S. Burton. Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa. Pharm Res 7:902-910 (1990).
15. 15. H. Lennernäs. Human jejunal effective permeability and its correlation with preclinical drug absorption models. J. Pharm. Pharmacol. 49:627-638 (1997).
16. 16. T. Abe, T. Mori, S. Hori, K. Koike, and M. Kuwano. Multidrug resistance protein (MRP). Nippon Rinsho 55:1077-1082 (1997).
17. 17. M. Kavallaris. The role of multidrug resistance-associated protein (MRP) expression in multidrug resistance. Anticancer Drugs 8:17-25 (1997).
18. 18. M. Müller and P. L. Jansen. Molecular aspects of hepatobiliary transport. Am. J. Physiol. 272:G1285-1303 (1997).
19. 19. H. Roelofsen, T. A. Vos, I. J. Schippers, F. Kuipers, H. Koning, H. Moshage, P. L. Jansen, and M. Müller. Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells. Gastroenterology 112:511-521 (1997).
20. 20. S. E. Mirski and S. P. Cole. Antigens associated with multidrug resistance in H69AR, a small cell lung cancer cell line. Cancer Res. 49:5719-5724 (1989).
21. 21. S. P. Cole, G. Bhardwaj, J. H. Gerlach, J. E. Mackie, C. E. Grant, K. C. Almquist, A. J. Stewart, E. U. Kurz, A. M. Duncan, and R. G. Deeley. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258:1650-1654 (1992).
22. 22. M. J. Flens, G. J. Zaman, P. van der Valk, M. A. Izquierdo, A. B. Schroeijers, G. L. Scheffer, P. van der Groep, M. de Haas, C. J. Meijer, and R. J. Scheper. Tissue distribution of the multidrug resistance protein. Am. J. Pathol 148:1237-1247 (1996).
23. 23. M. E. Cavet, M. West, and N. L. Simmons. Fluoroquinolone (ciprofloxacin) secretion by human intestinal epithelial (Caco-2) cells. Br. J. Pharmacol. 121:1567-1578 (1997).
24. 24. P. F. Augustijns, T. P. Bradshaw, L. S. Gan, R. W. Hendren, and D. R. Thakker. Evidence for a polarized efflux system in CACO-2 cells capable of modulating cyclosporin A transport. Biochem. Biophys. Res, Commun. 197:360-365 (1993).
25. 25. T. Terao, E. Hisanaga, Y. Sai, I. Tamai, and A. Tsuji : Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier. J. Pharm. Pharmacol. 48:1083-1089 (1996).
26. 26. K. I. Hosoya, K. J. Kim, and V. H. Lee. Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers. Pharm. Res. 13:885-890 (1996).
27. 27. M. A. Barrand, A. C. Heppell-Parton, K. A. Wright, P. H. Rabbitts, and P. R. Twentyman. A 190-kilodalton protein overexpressed in non-p-glycoprotein-containing multidrug-resistant cells and its relationship to the MRP gene. J. Natl. Cancer Inst. 86:110-117 (1994).
28. 28. S. P. Cole, K. E. Sparks, K. Fraser, D. W. Loe, C. E. Grant, G. M. Wilson, and R. G. Deely. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res. 54:5902-5910 (1994).
29. 29. G. Fricker and A. Fahr. Mechanisms of hepatic transport of cylosporin A-an explanation of its cholestatic action? Yale J. Biol. Med. 71:379-390 (1997).
30. 30. T. Fujita, H. Yamada, M. Fukuzumi, A. Nishimaki, A. Yamamoto, and S. Muranishi. Calcein is excreted from the intestinal mucosal cell membrane by the active transport system. Life Sci. 60:307-13 (1997).