Modulation of multidrug resistance protein expression in porcine brain capillary endothelial cells in vitro

Drug Metabolism and Disposition

Volumn 27, Issue 8, 1999, Pages 937-941

  Gutmann, Heike ^a   Török, Michael ^a   Fricker, Gert ^b   Huwyler, Jörg ^a,c   Beglinger, Christoph ^a   Drewe, Jürgen ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b Inst Pharmaceut and Biopharmacy   (Germany)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MULTIDRUG RESISTANCE PROTEIN; VERLUKAST; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN METABOLISM; CAPILLARY ENDOTHELIUM; CELL CULTURE; CONTROLLED STUDY; DRUG TRANSPORT; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SWINE;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BLOTTING, WESTERN; BRAIN CHEMISTRY; BRONCHODILATOR AGENTS; CAPILLARIES; CARCINOMA, SMALL CELL; ENDOTHELIUM, VASCULAR; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROPIONATES; QUINOLINES; SUBCELLULAR FRACTIONS; SWINE; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0345593808     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Almquist KC, Loe DW, Hipfner DR, Mackie JE, Cole SP and Deeley RG (1995) Characterization of the M(r) 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cell. Cancer Res 55:102-110.
2. Audus KL and Borchardt RT (1987) Bovine brain microvessel endothelial cell monolayers as a model system for the blood-brain barrier. Ann NY Acad Sci 507:9-18.
3. Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM and Deeley RG (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line [see comments]. Science (Wash DC) 258:1650-1654.
4. Flens MJ, Izquierdo MA, Scheffer GL, Fritz JM, Meijer CJ, Scheper RJ and Zaman GJ (1994) Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies. Cancer Res 54:4557-4563.
5. Flens MJ, Zaman GJ, van der Valk P, Izquierdo MA, Schroeijers AB, Scheffer GL, van der Groep P, de Haas M, Meijer CJ and Scheper RJ (1996) Tissue distribution of the multidrug resistance protein. Am J Pathol 148:1237-1247.
6. Gekeler V, Ise W, Sanders KH, Ulrich WR and Beck J (1995) The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance. Biochem Biophys Res Commun 208:345-352.
7. Gottesman MM and Pastan I (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Anna Rev Biochem 62:385-427.
8. Huai-Yun H, Secrest DT, Mark KS, Carney D, Brandquist C, Elmquist WF and Miller DW (1998) Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells. Biochem Biophys Res Commun 243:816-820.
9. Huwyler J, Drewe J, Klusemann C and Fricker G (1996) Evidence for P-glycoprotein-modulated penetration of morphine-6-glucuronide into brain capillary endothelium. Br J Pharmacol 118:1879-1885.
10. Kruh GD, Gaughan KT, Godwin A and Chan A (1995) Expression pattern of MRP in human tissues and adult solid tumor cell lines. J Natl Cancer Inst 87:1256-1258.
11. Leier I, Jedlitschky G, Buchholz U, Center M, Cole SP, Deeley RG and Keppler D (1996) ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. Biochem J 314:433-437.
12. Mirski SE and Cole SP (1989) Antigens associated with multidrug resistance in H69AR, a small cell lung cancer cell line. Cancer Res 49:5719-5724.
13. Mirski SE, Gerlach JH and Cole SP (1987) Multidrug resistance in a human small cell lung cancer cell line selected in Adriamycin. Cancer Res 47:2594-2598.
14. Müller M, Meijer C, Zaman GJ, Borst P, Scheper RJ, Mulder NH, de Vries EG and Jansen PL (1994) Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl Acad Sci USA 91:13033-13037.
15. Muruganandam A, Herx LM, Monette R, Durkin JP and Stanimirovic DB (1997) Development of immortalized human cerebromicrovascular endothelial cell line as an in vitro model of the human blood-brain barrier. FASEB J 11:1187-1197.
16. Narasaki F, Matsuo I, Ikuno N, Fukuda M, Soda H and Oka M (1996) Multidrug resistance-associated protein (MRP) gene expression in human lung cancer. Anticancer Res 16:2079-2082.
17. Nooter K, Brutel de la Riviere G, Look MP, van Wingerden KE, Henzen-Logmans SC, Scheper RJ, Flens MJ, Klijn JG, Stoter G and Foekens JA (1997) The prognostic significance of expression of the multidrug resistance-associated protein (MRP) in primary breast cancer. Br J Cancer 76:486-493.
18. Nooter K, de la Riviere GB, Klijn J, Stoter G and Foekens J (1997) Multidrug resistance protein in recurrent breast cancer (Letter). Lancet 349:1885-1886.
19. Regina A, Koman A, Piciotti M, El Hafny B, Center MS, Bergmann R, Couraud PO and Roux F (1998) Mrpl multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells. J Neurochem 71:705-715.
20. Roelofsen H, Vos TA, Schippers IJ, Kuipers F, Koning H, Moshage H, Jansen PL and Müller M (1997) Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells. Gastroenterology 112:511-521.
21. Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CA, van der Valk MA, Robanus-Maandag EC, te Riele HP, te Riele HPJ, Berns AJM and Borst P (1994) Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502.
22. Schinkel AH, Wagenaar E, Mol CA and van Deemter L (1996) P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 97:2517-2524.
23. Seetharaman S, Barrand MA, Maskell L and Scheper RJ (1998) Multidrug resistance-related transport proteins in isolated human brain microvessels and in cells cultured from these isolates. J Neurochem 70:1151-1159.
24. Tsuji A, Tamai I, Sakata A, Tenda Y and Terasaki T (1993) Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein. Biochem Pharmacol 46:1096-1099.
25. Welters MJ, Fichtinger-Schepmann AM, Baan RA, Flens MJ, Scheper RJ and Braakhuis BJ (1998) Role of glutathione, glutathione S-transferases and multidrug resistance-related proteins in cisplatin sensitivity of head and neck cancer cell lines. Br J Cancer 77:556-561.